Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products
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Title
Advanced control strategies for bioprocess chromatography: Challenges and opportunities for intensified processes and next generation products
Authors
Keywords
Process control, Biopharmaceuticals, Mechanistic modelling, Process intensification, Process analytical technology, Real-time release testing
Journal
JOURNAL OF CHROMATOGRAPHY A
Volume 1639, Issue -, Pages 461914
Publisher
Elsevier BV
Online
2021-01-18
DOI
10.1016/j.chroma.2021.461914
References
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Note: Only part of the references are listed.- Process‐wide control and automation of an integrated continuous manufacturing platform for antibodies
- (2020) Fabian Feidl et al. BIOTECHNOLOGY AND BIOENGINEERING
- Estimated Research and Development Investment Needed to Bring a New Medicine to Market, 2009-2018
- (2020) Olivier J. Wouters et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- A critical review of recent trends, and a future perspective of optical spectroscopy as PAT in biopharmaceutical downstream processing
- (2020) Laura Rolinger et al. ANALYTICAL AND BIOANALYTICAL CHEMISTRY
- Model-based design and control of a small-scale integrated continuous end-to-end mAb platform
- (2020) Joaquín Gomis-Fons et al. BIOTECHNOLOGY PROGRESS
- Technology outlook for real‐time quality attribute and process parameter monitoring in biopharmaceutical development—A review
- (2020) Dhanuka P. Wasalathanthri et al. BIOTECHNOLOGY AND BIOENGINEERING
- Toward in silico CMC: An industrial collaborative approach to model‐based process development
- (2020) David Roush et al. BIOTECHNOLOGY AND BIOENGINEERING
- Mechanistic Modeling of Preparative Column Chromatography for Biotherapeutics
- (2020) Vijesh Kumar et al. Annual Review of Chemical and Biomolecular Engineering
- Process Analytical Technologies and Data Analytics for the Manufacture of Monoclonal Antibodies
- (2020) Murali K. Maruthamuthu et al. TRENDS IN BIOTECHNOLOGY
- High-Throughput Raman Spectroscopy Combined with Innovate Data Analysis Workflow to Enhance Biopharmaceutical Process Development
- (2020) Stephen Goldrick et al. Processes
- Real‐time monitoring and model‐based prediction of purity and quantity during a chromatographic capture of fibroblast growth factor 2
- (2019) Dominik Georg Sauer et al. BIOTECHNOLOGY AND BIOENGINEERING
- A new flow cell and chemometric protocol for implementing in‐line Raman spectroscopy in chromatography
- (2019) Fabian Feidl et al. BIOTECHNOLOGY PROGRESS
- An overview of mechanistic modeling of liquid chromatography
- (2019) Lalita K. Shekhawat et al. PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
- Assisting continuous biomanufacturing through advanced control in downstream purification
- (2019) Maria M. Papathanasiou et al. COMPUTERS & CHEMICAL ENGINEERING
- Analytical tools for monitoring changes in physical and chemical properties of chromatography resin upon reuse
- (2019) Mili Pathak et al. ELECTROPHORESIS
- Combining Mechanistic Modeling and Raman Spectroscopy for Monitoring Antibody Chromatographic Purification
- (2019) Feidl et al. Processes
- An NIR‐based PAT approach for real‐time control of loading in Protein A chromatography in continuous manufacturing of monoclonal antibodies
- (2019) Garima Thakur et al. BIOTECHNOLOGY AND BIOENGINEERING
- On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements
- (2018) Stephen Goldrick et al. Biotechnology Journal
- Selective protein quantification for preparative chromatography using variable pathlength UV/Vis spectroscopy and partial least squares regression
- (2018) Nina Brestrich et al. CHEMICAL ENGINEERING SCIENCE
- Chromatography Analysis and Design Toolkit (CADET)
- (2018) Samuel Leweke et al. COMPUTERS & CHEMICAL ENGINEERING
- Process analytical technology in continuous manufacturing of a commercial pharmaceutical product
