Article
Chemistry, Multidisciplinary
Parichat Tawornchat, Thitiporn Pattarakankul, Tanapat Palaga, Varol Intasanta, Supason Wanichwecharungruang
Summary: In this study, luteolin was polymerized into water-dispersible nanospheres with anti-inflammatory properties using a mild one-pot polymerization method. The polymerized luteolin nanoparticles showed dose-dependent anti-inflammatory activity without causing cell death even at high concentrations, unlike luteolin which exhibited both dose-dependent anti-inflammatory activity and cytotoxicity.
Article
Immunology
Fengyuan Mandy Yang, Liya Shen, Dengxia Denise Fan, Yaqin Bai, Bizhou Li, Jongdae Lee
Summary: YAP9 is identified as an essential negative regulator of potent inflammatory stimuli like TNFα, IL-1β, and LPS, working in conjunction with A20 to suppress inflammatory responses. YAP9 and A20 utilize different structural domains to suppress inflammatory signaling, and synthetic peptides mimicking their functions can effectively suppress proinflammatory responses.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kazuki Nagata, Chiharu Nishiyama
Summary: Mast cells play critical roles in immune responses as initiators and suppressors, with IL-10 serving as a key anti-inflammatory cytokine in regulating their functions. IL-10 exerts diverse effects on mast cells in vivo and in vitro, influencing tissue homeostasis and immune-related diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Muhammad Qamar, Saeed Akhtar, Tariq Ismail, Muqeet Wahid, Sajed Ali, Yasir Nazir, Shahid Murtaza, Malik Waseem Abbas, Zyta M. Ziora
Summary: This study validates that Syzygium cumini fruit extracts are a rich source of bioactive compounds that can enhance biological activities with lesser side effects.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yusra Habib Khan, Sumera Qasim, Ambreen Malik Uttra, Nasser H. Alotaibi, Abdullah Salah Alanazi, Abdulaziz I. Alzarea, Ahmed D. Alatawi, Tauqeer Hussain Mallhi
Summary: Enalapril, with documented anti-inflammatory potential, was evaluated for its efficacy in treating arthritis. The study utilized a CFA-induced arthritic model and assessed various parameters such as paw volume, body weight, arthritic index, hematological and biochemical parameters, cytokine levels, radiographic analysis, and histopathological changes. The results showed that enalapril demonstrated significant anti-arthritic activity by reducing paw volume and arthritic index, while preserving body weight. It also normalized hematological and biochemical alterations, suppressed proinflammatory cytokines, and increased anti-inflammatory cytokines. Radiographic and histopathological analysis further confirmed enalapril's anti-arthritic properties. However, further mechanistic studies are needed to determine the exact mechanism of action.
Article
Pharmacology & Pharmacy
Jinling Xu, Qi Lv, Shumin Pan, Huanhuan Qiu, Yu Liao, Ming Zhou, Weijie Li, Caiyan Li, Pan Zhang, Yujian Li, Guanglin Xu, Qingfeng Yu
Summary: The novel NSAID M378 demonstrates strong anti-inflammatory activity and insignificant toxicity compared to existing NSAIDs. It inhibits the NLRP3 inflammasome signaling pathway, blocking the assembly of the inflammasome and the production of ROS. These findings shed light on the molecular mechanism of hydrogen sulfide-releasing NSAIDs and support the therapeutic potential of M378 in NLRP3-driven inflammatory diseases.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zhong Zhang, Di Wu, Wen Li, Wanchao Chen, Yanfang Liu, Jingsong Zhang, Jianing Wan, Hailong Yu, Shuai Zhou, Yan Yang
Summary: A proteoglycan LEPS1 was isolated from Lentinula edodes, an agricultural waste. It showed anti-inflammatory activity by inhibiting NO secretion and reducing levels of pro-inflammatory factors. LEPS1 also modulated JAK-STAT1 and p38 MAPK signaling pathway and promoted the expression of repair markers in macrophages. This study provides valuable information for utilizing L. edodes waste and suggests LEPS1 as a potential anti-inflammatory agent.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Immunology
Khalil Hajiasgharzadeh, Alireza Khabbazi, Ahad Mokhtarzadeh, Amir Baghbanzadeh, Zahra Asadzadeh, Elham Adlravan, Behzad Baradaran
Summary: Connective tissue diseases (CTDs) encompass a wide range of heterogeneous conditions caused by immune-mediated inflammation affecting various connective tissues, including rheumatoid arthritis and systemic lupus erythematosus. The intrinsic cholinergic anti-inflammatory pathway (CAP) has been investigated for its potential in modulating chronic inflammation, but the presence of autonomic neuropathy in CTDs may affect its effectiveness. Further research is needed to explore the benefits and limitations of CAP in controlling inflammatory responses and treating CTDs.
