High-Throughput Raman Spectroscopy Combined with Innovate Data Analysis Workflow to Enhance Biopharmaceutical Process Development
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Title
High-Throughput Raman Spectroscopy Combined with Innovate Data Analysis Workflow to Enhance Biopharmaceutical Process Development
Authors
Keywords
-
Journal
Processes
Volume 8, Issue 9, Pages 1179
Publisher
MDPI AG
Online
2020-09-18
DOI
10.3390/pr8091179
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- Glucose monitoring and adaptive feeding of mammalian cell culture in the presence of strong autofluorescence by near infrared Raman spectroscopy
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- Concomitant Raman spectroscopy and dynamic light scattering for characterization of therapeutic proteins at high concentrations
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- Raman spectroscopy of complex defined media: biopharmaceutical applications
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- Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry
- (2015) Markus Haberger et al. mAbs
- At-line mid infrared spectroscopy for monitoring downstream processing unit operations
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- Universal Capacitance Model for Real-Time Biomass in Cell Culture
- (2015) Viktor Konakovsky et al. SENSORS
- Monitoring Antibody Aggregation in Early Drug Development Using Raman Spectroscopy and Perturbation-Correlation Moving Windows
- (2014) Ramón Gómez de la Cuesta et al. ANALYTICAL CHEMISTRY
- Performance of line-scan Raman microscopy for high-throughput chemical imaging of cell population
- (2014) Ji Qi et al. APPLIED OPTICS
- Fluorescence-based soft sensor for at situ monitoring of chinese hamster ovary cell cultures
- (2014) Kaveh Ohadi et al. BIOTECHNOLOGY AND BIOENGINEERING
- Cross-scale predictive modeling of CHO cell culture growth and metabolites using Raman spectroscopy and multivariate analysis
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- (2014) Szabolcs Fekete et al. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
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- (2014) Stephen Craven et al. JOURNAL OF PROCESS CONTROL
- Application of an Online-Biomass Sensor in an Optical Multisensory Platform Prototype for Growth Monitoring of Biotechnical Relevant Microorganism and Cell Lines in Single-Use Shake Flasks
- (2014) Christian Ude et al. SENSORS
- Advances in size-exclusion separations of proteins and polymers by UHPLC
- (2014) Edouard S.P. Bouvier et al. TRAC-TRENDS IN ANALYTICAL CHEMISTRY
- Comparative study of non-invasive monitoring via infrared spectroscopy for mammalian cell cultivations
- (2013) M. Sandor et al. JOURNAL OF BIOTECHNOLOGY
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