Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges
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Title
Physiologically based pharmacokinetic (PBPK) modeling of RNAi therapeutics: Opportunities and challenges
Authors
Keywords
RNA therapeutics, Modeling, PBPK, RNAi, Oligonucleotides, siRNA
Journal
BIOCHEMICAL PHARMACOLOGY
Volume -, Issue -, Pages 114468
Publisher
Elsevier BV
Online
2021-02-10
DOI
10.1016/j.bcp.2021.114468
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Note: Only part of the references are listed.- Physiologically‐Based Pharmacokinetic Modeling of Remdesivir and Its Metabolites to Support Dose Selection for the Treatment of Pediatric Patients With COVID‐19
- (2021) Justin D. Lutz et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Meta-Analysis of Nanoparticle Delivery to Tumors Using a Physiologically Based Pharmacokinetic Modeling and Simulation Approach
- (2020) Yi-Hsien Cheng et al. ACS Nano
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- (2020) L.S. Lautz et al. ENVIRONMENT INTERNATIONAL
- A physiologically based pharmacokinetic model of doxycycline for predicting tissue residues and withdrawal intervals in grass carp (Ctenopharyngodon idella)
- (2020) Ning Xu et al. FOOD AND CHEMICAL TOXICOLOGY
- The effector mechanism of siRNA spherical nucleic acids
- (2020) Gokay Yamankurt et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Development and Application of a Physiologically-Based Pharmacokinetic Model to Predict the Pharmacokinetics of Therapeutic Proteins from Full-term Neonates to Adolescents
- (2020) Xian Pan et al. AAPS Journal
- Chloroquine Dosing Recommendations for Pediatric COVID‐19 Supported by Modeling and Simulation
- (2020) Laurens F. M. Verscheijden et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Excessive lysosomal ion-trapping of hydroxychloroquine and azithromycin
- (2020) Hartmut Derendorf INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
- Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development
- (2020) Sara C. Humphreys et al. JOURNAL OF MEDICINAL CHEMISTRY
- Physiological parameter values for physiologically based pharmacokinetic models in food-producing animals. Part I: Cattle and swine
- (2020) Zhoumeng Lin et al. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
- Population Pharmacokinetic–Pharmacodynamic Model of Serum Transthyretin Following Patisiran Administration
- (2020) Varun Goel et al. Nucleic Acid Therapeutics
- Less is more: Novel hepatocyte-targeted siRNA conjugates for treatment of liver-related disorders
- (2020) Adrien Weingärtner et al. Molecular Therapy-Nucleic Acids
- Quantification of the Impact of Partition Coefficient Prediction Methods on PBPK Model Output Using a Standardized Tissue Composition
- (2020) Kiersten Utsey et al. DRUG METABOLISM AND DISPOSITION
- A Physiologically Based Pharmacokinetic Model of Ertapenem in Pediatric Patients with Renal Impairment
- (2020) Lingling Ye et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Delivery of Oligonucleotides to the Liver with GalNAc: From Research to Registered Therapeutic Drug
- (2020) Alexandre J. Debacker et al. MOLECULAR THERAPY
- Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria
- (2020) Manisha Balwani et al. NEW ENGLAND JOURNAL OF MEDICINE
- Simulated Assessment of Pharmacokinetically Guided Dosing for Investigational Treatments of Pediatric Patients With Coronavirus Disease 2019
- (2020) Anil R. Maharaj et al. JAMA Pediatrics
- Approaches to Dose Finding in Neonates, Illustrating the Variability between Neonatal Drug Development Programs
- (2020) John N. Van den Anker et al. Pharmaceutics
- Use of a physiologically based pharmacokinetic–pharmacodynamic model for initial dose prediction and escalation during a paediatric clinical trial
- (2020) Trevor N. Johnson et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Pharmacokinetic and Pharmacodynamic Properties of Cemdisiran, an RNAi Therapeutic Targeting Complement Component 5, in Healthy Subjects and Patients with Paroxysmal Nocturnal Hemoglobinuria
- (2020) Prajakta Badri et al. CLINICAL PHARMACOKINETICS
- Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC
- (2020) Babak Basiri et al. Molecular Therapy-Nucleic Acids