- (2018) Jenny M. Vargas et al. INTERNATIONAL JOURNAL OF PHARMACEUTICS
- The Increasingly Human and Profitable Monoclonal Antibody Market
- (2018) António L. Grilo et al. TRENDS IN BIOTECHNOLOGY
- On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements
- (2018) Stephen Goldrick et al. Biotechnology Journal
- Multi-angle light scattering as a process analytical technology measuring real-time molecular weight for downstream process control
- (2018) Bhumit A. Patel et al. mAbs
- Model-assisted process characterization and validation for a continuous two-column protein A capture process
- (2018) Daniel Baur et al. BIOTECHNOLOGY AND BIOENGINEERING
- Process intensification in biologics manufacturing
- (2018) J. Strube et al. CHEMICAL ENGINEERING AND PROCESSING
- Prediction uncertainty assessment of chromatography models using Bayesian inference
- (2018) Till Briskot et al. JOURNAL OF CHROMATOGRAPHY A
- Biopharmaceutical benchmarks 2018
- (2018) Gary Walsh NATURE BIOTECHNOLOGY
- Upstream process intensification and continuous manufacturing
- (2018) Chun Chen et al. Current Opinion in Chemical Engineering
- Implementation of a fluorescence based PAT control for fouling of protein A chromatography resin
- (2017) Mili Pathak et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology
- (2017) Matthias Rüdt et al. JOURNAL OF CHROMATOGRAPHY A
- Definition and dynamic control of a continuous chromatography process independent of cell culture titer and impurities
- (2017) Rebecca A. Chmielowski et al. JOURNAL OF CHROMATOGRAPHY A
- Mechanistic Modeling Based PAT Implementation for Ion-Exchange Process Chromatography of Charge Variants of Monoclonal Antibody Products
- (2017) Vijesh Kumar et al. Biotechnology Journal
- Advanced control strategies for the multicolumn countercurrent solvent gradient purification process
- (2016) Maria M. Papathanasiou et al. AICHE JOURNAL
- Introduction to the application of QbD principles for the development of monoclonal antibodies
- (2016) Christof Finkler et al. BIOLOGICALS
- Real-time monitoring and control of the load phase of a protein A capture step
- (2016) Matthias Rüdt et al. BIOTECHNOLOGY AND BIOENGINEERING
- Model based adaptive control of a continuous capture process for monoclonal antibodies production
- (2016) Fabian Steinebach et al. JOURNAL OF CHROMATOGRAPHY A
- Characterization of Sizes of Aggregates of Insulin Analogs and the Conformations of the Constituent Protein Molecules: A Concomitant Dynamic Light Scattering and Raman Spectroscopy Study
- (2016) Chen Zhou et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Advances in inline quantification of co-eluting proteins in chromatography: Process-data-based model calibration and application towards real-life separation issues
- (2015) Nina Brestrich et al. BIOTECHNOLOGY AND BIOENGINEERING
- PAROC—An integrated framework and software platform for the optimisation and advanced model-based control of process systems
- (2015) Efstratios N. Pistikopoulos et al. CHEMICAL ENGINEERING SCIENCE
- Process Intensification through Continuous Spherical Crystallization Using a Two-Stage Mixed Suspension Mixed Product Removal (MSMPR) System
- (2015) Ramon Peña et al. CRYSTAL GROWTH & DESIGN
- Large-scale monoclonal antibody purification by continuous chromatography, from process design to scale-up
- (2015) Valérie Girard et al. JOURNAL OF BIOTECHNOLOGY
- Understanding Pharmaceutical Quality by Design
- (2014) Lawrence X. Yu et al. AAPS Journal
- A model based approach for identifying robust operating conditions for industrial chromatography with process variability
- (2014) Edward J. Close et al. CHEMICAL ENGINEERING SCIENCE
- Application of process analytical technology for downstream purification of biotherapeutics
- (2014) Anurag S. Rathore et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Mini-review: soft sensors as means for PAT in the manufacture of bio-therapeutics
