Incorporating target-mediated drug disposition in a minimal physiologically-based pharmacokinetic model for monoclonal antibodies

Onartuzumab (MetMAb): Using Nonclinical Pharmacokinetic and Concentration-Effect Data to Support Clinical Development

(2013) H. Xiang et al.   CLINICAL CANCER RESEARCH

Second-generation minimal physiologically-based pharmacokinetic model for monoclonal antibodies

(2013) Yanguang Cao et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Monoclonal antibody therapeutics: history and future

(2012) Nicholas APS Buss et al.   CURRENT OPINION IN PHARMACOLOGY

Applications of minimal physiologically-based pharmacokinetic models

(2012) Yanguang Cao et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Marketed therapeutic antibodies compendium

(2012) Janice M. Reichert   mAbs

Interstitial Fluid and Lymph Formation and Transport: Physiological Regulation and Roles in Inflammation and Cancer

(2012) Helge Wiig et al.   PHYSIOLOGICAL REVIEWS

Mavrilimumab, a human monoclonal antibody targeting GM-CSF receptor- , in subjects with rheumatoid arthritis: a randomised, double-blind, placebo-controlled, phase I, first-in-human study

(2011) G. R. Burmester et al.   ANNALS OF THE RHEUMATIC DISEASES

Preclinical pharmacokinetics of MEHD7945A, a novel EGFR/HER3 dual-action antibody, and prediction of its human pharmacokinetics and efficacious clinical dose

(2011) Amrita V. Kamath et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Epithelial Junction Opener JO-1 Improves Monoclonal Antibody Therapy of Cancer

(2011) I. Beyer et al.   CANCER RESEARCH

Determination of Serum and Plasma Sclerostin Concentrations by Enzyme-Linked Immunoassays

(2011) Melissa McNulty et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Effects of Charge on Antibody Tissue Distribution and Pharmacokinetics

(2010) C. Andrew Boswell et al.   BIOCONJUGATE CHEMISTRY

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Selection between Michaelis–Menten and target-mediated drug disposition pharmacokinetic models

(2009) Xiaoyu Yan et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Antibody tumor penetration: Transport opposed by systemic and antigen-mediated clearance

(2008) Greg M. Thurber et al.   ADVANCED DRUG DELIVERY REVIEWS

Potential use of tight junction modulators to reversibly open membranous barriers and improve drug delivery

(2008) Mária A. Deli   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Direct Visualization of Heterogeneous Extravascular Distribution of Trastuzumab in Human Epidermal Growth Factor Receptor Type 2 Overexpressing Xenografts

(2008) J. H.E. Baker et al.   CLINICAL CANCER RESEARCH

Monoclonal Antibody Pharmacokinetics and Pharmacodynamics

(2008) W Wang et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Approximations of the target-mediated drug disposition model and identifiability of model parameters

(2008) Leonid Gibiansky et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS