Multifaceted role of extracellular vesicles in atherosclerosis

Neutrophils as regulators of cardiovascular inflammation

(2020) Carlos Silvestre-Roig et al.   Nature Reviews Cardiology

Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium

(2020) Ingrid Gomez et al.   Nature Communications

Small extracellular vesicles deliver miR-21 and miR-217 as pro-senescence effectors to endothelial cells

(2020) Emanuela Mensà et al.   Journal of Extracellular Vesicles

Elevated Microparticle Tissue Factor Activity is Associated with Carotid Artery Plaque in HIV Infected Women

(2019) Juan Lin et al.   JAIDS-JOURNAL OF ACQUIRED IMMUNE DEFICIENCY SYNDROMES

Exosomes derived from mesenchymal stem cells attenuate the progression of atherosclerosis in ApoE−/- mice via miR-let7 mediated infiltration and polarization of M2 macrophage

(2019) Jiangbing Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cardioprotective microRNAs: Lessons from stem cell-derived exosomal microRNAs to treat cardiovascular disease

(2019) Abbas Shapouri Moghaddam et al.   ATHEROSCLEROSIS

Delivery of microRNAs by Chitosan Nanoparticles to Functionally Alter Macrophage Cholesterol Efflux In Vitro and In Vivo

(2019) My-Anh Nguyen et al.   ACS Nano

Inflammatory adipocyte-derived extracellular vesicles promote leukocyte attachment to vascular endothelial cells

(2019) Rebecca M. Wadey et al.   ATHEROSCLEROSIS

Advances in therapeutic applications of extracellular vesicles

(2019) Oscar P. B. Wiklander et al.   Science Translational Medicine

Small Extracellular Vesicles Are Key Regulators of Non-cell Autonomous Intercellular Communication in Senescence via the Interferon Protein IFITM3

(2019) Michela Borghesan et al.   Cell Reports

Extracellular vesicles in atherosclerosis

(2019) WenYi Deng et al.   CLINICA CHIMICA ACTA

Atherosclerosis

(2019) Peter Libby et al.   Nature Reviews Disease Primers

Platelet-derived microparticles promote phagocytosis of oxidized low-density lipoprotein by macrophages, potentially enhancing foam cell formation

(2019) Can Feng et al.   Annals of Translational Medicine

Mechanism of Enhanced MerTK-Dependent Macrophage Efferocytosis by Extracellular Vesicles

(2019) Geoffrey de Couto et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Diet microparticles and atherothrombosis

(2018) Lina Badimon   Frontiers in Bioscience-Landmark

Insulin resistance adipocyte-derived exosomes aggravate atherosclerosis by increasing vasa vasorum angiogenesis in diabetic ApoE −/− mice

(2018) Feng Wang et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

LDL extracellular vesicle coagulation protein levels change after initiation of statin therapy. Findings from the METEOR trial

(2018) Laura Verbree-Willemsen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Senescent Microvesicles: A Novel Advance in Molecular Mechanisms of Atherosclerotic Calcification

(2018) Matilde Alique et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular vesicles and their content in bioactive lipid mediators: more than a sack of microRNA

(2018) Eric Boilard   JOURNAL OF LIPID RESEARCH

Shedding light on the cell biology of extracellular vesicles

(2018) Guillaume van Niel et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Adipose‐Derived Exosomes Exert Proatherogenic Effects by Regulating Macrophage Foam Cell Formation and Polarization

(2018) Zulong Xie et al.   Journal of the American Heart Association

Anti-JNK2 peptide–siRNA nanostructures improve plaque endothelium and reduce thrombotic risk in atherosclerotic mice

(2018) Hua Pan et al.   International Journal of Nanomedicine

MLKL, the Protein that Mediates Necroptosis, Also Regulates Endosomal Trafficking and Extracellular Vesicle Generation

(2017) Seongmin Yoon et al.   IMMUNITY

Association of ficolin-3 with abdominal aortic aneurysm presence and progression

(2017) C.-E. Fernandez-García et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular vesicles in coronary artery disease

