Targeting Energy Metabolism in Cancer Stem Cells: Progress and Challenges in Leukemia and Solid Tumors

Emerging Roles for Branched-Chain Amino Acid Metabolism in Cancer

(2020) Sharanya Sivanand et al.   CANCER CELL

Restraining Lysosomal Activity Preserves Hematopoietic Stem Cell Quiescence and Potency

(2020) Raymond Liang et al.   Cell Stem Cell

Glioblastoma Exhibits Inter-Individual Heterogeneity of TSPO and LAT1 Expression in Neoplastic and Parenchymal Cells

(2020) Linzhi Cai et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting glutamine metabolism slows soft tissue sarcoma growth

(2020) Pearl Lee et al.   Nature Communications

Monocytic Subclones Confer Resistance to Venetoclax-Based Therapy in Acute Myeloid Leukemia Patients

(2020) Shanshan Pei et al.   Cancer Discovery

Relapse fated latent diagnosis subclones in acute B lineage leukaemia are drug tolerant and possess distinct metabolic programs

(2020) Stephanie M. Dobson et al.   Cancer Discovery

The mitochondrial peptidase, neurolysin, regulates respiratory chain supercomplex formation and is necessary for AML viability

(2020) Sara Mirali et al.   Science Translational Medicine

Induction of a Timed Metabolic Collapse to Overcome Cancer Chemoresistance

(2020) Nick van Gastel et al.   Cell Metabolism

A comparative pharmaco-metabolomic study of glutaminase inhibitors in glioma stem-like cells confirms biological effectiveness but reveals differences in target-specificity

(2020) Katharina Koch et al.   Cell Death Discovery

Nicotinamide Metabolism Mediates Resistance to Venetoclax in Relapsed Acute Myeloid Leukemia Stem Cells

(2020) Courtney L. Jones et al.   Cell Stem Cell

Mitochondrial Potentiation Ameliorates Age-Related Heterogeneity in Hematopoietic Stem Cell Function

(2020) Els Mansell et al.   Cell Stem Cell

The hepatic microenvironment uniquely protects leukemia cells through induction of growth and survival pathways mediated by LIPG

(2020) Haobin Ye et al.   Cancer Discovery

Sirtuins in Metabolic and Epigenetic Regulation of Stem Cells

(2019) Yi Fang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Metabolism-Based Therapeutic Strategies Targeting Cancer Stem Cells

(2019) Petra Jagust et al.   Frontiers in Pharmacology

EGCG-Derivative G28 Shows High Efficacy Inhibiting the Mammosphere-Forming Capacity of Sensitive and Resistant TNBC Models

(2019) Ariadna Giró-Perafita et al.   MOLECULES

Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II

(2019) Courtney L. Jones et al.   BLOOD

Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality

(2019) Jo Ishizawa et al.   CANCER CELL

Enasidenib, an inhibitor of mutant IDH2 proteins, induces durable remissions in older patients with newly diagnosed acute myeloid leukemia

(2019) Daniel A. Pollyea et al.   LEUKEMIA

Targeting mitochondrial structure sensitizes acute myeloid leukemia to Venetoclax treatment

(2019) Xufeng Chen et al.   Cancer Discovery

The TP53 Apoptotic Network is a Primary Mediator of Resistance to BCL2 inhibition in AML Cells

(2019) Tamilla Nechiporuk et al.   Cancer Discovery

The Hematopoietic Oxidase NOX2 Regulates Self-Renewal of Leukemic Stem Cells

(2019) Biniam Adane et al.   Cell Reports

Mutant Isocitrate Dehydrogenase Inhibitors as Targeted Cancer Therapeutics

(2019) Danielle Golub et al.   Frontiers in Oncology

Intersection of Epigenetic and Metabolic Regulation of Histone Modifications in Acute Myeloid Leukemia

(2019) Abhinav Dhall et al.   Frontiers in Oncology

Mubritinib Targets the Electron Transport Chain Complex I and Reveals the Landscape of OXPHOS Dependency in Acute Myeloid Leukemia

