Real‐time monitoring and model‐based prediction of purity and quantity during a chromatographic capture of fibroblast growth factor 2

Designing an Autonomous Integrated Downstream Sequence From a Batch Separation Process − An Industrial Case Study

(2018) Anton Löfgren et al.   Biotechnology Journal

In-line Fourier-transform infrared spectroscopy as a versatile process analytical technology for preparative protein chromatography

(2018) Steffen Großhans et al.   JOURNAL OF CHROMATOGRAPHY A

Designing an Autonomous Integrated Downstream Sequence From a Batch Separation Process − An Industrial Case Study

(2018) Anton Löfgren et al.   Biotechnology Journal

A two-step process for capture and purification of human basic fibroblast growth factor from E. coli homogenate: Yield versus endotoxin clearance

(2018) Dominik Georg Sauer et al.   PROTEIN EXPRESSION AND PURIFICATION

The parameter uncertainty inflation fallacy

(2017) Pascal Pernot   JOURNAL OF CHEMICAL PHYSICS

Advances in downstream processing of biologics – Spectroscopy: An emerging process analytical technology

(2017) Matthias Rüdt et al.   JOURNAL OF CHROMATOGRAPHY A

Model-Based Methods in the Biopharmaceutical Process Lifecycle

(2017) Paul Kroll et al.   PHARMACEUTICAL RESEARCH

Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing

(2016) Karen A. Esmonde-White et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Recent applications of light scattering measurement in the biological and biopharmaceutical sciences

(2016) Allen P. Minton   ANALYTICAL BIOCHEMISTRY

Hybrid modeling as a QbD/PAT tool in process development: an industrial E. coli case study

(2016) Moritz von Stosch et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Boosted structured additive regression for Escherichia coli fed-batch fermentation modeling

(2016) Michael Melcher et al.   BIOTECHNOLOGY AND BIOENGINEERING

Real-time monitoring and control of the load phase of a protein A capture step

(2016) Matthias Rüdt et al.   BIOTECHNOLOGY AND BIOENGINEERING

Quality by Design (QbD)-Based Process Development for Purification of a Biotherapeutic

(2016) Anurag S. Rathore   TRENDS IN BIOTECHNOLOGY

Advances in inline quantification of co-eluting proteins in chromatography: Process-data-based model calibration and application towards real-life separation issues

(2015) Nina Brestrich et al.   BIOTECHNOLOGY AND BIOENGINEERING

The potential of random forest and neural networks for biomass and recombinant protein modeling inEscherichia colifed-batch fermentations

(2015) Michael Melcher et al.   Biotechnology Journal

Controlling false discoveries in high-dimensional situations: boosting with stability selection

(2015) Benjamin Hofner et al.   BMC BIOINFORMATICS

The potential of random forest and neural networks for biomass and recombinant protein modeling inEscherichia colifed-batch fermentations

(2015) Michael Melcher et al.   Biotechnology Journal

Understanding Pharmaceutical Quality by Design

(2014) Lawrence X. Yu et al.   AAPS Journal

A tool for selective inline quantification of co-eluting proteins in chromatography using spectral analysis and partial least squares regression

(2014) Nina Brestrich et al.   BIOTECHNOLOGY AND BIOENGINEERING

Towards real-time monitoring of therapeutic protein quality in mammalian cell processes

(2014) Daniel A.M. Pais et al.   CURRENT OPINION IN BIOTECHNOLOGY

Intrinsic Tryptophan Fluorescence in the Detection and Analysis of Proteins: A Focus on Förster Resonance Energy Transfer Techniques

(2014) Amar Ghisaidoobe et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modeling and robust pooling design of a preparative cation-exchange chromatography step for purification of monoclonal antibody monomer from aggregates

(2014) Niklas Borg et al.   JOURNAL OF CHROMATOGRAPHY A

Utilizing Dynamic Light Scattering as a Process Analytical Technology for Protein Folding and Aggregation Monitoring in Vaccine Manufacturing

(2013) Zhou Yu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Protein analysis by dynamic light scattering: Methods and techniques for students

(2012) Bernard Lorber et al.   BIOCHEMISTRY AND MOLECULAR BIOLOGY EDUCATION

Implementation of proton transfer reaction-mass spectrometry (PTR-MS) for advanced bioprocess monitoring

(2012) Markus Luchner et al.   BIOTECHNOLOGY AND BIOENGINEERING

Host cell protein quantification by fourier transform mid infrared spectroscopy (FT-MIR)

(2012) Florian Capito et al.   BIOTECHNOLOGY AND BIOENGINEERING

Matrix effects during monitoring of antibody and host cell proteins using attenuated total reflection spectroscopy

(2012) Florian Capito et al.   BIOTECHNOLOGY PROGRESS

Process model comparison and transferability across bioreactor scales and modes of operation for a mammalian cell bioprocess

(2012) Stephen Craven et al.   BIOTECHNOLOGY PROGRESS

On the Distribution of Protein Refractive Index Increments

(2011) Huaying Zhao et al.   BIOPHYSICAL JOURNAL

A Framework for Unbiased Model Selection Based on Boosting

(2011) Benjamin Hofner et al.   JOURNAL OF COMPUTATIONAL AND GRAPHICAL STATISTICS

Overexpression in Escherichia coli and purification of human fibroblast growth factor (FGF-2)

(2009) M. E. Gasparian et al.   BIOCHEMISTRY-MOSCOW

Process analytical technology (PAT) for biopharmaceutical products: Part I. concepts and applications

(2009) E.K. Read et al.   BIOTECHNOLOGY AND BIOENGINEERING

Data reconciliation of concentration estimates from mid-infrared and dielectric spectral measurements for improved on-line monitoring of bioprocesses

(2009) Michal Dabros et al.   BIOTECHNOLOGY PROGRESS

Case study and application of process analytical technology (PAT) towards bioprocessing: Use of tryptophan fluorescence as at-line tool for making pooling decisions for process chromatography

(2009) Anurag S. Rathore et al.   BIOTECHNOLOGY PROGRESS

Case study and application of process analytical technology (PAT) towards bioprocessing: II. Use of ultra-performance liquid chromatography (UPLC) for making real-time pooling decisions for process chromatography

(2008) Anurag S. Rathore et al.   BIOTECHNOLOGY AND BIOENGINEERING

Case study and application of process analytical technology (PAT) towards bioprocessing: Use of on-line high-performance liquid chromatography (HPLC) for making real-time pooling decisions for process chromatography

(2007) Anurag S. Rathore et al.   BIOTECHNOLOGY AND BIOENGINEERING