Neurometals in the Pathogenesis of Prion Diseases

Carnosine as a Possible Drug for Zinc-Induced Neurotoxicity and Vascular Dementia

(2020) Masahiro Kawahara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Amyloids: Regulators of Metal Homeostasis in the Synapse

(2020) Masahiro Kawahara et al.   MOLECULES

Highly infectious prions are not directly neurotoxic

(2020) Iryna Benilova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Manganese induced nervous injury by α-synuclein accumulation via ATP-sensitive K(+) channels and GABA receptors

(2020) Yi Sun et al.   TOXICOLOGY LETTERS

Alpha-synuclein is involved in manganese-induced spatial memory and synaptic plasticity impairments via TrkB/Akt/Fyn-mediated phosphorylation of NMDA receptors

(2020) Zhuo Ma et al.   Cell Death & Disease

Copper Dyshomeostasis in Neurodegenerative Diseases—Therapeutic Implications

(2020) Grażyna Gromadzka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Copper Binding Regulates Cellular Prion Protein Function

(2019) Xuan T. A. Nguyen et al.   MOLECULAR NEUROBIOLOGY

Structural Consequences of Copper Binding to the Prion Protein

(2019) Giulia Salzano et al.   Cells

Prion Protein as a Toxic Acceptor of Amyloid-β Oligomers

(2018) Silvia A. Purro et al.   BIOLOGICAL PSYCHIATRY

Zinc, Carnosine, and Neurodegenerative Diseases

(2018) et al.   Nutrients

Prion Protein Regulates Iron Transport by Functioning as a Ferrireductase

(2018) Ajay Singh et al.   JOURNAL OF ALZHEIMERS DISEASE

Metallothioneins and the Central Nervous System: From a Deregulation in Neurodegenerative Diseases to the Development of New Therapeutic Approaches

(2018) Silvia Bolognin et al.   JOURNAL OF ALZHEIMERS DISEASE

Manganese causes neurotoxic iron accumulation via translational repression of Amyloid Precursor Protein (APP) and H-Ferritin

(2018) Vivek Venkataramani et al.   JOURNAL OF NEUROCHEMISTRY

The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis

(2018) Caterina Peggion et al.   MOLECULAR NEUROBIOLOGY

Geographic Accumulation of Creutzfeldt-Jakob Disease in Slovakia - Environmental Metal Imbalance as a Possible Cofactor

(2018) Dana Slivarichová et al.   Central European Journal of Public Health

Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions

(2018) Sun Huang et al.   Molecular Brain

Iron importers Zip8 and Zip14 are expressed in retina and regulated by retinal iron levels

(2017) Jacob Sterling et al.   EXPERIMENTAL EYE RESEARCH

The Impact of Synaptic Zn2+ Dynamics on Cognition and Its Decline

(2017) Atsushi Takeda et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Zinc and Copper Differentially Modulate Amyloid Precursor Protein Processing by γ-Secretase and Amyloid-β Peptide Production

(2017) Hermeto Gerber et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases

(2017) M. Kawahara et al.   Metallomics

Iron regulatory protein (IRP)-iron responsive element (IRE) signaling pathway in human neurodegenerative diseases

(2017) Zhi Dong Zhou et al.   Molecular Neurodegeneration

The Role of APP in Structural Spine Plasticity

(2017) Elena Montagna et al.   Frontiers in Molecular Neuroscience

Metal Dyshomeostasis and Their Pathological Role in Prion and Prion-Like Diseases: The Basis for a Nutritional Approach

(2017) Mattia Toni et al.   Frontiers in Neuroscience

Metallothionein, Copper and Alpha-Synuclein in Alpha-Synucleinopathies

(2017) Yuho Okita et al.   Frontiers in Neuroscience

PBT2 Rapidly Improves Cognition in Alzheimer's Disease: Additional Phase II Analyses

(2017) Noel G. Faux et al.   JOURNAL OF ALZHEIMERS DISEASE

α-Synuclein increases β-amyloid secretion by promoting β-/γ-secretase processing of APP

(2017) Hazel L. Roberts et al.   PLoS One

Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration

(2016) K. M. Taylor et al.   BIOCHEMICAL JOURNAL

Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements

(2016) Jian-Yong Wang et al.   Scientific Reports

Prion protein functions as a ferrireductase partner for ZIP14 and DMT1

(2015) Ajai K. Tripathi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density

(2015) Manuela Mellone et al.   JOURNAL OF NEUROCHEMISTRY

Prion infection in cells is abolished by a mutated manganese transporter but shows no relation to zinc

(2015) Rachel Pass et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Copper at synapse: Release, binding and modulation of neurotransmission

(2015) Nadia D'Ambrosi et al.   NEUROCHEMISTRY INTERNATIONAL

The non-octarepeat copper binding site of the prion protein is a key regulator of prion conversion

(2015) Gabriele Giachin et al.   Scientific Reports

Involvement of Trace Elements in the Pathogenesis of Prion Diseases

(2014) Dai Mizuno et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Bioinorganic chemistry of synucleinopathies: Deciphering the binding features of Met motifs and His-50 in AS–Cu(I) interactions

(2014) Marco C. Miotto et al.   JOURNAL OF INORGANIC BIOCHEMISTRY

Amyloid Precursor Protein Dimerization and Synaptogenic Function Depend on Copper Binding to the Growth Factor-Like Domain

(2014) F. Baumkotter et al.   JOURNAL OF NEUROSCIENCE

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Biology and Genetics of Prions Causing Neurodegeneration

(2013) Stanley B. Prusiner   Annual Review of Genetics

A Low-Molecular-Weight Ferroxidase Is Increased in the CSF of sCJD Cases: CSF Ferroxidase and Transferrin as Diagnostic Biomarkers for sCJD

(2013) Swati Haldar et al.   ANTIOXIDANTS & REDOX SIGNALING

Impact of the Discovery of Human Zinc Deficiency on Health

(2013) Ananda S. Prasad   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Disruption of zinc homeostasis and the pathogenesis of senile dementia

(2013) Masahiro Kawahara et al.   Metallomics

The ZIP5 Ectodomain Co-Localizes with PrP and May Acquire a PrP-Like Fold That Assembles into a Dimer

(2013) Cosmin L. Pocanschi et al.   PLoS One

Solvent Microenvironments and Copper Binding Alters the Conformation and Toxicity of a Prion Fragment

(2013) Mohammed Inayathullah et al.   PLoS One

Neuronal zinc regulation and the prion protein

(2013) Nicole T. Watt et al.   Prion

Zinc Drives a Tertiary Fold in the Prion Protein with Familial Disease Mutation Sites at the Interface

(2013) Ann R. Spevacek et al.   STRUCTURE

Low Copper and High Manganese Levels in Prion Protein Plaques

(2013) Christopher Johnson et al.   Viruses-Basel

Prion Protein Expression and Functional Importance in Developmental Angiogenesis: Role in Oxidative Stress and Copper Homeostasis

(2012) Nadia Alfaidy et al.   ANTIOXIDANTS & REDOX SIGNALING

Inherited Copper Transport Disorders: Biochemical Mechanisms, Diagnosis, and Treatment

(2012) Hiroko Kodama et al.   CURRENT DRUG METABOLISM

Ion channels induced by the prion protein

(2012) Isaac H. Solomon et al.   Prion

Disruption of copper homeostasis due to a mutation of Atp7a delays the onset of prion disease

(2012) O. M. Siggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Copper Alters Aggregation Behavior of Prion Protein and Induces Novel Interactions between Its N- and C-terminal Regions

(2011) Abhay Kumar Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126

(2011) Masahiro Kawahara et al.   Metallomics

Molecular and genetic features of zinc transporters in physiology and pathogenesis

(2011) Toshiyuki Fukada et al.   Metallomics

The pathological prion protein forms ionic conductance in lipid bilayer

(2011) Daniele Paulis et al.   NEUROCHEMISTRY INTERNATIONAL

Correction: Alpha-Synuclein Is a Cellular Ferrireductase

(2011) Paul Davies et al.   PLoS One

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice

(2011) Carlo Corona et al.   PLoS One

Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain

(2010) Claire Howells et al.   FEBS Journal

Prions and manganese: A maddening beast

(2010) David R. Brown   Metallomics

A novel mechanism of non-Aβ component of Alzheimer's disease amyloid (NAC) neurotoxicity. Interplay between p53 protein and cyclin-dependent kinase 5 (Cdk5)

(2010) Anna Kaźmierczak et al.   NEUROCHEMISTRY INTERNATIONAL

The Alzheimer's Disease-Associated Amyloid β-Protein Is an Antimicrobial Peptide

(2010) Stephanie J. Soscia et al.   PLoS One

Effects of clioquinol on memory impairment and the neurochemical modifications induced by scrapie infection in golden hamsters

(2009) Silvio R. Bareggi et al.   BRAIN RESEARCH

Copper Binding Extrinsic to the Octarepeat Region in the Prion Protein

(2009) Eric Walter et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Bioimaging of metals in brain tissue by laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and metallomics

(2009) J. Sabine Becker et al.   Metallomics

Prion Protein (PrP) Knock-Out Mice Show Altered Iron Metabolism: A Functional Role for PrP in Iron Uptake and Transport

(2009) Ajay Singh et al.   PLoS One

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

(2009) Gerold Schmitt-Ulms et al.   PLoS One

Functionally Relevant Domains of the Prion Protein Identified In Vivo

(2009) Frank Baumann et al.   PLoS One

Antimicrobial Activity of Human Prion Protein Is Mediated by Its N-Terminal Region

(2009) Mukesh Pasupuleti et al.   PLoS One

Amyloid precursor protein and alpha synuclein translation, implications for iron and inflammation in neurodegenerative diseases

(2008) Catherine M. Cahill et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases

(2008) Konstanze F Winklhofer et al.   EMBO JOURNAL

Copper(II) inhibits the formation of amylin amyloid in vitro

(2007) Benjamin Ward et al.   JOURNAL OF INORGANIC BIOCHEMISTRY