(2017) Chantal M. Boulanger et al.   Nature Reviews Cardiology

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

IL-33 stimulates the release of procoagulant microvesicles from human monocytes and differentially increases tissue factor in human monocyte subsets

(2017) Stefan Stojkovic et al.   THROMBOSIS AND HAEMOSTASIS

Biogenesis of Pro-senescent Microparticles by Endothelial Colony Forming Cells from Premature Neonates is driven by SIRT1-Dependent Epigenetic Regulation of MKK6

(2017) Stéphanie Simoncini et al.   Scientific Reports

Extracellular Vesicles Secreted by Atherogenic Macrophages Transfer MicroRNA to Inhibit Cell Migration

(2017) My-Anh Nguyen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence

(2017) Fumihiro Sanada et al.   Scientific Reports

Circulating cell-derived microparticles as biomarkers in cardiovascular disease

(2016) Åsa Thulin et al.   Biomarkers in Medicine

Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and ThrombogenicityClinical Perspective

(2016) Malak Abbas et al.   CIRCULATION

More Than Tiny Sacks

(2016) Raj Kishore et al.   CIRCULATION RESEARCH

Adaptive Response of T and B Cells in Atherosclerosis

(2016) Daniel F.J. Ketelhuth et al.   CIRCULATION RESEARCH

Assessment and consequences of cell senescence in atherosclerosis

(2016) Abel Martin Garrido et al.   CURRENT OPINION IN LIPIDOLOGY

Monocyte exosomes induce adhesion molecules and cytokines via activation of NF-κB in endothelial cells

(2016) Norina Tang et al.   FASEB JOURNAL

Exosomes derived from mature dendritic cells increase endothelial inflammation and atherosclerosisviamembrane TNF-α mediated NF-κB pathway

(2016) Wei Gao et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Zooming in on the genesis of atherosclerotic plaque microcalcifications

(2016) Jessica L. Ruiz et al.   JOURNAL OF PHYSIOLOGY-LONDON

Microparticle-Induced Coagulation Relates to Coronary Artery Atherosclerosis in Severe Aortic Valve Stenosis

(2016) Patrick Horn et al.   PLoS One

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Microparticles and Fibrinolysis

(2016) Loris Vallier et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Endothelial cell senescence and thrombosis: Ageing clots

(2016) Magdalena L. Bochenek et al.   THROMBOSIS RESEARCH

Macrophage Foam Cell–Derived Extracellular Vesicles Promote Vascular Smooth Muscle Cell Migration and Adhesion

(2016) Chenguang Niu et al.   Journal of the American Heart Association

The pattern of circulating microparticles in patients with diabetes mellitus with asymptomatic atherosclerosis

(2016) Alexander E. Berezin et al.   ACTA CLINICA BELGICA

Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection

(2016) Barbara W Sódar et al.   Scientific Reports

Long-term high fat feeding of rats results in increased numbers of circulating microvesicles with pro-inflammatory effects on endothelial cells

(2015) L. F. Heinrich et al.   BRITISH JOURNAL OF NUTRITION

Extracellular vesicles as new pharmacological targets to treat atherosclerosis

(2015) Min Yin et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Platelet microparticles are internalized in neutrophils via the concerted activity of 12-lipoxygenase and secreted phospholipase A2-IIA

(2015) Anne-Claire Duchez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High levels of TSP1+/CD142+ platelet-derived microparticles characterise young patients with high cardiovascular risk and subclinical atherosclerosis

(2015) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Predicting Carotid Artery Disease and Plaque Instability from Cell-derived Microparticles

(2014) A.L. Wekesa et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Senescence-associated release of transmembrane proteins involves proteolytic processing by ADAM17 and microvesicle shedding

(2014) Timo Effenberger et al.   FASEB JOURNAL

Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke

(2013) Chun-Jun Li et al.   AMERICAN JOURNAL OF PATHOLOGY

High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation

(2013) Felix Jansen et al.   CARDIOVASCULAR RESEARCH

Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice

(2013) Maulik D. Majmudar et al.   CIRCULATION

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Plasmatic Level of Leukocyte-Derived Microparticles Is Associated With Unstable Plaque in Asymptomatic Patients With High-Grade Carotid Stenosis

