Zinc, Carnosine, and Neurodegenerative Diseases

Pyruvic acid prevents Cu 2+ /Zn 2+ -induced neurotoxicity by suppressing mitochondrial injury

(2018) Ken-ichiro Tanaka et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Thioredoxin-albumin fusion protein prevents copper enhanced zinc-induced neurotoxicity via its antioxidative activity

(2018) Ken-ichiro Tanaka et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Cross talk between neurometals and amyloidogenic proteins at the synapse and the pathogenesis of neurodegenerative diseases

(2017) M. Kawahara et al.   Metallomics

The Role of Metal Binding in the Amyotrophic Lateral Sclerosis-Related Aggregation of Copper-Zinc Superoxide Dismutase

(2017) et al.   MOLECULES

Zinc as a Gatekeeper of Immune Function

(2017) et al.   Nutrients

Zinc in the Monoaminergic Theory of Depression: Its Relationship to Neural Plasticity

(2017) Urszula Doboszewska et al.   NEURAL PLASTICITY

On the Relationship between Energy Metabolism, Proteostasis, Aging and Parkinson’s Disease: Possible Causative Role of Methylglyoxal and Alleviative Potential of Carnosine

(2017) Alan R. Hipkiss   Aging and Disease

Structure and Synaptic Function of Metal Binding to the Amyloid Precursor Protein and its Proteolytic Fragments

(2017) Klemens Wild et al.   Frontiers in Molecular Neuroscience

Copper Enhances Zinc-Induced Neurotoxicity and the Endoplasmic Reticulum Stress Response in a Neuronal Model of Vascular Dementia

(2017) Ken-ichiro Tanaka et al.   Frontiers in Neuroscience

Anserine (beta-alanyl-3-methyl-L-histidine) improves neurovascular-unit dysfunction and spatial memory in aged AβPPswe/PSEN1dE9 Alzheimer’s-model mice

(2017) Jun Kaneko et al.   Scientific Reports

Zinc and infant nutrition

(2016) M. Leigh Ackland et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Systematic review and stratified meta-analysis of the efficacy of carnosine in animal models of ischemic stroke

(2016) Charles K Davis et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alzheimer’s disease due to loss of function: A new synthesis of the available data

(2016) Kasper P. Kepp   PROGRESS IN NEUROBIOLOGY

Infants and elderlies are susceptible to zinc deficiency

(2016) Hiroshi Yasuda et al.   Scientific Reports

Roles of Zinc Signaling in the Immune System

(2016) Shintaro Hojyo et al.   Journal of Immunology Research

Zinc transporter-1: a novel NMDA receptor-binding protein at the postsynaptic density

(2015) Manuela Mellone et al.   JOURNAL OF NEUROCHEMISTRY

International society of sports nutrition position stand: Beta-Alanine

(2015) Eric T. Trexler et al.   Journal of the International Society of Sports Nutrition

Protective activity of carnosine and anserine against zinc-induced neurotoxicity: a possible treatment for vascular dementia

(2015) Dai Mizuno et al.   Metallomics

Copper at synapse: Release, binding and modulation of neurotransmission

(2015) Nadia D'Ambrosi et al.   NEUROCHEMISTRY INTERNATIONAL

Daily Carnosine and Anserine Supplementation Alters Verbal Episodic Memory and Resting State Network Connectivity in Healthy Elderly Adults

(2015) Jaroslav Rokicki et al.   Frontiers in Aging Neuroscience

Involvement of Trace Elements in the Pathogenesis of Prion Diseases

(2014) Dai Mizuno et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Control of the Structural Stability of α-Crystallin under Thermal and Chemical Stress: The Role of Carnosine

(2014) Valentina Villari et al.   JOURNAL OF PHYSICAL CHEMISTRY B

APP Is Cleaved by Bace1 in Pre-Synaptic Vesicles and Establishes a Pre-Synaptic Interactome, via Its Intracellular Domain, with Molecular Complexes that Regulate Pre-Synaptic Vesicles Functions

(2014) Dolores Del Prete et al.   PLoS One

β-Amyloid Precursor Protein Does Not Possess Ferroxidase Activity but Does Stabilize the Cell Surface Ferrous Iron Exporter Ferroportin

