LRRK 2 activation controls the repair of damaged endomembranes in macrophages

LRRK2 maintains mitochondrial homeostasis and regulates innate immune responses to Mycobacterium tuberculosis

(2020) Chi G Weindel et al.   eLife

The ESCRT and autophagy machineries cooperate to repair ESX-1-dependent damage at the Mycobacterium-containing vacuole but have opposite impact on containing the infection

(2019) Ana T. López-Jiménez et al.   PLoS Pathogens

LRRK2 in infection: friend or foe?

(2019) Susanne Herbst et al.   ACS Infectious Diseases

Mycobacterium tuberculosis infection of host cells in space and time

(2019) Claudio Bussi et al.   FEMS MICROBIOLOGY REVIEWS

The ubiquitin‐conjugating enzyme UBE 2 QL 1 coordinates lysophagy in response to endolysosomal damage

(2019) Lisa Koerver et al.   EMBO REPORTS

Repair or Lysophagy: Dealing with Damaged Lysosomes

(2019) Chrisovalantis Papadopoulos et al.   JOURNAL OF MOLECULAR BIOLOGY

Lrrk2 alleles modulate inflammation during microbial infection of mice in a sex-dependent manner

(2019) Bojan Shutinoski et al.   Science Translational Medicine

LRRK2 is a negative regulator of Mycobacterium tuberculosis phagosome maturation in macrophages

(2018) Anetta Härtlova et al.   EMBO JOURNAL

Triggered recruitment of ESCRT machinery promotes endolysosomal repair

(2018) Michael L. Skowyra et al.   SCIENCE

An increase in LRRK2 suppresses autophagy and enhances Dectin-1–induced immunity in a mouse model of colitis

(2018) Tetsuya Takagawa et al.   Science Translational Medicine

Candida albicans Hyphal Expansion Causes Phagosomal Membrane Damage and Luminal Alkalinization

(2018) Johannes Westman et al.   mBio

ESCRT‐mediated lysosome repair precedes lysophagy and promotes cell survival

(2018) Maja Radulovic et al.   EMBO JOURNAL

The lysosome as a cellular centre for signalling, metabolism and quality control

(2018) Rosalie E. Lawrence et al.   NATURE CELL BIOLOGY

L-leucyl-L-leucine methyl ester does not release cysteine cathepsins to the cytosol but inactivates them in transiently permeabilized lysosomes

(2017) Urska Repnik et al.   JOURNAL OF CELL SCIENCE

Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis

(2017) Lilliana Radoshevich et al.   NATURE REVIEWS MICROBIOLOGY

NeuroChip, an updated version of the NeuroX genotyping platform to rapidly screen for variants associated with neurological diseases

(2017) Cornelis Blauwendraat et al.   NEUROBIOLOGY OF AGING

An updated review of Parkinson's disease genetics and clinicopathological correlations

(2016) M. Ferreira et al.   ACTA NEUROLOGICA SCANDINAVICA

Autophagy Proteins Promote Repair of Endosomal Membranes Damaged by the Salmonella Type Three Secretion System 1

(2015) Saskia Kreibich et al.   Cell Host & Microbe

Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury

(2013) Ikuko Maejima et al.   EMBO JOURNAL

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser910/Ser935, disruption of 14-3-3 binding and altered cytoplasmic localization

(2010) Nicolas Dzamko et al.   BIOCHEMICAL JOURNAL