Sealing holes in cellular membranes

Knocking ’em Dead: Pore-Forming Proteins in Immune Defense

(2020) Xing Liu et al.   Annual Review of Immunology

ESCRT-III/Vps4 Controls Heterochromatin-Nuclear Envelope Attachments

(2020) Gerard H. Pieper et al.   DEVELOPMENTAL CELL

AMPK, a Regulator of Metabolism and Autophagy, Is Activated by Lysosomal Damage via a Novel Galectin-Directed Ubiquitin Signal Transduction System

(2020) Jingyue Jia et al.   MOLECULAR CELL

Spatially and temporally defined lysosomal leakage facilitates mitotic chromosome segregation

(2020) Saara Hämälistö et al.   Nature Communications

Critical Role of Lipid Scramblase TMEM16F in Phosphatidylserine Exposure and Repair of Plasma Membrane after Pore Formation

(2020) Ning Wu et al.   Cell Reports

Regulated lipid synthesis and LEM2/CHMP7 jointly control nuclear envelope closure

(2020) Lauren Penfield et al.   JOURNAL OF CELL BIOLOGY

Autophagosome biogenesis: From membrane growth to closure

(2020) Thomas J. Melia et al.   JOURNAL OF CELL BIOLOGY

Annexin V Drives Stabilization of Damaged Asymmetric Phospholipid Bilayers

(2020) Jack Robinson et al.   LANGMUIR

BAF facilitates interphase nuclear membrane repair through recruitment of nuclear transmembrane proteins

(2020) Alexandra M. Young et al.   MOLECULAR BIOLOGY OF THE CELL

LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation

(2020) Alexander von Appen et al.   NATURE

Mechanisms generating cancer genome complexity from a single cell division error

(2020) Neil T. Umbreit et al.   SCIENCE

Interdisciplinary Synergy to Reveal Mechanisms of Annexin-Mediated Plasma Membrane Shaping and Repair

(2020) Poul Martin Bendix et al.   Cells

ESCRT puts its thumb on the nanoscale: Fixing tiny holes in endolysosomes

(2020) Kevin P. Bohannon et al.   CURRENT OPINION IN CELL BIOLOGY

LRRK 2 activation controls the repair of damaged endomembranes in macrophages

(2020) Susanne Herbst et al.   EMBO JOURNAL

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation

(2020) Marina Vietri et al.   NATURE CELL BIOLOGY

Endosomal membrane tension regulates ESCRT-III-dependent intra-lumenal vesicle formation

(2020) Vincent Mercier et al.   NATURE CELL BIOLOGY

Rab5-dependent autophagosome closure by ESCRT

(2019) Fan Zhou et al.   JOURNAL OF CELL BIOLOGY

An ESCRT-LEM protein surveillance system is poised to directly monitor the nuclear envelope and nuclear transport system

(2019) David J Thaller et al.   eLife

Repair of nuclear ruptures requires barrier-to-autointegration factor

(2019) Charles T. Halfmann et al.   JOURNAL OF CELL BIOLOGY

Annexin A7 is required for ESCRT III-mediated plasma membrane repair

(2019) Stine Lauritzen Sønder et al.   Scientific Reports

ESCRT-mediated phagophore sealing during mitophagy

(2019) Yan Zhen et al.   Autophagy

VPS37A directs ESCRT recruitment for phagophore closure

(2019) Yoshinori Takahashi et al.   JOURNAL OF CELL BIOLOGY

The many functions of ESCRTs

(2019) Marina Vietri et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Galectin-3 Coordinates a Cellular System for Lysosomal Repair and Removal

(2019) Jingyue Jia et al.   DEVELOPMENTAL CELL

Mutant lamins cause nuclear envelope rupture and DNA damage in skeletal muscle cells

(2019) Ashley J. Earle et al.   NATURE MATERIALS

The Dynamic Nature of the Nuclear Envelope

(2018) Paola De Magistris et al.   CURRENT BIOLOGY

Dynein pulling forces counteract lamin-mediated nuclear stability during nuclear envelope repair

(2018) Lauren Penfield et al.   MOLECULAR BIOLOGY OF THE CELL

Galectins Control mTOR in Response to Endomembrane Damage

(2018) Jingyue Jia et al.   MOLECULAR CELL

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

An autophagy assay reveals the ESCRT-III component CHMP2A as a regulator of phagophore closure

(2018) Yoshinori Takahashi et al.   Nature Communications

Membrane Repair Mechanisms against Permeabilization by Pore-Forming Toxins

(2018) Asier Etxaniz et al.   Toxins

CC2D1B Coordinates ESCRT-III Activity during the Mitotic Reformation of the Nuclear Envelope

(2018) Leandro N. Ventimiglia et al.   DEVELOPMENTAL CELL

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

cGAS surveillance of micronuclei links genome instability to innate immunity

(2017) Karen J. Mackenzie et al.   NATURE

Mitotic progression following DNA damage enables pattern recognition within micronuclei

