Extracellular vesicles in coronary artery disease

Extracellular vesicles for drug delivery

(2016) Pieter Vader et al.   ADVANCED DRUG DELIVERY REVIEWS

Microparticles generated during chronic cerebral ischemia increase the permeability of microvascular endothelial barriers in vitro

(2016) Hamidreza Edrissi et al.   BRAIN RESEARCH

Endothelial Microparticles From Acute Coronary Syndrome Patients Induce Premature Coronary Artery Endothelial Cell Aging and ThrombogenicityClinical Perspective

(2016) Malak Abbas et al.   CIRCULATION

Cell-matrix mechanics and pattern formation in inflammatory cardiovascular calcification

(2016) Jeffrey J Hsu et al.   HEART

Endothelial microparticles after antihypertensive and lipid-lowering therapy inhibit the adhesion of monocytes to endothelial cells

(2016) Lingyun Zu et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

CD3+/CD45+ and SMA-α+ circulating microparticles are increased in individuals at high cardiovascular risk who will develop a major cardiovascular event

(2016) Gemma Chiva-Blanch et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The Gas6-Axl Protein Interaction Mediates Endothelial Uptake of Platelet Microparticles

(2016) Kaisa E. Happonen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Exosomes surf on filopodia to enter cells at endocytic hot spots, traffic within endosomes, and are targeted to the ER

(2016) Wolf Heusermann et al.   JOURNAL OF CELL BIOLOGY

Sortilin mediates vascular calcification via its recruitment into extracellular vesicles

(2016) Claudia Goettsch et al.   JOURNAL OF CLINICAL INVESTIGATION

Exosomes as therapeutics: The implications of molecular composition and exosomal heterogeneity

(2016) Scott W. Ferguson et al.   JOURNAL OF CONTROLLED RELEASE

Cardiovascular progenitor–derived extracellular vesicles recapitulate the beneficial effects of their parent cells in the treatment of chronic heart failure

(2016) Anaïs Kervadec et al.   JOURNAL OF HEART AND LUNG TRANSPLANTATION

Genesis and growth of extracellular-vesicle-derived microcalcification in atherosclerotic plaques

(2016) Joshua D. Hutcheson et al.   NATURE MATERIALS

Proteomic comparison defines novel markers to characterize heterogeneous populations of extracellular vesicle subtypes

(2016) Joanna Kowal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes in human atherosclerosis: An ultrastructural analysis study

(2016) Ida Perrotta et al.   ULTRASTRUCTURAL PATHOLOGY

Coronary Artery-Bypass-Graft Surgery Increases the Plasma Concentration of Exosomes Carrying a Cargo of Cardiac MicroRNAs: An Example of Exosome Trafficking Out of the Human Heart with Potential for Cardiac Biomarker Discovery

(2016) Costanza Emanueli et al.   PLoS One

Isolation and characterization of vesicular and non-vesicular microRNAs circulating in sera of partially hepatectomized rats

(2016) Mirco Castoldi et al.   Scientific Reports

Circulating cell membrane microparticles transfer heme to endothelial cells and trigger vasoocclusions in sickle cell disease

(2015) S. M. Camus et al.   BLOOD

Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs

(2015) M.-S. Njock et al.   BLOOD

Vascular Smooth Muscle Cell Calcification Is Mediated by Regulated Exosome Secretion

(2015) A. N. Kapustin et al.   CIRCULATION RESEARCH

Endothelial microparticles mediate inflammation-induced vascular calcification

(2015) Paula Buendía et al.   FASEB JOURNAL

An Endocrine Genetic Signal Between Blood Cells and Vascular Smooth Muscle Cells

(2015) Zhen Shan et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Plasma Exosomes Protect the Myocardium From Ischemia-Reperfusion Injury

(2015) Jose M. Vicencio et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Recent developments in the nomenclature, presence, isolation, detection and clinical impact of extracellular vesicles

