In vitro anti-inflammatory properties of honey flavonoids: A review

Galangin Protects against Symptoms of Dextran Sodium Sulfate-Induced Acute Colitis by Activating Autophagy and Modulating the Gut Microbiota

(2020) Hongzhuan Xuan et al.   Nutrients

Inhibition of herpes simplex virus by myricetin through targeting viral gD protein and cellular EGFR/PI3K/Akt pathway

(2020) Wenmiao Li et al.   ANTIVIRAL RESEARCH

Quercetin loaded chitosan tripolyphosphate nanoparticles accelerated cutaneous wound healing in Wistar rats

(2020) Abhinav Choudhary et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Spectroscopy characterization, theoretical study and antioxidant activities of the flavonoids-Pb(II) complexes

(2020) Qian Wang et al.   JOURNAL OF MOLECULAR STRUCTURE

Echium plantagineum L. honey: Search of pyrrolizidine alkaloids and polyphenols, anti-inflammatory potential and cytotoxicity

(2020) Rute Moreira et al.   FOOD CHEMISTRY

Effect of Mimosa scabrella Bentham honeydew honey on inflammatory mediators

(2020) Bibiana Silva et al.   Journal of Functional Foods

Naringin regulates bone metabolism in glucocorticoid-induced osteonecrosis of the femoral head via the Akt/Bad signal cascades

(2019) Ming-jie Kuang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

The effect of ginger supplementation on some immunity and inflammation intermediate genes expression in patients with active Rheumatoid Arthritis

(2019) Naheed Aryaeian et al.   GENE

Genistein suppresses psoriasis-related inflammation through a STAT3–NF-κB-dependent mechanism in keratinocytes

(2019) Ailin Wang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Immunomodulatory effect of natural flavonoid chrysin (5, 7-dihydroxyflavone) on LPS stimulated RAW 264.7 macrophages via inhibition of NF-κB activation

(2019) Boothapandi Madakkannu et al.   PROCESS BIOCHEMISTRY

Antiviral activity of pinocembrin against Zika virus replication

(2019) Jia Le Lee et al.   ANTIVIRAL RESEARCH

Authentication of phacelia honeys (Phacelia tanacetifolia) based on a combination of HPLC and HPTLC analyses as well as spectrophotometric measurements

(2019) Natalia Stanek et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Evaluation of cellular antioxidant components of honeys using UPLC-MS/MS and HPLC-FLD based on the quantitative composition-activity relationship

(2019) Shi Shen et al.   FOOD CHEMISTRY

Sugaring-out assisted liquid-liquid extraction coupled with high performance liquid chromatography-electrochemical detection for the determination of 17 phenolic compounds in honey

(2019) Zuoyi Zhu et al.   JOURNAL OF CHROMATOGRAPHY A

Improved cardioprotective effects of hesperidin solid lipid nanoparticles prepared by supercritical antisolvent technology

(2019) Suma Saad et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

The bioactivity of flavonoid glucuronides and free aglycones in the context of their absorption, II phase metabolism and deconjugation at the inflammation site

(2019) Barbara Żyżyńska-Granica et al.   FOOD AND CHEMICAL TOXICOLOGY

Antioxidant characteristics of honey from Mozambique based on specific flavonoids and phenolic acid compounds

(2019) Fernando Tanleque-Alberto et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Pinocembrin inhibits the proliferation and migration and promotes the apoptosis of ovarian cancer cells through down-regulating the mRNA levels of N-cadherin and GABAB receptor

(2019) Jun Gao et al.   BIOMEDICINE & PHARMACOTHERAPY

Taxifolin attenuates IMQ-induced murine psoriasis-like dermatitis by regulating T helper cell responses via Notch1 and JAK2/STAT3 signal pathways

(2019) Xiaohong Yuan et al.   BIOMEDICINE & PHARMACOTHERAPY

Apigenin-rivastigmine hybrids as multi-target-directed liagnds for the treatment of Alzheimer’s disease

(2019) Zhipei Sang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Isorhamnetin alleviates esophageal mucosal injury in a chronic model of reflux esophagitis

