Molecular Mechanisms of Metal Toxicity in the Pathogenesis of Alzheimer’s Disease

Chromium picolinate attenuates cognitive deficit in ICV-STZ rat paradigm of sporadic Alzheimer’s-like dementia via targeting neuroinflammatory and IRS-1/PI3K/AKT/GSK-3β pathway

(2020) Ansab Akhtar et al.   INFLAMMOPHARMACOLOGY

Emerging Promise of Immunotherapy for Alzheimer’s Disease: A New Hope for the Development of Alzheimer’s Vaccine

(2020) Md. Tanvir Kabir et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Combination Drug Therapy for the Management of Alzheimer’s Disease

(2020) Md. Tanvir Kabir et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Molecular Insight into the Therapeutic Promise of Flavonoids against Alzheimer’s Disease

(2020) Md. Sahab Uddin et al.   MOLECULES

Novel Anti-Alzheimer’s Therapeutic Molecules Targeting Amyloid Precursor Protein Processing

(2020) Md. Sahab Uddin et al.   Oxidative Medicine and Cellular Longevity

Molecular Insight into the Therapeutic Promise of Targeting APOE4 for Alzheimer’s Disease

(2020) Abdullah Al Mamun et al.   Oxidative Medicine and Cellular Longevity

Circadian and sleep dysfunction in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   AGEING RESEARCH REVIEWS

Revisiting the blood-brain barrier: A hard nut to crack in the transportation of drug molecules

(2020) Seetha Harilal et al.   BRAIN RESEARCH BULLETIN

Pharmacological approaches to mitigate neuroinflammation in Alzheimer’s disease

(2020) Md. Sahab Uddin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Revisiting the role of brain and peripheral Aβ in the pathogenesis of Alzheimer's disease

(2020) Md. Sahab Uddin et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Cholinesterase Inhibitors for Alzheimer's Disease: Multitargeting Strategy Based on Anti-Alzheimer's Drugs Repositioning

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

NMDA Receptor Antagonists: Repositioning of Memantine as a Multitargeting Agent for Alzheimer's Therapy

(2019) Md. Tanvir Kabir et al.   CURRENT PHARMACEUTICAL DESIGN

Infant Exposure to Lead (Pb) and Epigenetic Modifications in the Aging Primate Brain: Implications for Alzheimer's Disease

(2018) Syed Waseem Bihaqi et al.   JOURNAL OF ALZHEIMERS DISEASE

Copper in Alzheimer's Disease: A Meta-Analysis of Serum, Plasma, and Cerebrospinal Fluid Studies

(2018) Serena Bucossi et al.   JOURNAL OF ALZHEIMERS DISEASE

Intronic rs2147363 Variant in ATP7B Transcription Factor-Binding Site Associated with Alzheimer's Disease

(2018) Serena Bucossi et al.   JOURNAL OF ALZHEIMERS DISEASE

High Manganese, A Risk for Alzheimer's Disease: High Manganese Induces Amyloid-β Related Cognitive Impairment

(2018) Yawei Tong et al.   JOURNAL OF ALZHEIMERS DISEASE

Perturbed Iron Distribution in Alzheimer's Disease Serum, Cerebrospinal Fluid, and Selected Brain Regions: A Systematic Review and Meta-Analysis

(2018) Yunlong Tao et al.   JOURNAL OF ALZHEIMERS DISEASE

The zinc paradigm for metalloneurochemistry

(2017) Chelsea A. Barr et al.   Essays in Biochemistry

Dynamics of the metal binding domains and regulation of the human copper transporters ATP7B and ATP7A

(2017) Corey H. Yu et al.   IUBMB LIFE

Sirtuin 2 regulates cellular iron homeostasis via deacetylation of transcription factor NRF2

(2017) Xiaoyan Yang et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatic metal ion transporter ZIP8 regulates manganese homeostasis and manganese-dependent enzyme activity

(2017) Wen Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Metal Transporter Zip14 ( Slc39a14 ) Deletion in Mice Increases Manganese Deposition and Produces Neurotoxic Signatures and Diminished Motor Activity

