Membrane Repair: Mechanisms and Pathophysiology

Neuronal Calcium Signaling, Mitochondrial Dysfunction, and Alzheimer's Disease

(2017) Charlene Supnet et al.   JOURNAL OF ALZHEIMERS DISEASE

Pore dynamics in lipid membranes

(2014) I. Gozen et al.   European Physical Journal-Special Topics

Rapid actin-cytoskeleton–dependent recruitment of plasma membrane–derived dysferlin at wounds is critical for muscle membrane repair

(2014) Joel R. McDade et al.   FASEB JOURNAL

Calpain cleavage within dysferlin exon 40a releases a synaptotagmin-like module for membrane repair

(2014) G. M. I. Redpath et al.   MOLECULAR BIOLOGY OF THE CELL

The intracellular Ca2+ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy

(2014) Xiping Cheng et al.   NATURE MEDICINE

Actin Dynamics, Architecture, and Mechanics in Cell Motility

(2014) Laurent Blanchoin et al.   PHYSIOLOGICAL REVIEWS

Annexin A6 modifies muscular dystrophy by mediating sarcolemmal repair

(2014) K. A. Swaggart et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ESCRT Machinery Is Required for Plasma Membrane Repair

(2014) A. J. Jimenez et al.   SCIENCE

Mechanism of Ca2+-triggered ESCRT assembly and regulation of cell membrane repair

(2014) Luana L. Scheffer et al.   Nature Communications

Membrane Fission Reactions of the Mammalian ESCRT Pathway

(2013) John McCullough et al.   Annual Review of Biochemistry

Annexin A1 is a biomarker of T-tubular repair in skeletal muscle of nonmyopathic patients undergoing statin therapy

(2013) Tilman Voigt et al.   FASEB JOURNAL

Membrane damage-induced vesicle–vesicle fusion of dysferlin-containing vesicles in muscle cells requires microtubules and kinesin

(2013) Joel R. McDade et al.   HUMAN MOLECULAR GENETICS

Calpains, Cleaved Mini-DysferlinC72, and L-Type Channels Underpin Calcium-Dependent Muscle Membrane Repair

(2013) A. Lek et al.   JOURNAL OF NEUROSCIENCE

Role of Pore-Forming Toxins in Bacterial Infectious Diseases

(2013) F. C. O. Los et al.   MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

(2013) Maofu Liao et al.   NATURE

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

(2013) Ruisheng Song et al.   NATURE

Dysferlin stabilizes stress-induced Ca2+ signaling in the transverse tubule membrane

(2013) J. P. Kerr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

More Than a Pore: The Cellular Response to Cholesterol-Dependent Cytolysins

(2013) Sara Cassidy et al.   Toxins

Caveolae internalization repairs wounded cells and muscle fibers

(2013) Matthias Corrotte et al.   eLife

Regulation and physiological roles of the calpain system in muscular disorders

(2012) H. Sorimachi et al.   CARDIOVASCULAR RESEARCH

Contribution of calpains to myocardial ischaemia/reperfusion injury

(2012) J. Inserte et al.   CARDIOVASCULAR RESEARCH

In Vivo Imaging of Molecular Interactions at Damaged Sarcolemma

(2012) Urmas Roostalu et al.   DEVELOPMENTAL CELL

Nonmuscle myosin IIA facilitates vesicle trafficking for MG53-mediated cell membrane repair

(2012) Peihui Lin et al.   FASEB JOURNAL

Intracellular calcium movements during excitation–contraction coupling in mammalian slow-twitch and fast-twitch muscle fibers

(2012) Stephen M. Baylor et al.   JOURNAL OF GENERAL PHYSIOLOGY

Distinct Initial SNARE Configurations Underlying the Diversity of Exocytosis

(2012) Haruo Kasai et al.   PHYSIOLOGICAL REVIEWS

Lack of Correlation between Outcomes of Membrane Repair Assay and Correction of Dystrophic Changes in Experimental Therapeutic Strategy in Dysferlinopathy

(2012) William Lostal et al.   PLoS One

Recombinant MG53 Protein Modulates Therapeutic Cell Membrane Repair in Treatment of Muscular Dystrophy

(2012) N. Weisleder et al.   Science Translational Medicine

Pathophysiology of myocardial reperfusion injury: preconditioning, postconditioning, and translational aspects of protective measures

(2011) Shoji Sanada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Actin Structure and Function

(2011) Roberto Dominguez et al.   Annual Review of Biophysics

Plasma membrane repair and cellular damage control: The annexin survival kit

(2011) Annette Draeger et al.   BIOCHEMICAL PHARMACOLOGY

RAB-5- and RAB-11-Dependent Vesicle-Trafficking Pathways Are Required for Plasma Membrane Repair after Attack by Bacterial Pore-Forming Toxin

(2011) Ferdinand C.O. Los et al.   Cell Host & Microbe

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

A Novel Cellular Defect in Diabetes

(2011) Amber C. Howard et al.   DIABETES

TRIM family: Pleiotropy and diversification through homomultimer and heteromultimer formation

(2011) Luisa M. Napolitano et al.   IUBMB LIFE

Structure of Human C8 Protein Provides Mechanistic Insight into Membrane Pore Formation by Complement

(2011) Leslie L. Lovelace et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Calpain Protects the Heart from Hemodynamic Stress

(2011) Manabu Taneike et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tailored Protection against Plasmalemmal Injury by Annexins with Different Ca2+Sensitivities

(2011) Sarah Potez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymerase Transcriptase Release Factor (PTRF) Anchors MG53 Protein to Cell Injury Site for Initiation of Membrane Repair

(2011) Hua Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The evolution of the cytoskeleton

(2011) Bill Wickstead et al.   JOURNAL OF CELL BIOLOGY

Cell wound repair inDrosophilaoccurs through three distinct phases of membrane and cytoskeletal remodeling

(2011) Maria Teresa Abreu-Blanco et al.   JOURNAL OF CELL BIOLOGY

Streptolysin O clearance through sequestration into blebs that bud passively from the plasma membrane

(2011) P. A. Keyel et al.   JOURNAL OF CELL SCIENCE

Dysferlin, Annexin A1, and Mitsugumin 53 Are Upregulated in Muscular Dystrophy and Localize to Longitudinal Tubules of the T-System With Stretch

(2011) Leigh B. Waddell et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells

(2011) Jerome Thiery et al.   NATURE IMMUNOLOGY

GPS-CCD: A Novel Computational Program for the Prediction of Calpain Cleavage Sites

(2011) Zexian Liu et al.   PLoS One

Ferlins: Regulators of Vesicle Fusion for Auditory Neurotransmission, Receptor Trafficking and Membrane Repair

(2011) Angela Lek et al.   TRAFFIC

Toxin Pores Endocytosed During Plasma Membrane Repair Traffic into the Lumen of MVBs for Degradation

(2011) Matthias Corrotte et al.   TRAFFIC

Annexin-A5 assembled into two-dimensional arrays promotes cell membrane repair

(2011) Anthony Bouter et al.   Nature Communications

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Statin Therapy and the Expression of Genes that Regulate Calcium Homeostasis and Membrane Repair in Skeletal Muscle

(2010) Annette Draeger et al.   AMERICAN JOURNAL OF PATHOLOGY

A New Role for the Muscle Repair Protein Dysferlin in Endothelial Cell Adhesion and Angiogenesis

(2010) Arpeeta Sharma et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phylogenetic analysis of ferlin genes reveals ancient eukaryotic origins

(2010) Angela Lek et al.   BMC EVOLUTIONARY BIOLOGY

Calcium and the damage pathways in muscular dystrophyThis article is one of a selection of papers published in this special issue on Calcium Signaling.

(2010) David G. Allen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon Guidance

(2010) Max A. Tischfield et al.   CELL

MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning

(2010) Chun-Mei Cao et al.   CIRCULATION

Cardioprotection of Ischemia/Reperfusion Injury by Cholesterol-Dependent MG53-Mediated Membrane Repair

(2010) Xianhua Wang et al.   CIRCULATION RESEARCH

Cell biology of Ca2+-triggered exocytosis

(2010) Zhiping P Pang et al.   CURRENT OPINION IN CELL BIOLOGY

Tripartite-motif proteins and innate immune regulation

(2010) Finlay W McNab et al.   CURRENT OPINION IN IMMUNOLOGY

Impaired muscle growth and response to insulin-like growth factor 1 in dysferlin-mediated muscular dystrophy

(2010) Alexis R. Demonbreun et al.   HUMAN MOLECULAR GENETICS

Reduced Plasma Membrane Expression of Dysferlin Mutants Is Attributed to Accelerated Endocytosis via a Syntaxin-4-associated Pathway

(2010) Frances J. Evesson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

m-calpain Activation Is Regulated by Its Membrane Localization and by Its Binding to Phosphatidylinositol 4,5-Bisphosphate

(2010) Ludovic Leloup et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exocytosis of acid sphingomyelinase by wounded cells promotes endocytosis and plasma membrane repair

(2010) Christina Tam et al.   JOURNAL OF CELL BIOLOGY

Membrane wounding triggers ATP release and dysferlin-mediated intercellular calcium signaling

(2010) J. F. Covian-Nares et al.   JOURNAL OF CELL SCIENCE

The structural basis for membrane binding and pore formation by lymphocyte perforin

(2010) Ruby H. P. Law et al.   NATURE

Hearing requires otoferlin-dependent efficient replenishment of synaptic vesicles in hair cells

(2010) Tina Pangršič et al.   NATURE NEUROSCIENCE

Calpain as a therapeutic target in traumatic brain injury

(2010) Kathryn E. Saatman et al.   Neurotherapeutics

A Naturally Occurring Human Minidysferlin Protein Repairs Sarcolemmal Lesions in a Mouse Model of Dysferlinopathy

(2010) M. Krahn et al.   Science Translational Medicine

Extensive mononuclear infiltration and myogenesis characterize recovery of dysferlin-null skeletal muscle from contraction-induced injuries

(2009) Joseph A. Roche et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Lipid Oxidation and Peroxidation in CNS Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities

(2009) Rao Muralikrishna Adibhatla et al.   ANTIOXIDANTS & REDOX SIGNALING

The mitochondrial permeability transition pore and ischemia-reperfusion injury

(2009) Christopher P. Baines   BASIC RESEARCH IN CARDIOLOGY

Calcium-dependent plasma membrane repair requires m- or μ-calpain, but not calpain-3, the proteasome, or caspases

(2009) Ronald L. Mellgren et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Perforin activates clathrin- and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis

(2009) J. Thiery et al.   BLOOD

Intracellular Ca2+ operates a switch between repair and lysis of streptolysin O-perforated cells

(2009) E B Babiychuk et al.   CELL DEATH AND DIFFERENTIATION

Calpains, skeletal muscle function and exercise

(2009) Robyn M Murphy   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexes

(2009) Mark C Field et al.   CURRENT OPINION IN CELL BIOLOGY

Membrane injury by pore-forming proteins

(2009) Mirko Bischofberger et al.   CURRENT OPINION IN CELL BIOLOGY

Identification and characterisation of human dysferlin transcript variants: implications for dysferlin mutational screening and isoforms

(2009) Zacharias Aloysius Dwi Pramono et al.   HUMAN GENETICS

The Molecular Basis for Perforin Oligomerization and Transmembrane Pore Assembly

(2009) Katherine Baran et al.   IMMUNITY

Identification of the Penta-EF-hand Protein ALG-2 as a Ca2+-dependent Interactor of Mucolipin-1

(2009) Silvia Vergarajauregui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Membrane Repair Defects in Muscular Dystrophy Are Linked to Altered Interaction between MG53, Caveolin-3, and Dysferlin

(2009) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

No strings attached: the ESCRT machinery in viral budding and cytokinesis

(2009) B. McDonald et al.   JOURNAL OF CELL SCIENCE

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

(2009) Yi Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Rapid Ca2+flux through the transverse tubular membrane, activated by individual action potentials in mammalian skeletal muscle