(2014) Bruce X. Wong et al.   PLoS One

Carnosine Inhibits Aβ42Aggregation by Perturbing the H-Bond Network in and around the Central Hydrophobic Cluster

(2013) Francesco Attanasio et al.   CHEMBIOCHEM

Impact of the Discovery of Human Zinc Deficiency on Health

(2013) Ananda S. Prasad   JOURNAL OF THE AMERICAN COLLEGE OF NUTRITION

Synaptic Zn2+ homeostasis and its significance

(2013) Atsushi Takeda et al.   Metallomics

d-Histidine and l-histidine attenuate zinc-induced neuronal death in GT1-7 cells

(2013) Masahiro Kawahara et al.   Metallomics

The effect of Cu2+ and Zn2+ on the Aβ42 peptide aggregation and cellular toxicity

(2013) Anuj K. Sharma et al.   Metallomics

Disruption of zinc homeostasis and the pathogenesis of senile dementia

(2013) Masahiro Kawahara et al.   Metallomics

β-Amyloid-aluminum complex alters cytoskeletal stability and increases ROS production in cortical neurons

(2013) Silvia Bolognin et al.   NEUROCHEMISTRY INTERNATIONAL

Physiology and Pathophysiology of Carnosine

(2013) Alexander A. Boldyrev et al.   PHYSIOLOGICAL REVIEWS

Anti-Aggregating Effect of the Naturally Occurring Dipeptide Carnosine on Aβ1-42 Fibril Formation

(2013) Alessandra Aloisi et al.   PLoS One

Neuronal zinc regulation and the prion protein

(2013) Nicole T. Watt et al.   Prion

Neurotoxicity of β-Amyloid Protein: Oligomerization, Channel Formation and Calcium Dyshomeostasis

(2012) Masahiro Kawahara   CURRENT PHARMACEUTICAL DESIGN

Zn2+-Aβ40 Complexes Form Metastable Quasi-spherical Oligomers That Are Cytotoxic to Cultured Hippocampal Neurons

(2012) Inna Solomonov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Copper-dependent regulation of NMDA receptors by cellular prion protein: implications for neurodegenerative disorders

(2012) Peter K. Stys et al.   JOURNAL OF PHYSIOLOGY-LONDON

Subclinical zinc deficiency impairs human brain function

(2012) Harold H. Sandstead   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Inhibitory circuits for visual processing in thalamus

(2011) Xin Wang et al.   CURRENT OPINION IN NEUROBIOLOGY

Carnosine pretreatment protects against hypoxia–ischemia brain damage in the neonatal rat model

(2011) Xiangmin Zhang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Biochemical Characterization of Human ZIP13 Protein

(2011) Bum-Ho Bin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Effects of Zn2+, Cu2+, Fe3+, and Al3+on Amyloid-β Stability, Oligomerization, and Aggregation

(2011) Wei-Ting Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Neurophysiology and Pathology of Brain Zinc

(2011) S. L. Sensi et al.   JOURNAL OF NEUROSCIENCE

Zinc, copper, and carnosine attenuate neurotoxicity of prion fragment PrP106-126

(2011) Masahiro Kawahara et al.   Metallomics

Molecular and genetic features of zinc transporters in physiology and pathogenesis

(2011) Toshiyuki Fukada et al.   Metallomics

Effects of Dietary Supplementation of Carnosine on Mitochondrial Dysfunction, Amyloid Pathology, and Cognitive Deficits in 3xTg-AD Mice

(2011) Carlo Corona et al.   PLoS One

Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain

(2010) Claire Howells et al.   FEBS Journal

Calcium Signaling and Amyloid Toxicity in Alzheimer Disease

(2010) Angelo Demuro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synaptotoxicity of Alzheimer Beta Amyloid Can Be Explained by Its Membrane Perforating Property

(2010) Fernando J. Sepulveda et al.   PLoS One

Brain proteins that mind metals: a neurodegenerative perspective

(2009) David R. Brown   DALTON TRANSACTIONS

Calcium dyshomeostasis and neurotoxicity of Alzheimer’s β-amyloid protein

(2009) Masahiro Kawahara et al.   Expert Review of Neurotherapeutics

Evolutionary Descent of Prion Genes from the ZIP Family of Metal Ion Transporters

(2009) Gerold Schmitt-Ulms et al.   PLoS One