A Wntless–SEC12 complex on the ER membrane regulates early Wnt secretory vesicle assembly and mature ligand export

Sec16 alternative splicing dynamically controls COPII transport efficiency

(2016) Ilka Wilhelmi et al.   Nature Communications

Dysfunction of Wntless triggers the retrograde Golgi-to-ER transport of Wingless and induces ER stress

(2016) Peng Zhang et al.   Scientific Reports

Drosophila p24 and Sec22 regulate Wingless trafficking in the early secretory pathway

(2015) Xue Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Rab8a vesicles regulate Wnt ligand delivery and Paneth cell maturation at the intestinal stem cell niche

(2015) S. Das et al.   DEVELOPMENT

Keeping Wnt Signalosome in Check by Vesicular Traffic

(2015) Qiang Feng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Discovery and Optimization of a Porcupine Inhibitor

(2015) Athisayamani Jeyaraj Duraiswamy et al.   JOURNAL OF MEDICINAL CHEMISTRY

Wnt addiction of genetically defined cancers reversed by PORCN inhibition

(2015) B Madan et al.   ONCOGENE

CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors

(2014) R. Sakamori et al.   CANCER RESEARCH

WLS Retrograde Transport to the Endoplasmic Reticulum during Wnt Secretion

(2014) Jia Yu et al.   DEVELOPMENTAL CELL

TLR sorting by Rab11 endosomes maintains intestinal epithelial‐microbial homeostasis

(2014) Shiyan Yu et al.   EMBO JOURNAL

Global Ablation of the Mouse Rab11a Gene Impairs Early Embryogenesis and Matrix Metalloproteinase Secretion

(2014) Shiyan Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Disulfide Bond Requirements for Active Wnt Ligands

(2014) Bryan T. MacDonald et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concentration of Sec12 at ER exit sites via interaction with cTAGE5 is required for collagen export

(2014) Kota Saito et al.   JOURNAL OF CELL BIOLOGY

A multidimensional approach to an in-depth proteomics analysis of transcriptional regulators in neuroblastoma cells

(2013) Qing Li et al.   JOURNAL OF NEUROSCIENCE METHODS

Single-cell imaging of Wnt palmitoylation by the acyltransferase porcupine

(2013) Xinxin Gao et al.   Nature Chemical Biology

Targeting Wnt-driven cancer through the inhibition of Porcupine by LGK974

(2013) J. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnt secretion is required to maintain high levels of Wnt activity in colon cancer cells

(2013) Oksana Voloshanenko et al.   Nature Communications

Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer

(2012) K. D. Proffitt et al.   CANCER RESEARCH

Wnt/β-Catenin Signaling and Disease

(2012) Hans Clevers et al.   CELL

The Structure of Sec12 Implicates Potassium Ion Coordination in Sar1 Activation

(2012) Conor McMahon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cdc42 and Rab8a are critical for intestinal stem cell division, survival, and differentiation in mice

(2012) Ryotaro Sakamori et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitin-dependent regulation of COPII coat size and function

(2012) Lingyan Jin et al.   NATURE

Active Wnt proteins are secreted on exosomes

(2012) Julia Christina Gross et al.   NATURE CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS

Sec12 Binds to Sec16 at Transitional ER Sites

(2012) Elisabeth A. Montegna et al.   PLoS One

Structural Basis of Wnt Recognition by Frizzled

(2012) C. Y. Janda et al.   SCIENCE

WNT secretion and signalling in human disease

(2012) Patrick Herr et al.   TRENDS IN MOLECULAR MEDICINE

Porcupine-mediated lipidation is required for Wnt recognition by Wls

(2011) Patrick Herr et al.   DEVELOPMENTAL BIOLOGY

p24 proteins are required for secretion of Wnt ligands

(2011) Tina Buechling et al.   EMBO REPORTS

A genome-wide RNA interference screen uncovers two p24 proteins as regulators of Wingless secretion

(2011) Fillip Port et al.   EMBO REPORTS

Identification of an Endocytosis Motif in an Intracellular Loop of Wntless Protein, Essential for Its Recycling and the Control of Wnt Protein Signaling

(2011) Isabelle Gasnereau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion

(2011) Martin Harterink et al.   NATURE CELL BIOLOGY

Sar1-dependent trafficking of the human calcium receptor to the cell surface

(2010) Xiaolei Zhuang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Interaction of the mu-opioid receptor with GPR177 (Wntless) inhibits Wnt secretion: potential implications for opioid dependence

(2010) Jay Jin et al.   BMC NEUROSCIENCE

WLS-dependent secretion of WNT3A requires Ser209 acylation and vacuolar acidification

(2010) G. S. Coombs et al.   JOURNAL OF CELL SCIENCE

WD40 proteins propel cellular networks

(2010) Christian U. Stirnimann et al.   TRENDS IN BIOCHEMICAL SCIENCES

Trans-Synaptic Transmission of Vesicular Wnt Signals through Evi/Wntless

(2009) Ceren Korkut et al.   CELL

TANGO1 Facilitates Cargo Loading at Endoplasmic Reticulum Exit Sites

(2009) Kota Saito et al.   CELL

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

Organisation of human ER-exit sites: requirements for the localisation of Sec16 to transitional ER

(2009) H. Hughes et al.   JOURNAL OF CELL SCIENCE

Small molecule–mediated disruption of Wnt-dependent signaling in tissue regeneration and cancer

(2009) Baozhi Chen et al.   Nature Chemical Biology

Reciprocal regulation of Wnt and Gpr177/mouse Wntless is required for embryonic axis formation

(2009) J. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endoplasmic reticulum export of adrenergic and angiotensin II receptors is differentially regulated by Sar1 GTPase

(2008) Chunmin Dong et al.   CELLULAR SIGNALLING

Cellular Trafficking of the Glypican Dally-like Is Required for Full-Strength Hedgehog Signaling and Wingless Transcytosis

(2008) Armel Gallet et al.   DEVELOPMENTAL CELL

Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7

(2008) Raul Rojas et al.   JOURNAL OF CELL BIOLOGY

Wingless secretion promotes and requires retromer-dependent cycling of Wntless

(2008) Fillip Port et al.   NATURE CELL BIOLOGY

Wingless secretion requires endosome-to-Golgi retrieval of Wntless/Evi/Sprinter by the retromer complex

(2008) Xavier Franch-Marro et al.   NATURE CELL BIOLOGY

The Retromer Complex Influences Wnt Secretion by Recycling Wntless from Endosomes to the Trans-Golgi Network

(2007) Tatyana Y. Belenkaya et al.   DEVELOPMENTAL CELL

Wnt Signaling Requires Retromer-Dependent Recycling of MIG-14/Wntless in Wnt-Producing Cells

(2007) Pei-Tzu Yang et al.   DEVELOPMENTAL CELL

C. elegans AP-2 and Retromer Control Wnt Signaling by Regulating MIG-14/Wntless

(2007) Chun-Liang Pan et al.   DEVELOPMENTAL CELL