(2017) Shane M. Harding et al.   NATURE

LEM2 recruits CHMP7 for ESCRT-mediated nuclear envelope closure in fission yeast and human cells

(2017) Mingyu Gu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clathrin-Independent Endocytosis Suppresses Cancer Cell Blebbing and Invasion

(2017) Mikkel Roland Holst et al.   Cell Reports

A Rab5 GTPase module is important for autophagosome closure

(2017) Fan Zhou et al.   PLoS Genetics

Membrane Binding by CHMP7 Coordinates ESCRT-III-Dependent Nuclear Envelope Reformation

(2016) Yolanda Olmos et al.   CURRENT BIOLOGY

TRIMs and Galectins Globally Cooperate and TRIM16 and Galectin-3 Co-direct Autophagy in Endomembrane Damage Homeostasis

(2016) Santosh Chauhan et al.   DEVELOPMENTAL CELL

Chm7 and Heh1 collaborate to link nuclear pore complex quality control with nuclear envelope sealing

(2016) Brant M Webster et al.   EMBO JOURNAL

Dysferlin function in skeletal muscle: Possible pathological mechanisms and therapeutical targets in dysferlinopathies

(2016) Ana M. Cárdenas et al.   EXPERIMENTAL NEUROLOGY

An actin-dependent annexin complex mediates plasma membrane repair in muscle

(2016) Alexis R. Demonbreun et al.   JOURNAL OF CELL BIOLOGY

Reverse-topology membrane scission by the ESCRT proteins

(2016) Johannes Schöneberg et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ESCRT III repairs nuclear envelope ruptures during cell migration to limit DNA damage and cell death

(2016) M. Raab et al.   SCIENCE

Nuclear envelope rupture and repair during cancer cell migration

(2016) C. M. Denais et al.   SCIENCE

Dysferlin-mediated phosphatidylserine sorting engages macrophages in sarcolemma repair

(2016) Volker Middel et al.   Nature Communications

Autophagosome closure requires membrane scission

(2015) Roland L Knorr et al.   Autophagy

Chromothripsis and Kataegis Induced by Telomere Crisis

(2015) John Maciejowski et al.   CELL

ER-endosome contact sites: molecular compositions and functions

(2015) C. Raiborg et al.   EMBO JOURNAL

ESCRT-III controls nuclear envelope reformation

(2015) Yolanda Olmos et al.   NATURE

Spastin and ESCRT-III coordinate mitotic spindle disassembly and nuclear envelope sealing

(2015) Marina Vietri et al.   NATURE

Chromothripsis from DNA damage in micronuclei

(2015) Cheng-Zhong Zhang et al.   NATURE

Membrane Repair: Mechanisms and Pathophysiology

(2015) Sandra T. Cooper et al.   PHYSIOLOGICAL REVIEWS

GRAF1 deficiency blunts sarcolemmal injury repair and exacerbates cardiac and skeletal muscle pathology in dystrophin-deficient mice

(2015) Kaitlin C. Lenhart et al.   Skeletal Muscle

Pore dynamics in lipid membranes

(2014) I. Gozen et al.   European Physical Journal-Special Topics

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Damage control: cellular mechanisms of plasma membrane repair

(2014) Norma W. Andrews et al.   TRENDS IN CELL BIOLOGY

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

Spatiotemporally controlled induction of autophagy-mediated lysosome turnover

(2013) Yu-Hsien Hung et al.   Nature Communications

The Hairpin-type Tail-Anchored SNARE Syntaxin 17 Targets to Autophagosomes for Fusion with Endosomes/Lysosomes

(2012) Eisuke Itakura et al.   CELL

Transient nuclear envelope rupturing during interphase in human cancer cells

(2012) Jesse D. Vargas et al.   Nucleus

The Role of Atg Proteins in Autophagosome Formation

(2011) Noboru Mizushima et al.   Annual Review of Cell and Developmental Biology

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Divergent Strategies for Controlling the Nuclear Membrane Satisfy Geometric Constraints during Nuclear Division

(2011) Candice Yam et al.   CURRENT BIOLOGY

Repetitive disruptions of the nuclear envelope invoke temporary loss of cellular compartmentalization in laminopathies

(2011) Winnok H. De Vos et al.   HUMAN MOLECULAR GENETICS

Trypanosoma cruzisubverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion

(2011) Maria Cecilia Fernandes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Staying in touch: the molecular era of organelle contact sites

(2011) Yael Elbaz et al.   TRENDS IN BIOCHEMICAL SCIENCES

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair

(2011) Anthony Bouter et al.   Nature Communications

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

(2010) Christina Tam et al.   JOURNAL OF CELL BIOLOGY

Roles of galectins in infection

(2009) Gerardo R. Vasta   NATURE REVIEWS MICROBIOLOGY

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

The life cycle of the metazoan nuclear envelope

(2008) Daniel J Anderson et al.   CURRENT OPINION IN CELL BIOLOGY

Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis

(2008) Vincent Idone et al.   JOURNAL OF CELL BIOLOGY

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY