On-Line Control of Glucose Concentration in High-Yielding Mammalian Cell Cultures Enabled Through Oxygen Transfer Rate Measurements

Quality by control: Towards model predictive control of mammalian cell culture bioprocesses

(2017) Wolfgang Sommeregger et al.   Biotechnology Journal

High-throughput screening and selection of mammalian cells for enhanced protein production

(2016) Joseph J. Priola et al.   Biotechnology Journal

High-throughput screening and selection of mammalian cells for enhanced protein production

(2016) Joseph J. Priola et al.   Biotechnology Journal

Macroscopic modeling of mammalian cell growth and metabolism

(2015) Bassem Ben Yahia et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Use of a small molecule cell cycle inhibitor to control cell growth and improve specific productivity and product quality of recombinant proteins in CHO cell cultures

(2014) Zhimei Du et al.   BIOTECHNOLOGY AND BIOENGINEERING

Amino acid and glucose metabolism in fed-batch CHO cell culture affects antibody production and glycosylation

(2014) Yuzhou Fan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Glucose concentration control of a fed-batch mammalian cell bioprocess using a nonlinear model predictive controller

(2014) Stephen Craven et al.   JOURNAL OF PROCESS CONTROL

Multivariate PAT solutions for biopharmaceutical cultivation: current progress and limitations

(2014) Sarah M. Mercier et al.   TRENDS IN BIOTECHNOLOGY

The challenge of applying Raman spectroscopy to monitor recombinant antibody production

(2013) Lorna Ashton et al.   ANALYST

A sensitive monitoring system for mammalian cell cultivation processes: a PAT approach

(2013) Silvia Winckler et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Comparison of control strategies for fed-batch culture of hybridoma cells based on on-line monitoring of oxygen uptake rate, optical cell density and glucose concentration

(2013) Antoni Casablancas et al.   JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY

Automated dynamic fed-batch process and media optimization for high productivity cell culture process development

(2012) Franklin Lu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Feeding lactate for CHO cell culture processes: Impact on culture metabolism and performance

(2011) Jincai Li et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-End pH-controlled delivery of glucose effectively suppresses lactate accumulation in CHO Fed-batch cultures

(2011) Matthew Gagnon et al.   BIOTECHNOLOGY AND BIOENGINEERING

Process analytical technology (PAT) for biopharmaceuticals

(2011) Jarka Glassey et al.   Biotechnology Journal

Simplified off-gas analyses in animal cell cultures for process monitoring and control purposes

(2011) Mathias Aehle et al.   BIOTECHNOLOGY LETTERS

Real time monitoring of multiple parameters in mammalian cell culture bioreactors using an in-line Raman spectroscopy probe

(2010) Nicholas R. Abu-Absi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimization of chemically defined cell culture media – Replacing fetal bovine serum in mammalian in vitro methods

(2010) J. van der Valk et al.   TOXICOLOGY IN VITRO

Glucose metabolism in mammalian cell culture: new insights for tweaking vintage pathways

(2010) Bhanu Chandra Mulukutla et al.   TRENDS IN BIOTECHNOLOGY

Optimal and consistent protein glycosylation in mammalian cell culture

(2009) P. Hossler et al.   GLYCOBIOLOGY

Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells

(2008) Chaya Mohan et al.   Biotechnology Journal