- Assessing global human exposure to T-2 toxin via poultry meat consumption using a lifetime physiologically based pharmacokinetic model
- (2019) Dongping Zeng et al. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
- Patisiran for the treatment of hereditary transthyretin-mediated amyloidosis
- (2019) Junyi Yang Expert Review of Clinical Pharmacology
- Pharmacokinetic Modeling in Nano-formulations: Concept, Implementation and Challenges
- (2019) Jatinder Kaur Mukker et al. CURRENT PHARMACEUTICAL DESIGN
- Lipid-Based Nanocarriers for Lymphatic Transportation
- (2019) Nikhar Vishwakarma et al. AAPS PHARMSCITECH
- Dissolution and Translational Modeling Strategies Toward Establishing an In Vitro-In Vivo Link—a Workshop Summary Report
- (2019) Tycho Heimbach et al. AAPS Journal
- Plasma and liver protein binding of GalNAc conjugated siRNA
- (2019) Sara C Humphreys et al. DRUG METABOLISM AND DISPOSITION
- An integrated experimental and physiologically based pharmacokinetic modeling study of penicillin G in heavy sows
- (2019) Miao Li et al. JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS
- Periodicity and dosage optimization of an RNAi model in eukaryotes cells
- (2019) Tongle Ma et al. BMC BIOINFORMATICS
- Pharmacokinetics and Clinical Pharmacology Considerations of GalNAc3-Conjugated Antisense Oligonucleotides
- (2019) Yanfeng Wang et al. Expert Opinion on Drug Metabolism & Toxicology
- Bayesian evaluation of a physiologically based pharmacokinetic (PBPK) model for perfluorooctane sulfonate (PFOS) to characterize the interspecies uncertainty between mice, rats, monkeys, and humans: Development and performance verification
- (2019) Wei-Chun Chou et al. ENVIRONMENT INTERNATIONAL
- Development and Application of a Life-Stage Physiologically Based Pharmacokinetic (PBPK) Model to the Assessment of Internal Dose of Pyrethroids in Humans
- (2019) Pankajini Mallick et al. TOXICOLOGICAL SCIENCES
- Food ingredient safety evaluation: Utility and relevance of toxicokinetic methods
- (2019) Shruti V. Kabadi et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Tutorial on Monoclonal Antibody Pharmacokinetics and its Considerations in Early Development
- (2018) Meric Ovacik et al. CTS-Clinical and Translational Science
- Neutralization of negative charges of siRNA results in improved safety and efficient gene silencing activity of lipid nanoparticles loaded with high levels of siRNA
- (2018) Yusuke Sato et al. JOURNAL OF CONTROLLED RELEASE
- Challenges and Opportunities for the Subcutaneous Delivery of Therapeutic Proteins
- (2018) Michael R. Turner et al. JOURNAL OF PHARMACEUTICAL SCIENCES
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- (2018) Ninad Varkhede et al. JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES
- Placental expression of asialoglycoprotein receptor associated with Hepatitis B virus transmission from mother to child
- (2018) Ashish Kumar Vyas et al. LIVER INTERNATIONAL
- Nusinersen versus Sham Control in Later-Onset Spinal Muscular Atrophy
- (2018) Eugenio Mercuri et al. NEW ENGLAND JOURNAL OF MEDICINE
- Probabilistic Physiologically Based Pharmacokinetic Model for Penicillin G in Milk From Dairy Cows Following Intramammary or Intramuscular Administrations
- (2018) Miao Li et al. TOXICOLOGICAL SCIENCES
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- (2018) Shannon M. Bell et al. TOXICOLOGY IN VITRO
- GalNAc-siRNA Conjugates: Leading the Way for Delivery of RNAi Therapeutics
- (2018) Aaron D. Springer et al. Nucleic Acid Therapeutics
- Cell penetrating peptides: A concise review with emphasis on biomedical applications
- (2018) Hossein Derakhshankhah et al. BIOMEDICINE & PHARMACOTHERAPY
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- (2018) Yuki Matsumoto et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Developmental Changes in Pharmacokinetics and Pharmacodynamics
- (2018) John van den Anker et al. JOURNAL OF CLINICAL PHARMACOLOGY
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- (2018) Eric Fabian et al. ARCHIVES OF TOXICOLOGY
- Physiologically-based modeling of monoclonal antibody pharmacokinetics in drug discovery and development
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- Biopharmaceutic IVIVE – Mechanistic Modelling of Single- and Two-Phase In Vitro Experiments to Obtain Drug-Specific Parameters for Incorporation into PBPK Models