(2019) Gang Liu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Possible osteoprotective effects of myricetin in STZ induced diabetic osteoporosis in rats

(2019) Xiaozhou Ying et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Investigation of phenolic compounds, antioxidant and anti-inflammatory activities in stingless bee honey (Meliponinae)

(2019) Fabíola Carina Biluca et al.   FOOD RESEARCH INTERNATIONAL

Wound healing with alginate/chitosan hydrogel containing hesperidin in rat model

(2019) Zohreh Bagher et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Improved strategy based on QuEChERS method followed by HPLC/DAD for the quantification of phenolic compounds from Mimosa scabrella Bentham honeydew honeys

(2019) Bibiana Silva et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Isorhamnetin: A hepatoprotective flavonoid inhibits apoptosis and autophagy via P38/PPAR-α pathway in mice

(2018) Xiya Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Hesperidin attenuates iron-induced oxidative damage and dopamine depletion in Drosophila melanogaster model of Parkinson's disease

(2018) Márcia Rósula Poetini et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Quercetin and chrysin inhibit nickel-induced invasion and migration by downregulation of TLR4/NF-κB signaling in A549 cells

(2018) Tzu-Chin Wu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Docking Techniques in Pharmacology: How Much Promising?

(2018) Meenakshi Gupta et al.   COMPUTATIONAL BIOLOGY AND CHEMISTRY

Biochemical properties, antibacterial and cellular antioxidant activities of buckwheat honey in comparison to manuka honey

(2018) Jianling Deng et al.   FOOD CHEMISTRY

A comparative study on the adsorption and desorption characteristics of flavonoids from honey by six resins

(2018) Cheng Lv et al.   FOOD CHEMISTRY

Phenolic composition, antioxidant, antibacterial and anti-inflammatory activities of leaf and stem extracts from Cryptotaenia japonica Hassk

(2018) Jun Lu et al.   INDUSTRIAL CROPS AND PRODUCTS

Kaempferol-3-o-β- d -glucuronate exhibit potential anti-inflammatory effect in LPS stimulated RAW 264.7 cells and mice model

(2018) Vidushi Khajuria et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Phenolic compounds, antioxidant capacity and physicochemical properties of Brazilian Apis mellifera honeys

(2018) Kelly Souza do Nascimento et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Malaysian stingless bee and Tualang honeys: A comparative characterization of total antioxidant capacity and phenolic profile using liquid chromatography-mass spectrometry

(2018) Yazan Ranneh et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Apigenin loaded nanoparticle delayed development of hepatocellular carcinoma in rats

(2018) Sanchari Bhattacharya et al.   Nanomedicine-Nanotechnology Biology and Medicine

Lipoxygenase inhibitors flavonoids from Cyperus rotundus aerial parts

(2018) Sabrin R.M. Ibrahim et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Identification of luteolin 7-O-β-D-glucuronide from Cirsium japonicum and its anti-inflammatory mechanism

(2018) Qin Ma et al.   Journal of Functional Foods

Structure-activity relationship of eight high content flavonoids analyzed with a preliminary assign-score method and their contribution to antioxidant ability of flavonoids-rich extract from Scutellaria baicalensis shoots

(2018) Ke Li et al.   Arabian Journal of Chemistry

Lipoxygenase inhibitors flavonoids from Cyperus rotundus aerial parts

(2018) Sabrin R.M. Ibrahim et al.   Revista Brasileira de Farmacognosia-Brazilian Journal of Pharmacognosy

Antioxidant activities of some monofloral honey types produced across Turkey

(2018) Aziz Gül et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Isorhamnetin suppresses PANC-1 pancreatic cancer cell proliferation through S phase arrest

(2018) Jia-Li Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Neuroprotective effect of naringin, a flavone glycoside in quinolinic acid-induced neurotoxicity: Possible role of PPAR-γ, Bax/Bcl-2, and caspase-3

(2018) Jian Cui et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 2: Control of oxidative stress induced damage, increase of antioxidant enzyme activities and attenuation of inflammation