(2019) Irène Baccelli et al.   CANCER CELL

MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion

(2019) Milind D. Chalishazar et al.   CLINICAL CANCER RESEARCH

Glioblastoma stem cells: lessons from the tumor hierarchy in a lethal cancer

(2019) Ryan C. Gimple et al.   GENES & DEVELOPMENT

SIRT1 regulates metabolism and leukemogenic potential in CML stem cells

(2019) Ajay Abraham et al.   JOURNAL OF CLINICAL INVESTIGATION

De Novo Design of Boron-Based Peptidomimetics as Potent Inhibitors of Human ClpP in the Presence of Human ClpX

(2019) Joanne Tan et al.   JOURNAL OF MEDICINAL CHEMISTRY

Targeting Metabolic Reprogramming in Acute Myeloid Leukemia

(2019) Isabel Castro et al.   Cells

Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response

(2019) David Sharon et al.   Science Translational Medicine

Adapt and conquer: Metabolic flexibility in cancer growth, invasion and evasion

(2019) Peter Kreuzaler et al.   Molecular Metabolism

Cancer stem cells (CSCs): metabolic strategies for their identification and eradication

(2018) Ernestina M. De Francesco et al.   BIOCHEMICAL JOURNAL

JAK/STAT3-Regulated Fatty Acid β-Oxidation Is Critical for Breast Cancer Stem Cell Self-Renewal and Chemoresistance

(2018) Tianyi Wang et al.   Cell Metabolism

AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells

(2018) Shanshan Pei et al.   Cell Stem Cell

The challenge of drug resistance in cancer treatment: a current overview

(2018) Michail Nikolaou et al.   CLINICAL & EXPERIMENTAL METASTASIS

Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study

(2018) Courtney D DiNardo et al.   LANCET ONCOLOGY

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

(2018) Jennifer R. Molina et al.   NATURE MEDICINE

Durable Remissions with Ivosidenib in IDH1-Mutated Relapsed or Refractory AML

(2018) Courtney D. DiNardo et al.   NEW ENGLAND JOURNAL OF MEDICINE

Cancer Stem Cell Metabolism and Potential Therapeutic Targets

(2018) Vusala Snyder et al.   Frontiers in Oncology

Subversion of Systemic Glucose Metabolism as a Mechanism to Support the Growth of Leukemia Cells

(2018) Haobin Ye et al.   CANCER CELL

Phase 1 study of an oxidative phosphorylation inhibitor IM156 in patients with advanced solid tumors.

(2018) Sun Young Rha et al.   JOURNAL OF CLINICAL ONCOLOGY

Metabolism and Epigenetics of Pancreatic Cancer Stem Cells

(2018) M. Perusina Lanfranca et al.   SEMINARS IN CANCER BIOLOGY

Characterization and targeting of malignant stem cells in patients with advanced myelodysplastic syndromes

(2018) Brett M. Stevens et al.   Nature Communications

Oxidative Phosphorylation: A Target for Novel Therapeutic Strategies Against Ovarian Cancer

(2018) Amruta Nayak et al.   Cancers

Inhibition of Amino Acid Metabolism Selectively Targets Human Leukemia Stem Cells

(2018) Courtney L. Jones et al.   CANCER CELL

Targeting Cancer Stemness in the Clinic: From Hype to Hope

(2018) Caner Saygin et al.   Cell Stem Cell

Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia

(2018) Daniel A. Pollyea et al.   NATURE MEDICINE

Targeting Cancer Stem Cell Redox Metabolism to Enhance Therapy Responses

(2018) Ming Luo et al.   SEMINARS IN RADIATION ONCOLOGY

Concise Reviews: Cancer Stem Cell Targeted Therapies: Toward Clinical Success

(2018) Amar Desai et al.   Stem Cells Translational Medicine

Targeting glutaminase 1 attenuates stemness properties in hepatocellular carcinoma by increasing reactive oxygen species and suppressing Wnt/beta-catenin pathway

(2018) Binghua Li et al.   EBioMedicine

Fumarate hydratase is a critical metabolic regulator of hematopoietic stem cell functions

(2017) Amelie V. Guitart et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia

(2017) Ayuna Hattori et al.   NATURE

Ascorbate regulates haematopoietic stem cell function and leukaemogenesis

(2017) Michalis Agathocleous et al.   NATURE

BCAT1 restricts αKG levels in AML stem cells leading to IDHmut-like DNA hypermethylation

