The Prion Protein Regulates Synaptic Transmission by Controlling the Expression of Proteins Key to Synaptic Vesicle Recycling and Exocytosis

Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau

(2018) Joseph McInnes et al.   NEURON

Neuronal pathophysiology featuring PrPC and its control over Ca2+ metabolism

(2018) Alessandro Bertoli et al.   Prion

The prion protein regulates glutamate-mediated Ca2+entry and mitochondrial Ca2+accumulation in neurons

(2017) Agnese De Mario et al.   JOURNAL OF CELL SCIENCE

Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons

(2017) Laura Urrea et al.   MOLECULAR NEUROBIOLOGY

α-synuclein interacts with PrPC to induce cognitive impairment through mGluR5 and NMDAR2B

(2017) Diana G Ferreira et al.   NATURE NEUROSCIENCE

The Biological Function of the Prion Protein: A Cell Surface Scaffold of Signaling Modules

(2017) Rafael Linden   Frontiers in Molecular Neuroscience

α-Synuclein Amyloids Hijack Prion Protein to Gain Cell Entry, Facilitate Cell-to-Cell Spreading and Block Prion Replication

(2017) Suzana Aulić et al.   Scientific Reports

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Rab1 in cell signaling, cancer and other diseases

(2016) X-Z Yang et al.   ONCOGENE

Prion Protein Deficiency Causes Diverse Proteome Shifts in Cell Models That Escape Detection in Brain Tissue

(2016) Mohadeseh Mehrabian et al.   PLoS One

Prion infection impairs lysosomal degradation capacity by interfering with rab7 membrane attachment in neuronal cells

(2016) Su Yeon Shim et al.   Scientific Reports

Multiple Roles of the Small GTPase Rab7

(2016) Flora Guerra et al.   Cells

Intrinsically disordered proteins: emerging interaction specialists

(2015) Peter Tompa et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The RIT2 and STX1B polymorphisms are associated with Parkinson's disease

(2015) Jian-Yong Wang et al.   PARKINSONISM & RELATED DISORDERS

The prion protein constitutively controls neuronal store-operated Ca2+ entry through Fyn kinase

(2015) Agnese De Mario et al.   Frontiers in Cellular Neuroscience

Cellular prion protein promotes post-ischemic neuronal survival, angioneurogenesis and enhances neural progenitor cell homing via proteasome inhibition

(2015) T R Doeppner et al.   Cell Death & Disease

Involvement of PrPC in kainate-induced excitotoxicity in several mouse strains

(2015) Patricia Carulla et al.   Scientific Reports

A Novel Inhibitor Prevents the Peripheral Neuroparalysis of Botulinum Neurotoxins

(2015) Domenico Azarnia Tehran et al.   Scientific Reports

Prion protein facilitates synaptic vesicle release by enhancing release probability

(2014) S. W. Robinson et al.   HUMAN MOLECULAR GENETICS

Loss of Prion Protein Leads to Age-Dependent Behavioral Abnormalities and Changes in Cytoskeletal Protein Expression

(2014) Matthias Schmitz et al.   MOLECULAR NEUROBIOLOGY

Mutations in STX1B, encoding a presynaptic protein, cause fever-associated epilepsy syndromes

(2014) Julian Schubert et al.   NATURE GENETICS

Syntaxin 1B, but Not Syntaxin 1A, Is Necessary for the Regulation of Synaptic Vesicle Exocytosis and of the Readily Releasable Pool at Central Synapses

(2014) Tatsuya Mishima et al.   PLoS One

Rab Proteins and the Compartmentalization of the Endosomal System

(2014) A. Wandinger-Ness et al.   Cold Spring Harbor Perspectives in Biology

mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo

(2014) Neng-Wei Hu et al.   Nature Communications

Intrinsically Disordered Segments Affect Protein Half-Life in the Cell and during Evolution

(2014) Robin van der Lee et al.   Cell Reports

WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013

(2013) Jing Wang et al.   NUCLEIC ACIDS RESEARCH

Altered behavioral aspects of aged mice lacking the cellular prion protein

(2013) Maria Lina Massimino et al.   PHYSIOLOGY & BEHAVIOR

oPOSSUM-3: Advanced Analysis of Regulatory Motif Over-Representation Across Genes or ChIP-Seq Datasets

(2013) Andrew T. Kwon et al.   G3-Genes Genomes Genetics

Selected reaction monitoring–based proteomics: workflows, potential, pitfalls and future directions

(2012) Paola Picotti et al.   NATURE METHODS

Alzheimer amyloid-β oligomer bound to postsynaptic prion protein activates Fyn to impair neurons

(2012) Ji Won Um et al.   NATURE NEUROSCIENCE

Mutant PrP Suppresses Glutamatergic Neurotransmission in Cerebellar Granule Neurons by Impairing Membrane Delivery of VGCC α2δ-1 Subunit

(2012) Assunta Senatore et al.   NEURON

A  neurotoxicity depends on interactions between copper ions, prion protein, and N-methyl-D-aspartate receptors

(2012) H. You et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sporadic Creutzfeldt-Jakob disease subtype-specific alterations of the brain proteome: Impact on Rab3a recycling

(2012) Joanna Gawinecka et al.   PROTEOMICS

Depressive-like behaviour of mice lacking cellular prion protein

(2011) Vinicius M. Gadotti et al.   BEHAVIOURAL BRAIN RESEARCH

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

The cellular prion protein mediates neurotoxic signalling of β-sheet-rich conformers independent of prion replication

(2011) Ulrike K Resenberger et al.   EMBO JOURNAL

Cellular prion protein is implicated in the regulation of local Ca2+ movements in cerebellar granule neurons

(2011) Cristian Lazzari et al.   JOURNAL OF NEUROCHEMISTRY

Relative Quantification of Membrane Proteins in Wild-Type and Prion Protein (PrP)-Knockout Cerebellar Granule Neurons

(2011) Roberto Stella et al.   JOURNAL OF PROTEOME RESEARCH

Proteomics Approach to Identify the Interacting Partners of Cellular Prion Protein and Characterization of Rab7a Interaction in Neuronal Cells

(2011) Saima Zafar et al.   JOURNAL OF PROTEOME RESEARCH

De novo generation of prion strains

(2011) David W. Colby et al.   NATURE REVIEWS MICROBIOLOGY

Synaptic dysfunction in Parkinson's disease: Figure 1

(2010) Vincenza Bagetta et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Skyline: an open source document editor for creating and analyzing targeted proteomics experiments

(2010) Brendan MacLean et al.   BIOINFORMATICS

Brain transcriptional stability upon prion protein-encoding gene invalidation in zygotic or adult mouse

(2010) Sead Chadi et al.   BMC GENOMICS

A Drosophila model of GSS syndrome suggests defects in active zones are responsible for pathogenesis of GSS syndrome

(2010) Jin-Kyu Choi et al.   HUMAN MOLECULAR GENETICS

Coomassie Staining as Loading Control in Western Blot Analysis

(2010) Charlotte Welinder et al.   JOURNAL OF PROTEOME RESEARCH

Cellular prion protein overexpression disturbs cellular homeostasis in SH-SY5Y neuroblastoma cells but does not alter p53 expression: a proteomic study

(2010) E. Weiss et al.   NEUROSCIENCE

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models

(2010) Eva Benito et al.   TRENDS IN NEUROSCIENCES

Early synaptic pathophysiology in neurodegeneration: insights from Huntington's disease

(2010) Austen J. Milnerwood et al.   TRENDS IN NEUROSCIENCES

Mutant Prion Protein Expression Is Associated with an Alteration of the Rab GDP Dissociation Inhibitor α (GDI)/Rab11 Pathway

(2009) Tania Massignan et al.   MOLECULAR & CELLULAR PROTEOMICS

Cellular prion protein mediates impairment of synaptic plasticity by amyloid-β oligomers

(2009) Juha Laurén et al.   NATURE

Universal sample preparation method for proteome analysis

(2009) Jacek R Wiśniewski et al.   NATURE METHODS

Multiplex peptide stable isotope dimethyl labeling for quantitative proteomics

(2009) Paul J Boersema et al.   Nature Protocols

Rab3 Dynamically Controls Protein Composition at Active Zones

(2009) Ethan R. Graf et al.   NEURON

The brain proteome profile is highly conserved between Prnp−/− and Prnp+/+ mice

(2009) Anna C. Crecelius et al.   NEUROREPORT

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Impaired Axonal Transport in Motor Neurons Correlates with Clinical Prion Disease

(2009) Vladimir Ermolayev et al.   PLoS Pathogens

From cell protection to death: May Ca2+ signals explain the chameleonic attributes of the mammalian prion protein?

(2008) M. Catia Sorgato et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

CREB-dependent gene regulation by prion protein: Impact on MMP-9 and β-dystroglycan

(2008) Elodie Pradines et al.   CELLULAR SIGNALLING

Prion protein attenuates excitotoxicity by inhibiting NMDA receptors

(2008) Houman Khosravani et al.   JOURNAL OF CELL BIOLOGY

Altered Neuron Excitability and Synaptic Plasticity in the Cerebellar Granular Layer of Juvenile Prion Protein Knock-Out Mice with Impaired Motor Control

(2008) F. Prestori et al.   JOURNAL OF NEUROSCIENCE

Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

(2008) Stefan H. Gerber et al.   SCIENCE