INFLAMMOPHARMACOLOGY
(2021)
Article
Anesthesiology
Weihua Ding, Zerong You, Qian Chen, Liuyue Yang, Jason Doheny, Xue Zhou, Na Li, Shiyu Wang, Kun Hu, Lucy Chen, Suyun Xia, Xinbo Wu, Changning Wang, Can Zhang, Liang Chen, Christine Ritchie, Peigen Huang, Jianren Mao, Shiqian Shen
Summary: This study found that oral antibiotics can alter gut microbiota and alleviate neuropathic pain induced by CCI, primarily through modulating proinflammatory and anti-inflammatory T cell responses. Depletion of regulatory T cells reversed the protective effect of gut microbiota changes on neuropathic pain.
ANESTHESIA AND ANALGESIA
(2021)
Article
Biochemistry & Molecular Biology
Xia Xu, Xiaofeng Huang, Yuedan Zheng, Xiaoling Wang, Jing Xie, Sha Liu, Kun Guo
Summary: The low water solubility of arctiin is the major hurdle in its development as a drug. A new water-soluble glucuronide derivative of arctiin was synthesized and showed improved anti-inflammatory activity in vivo. This compound can be considered as an innovative candidate for the drug development of arctiin.
Review
Pharmacology & Pharmacy
Abdalla M. Wedn, Hany M. El-Bassossy, Ali H. Eid, Mahmoud M. El-Mas
Summary: Research reports summarize the roles of peripheral and reflex cholinergic neuroinflammatory pathways in reprogramming preeclampsia complications, including the possible contributions of alpha7-nicotinic acetylcholine receptors, cholinesterases, immune cells, adhesion molecules, angiogenesis, and endothelial dysfunction to the interaction.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Oncology
Shuyu Liu, Zhenhan Deng, Kang Chen, Shengsheng Jian, Feifei Zhou, Yuan Yang, Zicai Fu, Huanyu Xie, Jianyi Xiong, Weimin Zhu
Summary: Osteoarthritis is a common joint disease with unclear etiology, influenced by factors like age, obesity, inflammation, trauma, and genetics. Imbalance between proinflammatory and anti-inflammatory cytokines in knee articular cartilage metabolism can deform and damage the joint. Cartilage tissue engineering shows promise in preventing OA by maintaining a balance between pro- and anti-inflammatory factors.
MOLECULAR MEDICINE REPORTS
(2022)
Review
Immunology
Wenting Wang, Hui Xu, Huan Lin, Megan Molnar, Hongsheng Ren
Summary: Septic cardiomyopathy (SCM) is a common condition in septic patients, leading to cardiovascular failure, with a complex pathogenesis and limited treatment options. The cholinergic anti-inflammatory pathway (CAP) plays a critical role in regulating inflammatory responses, particularly through the activation of alpha 7nAChR, to maintain the balance of inflammation-immune response in SCM.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Chemistry, Physical
Khaled R. A. Abdellatif, Eman K. A. Abdelall, Heba A. H. Elshemy, Phoebe F. Lamie, Elshaymaa Elnahaas, Dina M. E. Amin
Summary: A series of novel anti-inflammatory compounds were designed, synthesized, and evaluated for their high COX-2 selectivity and anti-inflammatory activity. These compounds showed promising potential in terms of COX-2 inhibition and safety in the gastrointestinal tract.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Cell Biology
Ferenc Kolonics, Erika Kajdacsi, Veronika J. Farkas, Daniel S. Veres, Delaram Khamari, Agnes Kittel, Michael L. Merchant, Kenneth R. McLeish, Akos M. Lorincz, Erzsebet Ligeti
Summary: Extracellular vesicles (EVs) play important roles in intercellular communication, with both anti-inflammatory and proinflammatory effects. These vesicles are customizable based on environmental factors, including reducing reactive oxygen, increasing cytokines, activating endothelial cells, and promoting coagulation.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shilpa Gupta, Vidushi Khajuria, Abubakar Wani, Yedukondalu Nalli, Asha Bhagat, Asif Ali, Zabeer Ahmed
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Shilpa Gupta, Aitizaz Ul Ahsan, Abubakar Wani, Vidushi Khajuria, Lone A. Nazir, Simmi Sharma, Asha Bhagat, Parduman Raj Sharma, Subhash Bhardwaj, Kaiser J. Peerzada, Bhahwal Ali Shah, Zabeer Ahmed
Correction
Chemistry, Organic
Yedukondalu Nalli, Vidushi Khajuria, Shilpa Gupta, Palak Arora, Syed Riyaz-Ul-Hassan, Zabeer Ahmed, Asif Ali
ORGANIC & BIOMOLECULAR CHEMISTRY
(2018)
Article
Immunology
Mowkshi Khullar, Ankita Sharma, Abubakar Wani, Neha Sharma, Neelam Sharma, B. K. Chandan, Ajay Kumar, Zabeer Ahmed
INTERNATIONAL IMMUNOPHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Mohd Ishaq Dar, Priya Mahajan, Suraya Jan, Shreyans K. Jain, Harshita Tiwari, Jagjeet Sandey, Sandip Bharate, Amit Nargotra, Sajad Hussain Syed
EUROPEAN JOURNAL OF PHARMACOLOGY
(2019)
Article
Genetics & Heredity
Umar Gani, Priyanka Sharma, Harshita Tiwari, Abhishek Kumar Nautiyal, Maridul Kundan, Mir Abdul Wajid, Ravi Kesari, Amit Nargotra, Prashant Misra
Summary: The study identified 138 MATE genes in N. tabacum, grouped into four major phylogenetic clades. Some NtMATE genes showed differential expression in different tissues, with upstream regions predicted to contain elements related to hormonal, developmental, and stress responses. Functional characterization of MATE transporter genes in N. tabacum was established, along with insights into key amino acid residues and putative functions of the transporters.
Article
Immunology
Amit Kumar, Gifty Sawhney, Rakesh Kumar Nagar, Narendra Chauhan, Nidhi Gupta, Anpurna Kaul, Zabeer Ahmed, P. L. Sangwan, P. Satheesh Kumar, Govind Yadav
Summary: Bakuchiol (BAK) exhibits significant immunomodulatory and anti-inflammatory effects by suppressing pro-inflammatory cytokine expression and reducing hypersensitivity responses.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Diksha Raina, Harshita Tiwari, Smriti Sharma, Deepika, Praveen Kumar Chinthakindi, Amit Nargotra, Payare L. Sangwan, Kandasamy Eniyan, Urmi Bajpai, Ram A. Vishwakarma, Farrah Gul Khan, Saurabh Saran, Inshad Ali Khan
Summary: This study aimed to identify novel chemical structures targeting the MurA enzyme of Escherichia coli through in silico screening, resulting in the discovery of two compounds with potent inhibitory activity. These compounds showed increased activity in the presence of the permeabilizer EDTA, indicating potential for antimicrobial drug discovery.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Harshita Tiwari, Diksha Raina, Monika Gupta, Manas Ranjan Barik, Inshad Ali Khan, Farrah Khan, Amit Nargotra
Summary: UDP-N-acetylglucosamine enolpyruvyl transferase (MurA) is an important enzyme involved in bacterial cell wall synthesis. This study identified two potent inhibitors of MurA through virtual screening and validated their efficacy through in vitro assays. The study also discovered a novel binding site and revealed the mechanism of enzyme inhibition through conformational changes.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Applied
Poonam Khandelwal, Harshita Tiwari, Venu Sharma, Deepak Mali, Pooja Vyas, Barkha Darra Wadhwani
Summary: The study isolated tectonaquinone B and 2-methylquinizarin from the heartwood of Tecomella undulata for the first time, revealing their potential inhibitory action towards CDK7 with high binding affinities. Among the compounds tested, 2-methylquinizarin exhibited the best docking score, indicating potent anticancer activity through interaction with Met94.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Ravi S. Manhas, Harshita Tiwari, Mateen Noor, Ajaz Ahmed, Jyoti Vishwakarma, Raja B. M. Tripathi, Ravishankar Ramachandran, Sreedhar Madishetti, Debaraj Mukherjee, Asha Chaubey, Amit Nargotra
Summary: This study investigates the potential of setomimycin as a therapeutic drug for COVID-19. Pure setomimycin was isolated from Streptomyces sp. RA-WS2 strain, and its in silico and in vitro anti-SARS-CoV-2 activity was evaluated. The compound was found to target the main protease (M-Pro) of SARS-CoV-2, inhibiting its dimerization. Additionally, setomimycin exhibited anti-inflammatory and anti-oxidant properties, suggesting its potential application against COVID-19 infections.
MOLECULAR DIVERSITY
(2023)
Article
Microbiology
Diksha Raina, Farrah Gul Khan, Harshita Tiwari, Payare L. Sangwan, Amit Nargotra, Vinod Kumar, Inshad Ali Khan, Saurabh Saran
Summary: This study reports the potential of compounds from Boswellia serrata as antibacterial agents targeting MurA enzyme, and reveals the inhibitory mode of these compounds.
ARCHIVES OF MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Davinder Singh, Tenzen Yodun, Gulshan Kumar, Javeed Ahmad Tali, Harshita Tiwari, Jasvinder Singh, Amit Nargotra, Abhilash Samykutty, Shashank Singh, Ravi Shankar
Summary: A library of 49 analogs of imidazo[1,2-a]pyridine with various substitutions have been synthesized and evaluated for their anticancer activity. Compound 5b exhibited the best potential against multiple cancer cell lines, inducing apoptosis and inhibiting the AKT pathway.
BIOORGANIC CHEMISTRY
(2022)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