(2018) Massimiliano Gasparrini et al.   FOOD AND CHEMICAL TOXICOLOGY

Protective effects of Manuka honey on LPS-treated RAW 264.7 macrophages. Part 1: Enhancement of cellular viability, regulation of cellular apoptosis and improvement of mitochondrial functionality

(2018) Sadia Afrin et al.   FOOD AND CHEMICAL TOXICOLOGY

Supercritical anti-solvent fractionation for improving antioxidant and anti-inflammatory activities of an Achillea millefolium L. extract

(2018) M. Villalva et al.   FOOD RESEARCH INTERNATIONAL

Physicochemical characteristics of bracatinga honeydew honey and blossom honey produced in the state of Santa Catarina: An approach to honey differentiation

(2018) Greici Bergamo et al.   FOOD RESEARCH INTERNATIONAL

Triterpenoid saponins and flavonoids from licorice residues with anti-inflammatory activity

(2018) Ming Bai et al.   INDUSTRIAL CROPS AND PRODUCTS

Bioassay-guided isolation and UHPLC-DAD-ESI-MS/MS quantification of potential anti-inflammatory phenolic compounds from flowers of Inula montana L

(2018) Elnur Garayev et al.   JOURNAL OF ETHNOPHARMACOLOGY

Simplex-centroid design and Derringer’s desirability function approach for simultaneous separation of phenolic compounds from Mimosa scabrella Bentham honeydew honeys by HPLC/DAD

(2018) Bibiana da Silva et al.   JOURNAL OF CHROMATOGRAPHY A

Wound Healing Effect of Kaempferol in Diabetic and Nondiabetic Rats

(2018) Yusuf Özay et al.   JOURNAL OF SURGICAL RESEARCH

Antioxidant and anti-inflammatory properties of flavonoids from lotus plumule

(2018) Gui-Lin Chen et al.   FOOD CHEMISTRY

Anti-inflammatory effects of new catechin derivatives in a hapten-induced mouse contact dermatitis model

(2018) Eriko Nakano et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Antioxidant and anti-inflammatory activities of phenolic compounds isolated from Melipona beecheii honey

(2017) Jorge Carlos Ruiz-Ruiz et al.   FOOD AND AGRICULTURAL IMMUNOLOGY

Flavonoid composition of orange peel and its association with antioxidant and anti-inflammatory activities

(2017) Xiu-Min Chen et al.   FOOD CHEMISTRY

Effect of in vitro gastrointestinal digestion on the bioaccessibility of phenolic compounds, minerals, and antioxidant capacity of Mimosa scabrella Bentham honeydew honeys

(2017) Siluana Katia Tischer Seraglio et al.   FOOD RESEARCH INTERNATIONAL

Chlorinated Flavonoids Modulate the Inflammatory Process in Human Blood

(2017) Carina Proença et al.   INFLAMMATION

Pinocembrin attenuates allergic airway inflammation via inhibition of NF-κB pathway in mice

(2017) Xiaoyan Gu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Enrichment and separation of quercetin-3-O-β- d -glucuronide from lotus leaves ( nelumbo nucifera gaertn.) and evaluation of its anti-inflammatory effect

(2017) Fei Li et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Antioxidant and anti-inflammatory activities of the major phenolics from Zygophyllum simplex L.

(2017) Hossam M. Abdallah et al.   JOURNAL OF ETHNOPHARMACOLOGY

Phenolic compounds, antioxidant capacity and bioaccessibility of minerals of stingless bee honey ( Meliponinae )

(2017) Fabíola Carina Biluca et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

Effect of luteolin on inflammatory responses in RAW264.7 macrophages activated with LPS and IFN-γ

(2017) Shuxia Wang et al.   Journal of Functional Foods

Protein-bound Vaccinium fruit polyphenols decrease IgE binding to peanut allergens and RBL-2H3 mast cell degranulation in vitro

(2017) Nathalie J. Plundrich et al.   Food & Function

Chrysin: Sources, beneficial pharmacological activities, and molecular mechanism of action

