Rab8 attenuates Wnt signaling and is required for mesenchymal differentiation into adipocytes

Elevating EGFR-MAPK program by a non-conventional Cdc42 enhances intestinal epithelial survival and regeneration

(2020) Xiao Zhang et al.   JCI Insight

Recycling endosomes in mature epithelia restrain tumorigenic signaling

(2019) Luca D'Agostino et al.   CANCER RESEARCH

Rab GTPases and Membrane Trafficking in Neurodegeneration

(2018) Ferdi Ridvan Kiral et al.   CURRENT BIOLOGY

A Wntless–SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export

(2017) Jiaxin Sun et al.   JOURNAL OF CELL SCIENCE

Disruption of Rab8a and Rab11a causes formation of basolateral microvilli in neonatal enteropathy

(2017) Qiang Feng et al.   JOURNAL OF CELL SCIENCE

Exosomes Derived From Hypoxic Colorectal Cancer Cells Promote Angiogenesis Through Wnt4-Induced β-Catenin Signaling in Endothelial Cells

(2017) Zhe Huang et al.   ONCOLOGY RESEARCH

Rab proteins as regulators of lipid droplet formation and lipolysis

(2016) Chunman Li et al.   CELL BIOLOGY INTERNATIONAL

Rab14 is overexpressed in ovarian cancers and promotes ovarian cancer proliferation through Wnt pathway

(2016) Rui Hou et al.   TUMOR BIOLOGY

Rab11a sustains GSK3β/Wnt/β-catenin signaling to enhance cancer progression in pancreatic cancer

(2016) Li Yu et al.   TUMOR BIOLOGY

Primary cilia in energy balance signaling and metabolic disorder

(2015) Hankyu Lee et al.   BMB Reports

Compartmentalizing intestinal epithelial cell toll-like receptors for immune surveillance

(2015) Shiyan Yu et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

(2015) S. Das et al.   DEVELOPMENT

Wnt directs the endosomal flux of LDL-derived cholesterol and lipid droplet homeostasis

(2015) C. C. Scott et al.   EMBO REPORTS

Rab11a regulates syntaxin 3 localization and microvillus assembly in enterocytes

(2015) B. C. Knowles et al.   JOURNAL OF CELL SCIENCE

Keeping Wnt Signalosome in Check by Vesicular Traffic

(2015) Qiang Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development

(2015) LaGina Nosavanh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipogenic Differentiation of hMSCs is Mediated by Recruitment of IGF-1r Onto the Primary Cilium Associated With Cilia Elongation

(2015) Melis T. Dalbay et al.   STEM CELLS

Overexpression of Rab25 promotes hepatocellular carcinoma cell proliferation and invasion

(2015) Donghua Geng et al.   TUMOR BIOLOGY

CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors

(2014) R. Sakamori et al.   CANCER RESEARCH

Rab8a-AS160-MSS4 Regulatory Circuit Controls Lipid Droplet Fusion and Growth

(2014) Lizhen Wu et al.   DEVELOPMENTAL CELL

TLR sorting by Rab11 endosomes maintains intestinal epithelial‐microbial homeostasis

(2014) Shiyan Yu et al.   EMBO JOURNAL

Global Ablation of the Mouse Rab11a Gene Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion

(2014) Shiyan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RAB11-mediated trafficking in host–pathogen interactions

(2014) Annabel Guichard et al.   NATURE REVIEWS MICROBIOLOGY

Rab8a and Rab8b are essential for several apical transport pathways but insufficient for ciliogenesis

(2013) T. Sato et al.   JOURNAL OF CELL SCIENCE

The PCP effector Fuzzy controls cilial assembly and signaling by recruiting Rab8 and Dishevelled to the primary cilium

(2013) Yulia Zilber et al.   MOLECULAR BIOLOGY OF THE CELL

RAB8B Is Required for Activity and Caveolar Endocytosis of LRP6

(2013) Kubilay Demir et al.   Cell Reports

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

(2012) Ryotaro Sakamori et al.   JOURNAL OF CLINICAL INVESTIGATION

Disruption of IFT Complex A Causes Cystic Kidneys without Mitotic Spindle Misorientation

(2012) J. A. Jonassen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Wnt6, Wnt10a and Wnt10b inhibit adipogenesis and stimulate osteoblastogenesis through a β-catenin-dependent mechanism