(2017) Simon Raffel et al.   NATURE

Tracing the origins of relapse in acute myeloid leukaemia to stem cells

(2017) Liran I. Shlush et al.   NATURE

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Cancer stem cells revisited

(2017) Eduard Batlle et al.   NATURE MEDICINE

Metabolic heterogeneity and plasticity of glioma stem cells in a mouse glioblastoma model

(2017) Shunsuke Shibao et al.   NEURO-ONCOLOGY

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

(2017) Katharine Yen et al.   Cancer Discovery

Evolution of acute myelogenous leukemia stem cell properties after treatment and progression

(2016) T.-C. Ho et al.   BLOOD

Leukemic Stem Cells Evade Chemotherapy by Metabolic Adaptation to an Adipose Tissue Niche

(2016) Haobin Ye et al.   Cell Stem Cell

Targeting cancer stem-like cells in glioblastoma and colorectal cancer through metabolic pathways

(2016) U.D. Kahlert et al.   INTERNATIONAL JOURNAL OF CANCER

Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth

(2016) Shira L Cramer et al.   NATURE MEDICINE

Liver cancer stem cell markers: Progression and therapeutic implications

(2016) Jing-Hui Sun et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Sensitivity of hematopoietic stem cells to mitochondrial dysfunction by SdhD gene deletion

(2016) José Antonio Bejarano-García et al.   Cell Death & Disease

Therapeutic potential of the metabolic modulator phenformin in targeting the stem cell compartment in melanoma

(2016) Tiziana Petrachi et al.   Oncotarget

Spheroid cancer stem cells display reprogrammed metabolism and obtain energy by actively running the tricarboxylic acid (TCA) cycle

(2016) Masakazu Sato et al.   Oncotarget

Cancer Stem Cells – Are Surface Markers Alone Sufficient?

(2016) Rohit Nagare et al.   Current Stem Cell Research & Therapy

A Phase 1 study of intravenous infusions of tigecycline in patients with acute myeloid leukemia

(2016) Gregory A. Reed et al.   Cancer Medicine

Cancer Stem Cells in Small Cell Lung Cancer Cell Line H446: Higher Dependency on Oxidative Phosphorylation and Mitochondrial Substrate-Level Phosphorylation than Non-Stem Cancer Cells

(2016) Cuicui Gao et al.   PLoS One

Cancer stem cell markers: premises and prospects

(2015) Madhura Murar et al.   Biomarkers in Medicine

AML cells have low spare reserve capacity in their respiratory chain that renders them susceptible to oxidative metabolic stress

(2015) S. Sriskanthadevan et al.   BLOOD

Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2015) Alicia Cole et al.   CANCER CELL

MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells

(2015) Patricia Sancho et al.   Cell Metabolism

AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow

(2015) Yusuke Saito et al.   Cell Stem Cell

TPO-Induced Metabolic Reprogramming Drives Liver Metastasis of Colorectal Cancer CD110+ Tumor-Initiating Cells

(2015) ZhengMing Wu et al.   Cell Stem Cell

SIRT1/PGC1 -Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer

(2015) T. T. Vellinga et al.   CLINICAL CANCER RESEARCH

Metformin in patients with advanced pancreatic cancer: a double-blind, randomised, placebo-controlled phase 2 trial

(2015) Sil Kordes et al.   LANCET ONCOLOGY

Mitochondrial biogenesis is required for the anchorage-independent survival and propagation of stem-like cancer cells

(2015) Arianna De Luca et al.   Oncotarget

High mitochondrial mass identifies a sub-population of stem-like cancer cells that are chemo-resistant

(2015) Gillian Farnie et al.   Oncotarget

5-Fluorouracil resistant colon cancer cells are addicted to OXPHOS to survive and enhance stem-like traits

(2015) Corti Denise et al.   Oncotarget

Inhibition of glucose turnover by 3-bromopyruvate counteracts pancreatic cancer stem cell features and sensitizes cells to gemcitabine

(2015) Orkhan Isayev et al.   Oncotarget

Cancer stem cells from epithelial ovarian cancer patients privilege oxidative phosphorylation, and resist glucose deprivation

