A PBPK workflow for first-in-human dose selection of a subcutaneously administered pegylated peptide

Pharmacokinetics, metabolism and distribution of PEGs and PEGylated proteins: quo vadis?

(2014) Andreas Baumann et al.   DRUG DISCOVERY TODAY

Estimation of Glomerular Filtration Rate in Cynomolgus Monkeys (Macaca fascicularis)

(2014) Ryosuke IWAMA et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Therapeutic targeting of microRNAs: current status and future challenges

(2014) Zhonghan Li et al.   NATURE REVIEWS DRUG DISCOVERY

The Antibody Drug Absorption Following Subcutaneous or Intramuscular Administration and Its Mathematical Description by Coupling Physiologically Based Absorption Process with the Conventional Compartment Pharmacokinetic Model

(2013) Liang Zhao et al.   JOURNAL OF CLINICAL PHARMACOLOGY

The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats

(2013) Annette M. Dahlberg et al.   MOLECULAR PHARMACEUTICS

Mechanistic Determinants of Biotherapeutics Absorption Following SC Administration

(2012) Wolfgang F. Richter et al.   AAPS Journal

Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration

(2012) Yanan Zheng et al.   mAbs

Contrasting toxicokinetic evaluations and interspecies pharmacokinetic scaling approaches for small molecules and biologics: applicability to biosimilar development

(2012) Elliot Offman et al.   XENOBIOTICA

Quantitative Prediction of Human Pharmacokinetics for Monoclonal Antibodies

(2011) Jennifer Q. Dong et al.   CLINICAL PHARMACOKINETICS

Towards a platform PBPK model to characterize the plasma and tissue disposition of monoclonal antibodies in preclinical species and human

(2011) Dhaval K. Shah et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

BioDMET: a physiologically based pharmacokinetic simulation tool for assessing proposed solutions to complex biological problems

(2011) John F. Graf et al.   JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS

Interspecies Scaling of Therapeutic Monoclonal Antibodies: Initial Look

(2009) Jie Ling et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Determination of protein aggregation with differential mobility analysis: Application to IgG antibody

(2008) Leonard F. Pease et al.   BIOTECHNOLOGY AND BIOENGINEERING

A physiologically based pharmacokinetic (PBPK) model to characterize and predict the disposition of monoclonal antibody CC49 and its single chain Fv constructs

(2007) Jasmine P. Davda et al.   INTERNATIONAL IMMUNOPHARMACOLOGY