(2017) Tolunay Beker Aydemir et al.   JOURNAL OF NEUROSCIENCE

Soluble oligomeric amyloid-β induces calcium dyshomeostasis that precedes synapse loss in the living mouse brain

(2017) Michal Arbel-Ornath et al.   Molecular Neurodegeneration

Accumulated Amyloid-β Peptide and Hyperphosphorylated Tau Protein: Relationship and Links in Alzheimer's Disease

(2017) Han-Chang Huang et al.   JOURNAL OF ALZHEIMERS DISEASE

Does Inorganic Mercury Play a Role in Alzheimer's Disease? A Systematic Review and an Integrated Molecular Mechanism

(2017) Joachim Mutter et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain biometals and Alzheimer's disease – boon or bane?

(2016) Atish Prakash et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Patterns of Brain Iron Accumulation in Vascular Dementia and Alzheimer’s Dementia Using Quantitative Susceptibility Mapping Imaging

(2016) Yeonsil Moon et al.   JOURNAL OF ALZHEIMERS DISEASE

Ten Challenges of the Amyloid Hypothesis of Alzheimer’s Disease

(2016) Kasper Planeta Kepp   JOURNAL OF ALZHEIMERS DISEASE

The β isoform of GSK3 mediates podocyte autonomous injury in proteinuric glomerulopathy

(2016) Changbin Li et al.   JOURNAL OF PATHOLOGY

Characterization of Mn(II) ion binding to the amyloid-β peptide in Alzheimer⿿s disease

(2016) Cecilia Wallin et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Lithium suppression of tau induces brain iron accumulation and neurodegeneration

(2016) P Lei et al.   MOLECULAR PSYCHIATRY

Ammonium Increases TRPC1 Expression Via Cav-1/PTEN/AKT/GSK3β Pathway

(2016) Wei Wang et al.   NEUROCHEMICAL RESEARCH

Autophagy in Neurodegenerative Diseases and Metal Neurotoxicity

(2016) Ziyan Zhang et al.   NEUROCHEMICAL RESEARCH

Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3β enzyme, β-amyloid and tau protein levels

(2015) Javier del Pino et al.   ARCHIVES OF TOXICOLOGY

Modulatory Role of Simvastatin against Aluminium Chloride-Induced Behavioural and Biochemical Changes in Rats

(2015) Madhavan Nampoothiri et al.   BEHAVIOURAL NEUROLOGY

A novel LDL-mimic nanocarrier for the targeted delivery of curcumin into the brain to treat Alzheimer's disease

(2015) Fanfei Meng et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Ferroportin deficiency impairs manganese metabolism in flatiron mice

(2015) Young Ah Seo et al.   FASEB JOURNAL

The Transient Receptor Potential Melastatin 2 (TRPM2) Channel Contributes to  -Amyloid Oligomer-Related Neurotoxicity and Memory Impairment

(2015) V. G. Ostapchenko et al.   JOURNAL OF NEUROSCIENCE

Age-related changes of brain iron load changes in the frontal cortex in APPswe/PS1ΔE9 transgenic mouse model of Alzheimer's disease

(2015) Dong Xian-hui et al.   JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY

Iron and Neurodegeneration: Is Ferritinophagy the Link?

(2015) Giorgio Biasiotto et al.   MOLECULAR NEUROBIOLOGY

Aβ induces PUMA activation: a new mechanism for Aβ-mediated neuronal apoptosis

(2015) Jie Feng et al.   NEUROBIOLOGY OF AGING

Clioquinol rescues Parkinsonism and dementia phenotypes of the tau knockout mouse

(2015) Peng Lei et al.   NEUROBIOLOGY OF DISEASE

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases

(2015) Miguel Chin-Chan et al.   Frontiers in Cellular Neuroscience

Metallothionein-3 modulates the amyloid β endocytosis of astrocytes through its effects on actin polymerization

(2015) Sook-Jeong Lee et al.   Molecular Brain

Age-related iron deposition in the basal ganglia of controls and Alzheimer disease patients quantified using susceptibility weighted imaging

(2014) Dan Wang et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Protection of SK-N-MC cells against β-amyloid peptide-induced degeneration using neuron growth factor-loaded liposomes with surface lactoferrin

(2014) Yung-Chih Kuo et al.   BIOMATERIALS

Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1–42. Possible implications for Alzheimer’s disease

(2014) Gabriella Notarachille et al.   BIOMETALS

In vivo and in vitro properties of STX2484: a novel non-steroidal anti-cancer compound active in taxane-resistant breast cancer

(2014) C Stengel et al.   BRITISH JOURNAL OF CANCER

Trafficking mechanisms and regulation of TRPC channels

(2014) Lorena Brito de Souza et al.   CELL CALCIUM

sAPP modulates iron efflux from brain microvascular endothelial cells by stabilizing the ferrous iron exporter ferroportin

(2014) R. C. McCarthy et al.   EMBO REPORTS

Regulation of MDA-MB-231 cell proliferation by GSK-3β involves epigenetic modifications under high glucose conditions

(2014) Chanchal Gupta et al.   EXPERIMENTAL CELL RESEARCH

Is the Aluminum Hypothesis Dead?

(2014) Theodore I. Lidsky   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Assessment of ZnT3 and PSD95 protein levels in Lewy body dementias and Alzheimer's disease: association with cognitive impairment

(2014) David R. Whitfield et al.   NEUROBIOLOGY OF AGING

Biometals and Their Therapeutic Implications in Alzheimer’s Disease

(2014) Scott Ayton et al.   Neurotherapeutics

Magnesium Protects Cognitive Functions and Synaptic Plasticity in Streptozotocin-Induced Sporadic Alzheimer’s Model

(2014) Zhi-Peng Xu et al.   PLoS One

Metabolism and functions of copper in brain

(2014) Ivo F. Scheiber et al.   PROGRESS IN NEUROBIOLOGY

Elevation of brain magnesium prevents synaptic loss and reverses cognitive deficits in Alzheimer’s disease mouse model

(2014) Wei Li et al.   Molecular Brain

Manganese neurotoxicity and the role of reactive oxygen species

(2013) Ebany J. Martinez-Finley et al.   FREE RADICAL BIOLOGY AND MEDICINE

FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease

(2013) Tae-In Kam et al.   JOURNAL OF CLINICAL INVESTIGATION

The SLC30 family of zinc transporters – A review of current understanding of their biological and pathophysiological roles

(2013) Liping Huang et al.   MOLECULAR ASPECTS OF MEDICINE

Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease–like symptoms

(2013) Minglin Lang et al.   NEUROBIOLOGY OF AGING

Dysfunctional synapse in Alzheimer's disease – A focus on NMDA receptors

(2013) Sandra I. Mota et al.   NEUROPHARMACOLOGY

Inhibition of specificity protein 1 by dibenzylideneacetone, a curcumin analogue, induces apoptosis in mucoepidermoid carcinomas and tumor xenografts through Bim and truncated Bid

(2013) Heang-Eun Lee et al.   ORAL ONCOLOGY

Altered Expression of ZnT10 in Alzheimer's Disease Brain

(2013) Helen J. Bosomworth et al.   PLoS One

Chronic manganese exposure impairs visuospatial associative learning in non-human primates

(2013) J.S. Schneider et al.   TOXICOLOGY LETTERS

Magnesium in Disease Prevention and Overall Health

(2013) Stella Lucia Volpe   Advances in Nutrition

Zinc Biochemistry: From a Single Zinc Enzyme to a Key Element of Life

(2013) Wolfgang Maret   Advances in Nutrition

Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates

(2013) Tomás R. Guilarte   Frontiers in Aging Neuroscience

SB216763, a selective small molecule inhibitor of glycogen synthase kinase-3, improves bleomycin-induced pulmonary fibrosis via activating autophagy

(2013) Hong Liu et al.   Acta Pharmaceutica Sinica B

ATP13A2 (PARK9) protein levels are reduced in brain tissue of cases with Lewy bodies

(2013) Karen E Murphy et al.   Acta Neuropathologica Communications

The systemic iron-regulatory proteins hepcidin and ferroportin are reduced in the brain in Alzheimer’s disease

(2013) Animesh Raha et al.   Acta Neuropathologica Communications

Syndrome of Hepatic Cirrhosis, Dystonia, Polycythemia, and Hypermanganesemia Caused by Mutations in SLC30A10 , a Manganese Transporter in Man

(2012) Karin Tuschl et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Proteomic Changes in Cerebrospinal Fluid of Presymptomatic and Affected Persons Carrying Familial Alzheimer Disease Mutations

(2012) John M. Ringman   ARCHIVES OF NEUROLOGY

Rapid Exchange of Metal between Zn7–Metallothionein-3 and Amyloid-β Peptide Promotes Amyloid-Related Structural Changes

(2012) Jeppe T. Pedersen et al.   BIOCHEMISTRY

The role of iron as a mediator of oxidative stress in Alzheimer disease

(2012) Rudy J. Castellani et al.   BIOFACTORS

Characterization of the role of the antioxidant proteins metallothioneins 1 and 2 in an animal model of Alzheimer’s disease

(2012) Yasmina Manso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Characterization of the role of metallothionein-3 in an animal model of Alzheimer’s disease

(2012) Yasmina Manso et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PTEN regulates apoptotic cell death through PI3-K/Akt/GSK3β signaling pathway in DMH induced early colon carcinogenesis in rat

(2012) Manpreet Kaur Saini et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Drug Transport across the Blood–Brain Barrier

(2012) William M Pardridge   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

The metal transporter SMF-3/DMT-1 mediates aluminum-induced dopamine neuron degeneration

(2012) Natalia VanDuyn et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid neurotoxicity is attenuated by metallothionein: dual mechanisms at work

(2012) Jong-Heon Kim et al.   JOURNAL OF NEUROCHEMISTRY

Pharmacological inhibition of Akt and downstream pathways modulates the expression of COX-2 and mPGES-1 in activated microglia

(2012) Antonio CP de Oliveira et al.   Journal of Neuroinflammation

Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells

(2012) Hitomi Fujishiro et al.   Metallomics

Tau deficiency induces parkinsonism with dementia by impairing APP-mediated iron export

(2012) Peng Lei et al.   NATURE MEDICINE

The effect of cadmium on Aβ levels in APP/PS1 transgenic mice

(2012) XIAOLING LI et al.   Experimental and Therapeutic Medicine

Dysregulation of Ca2+ signaling in astrocytes from mice lacking amyloid precursor protein

(2011) Cristina I. Linde et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cellular magnesium homeostasis

(2011) Andrea M.P. Romani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

The iron transporter ferroportin can also function as a manganese exporter

(2011) Michael S. Madejczyk et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Aging and amyloid beta-induced oxidative DNA damage and mitochondrial dysfunction in Alzheimer's disease: Implications for early intervention and therapeutics

(2011) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Epothilones in Development for Non–Small-Cell Lung Cancer: Novel Anti-Tubulin Agents With the Potential to Overcome Taxane Resistance

(2011) Martin J. Edelman et al.   Clinical Lung Cancer

Modulation of transient receptor potential melastatin related 7 channel by presenilins

(2011) Hyun Geun Oh et al.   Developmental Neurobiology

Presenilins Promote the Cellular Uptake of Copper and Zinc and Maintain Copper Chaperone of SOD1-dependent Copper/Zinc Superoxide Dismutase Activity

(2011) Mark A. Greenough et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of brain iron and copper homeostasis by brain barrier systems: Implication in neurodegenerative diseases

(2011) Wei Zheng et al.   PHARMACOLOGY & THERAPEUTICS

Activation of mixed glia by Aβ-specific Th1 and Th17 cells and its regulation by Th2 cells

(2010) K. McQuillan et al.   BRAIN BEHAVIOR AND IMMUNITY

Mg2+ ions reduce microglial and THP-1 cell neurotoxicity by inhibiting Ca2+ entry through purinergic channels

(2010) Moonhee Lee et al.   BRAIN RESEARCH

Dendritic Function of Tau Mediates Amyloid-β Toxicity in Alzheimer's Disease Mouse Models

(2010) Lars M. Ittner et al.   CELL

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Altered microglial copper homeostasis in a mouse model of Alzheimer’s disease

(2010) Zhiqiang Zheng et al.   JOURNAL OF NEUROCHEMISTRY

Cognitive Loss in Zinc Transporter-3 Knock-Out Mice: A Phenocopy for the Synaptic and Memory Deficits of Alzheimer's Disease?

