Elucidating the influence of environmentally relevant toxic metal mixture on molecular mechanisms involved in the development of neurodegenerative diseases: In silico toxicogenomic data-mining

Leveraging complementary computational models for prioritizing chemicals of developmental and reproductive toxicity concern: an example of food contact materials

(2020) Chun-Wei Tung et al.   ARCHIVES OF TOXICOLOGY

Development of novel phosphodiesterase 5 inhibitors for the therapy of Alzheimer’s disease

(2020) Elisa Zuccarello et al.   BIOCHEMICAL PHARMACOLOGY

Elevated cerebrospinal fluid homocysteine is associated with blood-brain barrier disruption in amyotrophic lateral sclerosis patients

(2020) Yonghua Wu et al.   NEUROLOGICAL SCIENCES

Toxic Effects of the Mixture of Phthalates and Bisphenol A—Subacute Oral Toxicity Study in Wistar Rats

(2020) Katarina Baralić et al.   International Journal of Environmental Research and Public Health

Arsenic Toxicity: Molecular Targets and Therapeutic Agents

(2020) Valeria M. Nurchi et al.   Biomolecules

Selenium-associated DNA methylation modifications in placenta and neurobehavioral development of newborns: An epigenome-wide study of two U.S. birth cohorts

(2020) Fu-Ying Tian et al.   ENVIRONMENT INTERNATIONAL

Toxic-Metal-Induced Alteration in miRNA Expression Profile as a Proposed Mechanism for Disease Development

(2020) David R. Wallace et al.   Cells

The Role of Neurovascular System in Neurodegenerative Diseases

(2020) Ajmal Ahmad et al.   MOLECULAR NEUROBIOLOGY

Redox and essential metal status in the brain of Wistar rats acutely exposed to a cadmium and lead mixture

(2020) Dragana Javorac et al.   Arhiv za Higijenu Rada i Toksikologiju-Archives of Industrial Hygiene and Toxicology

Multi-strain probiotic ameliorated toxic effects of phthalates and bisphenol A mixture in Wistar rats

(2020) Katarina Baralić et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer’s Disease

(2020) Md. Tanvir Kabir et al.   MOLECULAR NEUROBIOLOGY

Toxic Effect of Acute Cadmium and Lead Exposure in Rat Blood, Liver, and Kidney

(2019) Milena Andjelkovic et al.   International Journal of Environmental Research and Public Health

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

(2019) Darshpreet Kaur et al.   INFLAMMOPHARMACOLOGY

MAPT mutations, tauopathy, and mechanisms of neurodegeneration

(2019) Kevin H. Strang et al.   LABORATORY INVESTIGATION

Interleukin-4 and Interleukin-13 Exacerbate Neurotoxicity of Prothrombin Kringle-2 in Cortex In Vivo via Oxidative Stress

(2019) Jae Yeong Jeong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AGE–RAGE stress: a changing landscape in pathology and treatment of Alzheimer’s disease

(2019) Kailash Prasad   MOLECULAR AND CELLULAR BIOCHEMISTRY

Environmental cadmium exposure and pancreatic cancer: Evidence from case control, animal and in vitro studies

(2019) Vladimir R. Djordjevic et al.   ENVIRONMENT INTERNATIONAL

The relative impact of toxic heavy metals (THMs) (arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview

(2019) Zeeshanur Rahman et al.   ENVIRONMENTAL MONITORING AND ASSESSMENT

Aberrations in Oxidative Stress Markers in Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis

(2019) Zihao Wang et al.   Oxidative Medicine and Cellular Longevity

Critical assessment and integration of separate lines of evidence for risk assessment of chemical mixtures

(2019) Antonio F. Hernandez et al.   ARCHIVES OF TOXICOLOGY

Impaired dopamine metabolism in Parkinson’s disease pathogenesis

(2019) Anna Masato et al.   Molecular Neurodegeneration

High-throughput assessment of toxic effects of metal mixtures of cadmium(Cd), lead(Pb), and manganese(Mn) in nematode Caenorhabditis elegans

(2019) Bowen Tang et al.   CHEMOSPHERE

Systemic activation of Nrf2 pathway in Parkinson's disease

(2019) Sara Petrillo et al.   MOVEMENT DISORDERS

Lead induces DNA damage and alteration of ALAD and antioxidant genes mRNA expression in construction site workers

(2018) Zertashia Akram et al.   Archives of Environmental & Occupational Health

Overview of Cadmium Thyroid Disrupting Effects and Mechanisms

(2018) Aleksandra Buha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Differential protein expression of hippocampal cells associated with heavy metals (Pb, As, and MeHg) neurotoxicity: Deepening into the molecular mechanism of neurodegenerative diseases

(2018) Venkatanaidu Karri et al.   Journal of Proteomics

Advanced Glycation End Products Are Associated With Physical Activity and Physical Functioning in the Older Population

(2018) Hans Drenth et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

GeneMANIA update 2018

(2018) Max Franz et al.   NUCLEIC ACIDS RESEARCH

BDNF Polymorphism: A Review of Its Diagnostic and Clinical Relevance in Neurodegenerative Disorders

(2018) Ting Shen et al.   Aging and Disease

Glutathione transferases: substrates, inihibitors and pro-drugs in cancer and neurodegenerative diseases

(2018) Nerino Allocati et al.   Oncogenesis

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

Lead, cadmium, arsenic, and mercury combined exposure disrupted synaptic homeostasis through activating the Snk-SPAR pathway

(2018) Fankun Zhou et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Metallic Air Pollutants and Breast Cancer Risk in a Nationwide Cohort Study

(2018) Alexandra J. White et al.   EPIDEMIOLOGY

Heat Shock Proteins in Alzheimer’s Disease: Role and Targeting

(2018) Claudia Campanella et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Cancer Prevention, Anti-Inflammatory and Anti-Oxidation of Bioactive Phytochemicals Targeting the TLR4 Signaling Pathway

(2018) Chung-Yi Chen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The Comparative Toxicogenomics Database: update 2019

(2018) Allan Peter Davis et al.   NUCLEIC ACIDS RESEARCH

Neuronal Cell Death Mechanisms in Major Neurodegenerative Diseases

(2018) Hao Chi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Toxicogenomics: A 2020 Vision

(2018) Zhichao Liu et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Decreased lung function with mediation of blood parameters linked to e-waste lead and cadmium exposure in preschool children

(2017) Xiang Zeng et al.   ENVIRONMENTAL POLLUTION

Nonmonotonic responses to low doses of xenoestrogens: A review

(2017) Zhixiang Xu et al.   ENVIRONMENTAL RESEARCH

Metals and neurodegenerative diseases. A systematic review

(2017) Calogero Edoardo Cicero et al.   ENVIRONMENTAL RESEARCH

Amyotrophic lateral sclerosis as a protein level, non-genomic disease: Therapy with S2RM exosome released molecules

(2017) Greg Maguire   World Journal of Stem Cells

Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: A general review of metal mixture mechanism in brain

(2016) Venkatanaidu Karri et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Plasma levels of soluble receptor for advanced glycation end products in Alzheimer's disease

(2016) Xiao-Yan Xu et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Altered Metabolic Homeostasis in Amyotrophic Lateral Sclerosis: Mechanisms of Energy Imbalance and Contribution to Disease Progression

(2016) Zara A. Ioannides et al.   Neurodegenerative Diseases

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Redox- and non-redox-metal-induced formation of free radicals and their role in human disease

(2015) Marian Valko et al.   ARCHIVES OF TOXICOLOGY

Oxidative stress, mitochondrial dysfunction and neurodegenerative diseases; a mechanistic insight

(2015) Aashiq Hussain Bhat et al.   BIOMEDICINE & PHARMACOTHERAPY

Insight into the oxidative stress induced by lead and/or cadmium in blood, liver and kidneys

(2015) Vesna Matović et al.   FOOD AND CHEMICAL TOXICOLOGY

Review of Amyotrophic Lateral Sclerosis, Parkinson’s and Alzheimer’s diseases helps further define pathology of the novel paradigm for Alzheimer’s with heavy metals as primary disease cause

(2015) Franco Cavaleri   MEDICAL HYPOTHESES

Glutathione transferases and neurodegenerative diseases

(2015) Anna Paola Mazzetti et al.   NEUROCHEMISTRY INTERNATIONAL

Selenium reduces bradykinesia and DNA damage in a rat model of Parkinson's disease

(2015) Joel Henrique Ellwanger et al.   NUTRITION

Interrelation of Oxidative Stress and Inflammation in Neurodegenerative Disease: Role of TNF

(2015) Roman Fischer et al.   Oxidative Medicine and Cellular Longevity

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis

(2014) Simone G. J. van Breda et al.   ARCHIVES OF TOXICOLOGY

Arsenic and Manganese Alter Lead Deposition in the Rat

(2014) V. Andrade et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

Low dose mixture effects of endocrine disrupters and their implications for regulatory thresholds in chemical risk assessment

(2014) Andreas Kortenkamp   CURRENT OPINION IN PHARMACOLOGY

Exposure to As-, Cd-, and Pb-Mixture Induces Aβ, Amyloidogenic APP Processing and Cognitive Impairments via Oxidative Stress-Dependent Neuroinflammation in Young Rats

(2014) Anushruti Ashok et al.   TOXICOLOGICAL SCIENCES

Interaction effects of lead on bioavailability and pharmacokinetics of arsenic in the rat