(2013) Gabrielle Sarlon-Bartoli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop

(2013) R. Lacroix et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Circulating CD45+/CD3+ lymphocyte-derived microparticles map lipid-rich atherosclerotic plaques in familial hypercholesterolaemia patients

(2013) R. Suades et al.   THROMBOSIS AND HAEMOSTASIS

Cholesterol-Induced Membrane Microvesicles As Novel Carriers of Damage–Associated Molecular Patterns

(2012) Ming-Lin Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Macrophage microvesicles induce macrophage differentiation and miR-223 transfer

(2012) N. Ismail et al.   BLOOD

Leukocyte- and endothelial-derived microparticles: a circulating source for fibrinolysis

(2012) R. Lacroix et al.   HAEMATOLOGICA

Monocytic microparticles promote atherogenesis by modulating inflammatory cells in mice

(2012) Friedrich Felix Hoyer et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Coordinate Stimulation of Macrophages by Microparticles and TLR Ligands Induces Foam Cell Formation

(2012) Peter A. Keyel et al.   JOURNAL OF IMMUNOLOGY

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques

(2012) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Microparticles, Vascular Function, and Atherothrombosis

(2011) Pierre-Emmanuel Rautou et al.   CIRCULATION RESEARCH

Microparticles in Hemostasis and Thrombosis

(2011) A. Phillip Owens et al.   CIRCULATION RESEARCH

Plaque Rupture is a Determinant of Vascular Events in Carotid Artery Atherosclerotic Disease: Involvement of Matrix Metalloproteinases 2 and 9

(2011) Sung Hyuk Heo et al.   Journal of Clinical Neurology

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Hemostatic System as a Modulator of Atherosclerosis

(2011) Julian Ilcheff Borissoff et al.   NEW ENGLAND JOURNAL OF MEDICINE

Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients

(2011) Bela Nagy et al.   THROMBOSIS AND HAEMOSTASIS

Atorvastatin reduces thrombin generation and expression of tissue factor, P-selectin and GPIIIa on platelet-derived microparticles in patients with peripheral arterial occlusive disease

(2011) Fariborz Mobarrez et al.   THROMBOSIS AND HAEMOSTASIS

Microparticles from apoptotic platelets promote resident macrophage differentiation

(2011) E M Vasina et al.   Cell Death & Disease

Alterations in Platelet Function and Cell-Derived Microvesicles in Recently Menopausal Women: Relationship to Metabolic Syndrome and Atherogenic Risk

(2011) Muthuvel Jayachandran et al.   Journal of Cardiovascular Translational Research

Tobacco Smoke Induces the Generation of Procoagulant Microvesicles From Human Monocytes/Macrophages

(2010) Mingzhen Li et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Matrix vesicles in the fibrous cap of atherosclerotic plaque: possible contribution to plaque rupture

(2010) Y. V. Bobryshev et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Circulating microparticles may influence early carotid artery remodeling

(2010) Gilles N Chironi et al.   JOURNAL OF HYPERTENSION

Secreted Monocytic miR-150 Enhances Targeted Endothelial Cell Migration

(2010) Yujing Zhang et al.   MOLECULAR CELL

Microparticle-associated endothelial protein C receptor and the induction of cytoprotective and anti-inflammatory effects

(2009) M. Perez-Casal et al.   HAEMATOLOGICA

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

CD40 Ligand+ Microparticles From Human Atherosclerotic Plaques Stimulate Endothelial Proliferation and Angiogenesis

(2008) Aurélie S. Leroyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Phase I Clinical Trial of Autologous Ascites-derived Exosomes Combined With GM-CSF for Colorectal Cancer

(2008) Shengming Dai et al.   MOLECULAR THERAPY

Simvastatin-induced endothelial cell detachment and microparticle release are prenylation dependent

(2008) Michaela Diamant et al.   THROMBOSIS AND HAEMOSTASIS