(2010) P. A. Adlard et al.   JOURNAL OF NEUROSCIENCE

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

HTLV-I p30: A versatile protein modulating virus replication and pathogenesis

(2010) Xue Tao Bai et al.   MOLECULAR ASPECTS OF MEDICINE

Aluminum induces neurodegeneration and its toxicity arises from increased iron accumulation and reactive oxygen species (ROS) production

(2010) Zhihao Wu et al.   NEUROBIOLOGY OF AGING

Deposition of lactoferrin in fibrillar-type senile plaques in the brains of transgenic mouse models of Alzheimer's disease

(2010) Ligang Wang et al.   NEUROSCIENCE LETTERS

APLP1, Alzheimer's-like pathology and neurodegeneration in the frontal cortex of manganese-exposed non-human primates

(2010) Tomás R. Guilarte   NEUROTOXICOLOGY

Copper Homeostasis: The Role of Cellular Transporters

(2010) Edward D. Harris   NUTRITION REVIEWS

Manganese Accumulates within Golgi Apparatus in Dopaminergic Cells as Revealed by Synchrotron X-ray Fluorescence Nanoimaging

(2009) Asunción Carmona et al.   ACS Chemical Neuroscience

Neuronal expression of vimentin in the Alzheimer's disease brain may be part of a generalized dendritic damage-response mechanism

(2009) Eli C. Levin et al.   BRAIN RESEARCH

The Death Receptor CD95 Activates Adult Neural Stem Cells for Working Memory Formation and Brain Repair

(2009) Nina S. Corsini et al.   Cell Stem Cell

Subcellular and metabolic examination of amyloid-β peptides in Alzheimer disease pathogenesis: Evidence for Aβ25–35

(2009) Yury G. Kaminsky et al.   EXPERIMENTAL NEUROLOGY

Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer’s disease

(2009) Magali Dumont et al.   FASEB JOURNAL

Low Micromolar Zinc Accelerates the Fibrillization of Human Tau via Bridging of Cys-291 and Cys-322

(2009) Zhong-Ying Mo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of telomere dysfunction in aging and its detection by biomarkers

(2009) Guido von Figura et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Chronic copper exposure exacerbates both amyloid and tau pathology and selectively dysregulates cdk5 in a mouse model of AD

(2009) Masashi Kitazawa et al.   JOURNAL OF NEUROCHEMISTRY

Mg2+ Imparts NMDA Receptor Subtype Selectivity to the Alzheimer's Drug Memantine

(2009) S. E. Kotermanski et al.   JOURNAL OF NEUROSCIENCE

Expression and localization of lactotransferrin messenger RNA in the cortex of Alzheimer's disease

(2009) Li An et al.   NEUROSCIENCE LETTERS

Small molecule blockers of the Alzheimer A  calcium channel potently protect neurons from A  cytotoxicity

(2009) J. C. Diaz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Abundant expression of zinc transporters in the amyloid plaques of Alzheimer's disease brain

(2008) Li-Hong Zhang et al.   BRAIN RESEARCH BULLETIN

Aβ40 promotes neuronal cell fate in neural progenitor cells

(2008) Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Alzheimer's Disease (AD)-Like Pathology in Aged Monkeys after Infantile Exposure to Environmental Metal Lead (Pb): Evidence for a Developmental Origin and Environmental Link for AD

(2008) J. Wu et al.   JOURNAL OF NEUROSCIENCE

Mechanism of Ca2+ Disruption in Alzheimer's Disease by Presenilin Regulation of InsP3 Receptor Channel Gating

(2008) King-Ho Cheung et al.   NEURON

Therapeutics for Alzheimer’s disease based on the metal hypothesis

(2008) Ashley I. Bush et al.   Neurotherapeutics

Amyloid beta peptides and glutamatergic synaptic dysregulation

(2007) Kodeeswaran Parameshwaran et al.   EXPERIMENTAL NEUROLOGY

Alzheimer’s disease as copper deficiency

(2007) Leslie M. Klevay   MEDICAL HYPOTHESES