(2015) E. van der Pol et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Ultrafiltration with size-exclusion liquid chromatography for high yield isolation of extracellular vesicles preserving intact biophysical and functional properties

(2015) Joel Z. Nordin et al.   Nanomedicine-Nanotechnology Biology and Medicine

Pathophysiology of native coronary, vein graft and in-stent atherosclerosis

(2015) Kazuyuki Yahagi et al.   Nature Reviews Cardiology

Effects of lipid-lowering treatment on circulating microparticles in patients with diabetes mellitus and chronic kidney disease

(2015) Tora Almquist et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Improved Characterization of EV Preparations Based on Protein to Lipid Ratio and Lipid Properties

(2015) Xabier Osteikoetxea et al.   PLoS One

Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms

(2015) Chunjun Li et al.   THROMBOSIS AND HAEMOSTASIS

High levels of TSP1+/CD142+ platelet-derived microparticles characterise young patients with high cardiovascular risk and subclinical atherosclerosis

(2015) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Gap junctional protein Cx43 is involved in the communication between extracellular vesicles and mammalian cells

(2015) Ana Rosa Soares et al.   Scientific Reports

Mononuclear Phagocyte-Derived Microparticulate Caspase-1 Induces Pulmonary Vascular Endothelial Cell Injury

(2015) Srabani Mitra et al.   PLoS One

Has Our Understanding of Calcification in Human Coronary Atherosclerosis Progressed?

(2014) Fumiyuki Otsuka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Microparticles generated during chronic cerebral ischemia deliver proapoptotic signals to cultured endothelial cells

(2014) Sarah C. Schock et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Microparticles in multiple sclerosis and clinically isolated syndrome: effect on endothelial barrier function

(2014) Beatriz Marcos-Ramiro et al.   BMC NEUROSCIENCE

Effects of simvastatin/ezetimibe on microparticles, endothelial progenitor cells and platelet aggregation in subjects with coronary heart disease under antiplatelet therapy

(2014) L.M. Camargo et al.   BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH

Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study

(2014) Nicolas Amabile et al.   EUROPEAN HEART JOURNAL

Red blood cell and platelet microparticles in myocardial infarction patients treated with primary angioplasty

(2014) Georgios Giannopoulos et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Exosome Uptake through Clathrin-mediated Endocytosis and Macropinocytosis and Mediating miR-21 Delivery

(2014) Tian Tian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prostaglandin E2promotesMYCNnon-amplified neuroblastoma cell survivalviaβ-catenin stabilization

(2014) Sepp R. Jansen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Circulating microparticles carry oxidation-specific epitopes and are recognized by natural IgM antibodies

(2014) Dimitrios Tsiantoulas et al.   JOURNAL OF LIPID RESEARCH

Exosome poly-ubiquitin inhibits platelet activation, downregulates CD36 and inhibits pro-atherothombotic cellular functions

(2014) S. Srikanthan et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration

(2014) N. Arraud et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Clinical classification of plaque morphology in coronary disease

(2014) Fumiyuki Otsuka et al.   Nature Reviews Cardiology

Quantitative and stoichiometric analysis of the microRNA content of exosomes

(2014) J. R. Chevillet et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TNF-induced endothelial barrier disruption: beyond actin and Rho

(2014) Beatriz Marcos-Ramiro et al.   THROMBOSIS AND HAEMOSTASIS

MicroRNA Expression in Circulating Microvesicles Predicts Cardiovascular Events in Patients With Coronary Artery Disease

(2014) Felix Jansen et al.   Journal of the American Heart Association

Exosomes as Critical Agents of Cardiac Regeneration Triggered by Cell Therapy

(2014) Ahmed Gamal-Eldin Ibrahim et al.   Stem Cell Reports

Novel Proteolytic Microvesicles Released from Human Macrophages after Exposure to Tobacco Smoke

(2013) Chun-Jun Li et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of Extracellular Vesicles in De Novo Mineralization