(2015) Anna Pastò et al.   Oncotarget

Metabolic differences in breast cancer stem cells and differentiated progeny

(2014) Erina Vlashi et al.   BREAST CANCER RESEARCH AND TREATMENT

Evolution of the Cancer Stem Cell Model

(2014) Antonija Kreso et al.   Cell Stem Cell

Ovarian tumor-initiating cells display a flexible metabolism

(2014) Angela S. Anderson et al.   EXPERIMENTAL CELL RESEARCH

Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function

(2014) Andrea Viale et al.   NATURE

Integrated analysis identifies different metabolic signatures for tumor-initiating cells in a murine glioblastoma model

(2014) I. Saga et al.   NEURO-ONCOLOGY

Ovarian Cancer Spheroid Cells with Stem Cell-Like Properties Contribute to Tumor Generation, Metastasis and Chemotherapy Resistance through Hypoxia-Resistant Metabolism

(2014) Jianqun Liao et al.   PLoS One

A Novel Formulation of Tigecycline Has Enhanced Stability and Sustained Antibacterial and Antileukemic Activity

(2014) Yulia Jitkova et al.   PLoS One

Breast cancer stem cells rely on fermentative glycolysis and are sensitive to 2-deoxyglucose treatment

(2014) D Ciavardelli et al.   Cell Death & Disease

Overcoming Intrinsic Multidrug Resistance in Melanoma by Blocking the Mitochondrial Respiratory Chain of Slow-Cycling JARID1Bhigh Cells

(2013) Alexander Roesch et al.   CANCER CELL

Regulation of Glycolysis by Pdk Functions as a Metabolic Checkpoint for Cell Cycle Quiescence in Hematopoietic Stem Cells

(2013) Keiyo Takubo et al.   Cell Stem Cell

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Targeting Aberrant Glutathione Metabolism to Eradicate Human Acute Myelogenous Leukemia Cells

(2013) Shanshan Pei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Brain tumor initiating cells adapt to restricted nutrition through preferential glucose uptake

(2013) William A Flavahan et al.   NATURE NEUROSCIENCE

Metabolic Adaptation to Chronic Inhibition of Mitochondrial Protein Synthesis in Acute Myeloid Leukemia Cells

(2013) Bozhena Jhas et al.   PLoS One

Strategies for Isolating and Enriching Cancer Stem Cells: Well Begun Is Half Done

(2013) Jiang-jie Duan et al.   STEM CELLS AND DEVELOPMENT

Reactive Oxygen Species in Cancer Stem Cells

(2012) Xiaoke Shi et al.   ANTIOXIDANTS & REDOX SIGNALING

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

(2012) V. Leko et al.   BLOOD

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Imp2 controls oxidative phosphorylation and is crucial for preserving glioblastoma cancer stem cells

(2012) M. Janiszewska et al.   GENES & DEVELOPMENT

Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia

(2011) Marko Škrtić et al.   CANCER CELL

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Mitochondrial and energy metabolism-related properties as novel indicators of lung cancer stem cells

(2011) Xiao-Qun Ye et al.   INTERNATIONAL JOURNAL OF CANCER

Metabolic state of glioma stem cells and nontumorigenic cells

(2011) E. Vlashi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance

(2010) P. P. L. Chiu et al.   BLOOD

AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species

(2010) M. M. Juntilla et al.   BLOOD

Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation

(2010) Maria E. Figueroa et al.   CANCER CELL

TIM-3 Is a Promising Target to Selectively Kill Acute Myeloid Leukemia Stem Cells

(2010) Yoshikane Kikushige et al.   Cell Stem Cell

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Monoclonal antibody therapy directed against human acute myeloid leukemia stem cells

(2010) R Majeti   ONCOGENE

Targeting Myeloid Leukemia Stem Cells

(2010) C. T. Jordan   Science Translational Medicine

Association of reactive oxygen species levels and radioresistance in cancer stem cells

(2009) Maximilian Diehn et al.   NATURE

Cancer-associated IDH1 mutations produce 2-hydroxyglutarate

(2009) Lenny Dang et al.   NATURE

Cancer Stem Cells in Solid Tumors: An Overview

(2009) Catherine Adell O'Brien et al.   SEMINARS IN RADIATION ONCOLOGY

CD44+CD24− prostate cells are early cancer progenitor/stem cells that provide a model for patients with poor prognosis

(2008) E M Hurt et al.   BRITISH JOURNAL OF CANCER

Current management and challenges of malignant disease in the CNS in paediatric leukaemia

(2008) Ching-Hon Pui et al.   LANCET ONCOLOGY