- (2018) Shriram M. Pathak et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Development and application of a population physiologically based pharmacokinetic model for penicillin G in swine and cattle for food safety assessment
- (2017) Miao Li et al. FOOD AND CHEMICAL TOXICOLOGY
- Capacity limits of asialoglycoprotein receptor-mediated liver targeting
- (2017) Charlotte Bon et al. mAbs
- Targeting of Antithrombin in Hemophilia A or B with RNAi Therapy
- (2017) K. John Pasi et al. NEW ENGLAND JOURNAL OF MEDICINE
- Nusinersen versus Sham Control in Infantile-Onset Spinal Muscular Atrophy
- (2017) Richard S. Finkel et al. NEW ENGLAND JOURNAL OF MEDICINE
- Impact of enhanced metabolic stability on pharmacokinetics and pharmacodynamics of GalNAc–siRNA conjugates
- (2017) Jayaprakash K. Nair et al. NUCLEIC ACIDS RESEARCH
- Developing integrated PBPK/PD coupled mechanistic pathway model (miRNA-BDNF): An approach towards system toxicology
- (2017) Raju Prasad Sharma et al. TOXICOLOGY LETTERS
- Gene Silencing Activity and Hepatic Accumulation of Antisense Oligonucleotides Bearing Cholesterol-Conjugated Thiono Triester at the Gap Region
- (2017) Mado Nakajima et al. Nucleic Acid Therapeutics
- Assessment of the Drug Interaction Potential of Unconjugated and GalNAc 3 -Conjugated 2′-MOE-ASOs
- (2017) Colby S. Shemesh et al. Molecular Therapy-Nucleic Acids
- Physiologically Based Pharmacokinetic (PBPK) Modeling of Pharmaceutical Nanoparticles
- (2016) Min Li et al. AAPS Journal
- Imaging-guided delivery of RNAi for anticancer treatment
- (2016) Junqing Wang et al. ADVANCED DRUG DELIVERY REVIEWS
- Physiologically based pharmacokinetic models of small molecules and therapeutic antibodies: a mini-review on fundamental concepts and applications
- (2016) Gregory Z. Ferl et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- A Liver-Centric Multiscale Modeling Framework for Xenobiotics
- (2016) James P. Sluka et al. PLoS One
- A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide
- (2015) Elliot Offman et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Key factors influencing ADME properties of therapeutic proteins: A need for ADME characterization in drug discovery and development
- (2015) Jay Tibbitts et al. mAbs
- Knocking down disease: a progress report on siRNA therapeutics
- (2015) Anders Wittrup et al. NATURE REVIEWS GENETICS
- Across-Species Scaling of Monoclonal Antibody Pharmacokinetics Using a Minimal PBPK Model
- (2015) Jie Zhao et al. PHARMACEUTICAL RESEARCH
- Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)
- (2015) Manthena V. Varma et al. PHARMACEUTICAL RESEARCH
- Versatile RNA Interference Nanoplatform for Systemic Delivery of RNAs
- (2014) Ki Young Choi et al. ACS Nano
- PBPK Model Describes the Effects of Comedication and Genetic Polymorphism on Systemic Exposure of Drugs That Undergo Multiple Clearance Pathways
- (2014) M d L T Vieira et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Development of lipid nanoparticle formulations of siRNA for hepatocyte gene silencing following subcutaneous administration
- (2014) Sam Chen et al. JOURNAL OF CONTROLLED RELEASE
- Target-specific delivery of siRNA by stabilized calcium phosphate nanoparticles using dopa–hyaluronic acid conjugate
- (2014) Min Sang Lee et al. JOURNAL OF CONTROLLED RELEASE
- Predicting Passive and Active Tissue:Plasma Partition Coefficients: Interindividual and Interspecies Variability
- (2014) Christopher D. Ruark et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Pharmacokinetic–pharmacodynamic modeling for reduction of hepatic apolipoprotein B mRNA and plasma total cholesterol after administration of antisense oligonucleotide in mice
- (2014) Ryosuke Shimizu et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies
- (2014) Yanguang Cao et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Pharmacokinetics of metallic nanoparticles
- (2014) Zhoumeng Lin et al. Wiley Interdisciplinary Reviews-Nanomedicine and Nanobiotechnology
- Estimate hidden dynamic profiles of siRNA effect on apoptosis
- (2013) Takanori Ueda et al. BMC BIOINFORMATICS
- Combining the ‘bottom up’ and ‘top down’ approaches in pharmacokinetic modelling: fitting PBPK models to observed clinical data