(2013) Sophie E. P. New et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Small-size circulating microparticles in acute coronary syndromes: Relevance to fibrinolytic status, reparative markers and outcomes

(2013) Silvia Montoro-García et al.   ATHEROSCLEROSIS

Local increase in microparticles from the aspirate of culprit coronary arteries in patients with ST-segment elevation myocardial infarction

(2013) Pil-Ki Min et al.   ATHEROSCLEROSIS

Cardiac progenitor-derived exosomes protect ischemic myocardium from acute ischemia/reperfusion injury

(2013) Lijuan Chen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

High glucose condition increases NADPH oxidase activity in endothelial microparticles that promote vascular inflammation

(2013) Felix Jansen et al.   CARDIOVASCULAR RESEARCH

Endothelial Microparticle–Mediated Transfer of MicroRNA-126 Promotes Vascular Endothelial Cell Repair via SPRED1 and Is Abrogated in Glucose-Damaged Endothelial Microparticles

(2013) Felix Jansen et al.   CIRCULATION

Dyslipidemia, Coronary Artery Calcium, and Incident Atherosclerotic Cardiovascular Disease

(2013) Seth S. Martin et al.   CIRCULATION

Macrophage-Derived Matrix Vesicles

(2013) Sophie E. P. New et al.   CIRCULATION RESEARCH

Circulating p53-Responsive MicroRNAs Are Predictive Indicators of Heart Failure After Acute Myocardial Infarction

(2013) Sen Matsumoto et al.   CIRCULATION RESEARCH

Regulation of Vascular Smooth Muscle Cell Turnover by Endothelial Cell–Secreted MicroRNA-126

(2013) Jing Zhou et al.   CIRCULATION RESEARCH

Shear Stress Regulates Endothelial Microparticle Release

(2013) Anne-Clémence Vion et al.   CIRCULATION RESEARCH

Dynamic Release and Clearance of Circulating Microparticles During Cardiac Stress

(2013) Daniel Augustine et al.   CIRCULATION RESEARCH

Calcium Density of Coronary Artery Plaque and Risk of Incident Cardiovascular Events

(2013) Michael H. Criqui et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Exosome Uptake Depends on ERK1/2-Heat Shock Protein 27 Signaling and Lipid Raft-mediated Endocytosis Negatively Regulated by Caveolin-1

(2013) Katrin J. Svensson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasmatic Level of Leukocyte-Derived Microparticles Is Associated With Unstable Plaque in Asymptomatic Patients With High-Grade Carotid Stenosis

(2013) Gabrielle Sarlon-Bartoli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Histopathologic Characteristics of Atherosclerotic Coronary Disease and Implications of the Findings for the Invasive and Noninvasive Detection of Vulnerable Plaques

(2013) Jagat Narula et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Standardization of pre-analytical variables in plasma microparticle determination: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop

(2013) R. Lacroix et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Innovation in detection of microparticles and exosomes

(2013) E. van der Pol et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Revised microcalcification hypothesis for fibrous cap rupture in human coronary arteries

(2013) A. Kelly-Arnold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cell-derived exosomes increase ATP levels, decrease oxidative stress and activate PI3K/Akt pathway to enhance myocardial viability and prevent adverse remodeling after myocardial ischemia/reperfusion injury

(2013) Fatih Arslan et al.   Stem Cell Research

Lipid-lowering therapy with statins reduces microparticle shedding from endothelium, platelets and inflammatory cells

(2013) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Sumoylated hnRNPA2B1 controls the sorting of miRNAs into exosomes through binding to specific motifs

(2013) Carolina Villarroya-Beltri et al.   Nature Communications

Number of Microparticles Generated During Acute Myocardial Infarction and Stable Angina Correlates with Platelet Activation

(2012) Ewa Stępień et al.   ARCHIVES OF MEDICAL RESEARCH

Synergistic Effect of Thrombin and CD40 Ligand on Endothelial Matrix Metalloproteinase-10 Expression and Microparticle Generation In Vitro and In Vivo

