The hypoxia-adenosine link during inflammation

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Beneficial Role of Erythrocyte Adenosine A2B Receptor–Mediated AMP-Activated Protein Kinase Activation in High-Altitude HypoxiaClinical Perspective

(2016) Hong Liu et al.   CIRCULATION

AltitudeOmics: Red Blood Cell Metabolic Adaptation to High Altitude Hypoxia

(2016) Angelo D’Alessandro et al.   JOURNAL OF PROTEOME RESEARCH

Unraveling the role of adenosine in remote ischemic preconditioning-induced cardioprotection

(2016) Puneet Kaur Randhawa et al.   LIFE SCIENCES

A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

(2016) Akio Ohta   Frontiers in Immunology

Hypoxia Induced NF-κB

(2016) Laura D’Ignazio et al.   Cells

Hypoxia signaling during acute lung injury

(2015) Christine U. Vohwinkel et al.   JOURNAL OF APPLIED PHYSIOLOGY

Loss of CD73-mediated actin polymerization promotes endometrial tumor progression

(2015) Jessica L. Bowser et al.   JOURNAL OF CLINICAL INVESTIGATION

Alveolar Epithelial A2B Adenosine Receptors in Pulmonary Protection during Acute Lung Injury

(2015) Sandra Hoegl et al.   JOURNAL OF IMMUNOLOGY

Epithelial-specific A2B adenosine receptor signaling protects the colonic epithelial barrier during acute colitis

(2015) C M Aherne et al.   Mucosal Immunology

Metabolic control of type 1 regulatory T cell differentiation by AHR and HIF1-α

(2015) Ivan D Mascanfroni et al.   NATURE MEDICINE

Control of IFN- A by CD73: Implications for Mucosal Inflammation

(2014) N. A. Louis et al.   JOURNAL OF IMMUNOLOGY

Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury

(2014) T. Eckle et al.   JOURNAL OF IMMUNOLOGY

Nucleotide signalling during inflammation

(2014) Marco Idzko et al.   NATURE

Targeting hypoxia signalling for the treatment of ischaemic and inflammatory diseases

(2014) Holger K. Eltzschig et al.   NATURE REVIEWS DRUG DISCOVERY

Hypoxia-Inducible Factor 3 Is an Oxygen-Dependent Transcription Activator and Regulates a Distinct Transcriptional Response to Hypoxia

(2014) Peng Zhang et al.   Cell Reports

Crosstalk between the equilibrative nucleoside transporter ENT2 and alveolar Adora2b adenosine receptors dampens acute lung injury

(2013) Tobias Eckle et al.   FASEB JOURNAL

Endothelial PAS Domain Protein 1 Activates the Inflammatory Response in the Intestinal Epithelium to Promote Colitis in Mice

(2013) Xiang Xue et al.   GASTROENTEROLOGY

Extracellular adenosine signaling in molecular medicine

(2013) Holger K. Eltzschig   JOURNAL OF MOLECULAR MEDICINE-JMM

Contribution of epithelial innate immunity to systemic protection afforded by prolyl hydroxylase inhibition in murine colitis

(2013) S Keely et al.   Mucosal Immunology

Succinate is an inflammatory signal that induces IL-1β through HIF-1α

(2013) G. M. Tannahill et al.   NATURE

AstraZeneca bets on FibroGen's anaemia drug

(2013) Monica Hoyos Flight   NATURE REVIEWS DRUG DISCOVERY

Adenosine receptors as drug targets — what are the challenges?

(2013) Jiang-Fan Chen et al.   NATURE REVIEWS DRUG DISCOVERY

Acute High-Altitude Illnesses

(2013) Peter Bärtsch et al.   NEW ENGLAND JOURNAL OF MEDICINE

CF102 for the Treatment of Hepatocellular Carcinoma: A Phase I/II, Open-Label, Dose-Escalation Study

(2013) S. M. Stemmer et al.   ONCOLOGIST

Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart

(2013) Z. Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF1A Reduces Acute Lung Injury by Optimizing Carbohydrate Metabolism in the Alveolar Epithelium

(2013) Tobias Eckle et al.   PLOS BIOLOGY

Ecto-Nucleoside Triphosphate Diphosphohydrolase 7 Controls Th17 Cell Responses through Regulation of Luminal ATP in the Small Intestine