(2011) William P. Cawthorn et al.   BONE

Rab8 GTPase as a regulator of cell shape

(2011) Johan Peränen   Cytoskeleton

Primary cilia and coordination of receptor tyrosine kinase (RTK) signalling

(2011) Søren T Christensen et al.   JOURNAL OF PATHOLOGY

A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1

(2011) Heather H. Ward et al.   MOLECULAR BIOLOGY OF THE CELL

Subcellular spatial regulation of canonical Wnt signalling at the primary cilium

(2011) Madeline A. Lancaster et al.   NATURE CELL BIOLOGY

Forming functional fat: a growing understanding of adipocyte differentiation

(2011) Ana G. Cristancho et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulation of Wnt/β-Catenin Signaling by CCAAT/Enhancer Binding Protein β During Adipogenesis

(2011) Sung Soo Chung et al.   Obesity

Primary cilia membrane assembly is initiated by Rab11 and transport protein particle II (TRAPPII) complex-dependent trafficking of Rabin8 to the centrosome

(2011) C. J. Westlake et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ERK1 and ERK2 are involved in recruitment and maturation of human mesenchymal stem cells induced to adipogenic differentiation

(2011) Elisabetta Donzelli et al.   Journal of Molecular Cell Biology

Trafficking to the Ciliary Membrane: How to Get Across the Periciliary Diffusion Barrier?

(2010) Maxence V. Nachury et al.   Annual Review of Cell and Developmental Biology

Wnt Signaling Requires Sequestration of Glycogen Synthase Kinase 3 inside Multivesicular Endosomes

(2010) Vincent F. Taelman et al.   CELL

Repression of β-catenin signaling by PPARγ ligands

(2010) Desheng Lu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration

(2010) C. A. Murga-Zamalloa et al.   HUMAN MOLECULAR GENETICS

The nuclear import of Frizzled2-C by Importins-β11 and α2 promotes postsynaptic development

(2010) Timothy J Mosca et al.   NATURE NEUROSCIENCE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Kif3a Deficiency Reverses the Skeletal Abnormalities in Pkd1 Deficient Mice by Restoring the Balance Between Osteogenesis and Adipogenesis

(2010) Ni Qiu et al.   PLoS One

Coordination of Rab8 and Rab11 in primary ciliogenesis

(2010) A. Knodler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ciliary dysfunction and obesity

(2009) CA Mok et al.   CLINICAL GENETICS

The Primary Cilium as a Complex Signaling Center

(2009) Nicolas F. Berbari et al.   CURRENT BIOLOGY

Establishment of Intestinal Identity and Epithelial-Mesenchymal Signaling by Cdx2

(2009) Nan Gao et al.   DEVELOPMENTAL CELL

Sailing with the Wnt: Charting the Wnt processing and secretion route

(2009) Magdalena J. Lorenowicz et al.   EXPERIMENTAL CELL RESEARCH

Growth arrest induces primary-cilium formation and sensitizes IGF-1-receptor signaling during differentiation induction of 3T3-L1 preadipocytes

(2009) D. Zhu et al.   JOURNAL OF CELL SCIENCE

Can faulty antennae increase adiposity? The link between cilia proteins and obesity

(2009) Piya Sen Gupta et al.   JOURNAL OF ENDOCRINOLOGY

WNTs tune up the neuromuscular junction

(2009) Ceren Korkut et al.   NATURE REVIEWS NEUROSCIENCE

Smoothened Adopts Multiple Active and Inactive Conformations Capable of Trafficking to the Primary Cilium

(2009) Christopher W. Wilson et al.   PLoS One

Transient ciliogenesis involving Bardet-Biedl syndrome proteins is a fundamental characteristic of adipogenic differentiation

(2009) Vincent Marion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective ciliogenesis, embryonic lethality and severe impairment of the Sonic Hedgehog pathway caused by inactivation of the mouse complex A intraflagellar transport gene Ift122/Wdr10, partially overlapping with the DNA repair gene Med1/Mbd4

(2008) Salvatore Cortellino et al.   DEVELOPMENTAL BIOLOGY

Wnt3a and Dkk1 Regulate Distinct Internalization Pathways of LRP6 to Tune the Activation of β-Catenin Signaling

(2008) Hideki Yamamoto et al.   DEVELOPMENTAL CELL

Rab8b GTPase, a protein transport regulator, is an interacting partner of otoferlin, defective in a human autosomal recessive deafness form

(2008) P. Heidrych et al.   HUMAN MOLECULAR GENETICS

New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure

(2008) Yu-Hua Tseng et al.   NATURE

elipsa is an early determinant of ciliogenesis that links the IFT particle to membrane-associated small GTPase Rab8

(2008) Yoshihiro Omori et al.   NATURE CELL BIOLOGY