(2012) Sara Martínez de Lizarrondo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Erythrocyte microparticles can induce kidney vaso-occlusions in a murine model of sickle cell disease

(2012) S. M. Camus et al.   BLOOD

Developmental Endothelial Locus-1 (Del-1) Mediates Clearance of Platelet Microparticles by the Endothelium

(2012) Swapan Kumar Dasgupta et al.   CIRCULATION

Differences in Microparticle Release in Patients With Acute Coronary Syndrome and Stable Angina

(2012) Luigi Marzio Biasucci et al.   CIRCULATION JOURNAL

Sonic Hedgehog–Modified Human CD34+ Cells Preserve Cardiac Function After Acute Myocardial Infarction

(2012) Alexander R. Mackie et al.   CIRCULATION RESEARCH

Effect of 40 mg Versus 10 mg of Atorvastatin on Oxidized Low-Density Lipoprotein, High-Sensitivity C-Reactive Protein, Circulating Endothelial-Derived Microparticles, and Endothelial Progenitor Cells in Patients With Ischemic Cardiomyopathy

(2012) Bingsheng Huang et al.   CLINICAL CARDIOLOGY

Intracoronary microparticles and microvascular obstruction in patients with ST elevation myocardial infarction undergoing primary percutaneous intervention

(2012) I. Porto et al.   EUROPEAN HEART JOURNAL

Update on acute coronary syndromes: the pathologists' view

(2012) Erling Falk et al.   EUROPEAN HEART JOURNAL

Dynamics of exosome internalization and trafficking

(2012) Tian Tian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Coordinate Stimulation of Macrophages by Microparticles and TLR Ligands Induces Foam Cell Formation

(2012) Peter A. Keyel et al.   JOURNAL OF IMMUNOLOGY

Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs

(2012) Eduard Hergenreider et al.   NATURE CELL BIOLOGY

Increased Shedding of Microvesicles from Intimal Smooth Muscle Cells in Athero-Prone Areas of the Human Aorta: Implications for Understanding of the Predisease Stage

(2012) Yuri V. Bobryshev et al.   PATHOBIOLOGY

Endothelial Cell–derived Microparticles Loaded with Iron Oxide Nanoparticles: Feasibility of MR Imaging Monitoring in Mice

(2012) Achraf Al Faraj et al.   RADIOLOGY

Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques

(2012) Rosa Suades et al.   THROMBOSIS AND HAEMOSTASIS

Role of Exosomes/Microvesicles in the Nervous System and Use in Emerging Therapies

(2012) Charles Pin-Kuang Lai et al.   Frontiers in Physiology

Circulating Endothelial Microparticles as a Measure of Early Lung Destruction in Cigarette Smokers

(2011) Cynthia Gordon et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Calcium Regulates Key Components of Vascular Smooth Muscle Cell–Derived Matrix Vesicles to Enhance Mineralization

(2011) Alexander N. Kapustin et al.   CIRCULATION RESEARCH

Intraplaque haemorrhages as the trigger of plaque vulnerability

(2011) J.-B. Michel et al.   EUROPEAN HEART JOURNAL

Selective transfer of exosomes from oligodendrocytes to microglia by macropinocytosis

(2011) D. Fitzner et al.   JOURNAL OF CELL SCIENCE

Endothelial cell microparticles act as centers of matrix metalloproteinsase-2 (MMP-2) activation and vascular matrix remodeling

(2011) Thomas P. Lozito et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Impact of pre-analytical parameters on the measurement of circulating microparticles: towards standardization of protocol

(2011) R. LACROIX et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

(2011) Kasey C. Vickers et al.   NATURE CELL BIOLOGY

Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma

(2011) J. D. Arroyo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease

(2011) Ruenn Chai Lai et al.   Regenerative Medicine

Human mesenchymal stem cell-conditioned medium improves cardiac function following myocardial infarction

(2011) Leo Timmers et al.   Stem Cell Research

Release of endothelial microparticles in vivo during atorvastatin treatment; a randomized double-blind placebo-controlled study

(2011) Fariborz Mobarrez et al.   THROMBOSIS RESEARCH

Cellular Mechanisms Underlying the Formation of Circulating Microparticles

(2010) Olivier Morel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Microparticles From Human Atherosclerotic Plaques Promote Endothelial ICAM-1–Dependent Monocyte Adhesion and Transendothelial Migration

(2010) Pierre-Emmanuel Rautou et al.   CIRCULATION RESEARCH

Circulating CD31+/Annexin V+ microparticles correlate with cardiovascular outcomes

(2010) J.-M. Sinning et al.   EUROPEAN HEART JOURNAL

Microparticles Carrying Sonic Hedgehog Favor Neovascularization through the Activation of Nitric Oxide Pathway in Mice

(2010) Tarek Benameur et al.   PLoS One

Microparticles: Key Protagonists in Cardiovascular Disorders

(2010) Nicolas Amabile et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Exosome secreted by MSC reduces myocardial ischemia/reperfusion injury

(2010) Ruenn Chai Lai et al.   Stem Cell Research

The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib

(2010) Thomas Exner et al.   THROMBOSIS AND HAEMOSTASIS

Cellular Internalization of Exosomes Occurs Through Phagocytosis

(2010) Du Feng et al.   TRAFFIC

Effects of pitavastatin on monocyte chemoattractant protein-1 in hyperlipidemic patients

(2009) Shosaku Nomura et al.   BLOOD COAGULATION & FIBRINOLYSIS

Tumor cells expressing tissue factor influence the migration of smooth muscle cells in a catalytic activity-dependent way

(2009) Catherine Brousseau et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors

(2009) R. Soleti et al.   CARCINOGENESIS

Proteomics, Metabolomics, and Immunomics on Microparticles Derived From Human Atherosclerotic Plaques

(2009) Manuel Mayr et al.   Circulation-Cardiovascular Genetics

Microparticles in endothelial cell and vascular homeostasis: are they really noxious?

(2009) O. Morel et al.   HAEMATOLOGICA

Microenvironmental pH Is a Key Factor for Exosome Traffic in Tumor Cells

(2009) Isabella Parolini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Significance of a Multiple Biomarkers Strategy Including Endothelial Dysfunction to Improve Risk Stratification for Cardiovascular Events in Patients at High Risk for Coronary Heart Disease

(2009) Toshimitsu Nozaki et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles

(2009) A. M. CURTIS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

The effects of pitavastatin, eicosapentaenoic acid and combined therapy on platelet-derived microparticles and adiponectin in hyperlipidemic, diabetic patients

(2009) Shosaku Nomura et al.   PLATELETS

Monocyte Derived Microvesicles Deliver a Cell Death Message via Encapsulated Caspase-1

(2009) Anasuya Sarkar et al.   PLoS One

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Endothelial Dysfunction Caused by Circulating Microparticles from Patients with Metabolic Syndrome

(2008) Abdelali Agouni et al.   AMERICAN JOURNAL OF PATHOLOGY

Lactadherin and clearance of platelet-derived microvesicles

(2008) S. K. Dasgupta et al.   BLOOD

Brief Secondhand Smoke Exposure Depresses Endothelial Progenitor Cells Activity and Endothelial Function

(2008) Christian Heiss et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

CD40 Ligand+ Microparticles From Human Atherosclerotic Plaques Stimulate Endothelial Proliferation and Angiogenesis

(2008) Aurélie S. Leroyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Insulin inhibits tissue factor expression in monocytes

(2008) A. J. GERRITS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet microparticles contain active caspase 3

(2008) Anita N. Böing et al.   PLATELETS

Reduction of myocardial infarct size by human mesenchymal stem cell conditioned medium

(2008) Leo Timmers et al.   Stem Cell Research