- (2014) Carl-Fredrik Mandenius et al. JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
- Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates
- (2014) Niklas Borg et al. JOURNAL OF CHROMATOGRAPHY A
- Modelling of industrial biopharmaceutical multicomponent chromatography
- (2013) Edward J. Close et al. CHEMICAL ENGINEERING RESEARCH & DESIGN
- Online control of the twin-column countercurrent solvent gradient process for biochromatography
- (2013) M. Krättli et al. JOURNAL OF CHROMATOGRAPHY A
- Optimising the design and operation of semi-continuous affinity chromatography for clinical and commercial manufacture
- (2013) James Pollock et al. JOURNAL OF CHROMATOGRAPHY A
- Selective high throughput protein quantification based on UV absorption spectra
- (2012) Sigrid K. Hansen et al. BIOTECHNOLOGY AND BIOENGINEERING
- Integrated continuous production of recombinant therapeutic proteins
- (2012) Veena Warikoo et al. BIOTECHNOLOGY AND BIOENGINEERING
- Soft sensors in bioprocessing: A status report and recommendations
- (2012) Reiner Luttmann et al. Biotechnology Journal
- Periodic counter-current chromatography - design and operational considerations for integrated and continuous purification of proteins
- (2012) Rahul Godawat et al. Biotechnology Journal
- Chemometrics applications in biotechnology processes: Predicting column integrity and impurity clearance during reuse of chromatography resin
- (2012) Anurag S. Rathore et al. BIOTECHNOLOGY PROGRESS
- A review of variable selection methods in Partial Least Squares Regression
- (2012) Tahir Mehmood et al. CHEMOMETRICS AND INTELLIGENT LABORATORY SYSTEMS
- Optimal cut-times finding strategies for collecting a target component from overloaded elution chromatograms
- (2012) Balamurali Sreedhar et al. COMPUTERS & CHEMICAL ENGINEERING
- Risk–benefit evaluation of on-line high-performance liquid chromatography analysis for pooling decisions in large-scale chromatography
- (2012) Oliver Kaltenbrunner et al. JOURNAL OF CHROMATOGRAPHY A
- Optimizing a chromatographic three component separation: A comparison of mechanistic and empiric modeling approaches
- (2012) A. Osberghaus et al. JOURNAL OF CHROMATOGRAPHY A
- Improving affinity chromatography resin efficiency using semi-continuous chromatography
- (2012) Ekta Mahajan et al. JOURNAL OF CHROMATOGRAPHY A
- Diagnosing the decline in pharmaceutical R&D efficiency
- (2012) Jack W. Scannell et al. NATURE REVIEWS DRUG DISCOVERY
- Closed loop control of the multi-column solvent gradient purification process
- (2011) M. Krättli et al. JOURNAL OF CHROMATOGRAPHY A
- Technology trends in antibody purification
- (2011) Pete Gagnon JOURNAL OF CHROMATOGRAPHY A
- A tool for increasing the lifetime of chromatography resins
- (2011) Anna Grönberg et al. mAbs
- Optimizing model predictive control of the chromatographic multi-column solvent gradient purification (MCSGP) process
- (2010) Cristian Grossmann et al. JOURNAL OF PROCESS CONTROL
- Pooling control in variable preparative chromatography processes
- (2009) Karin Westerberg et al. BIOPROCESS AND BIOSYSTEMS ENGINEERING
- Case study and application of process analytical technology (PAT) towards bioprocessing: II. Use of ultra-performance liquid chromatography (UPLC) for making real-time pooling decisions for process chromatography
- (2008) Anurag S. Rathore et al. BIOTECHNOLOGY AND BIOENGINEERING
- Chromatographic separation of three monoclonal antibody variants using multicolumn countercurrent solvent gradient purification (MCSGP)
- (2008) Thomas Müller-Späth et al. BIOTECHNOLOGY AND BIOENGINEERING
- Case study and application of process analytical technology (PAT) towards bioprocessing: Use of on-line high-performance liquid chromatography (HPLC) for making real-time pooling decisions for process chromatography
- (2007) Anurag S. Rathore et al. BIOTECHNOLOGY AND BIOENGINEERING
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