(2017) Renuka Mani et al.   PHYTOCHEMISTRY

Ruthenium-conjugated chrysin analogues modulate platelet activity, thrombus formation and haemostasis with enhanced efficacy

(2017) Divyashree Ravishankar et al.   Scientific Reports

The dual anti-inflammatory and antioxidant activities of natural honey promote cell proliferation and neural regeneration in a rat model of colitis

(2016) Hanaa Z. Nooh et al.   ACTA HISTOCHEMICA

Characterisation of phenolics and other quality parameters of different types of honey

(2016) Halouzka Rostislav et al.   CZECH JOURNAL OF FOOD SCIENCES

Flavonoid myricetin inhibits TNF-α-stimulated production of inflammatory mediators by suppressing the Akt, mTOR and NF-κB pathways in human keratinocytes

(2016) Da Hee Lee et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Honey: Chemical composition, stability and authenticity

(2016) Priscila Missio da Silva et al.   FOOD CHEMISTRY

Development and validation of a LC-ESI-MS/MS method for the determination of phenolic compounds in honeydew honeys with the diluted-and-shoot approach

(2016) Siluana Katia Tischer Seraglio et al.   FOOD RESEARCH INTERNATIONAL

Polyphenolic profile and antioxidant and antibacterial activities of monofloral honeys produced by Meliponini in the Brazilian semiarid region

(2016) Janaína Maria Sousa et al.   FOOD RESEARCH INTERNATIONAL

Inhibitory effects of flavonoids extracted from Nepalese propolis on the LPS signaling pathway

(2016) Megumi Funakoshi-Tago et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Isolates of Alpinia officinarum Hance as COX-2 inhibitors: Evidence from anti-inflammatory, antioxidant and molecular docking studies

(2016) Varsha S. Honmore et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Physicochemical profiles, minerals and bioactive compounds of stingless bee honey ( Meliponinae )

(2016) Fabíola Carina Biluca et al.   JOURNAL OF FOOD COMPOSITION AND ANALYSIS

A novel in vitro co-culture model comprised of Caco-2/RBL-2H3 cells to evaluate anti-allergic effects of food factors through the intestine

(2016) Sae Yamashita et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Hepatoprotective effect of isoquercitrin against acetaminophen-induced liver injury

(2016) Wenyan Xie et al.   LIFE SCIENCES

Antibacterial and antioxidant activity of honeys from the state of Rio Grande do Sul, Brazil

(2016) Francine Manhago Bueno-Costa et al.   LWT-FOOD SCIENCE AND TECHNOLOGY

Protective effect of isoquercitrin against acute dextran sulfate sodium-induced rat colitis depends on the severity of tissue damage

(2016) Norbert Cibiček et al.   Pharmacological Reports

Cyanidin-3- O -glucoside inhibits NF-kB signalling in intestinal epithelial cells exposed to TNF-α and exerts protective effects via Nrf2 pathway activation

(2016) Daniela Ferrari et al.   TOXICOLOGY LETTERS

Protective effect of kaempferol, a flavonoid widely present in varieties of edible plants, on IL-1β-induced inflammatory response via inhibiting MAPK, Akt, and NF-κB signalling in SW982 cells

(2016) Jun-Jiang Lian et al.   Journal of Functional Foods

Activation of AMPK/Nrf2 signalling by Manuka honey protects human dermal fibroblasts against oxidative damage by improving antioxidant response and mitochondrial function promoting wound healing

(2016) José Miguel Alvarez-Suarez et al.   Journal of Functional Foods

Stereospecific inhibition of nitric oxide production in macrophage cells by flavanonols: Synthesis and the structure–activity relationship

(2015) Wen-Jun Jiang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Suppression of inflammatory response by chrysin, a flavone isolated from Potentilla evestita Th. Wolf. In silico predictive study on its mechanistic effect

(2015) Abdur Rauf et al.   FITOTERAPIA

An investigation of Turkish honeys: Their physico-chemical properties, antioxidant capacities and phenolic profiles