- (2013) Nikolaos Tsamandouras et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Quantitative Integration of Biological, Pharmacokinetic, and Medical Imaging Data for Organ-Wide Dose-Response Predictions
- (2013) Ying Hsu et al. IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
- Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies
- (2013) Yanguang Cao et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Synthesis of 18O-labeled RNA for application to kinetic studies and imaging
- (2013) Tomohiro Hamasaki et al. NUCLEIC ACIDS RESEARCH
- Evaluation of Perturbations in Serum Thyroid Hormones During Human Pregnancy Due to Dietary Iodide and Perchlorate Exposure Using a Biologically Based Dose-Response Model
- (2013) Annie Lumen et al. TOXICOLOGICAL SCIENCES
- Anatomical, Physiological and Metabolic Changes with Gestational Age during Normal Pregnancy
- (2012) Khaled Abduljalil et al. CLINICAL PHARMACOKINETICS
- Applications of minimal physiologically-based pharmacokinetic models
- (2012) Yanguang Cao et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Action and Reaction: The Biological Response to siRNA and Its Delivery Vehicles
- (2012) Rosemary L Kanasty et al. MOLECULAR THERAPY
- Physiologically Based Pharmacokinetic Model for Composite Nanodevices: Effect of Charge and Size on In Vivo Disposition
- (2012) Donald E. Mager et al. PHARMACEUTICAL RESEARCH
- Modeling RNA interference in mammalian cells
- (2011) Giulia Cuccato et al. BMC Systems Biology
- Viral RNAi Suppressor Reversibly Binds siRNA to Outcompete Dicer and RISC via Multiple Turnover
- (2011) Renata A. Rawlings et al. JOURNAL OF MOLECULAR BIOLOGY
- Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human
- (2011) Dhaval K. Shah et al. JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS
- Development of Double-Stranded siRNA Labeling Method Using Positron Emitter and Its In Vivo Trafficking Analyzed by Positron Emission Tomography
- (2010) Kentaro Hatanaka et al. BIOCONJUGATE CHEMISTRY
- The kinetics of the tissue distribution of silver nanoparticles of different sizes
- (2010) D.P.K. Lankveld et al. BIOMATERIALS
- Physiologically Based Pharmacokinetic (PBPK) Models for Lifetime Exposure to PCB 153 in Male and Female Harbor Porpoises (Phocoena phocoena): Model Development and Evaluation
- (2010) Liesbeth Weijs et al. ENVIRONMENTAL SCIENCE & TECHNOLOGY
- Nanoparticles Targeted With NGR Motif Deliver c-myc siRNA and Doxorubicin for Anticancer Therapy
- (2010) Yunching Chen et al. MOLECULAR THERAPY
- Physiologically Based Pharmacokinetics of Molecular Imaging Nanoparticles for mRNA Detection Determined in Tumor-Bearing Mice
- (2010) Armin W. Opitz et al. OLIGONUCLEOTIDES
- Paradoxical glomerular filtration of carbon nanotubes
- (2010) A. Ruggiero et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Antisense oligonucleotide pharmacokinetics and metabolism
- (2009) Richard S Geary Expert Opinion on Drug Metabolism & Toxicology
- Nanomedicine based approaches for the delivery of siRNA in cancer
- (2009) B. Ozpolat et al. JOURNAL OF INTERNAL MEDICINE
- Development of a novel method for predicting human volume of distribution at steady-state of basic drugs and comparative assessment with existing methods
- (2009) Patrick Poulin et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Physiologically-Based PK/PD Modelling of Therapeutic Macromolecules
- (2009) Peter Thygesen et al. PHARMACEUTICAL RESEARCH
- Development of Translational Pharmacokinetic–Pharmacodynamic Models
- (2008) DE Mager et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Physiologically Based Pharmacokinetic Modeling of Persistent OrganicPollutants for Lifetime Exposure Assessment: A New Tool in Breast CancerEpidemiologic Studies
- (2008) Marc-André Verner et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Modeling Recursive RNA Interference
- (2008) Wallace F. Marshall PLoS Computational Biology
- Impact of tumor-specific targeting and dosing schedule on tumor growth inhibition after intravenous administration of siRNA-containing nanoparticles
- (2007) Derek W. Bartlett et al. BIOTECHNOLOGY AND BIOENGINEERING
- General approach for the calculation of tissue to plasma partition coefficients
- (2007) Walter Schmitt TOXICOLOGY IN VITRO
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