(2009) Bradley S. Launikonis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Hemoglobin-Based Oxygen Carrier Induces Heme Oxygenase-1 in the Heart and Lung but Not Brain

(2009) Sagar S. Damle et al.   JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Helical extension of the neuronal SNARE complex into the membrane

(2009) Alexander Stein et al.   NATURE

Membrane repair redux: redox of MG53

(2009) Paul McNeil   NATURE CELL BIOLOGY

Calcium influx is sufficient to induce muscular dystrophy through a TRPC-dependent mechanism

(2009) Douglas P. Millay et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ancient ESCRTs and the evolution of binary fission

(2009) Rachel Y. Samson et al.   TRENDS IN MICROBIOLOGY

Direct observation of failing fibers in muscles of dystrophic mice provides mechanistic insight into muscular dystrophy

(2008) Dennis R. Claflin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Pore formation: An ancient yet complex form of attack

(2008) Ioan Iacovache et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

(2008) Marco Sardiello et al.   BMC EVOLUTIONARY BIOLOGY

The MACPF/CDC family of pore-forming toxins

(2008) Carlos J. Rosado et al.   CELLULAR MICROBIOLOGY

ESCRT complexes and the biogenesis of multivesicular bodies

(2008) James H Hurley   CURRENT OPINION IN CELL BIOLOGY

Elimination of a bacterial pore-forming toxin by sequential endocytosis and exocytosis

(2008) Matthias Husmann et al.   FEBS LETTERS

Evolution of specificity in the eukaryotic endomembrane system

(2008) Joel B. Dacks et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

MG53 Regulates Membrane Budding and Exocytosis in Muscle Cells

(2008) Chuanxi Cai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repair of injured plasma membrane by rapid Ca2+-dependent endocytosis

(2008) Vincent Idone et al.   JOURNAL OF CELL BIOLOGY

Plasma membrane deformation by circular arrays of ESCRT-III protein filaments

(2008) Phyllis I. Hanson et al.   JOURNAL OF CELL BIOLOGY

Reduced SERCA2a converts sub-lethal myocardial injury to infarction and affects postischemic functional recovery

(2008) M.A. Hassan Talukder et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The accessibility and interconnectivity of the tubular system network in toad skeletal muscle

(2008) Joshua N. Edwards et al.   JOURNAL OF PHYSIOLOGY-LONDON

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel

(2008) Xian-Ping Dong et al.   NATURE

MG53 nucleates assembly of cell membrane repair machinery

(2008) Chuanxi Cai et al.   NATURE CELL BIOLOGY

Synaptic vesicle fusion

(2008) Josep Rizo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Calpain 3, the “gatekeeper” of proper sarcomere assembly, turnover and maintenance

(2008) Jacques S. Beckmann et al.   NEUROMUSCULAR DISORDERS

Impaired recovery of dysferlin-null skeletal muscle after contraction-induced injury in vivo

(2008) Joseph A. Roche et al.   NEUROREPORT

Mechanisms Underlying Acute Protection From Cardiac Ischemia-Reperfusion Injury

(2008) Elizabeth Murphy et al.   PHYSIOLOGICAL REVIEWS

A Role for the ESCRT System in Cell Division in Archaea

(2008) R. Y. Samson et al.   SCIENCE

Evolution of the Multivesicular Body ESCRT Machinery; Retention Across the Eukaryotic Lineage

(2008) Ka Fai Leung et al.   TRAFFIC

Two-way traffic on the road to plasma membrane repair

(2008) Vincent Idone et al.   TRENDS IN CELL BIOLOGY

Lysenin: A sphingomyelin specific pore-forming toxin

(2007) Hidehiko Shogomori et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Immuno-proteomic approach to excitation–contraction coupling in skeletal and cardiac muscle: Molecular insights revealed by the mitsugumins

(2007) Noah Weisleder et al.   CELL CALCIUM

Limb–girdle muscular dystrophy: Diagnostic evaluation, frequency and clues to pathogenesis

(2007) Harriet P. Lo et al.   NEUROMUSCULAR DISORDERS