(2012) T. Kusu et al.   JOURNAL OF IMMUNOLOGY

An oxygen-regulated switch in the protein synthesis machinery

(2012) James Uniacke et al.   NATURE

Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia

(2012) Tobias Eckle et al.   NATURE MEDICINE

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

(2012) Brian D Gulbransen et al.   NATURE MEDICINE

Purinergic Signaling during Inflammation

(2012) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Adenosine and Hypoxia-Inducible Factor Signaling in Intestinal Injury and Recovery

(2011) Sean P. Colgan et al.   Annual Review of Physiology

Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis

(2011) Carol M Aherne et al.   GUT

Adenosine Receptor-Mediated Cardioprotection

(2011) Victoria J. McIntosh et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Hypoxia and Inflammation

(2011) Holger K. Eltzschig et al.   NEW ENGLAND JOURNAL OF MEDICINE

Netrin-1 Dampens Pulmonary Inflammation during Acute Lung Injury

(2010) Valbona Mirakaj et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Extracellular Adenosine: A Safety Signal That Dampens Hypoxia-Induced Inflammation During Ischemia

(2010) Almut Grenz et al.   ANTIOXIDANTS & REDOX SIGNALING

Loss of Prolyl Hydroxylase-1 Protects Against Colitis Through Reduced Epithelial Cell Apoptosis and Increased Barrier Function

(2010) Murtaza M. Tambuwala et al.   GASTROENTEROLOGY

SP1-Dependent Induction of CD39 Facilitates Hepatic Ischemic Preconditioning

(2010) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury

(2010) U. Schingnitz et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypoxia: an alarm signal during intestinal inflammation

(2010) Sean P. Colgan et al.   Nature Reviews Gastroenterology & Hepatology

Equilibrative nucleoside transporter 1 plays an essential role in cardioprotection

(2009) Jennifer B. Rose et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Cutting Edge: A2B Adenosine Receptor Signaling Provides Potent Protection during Intestinal Ischemia/Reperfusion Injury

(2009) M. L. Hart et al.   JOURNAL OF IMMUNOLOGY

Contribution of Adenosine A2B Receptors to Inflammatory Parameters of Experimental Colitis

(2009) J.-S. Frick et al.   JOURNAL OF IMMUNOLOGY

Intestinal alkaline phosphatase regulates protective surface microclimate pH in rat duodenum

(2009) Misa Mizumori et al.   JOURNAL OF PHYSIOLOGY-LONDON

Current Status of Older and New Purine Nucleoside Analogues in the Treatment of Lymphoproliferative Diseases

(2009) Tadeusz Robak et al.   MOLECULES

Hypoxia-inducible factor–dependent induction of netrin-1 dampens inflammation caused by hypoxia

(2009) Peter Rosenberger et al.   NATURE IMMUNOLOGY

Inhibition of oxygen sensors as a therapeutic strategy for ischaemic and inflammatory disease

(2009) Peter Fraisl et al.   NATURE REVIEWS DRUG DISCOVERY

Role of Extracellular Adenosine in Acute Lung Injury

(2009) Tobias Eckle et al.   PHYSIOLOGY

Adenosine A2A receptor is a unique angiogenic target of HIF-2  in pulmonary endothelial cells

(2009) A. Ahmad et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CD39 deletion exacerbates experimental murine colitis and human polymorphisms increase susceptibility to inflammatory bowel disease

(2009) D. J. Friedman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Donor Toll-like receptor 4 contributes to ischemia and reperfusion injury following human kidney transplantation

(2009) B. Kruger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak

(2008) J. C. Morote-Garcia et al.   BLOOD

Central role of Sp1-regulated CD39 in hypoxia/ischemia protection

(2008) H. K. Eltzschig et al.   BLOOD

Hypoxia-Inducible Factor-1 Is Central to Cardioprotection

(2008) Tobias Eckle et al.   CIRCULATION

Hypoxia-Independent Activation of HIF-1 by Enterobacteriaceae and Their Siderophores

(2008) Hanna Hartmann et al.   GASTROENTEROLOGY

Hypoxia-Inducible Factor–Dependent Repression of Equilibrative Nucleoside Transporter 2 Attenuates Mucosal Inflammation During Intestinal Hypoxia

(2008) Julio C. Morote–Garcia et al.   GASTROENTEROLOGY

The Reno-Vascular A2B Adenosine Receptor Protects the Kidney from Ischemia

(2008) Almut Grenz et al.   PLOS MEDICINE

The Hydroxylase Inhibitor Dimethyloxalylglycine Is Protective in a Murine Model of Colitis

(2007) Eoin P. Cummins et al.   GASTROENTEROLOGY

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

(2007) Andreas Robinson et al.   GASTROENTEROLOGY