SIRT1 regulates metabolism and leukemogenic potential in CML stem cells

Autophagic flux blockage by accumulation of weakly basic tenovins leads to elimination of B-Raf mutant tumour cells that survive vemurafenib

(2018) Marcus J. G. W. Ladds et al.   PLoS One

Targeting mitochondrial oxidative phosphorylation eradicates therapy-resistant chronic myeloid leukemia stem cells

(2017) Elodie M Kuntz et al.   NATURE MEDICINE

Chemotherapy-Resistant Human Acute Myeloid Leukemia Cells Are Not Enriched for Leukemic Stem Cells but Require Oxidative Metabolism

(2017) Thomas Farge et al.   Cancer Discovery

Inhibition of interleukin-1 signaling enhances elimination of tyrosine kinase inhibitor-treated CML stem cells

(2016) B. Zhang et al.   BLOOD

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia

(2014) D. Sasca et al.   BLOOD

SIRT1 Activation by a c-MYC Oncogenic Network Promotes the Maintenance and Drug Resistance of Human FLT3-ITD Acute Myeloid Leukemia Stem Cells

(2014) Ling Li et al.   Cell Stem Cell

PGC-1α mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis

(2014) Valerie S. LeBleu et al.   NATURE CELL BIOLOGY

Metabolic requirements for the maintenance of self-renewing stem cells

(2014) Keisuke Ito et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aging-like Phenotype and Defective Lineage Specification in SIRT1-Deleted Hematopoietic Stem and Progenitor Cells

(2014) Pauline Rimmelé et al.   Stem Cell Reports

Microenvironmental protection of CML stem and progenitor cells from tyrosine kinase inhibitors through N-cadherin and Wnt- -catenin signaling

(2013) B. Zhang et al.   BLOOD

BCL-2 Inhibition Targets Oxidative Phosphorylation and Selectively Eradicates Quiescent Human Leukemia Stem Cells

(2013) Eleni D. Lagadinou et al.   Cell Stem Cell

Sirt1 ablation promotes stress-induced loss of epigenetic and genomic hematopoietic stem and progenitor cell maintenance

(2013) Satyendra K. Singh et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Methods for defining distinct bioenergetic profiles in platelets, lymphocytes, monocytes and neutrophils and the oxidative burst from human blood

(2013) Balu K Chacko et al.   LABORATORY INVESTIGATION

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

SIRT1 is dispensable for function of hematopoietic stem cells in adult mice

(2012) V. Leko et al.   BLOOD

Estimations of the increasing prevalence and plateau prevalence of chronic myeloid leukemia in the era of tyrosine kinase inhibitor therapy

(2012) Xuelin Huang et al.   CANCER

Activation of p53 by SIRT1 Inhibition Enhances Elimination of CML Leukemia Stem Cells in Combination with Imatinib

(2012) Ling Li et al.   CANCER CELL

Altered Microenvironmental Regulation of Leukemic and Normal Stem Cells in Chronic Myelogenous Leukemia

(2012) Bin Zhang et al.   CANCER CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Histone Deacetylase in Chronic Lymphocytic Leukemia

(2012) J.C. Wang et al.   ONCOLOGY

SIRT1 and c-Myc Promote Liver Tumor Cell Survival and Predict Poor Survival of Human Hepatocellular Carcinomas

(2012) Kyu Yun Jang et al.   PLoS One

Activation of stress response gene SIRT1 by BCR-ABL promotes leukemogenesis

(2011) H. Yuan et al.   BLOOD

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

(2011) A. Hamilton et al.   BLOOD

Persistence of leukemia stem cells in chronic myelogenous leukemia patients in prolonged remission with imatinib treatment

(2011) S. Chu et al.   BLOOD

Metabolic Regulation of Hematopoietic Stem Cells in the Hypoxic Niche

(2011) Toshio Suda et al.   Cell Stem Cell

Mammalian Sirtuins: Biological Insights and Disease Relevance

(2010) Marcia C. Haigis et al.   Annual Review of Pathology-Mechanisms of Disease

BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells

(2010) M. Schemionek et al.   BLOOD

SIRT1 deficiency compromises mouse embryonic stem cell hematopoietic differentiation, and embryonic and adult hematopoiesis in the mouse

(2010) X. Ou et al.   BLOOD

Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate

(2010) Bin Zhang et al.   CANCER CELL

The Distinct Metabolic Profile of Hematopoietic Stem Cells Reflects Their Location in a Hypoxic Niche

(2010) Tugba Simsek et al.   Cell Stem Cell

Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes

(2010) Nirmala Hariharan et al.   CIRCULATION RESEARCH

Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: the prospective, multicentre Stop Imatinib (STIM) trial

(2010) François-Xavier Mahon et al.   LANCET ONCOLOGY

PGC-1α, SIRT1 and AMPK, an energy sensing network that controls energy expenditure

(2009) Carles Cantó et al.   CURRENT OPINION IN LIPIDOLOGY

IFNα activates dormant haematopoietic stem cells in vivo

(2009) Marieke A. G. Essers et al.   NATURE

Imatinib and beyond—exploring the full potential of targeted therapy for CML

(2009) Alfonso Quintás-Cardama et al.   Nature Reviews Clinical Oncology

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

SIRT1 Expression is Associated With Poor Prognosis of Diffuse Large B-Cell Lymphoma

(2008) Kyu Yun Jang et al.   AMERICAN JOURNAL OF SURGICAL PATHOLOGY

SirT1 Regulates Energy Metabolism and Response to Caloric Restriction in Mice

(2008) Gino Boily et al.   PLoS One