(2013) Violet Diacomanolis et al.   ENVIRONMENTAL GEOCHEMISTRY AND HEALTH

Cardiovascular Outcomes and the Physical and Chemical Properties of Metal Ions Found in Particulate Matter Air Pollution: a QICAR Study

(2013) Qingyu Meng et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

SOD2 in mitochondrial dysfunction and neurodegeneration

(2013) James M. Flynn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Upregulation of phagocyte-like NADPH oxidase by cytokines in pancreatic beta-cells: Attenuation of oxidative and nitrosative stress by 2-bromopalmitate

(2012) Abiy M. Mohammed et al.   BIOCHEMICAL PHARMACOLOGY

Neurotoxicity of Engineered Nanoparticles from Metals

(2012) Hari Shanker Sharma et al.   CNS & Neurological Disorders-Drug Targets

Modeling non-monotonic dose–response relationships: Model evaluation and hormetic quantities exploration

(2012) Xiang-Wei Zhu et al.   ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY

Intracerebral microinjection of interleukin-4/interleukin-13 reduces β-amyloid accumulation in the ipsilateral side and improves cognitive deficits in young amyloid precursor protein 23 mice

(2012) K. Kawahara et al.   NEUROSCIENCE

Developmental origins of adult diseases and neurotoxicity: Epidemiological and experimental studies

(2012) Donald A. Fox et al.   NEUROTOXICOLOGY

Comparison of the effect of chronic cadmium exposure on the antioxidant defense systems of kidney and brain in rat

(2012) Jessica Elena Mendieta-Wejebe et al.   TOXICOLOGY MECHANISMS AND METHODS

One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?

(2011) Andrea Fuso et al.   NEUROBIOLOGY OF AGING

Role of p53 in Neurodegenerative Diseases

(2011) J. Robert Chang et al.   Neurodegenerative Diseases

Vitamin B12, cognition, and brain MRI measures: A cross-sectional examination

(2011) C. C. Tangney et al.   NEUROLOGY

Toll-like receptor signaling in amyotrophic lateral sclerosis spinal cord tissue

(2011) M. Casula et al.   NEUROSCIENCE

One-Carbon Metabolism and Alzheimers Disease: Focus on Epigenetics

(2010) Fabio Coppede   CURRENT GENOMICS

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function

(2010) David Warde-Farley et al.   NUCLEIC ACIDS RESEARCH

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

ClueGO: a Cytoscape plug-in to decipher functionally grouped gene ontology and pathway annotation networks

(2009) Gabriela Bindea et al.   BIOINFORMATICS

Oxidative stress in ALS: Key role in motor neuron injury and therapeutic target

(2009) Siân C. Barber et al.   FREE RADICAL BIOLOGY AND MEDICINE

Heme oxygenase-1 and neurodegeneration: expanding frontiers of engagement

(2009) Hyman M. Schipper et al.   JOURNAL OF NEUROCHEMISTRY

Methylmercury inhibits dopaminergic function in rat pup synaptosomes in an age-dependent manner

(2009) Anne Dreiem et al.   NEUROTOXICOLOGY AND TERATOLOGY

ToppGene Suite for gene list enrichment analysis and candidate gene prioritization

(2009) J. Chen et al.   NUCLEIC ACIDS RESEARCH

Toxic effects of dopamine metabolism in Parkinson's disease

(2009) Nobutaka Hattori et al.   PARKINSONISM & RELATED DISORDERS

Dietary Intake of Arsenic, Cadmium, Mercury, and Lead by the Population of Catalonia, Spain

(2008) Roser Martí-Cid et al.   BIOLOGICAL TRACE ELEMENT RESEARCH

The Comparative Toxicogenomics Database facilitates identification and understanding of chemical-gene-disease associations: arsenic as a case study

(2008) Allan P Davis et al.   BMC Medical Genomics

Hippocampal RAGE immunoreactivity in early and advanced Alzheimer's disease

(2008) Miles C. Miller et al.   BRAIN RESEARCH

Low dose mixture effects of endocrine disrupters: implications for risk assessment and epidemiology

(2008) Andreas Kortenkamp   INTERNATIONAL JOURNAL OF ANDROLOGY

Neuronal cell death in neurodegenerative diseases: recurring themes around protein handling

(2008) Adrienne M. Gorman   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

TNF signaling inhibition in the CNS: implications for normal brain function and neurodegenerative disease

(2008) Melissa K McCoy et al.   Journal of Neuroinflammation

Vitamin B12 status and rate of brain volume loss in community-dwelling elderly

(2008) A. Vogiatzoglou et al.   NEUROLOGY

Comparative Toxicogenomics Database: a knowledgebase and discovery tool for chemical-gene-disease networks

(2008) A. P. Davis et al.   NUCLEIC ACIDS RESEARCH