(2015) Zehra Can et al.   FOOD CHEMISTRY

The flavonoid quercetin ameliorates Alzheimer's disease pathology and protects cognitive and emotional function in aged triple transgenic Alzheimer's disease model mice

(2015) Angélica Maria Sabogal-Guáqueta et al.   NEUROPHARMACOLOGY

Anti-inflammatory activity of flavonoids from Chrozophora tinctoria

(2015) Hossam M. Abdallah et al.   Phytochemistry Letters

Luteolin inhibited the gene expression, production and secretion of MUC5AC mucin via regulation of nuclear factor kappa B signaling pathway in human airway epithelial cells

(2015) Hyun Jae Lee et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Structural Insight into the interaction of Flavonoids with Human Telomeric Sequence

(2015) Arpita Tawani et al.   Scientific Reports

Complementary treatment of contact lens-induced corneal ulcer using honey: A case report

(2015) Nora Majtanova et al.   Contact Lens & Anterior Eye

Identification of epicatechin as one of the key bioactive constituents of polyphenol-enriched extracts that demonstrate an anti-allergic effect in a murine model of food allergy

(2014) Anurag Singh et al.   BRITISH JOURNAL OF NUTRITION

Anti-psoriatic activity of Givotia rottleriformis in rats

(2014) A Vijayalakshmi et al.   INDIAN JOURNAL OF PHARMACOLOGY

Topical Anti-Inflammatory Activity of a Monofloral Honey of Mimosa scabrella Provided by Melipona marginata During Winter in Southern Brazil

(2014) Débora M. Borsato et al.   JOURNAL OF MEDICINAL FOOD

Structure-Activity Association of Flavonoids in Lung Diseases

(2014) João Lago et al.   MOLECULES

Chemical characterization and anti-inflammatory activity of luteolin glycosides isolated from lemongrass

(2014) Vera Francisco et al.   Journal of Functional Foods

Treatment of non-healing leg ulcers with honeydew honey

(2014) Alexander Mayer et al.   Journal of Tissue Viability

'Benifuuki' Green Tea Containing O-Methylated Catechin Reduces Symptoms of Japanese Cedar Pollinosis: A Randomized, Double- Blind, Placebo-Controlled Trial

(2014) Sawako Masuda et al.   ALLERGOLOGY INTERNATIONAL

Inhibition of LOX by flavonoids: a structure–activity relationship study

(2013) Daniela Ribeiro et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Effects of C-glycosylation on anti-diabetic, anti-Alzheimer’s disease and anti-inflammatory potential of apigenin

(2013) Jae Sue Choi et al.   FOOD AND CHEMICAL TOXICOLOGY

Effect of floral sources on the antioxidant, antimicrobial, and anti-inflammatory activities of honeys in Taiwan

(2013) Je-Ruei Liu et al.   FOOD CHEMISTRY

Suitability of antioxidant capacity, flavonoids and phenolic acids for floral authentication of honey. Impact of industrial thermal treatment

(2013) Isabel Escriche et al.   FOOD CHEMISTRY

Anti-inflammatory activity and percutaneous absorption of quercetin and its polymethoxylated compound and glycosides: The relationships to chemical structures

(2012) Chwan-Fwu Lin et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Anti-inflammatory activity of structurally related flavonoids, Apigenin, Luteolin and Fisetin

(2011) Megumi Funakoshi-Tago et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

(2010) Kyung Mi Lee et al.   BIOCHEMICAL PHARMACOLOGY

Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium

(2010) Thérèse Sergent et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease

(2009) Ana García-Lafuente et al.   INFLAMMATION RESEARCH

Characterisation of the phenolic and flavonoid fractions and antioxidant power of Italian honeys of different botanical origin

(2009) Elena Pichichero et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Effect of flavonoids on rat splenocytes, a structure–activity relationship study

(2008) Rocío López-Posadas et al.   BIOCHEMICAL PHARMACOLOGY

Analysis of Phenolic and Other Aromatic Compounds in Honeys by Solid-Phase Microextraction Followed by Gas Chromatography−Mass Spectrometry

(2008) Sawsan Daher et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY