Targeting alveolar‐specific succinate dehydrogenase A attenuates pulmonary inflammation during acute lung injury

Characterization of pulmonary immune responses to hyperoxia by high-dimensional mass cytometry analyses

(2020) D. Hanidziar et al.   Scientific Reports

Acute Respiratory Distress Syndrome

(2020) George W. Williams et al.   ANESTHESIOLOGY

Use of Electron Paramagnetic Resonance in Biological Samples at Ambient Temperature and 77 K

(2019) Hanan B. Elajaili et al.   Jove-Journal of Visualized Experiments

Endothelial HIF-1α Is Required for Vascular Repair and Resolution of Inflammatory Lung Injury through FoxM1

(2019) Xiaojia Huang et al.   AMERICAN JOURNAL OF PATHOLOGY

Roxadustat Treatment for Anemia in Patients Undergoing Long-Term Dialysis

(2019) Nan Chen et al.   NEW ENGLAND JOURNAL OF MEDICINE

Activation of hypoxia-inducible factor -1α via succinate dehydrogenase pathway during acute lung injury induced by trauma/hemorrhagic shock

(2019) Mengya Li et al.   SHOCK

Transcription-independent Induction of ERBB1 through Hypoxia-inducible Factor 2A Provides Cardioprotection during Ischemia and Reperfusion

(2019) Jae W. Lee et al.   ANESTHESIOLOGY

Role of HIF-1α-miR30a-Snai1 Axis in Neonatal Hyperoxic Lung Injury

(2019) Yuhao Zhang et al.   Oxidative Medicine and Cellular Longevity

Adiponectin deficiency induces mitochondrial dysfunction and promotes endothelial activation and pulmonary vascular injury

(2019) Dilip Shah et al.   FASEB JOURNAL

Targeting Hypoxia Signaling for Perioperative Organ Injury

(2018) Xiaoyi Yuan et al.   ANESTHESIA AND ANALGESIA

Enhancement of glycolysis by inhibition of oxygen-sensing prolyl hydroxylases protects alveolar epithelial cells from acute lung injury

(2018) Kentaro Tojo et al.   FASEB JOURNAL

Succinate induces synovial angiogenesis in rheumatoid arthritis through metabolic remodeling and HIF-1α/VEGF axis

(2018) Yi Li et al.   FREE RADICAL BIOLOGY AND MEDICINE

Effects of vadadustat on hemoglobin concentrations in patients receiving hemodialysis previously treated with erythropoiesis-stimulating agents

(2018) Volker H Haase et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Krebs Cycle Reimagined: The Emerging Roles of Succinate and Itaconate as Signal Transducers

(2018) Michael P. Murphy et al.   CELL

Succinate Dehydrogenase Complex: An Updated Review

(2018) Mohamed Rizwan Haroon Al Rasheed et al.   ARCHIVES OF PATHOLOGY & LABORATORY MEDICINE

The hypoxia-adenosine link during inflammation

(2017) Jessica L. Bowser et al.   JOURNAL OF APPLIED PHYSIOLOGY

Neutrophil transfer of miR-223 to lung epithelial cells dampens acute lung injury in mice

(2017) Viola Neudecker et al.   Science Translational Medicine

Detrimental ELAVL-1/HuR-dependent GSK3β mRNA stabilization impairs resolution in acute respiratory distress syndrome

(2017) Olivia Hoffman et al.   PLoS One

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation

(2016) Vicky Lampropoulou et al.   Cell Metabolism

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-throughput discovery of novel developmental phenotypes

(2016) Mary E. Dickinson et al.   NATURE

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

(2015) Sandra Hoegl et al.   JOURNAL OF IMMUNOLOGY

Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury

(2014) T. Eckle et al.   JOURNAL OF IMMUNOLOGY

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

Lipid Mediators in the Resolution of Inflammation

(2014) Charles N. Serhan et al.   Cold Spring Harbor Perspectives in Biology

Pulmonary Natural Killer T Cells Play an Essential Role in Mediating Hyperoxic Acute Lung Injury

(2013) Martina Nowak-Machen et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Resolution of Acute Inflammation in the Lung

(2013) Bruce D. Levy et al.   Annual Review of Physiology

CD73+ regulatory T cells contribute to adenosine-mediated resolution of acute lung injury

(2013) Heidi Ehrentraut et al.   FASEB JOURNAL

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

(2013) Tobias Eckle et al.   FASEB JOURNAL

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production

(2013) A. Michelucci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Acute Respiratory Distress Syndrome

(2012)   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Transcriptional control of adenosine signaling by hypoxia-inducible transcription factors during ischemic or inflammatory disease

(2012) Jens M. Poth et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation

(2012) Peppi Koivunen et al.   NATURE

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

SPC-Cre-ERT2 Transgenic Mouse for Temporal Gene Deletion in Alveolar Epithelial Cells

(2012) Yao-Song Gui et al.   PLoS One

The a“MAZE”ing World of Lung-Specific Transgenic Mice

(2011) Emma L. Rawlins et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

The ALIEN study: incidence and outcome of acute respiratory distress syndrome in the era of lung protective ventilation

(2011) Jesús Villar et al.   INTENSIVE CARE MEDICINE

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Functional Disability 5 Years after Acute Respiratory Distress Syndrome

(2011) Margaret S. Herridge et al.   NEW ENGLAND JOURNAL OF MEDICINE

Multiple stromal populations contribute to pulmonary fibrosis without evidence for epithelial to mesenchymal transition

(2011) J. R. Rock et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury

(2010) U. Schingnitz et al.   JOURNAL OF IMMUNOLOGY

Succinate dehydrogenase – Assembly, regulation and role in human disease

(2010) Jared Rutter et al.   MITOCHONDRION

Critical Roles of Inflammation and Apoptosis in Improved Survival in a Model of Hyperoxia-Induced Acute Lung Injury in Pneumocystis murina-Infected Mice

(2009) J. M. Beck et al.   INFECTION AND IMMUNITY

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Usefulness of pressure-controlled ventilation at high inspiratory pressures to induce acute lung injury in mice

(2008) Tobias Eckle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Pulmonary Epithelium Is a Prominent Source of Proteinase-activated Receptor-1–inducible CCL2 in Pulmonary Fibrosis

(2008) Paul F. Mercer et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL