Low Copper and High Manganese Levels in Prion Protein Plaques

Prion protein facilitates uptake of zinc into neuronal cells

(2012) Nicole T. Watt et al.   Nature Communications

Prion protein expression level alters regional copper, iron and zinc content in the mouse brain

(2011) M. Jake Pushie et al.   Metallomics

Prions

(2011) D. W. Colby et al.   Cold Spring Harbor Perspectives in Biology

Manganese chelation therapy extends survival in a mouse model of M1000 prion disease

(2010) Marcus W. Brazier et al.   JOURNAL OF NEUROCHEMISTRY

Prions and manganese: A maddening beast

(2010) David R. Brown   Metallomics

Consequences of dietary manganese and copper imbalance on neuronal apoptosis in a murine model of scrapie

(2010) R. Bolea et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Role of copper and manganese in prion disease progression

(2009) Gerda Mitteregger et al.   BRAIN RESEARCH

Abnormal Brain Iron Homeostasis in Human and Animal Prion Disorders

(2009) Ajay Singh et al.   PLoS Pathogens

The chemistry of copper binding to PrP: is there sufficient evidence to elucidate a role for copper in protein function?

(2008) Paul Davies et al.   BIOCHEMICAL JOURNAL

Manganese Binding to the Prion Protein

(2008) Marcus W. Brazier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Elevated manganese levels in blood and CNS in human prion disease

(2008) Shirley Hesketh et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Oxidative impairment in scrapie-infected mice is associated with brain metals perturbations and altered antioxidant activities

(2003) Boon-Seng Wong et al.   JOURNAL OF NEUROCHEMISTRY