Structure, regulation, and biological functions of TIGAR and its role in diseases

Dynamic ROS Control by TIGAR Regulates the Initiation and Progression of Pancreatic Cancer

(2020) Eric C. Cheung et al.   CANCER CELL

S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis

(2020) Qianqian Wang et al.   CHEMICO-BIOLOGICAL INTERACTIONS

TIGAR/AP-1 axis accelerates the division of Lgr5− reserve intestinal stem cells to reestablish intestinal architecture after lethal radiation

(2020) Fei Chen et al.   Cell Death & Disease

TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation

(2019) Wenjuan Zhou et al.   Cell Death & Disease

TIGAR regulates mitochondrial functions through SIRT1-PGC1α pathway and translocation of TIGAR into mitochondria in skeletal muscle

(2019) Ji Geng et al.   FASEB JOURNAL

miR‐885‐5p plays an accomplice role in liver cancer by instigating TIGAR expression via targeting its promoter

(2019) Shubiao Zou et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

p53-TP53-Induced Glycolysis Regulator Mediated Glycolytic Suppression Attenuates DNA Damage and Genomic Instability in Fanconi Anemia Hematopoietic Stem Cells

(2019) Xue Li et al.   STEM CELLS

Ablation of cardiac TIGAR preserves myocardial energetics and cardiac function in the pressure overload heart failure model

(2019) Yoshifumi Okawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

(2019) Ding-Mei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway

(2019) Wenjuan Zhou et al.   Frontiers in Molecular Neuroscience

Regulation of Mitochondrial ATP Production: Ca2+ Signaling and Quality Control

(2019) Liron Boyman et al.   TRENDS IN MOLECULAR MEDICINE

LKB1/p53/TIGAR/autophagy-dependent VEGF expression contributes to PM2.5-induced pulmonary inflammatory responses

(2019) Huan Xu et al.   Scientific Reports

NADPH ameliorates MPTP-induced dopaminergic neurodegeneration through inhibiting p38MAPK activation

(2018) Jing-si Zhou et al.   ACTA PHARMACOLOGICA SINICA

Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea

(2018) Wenwen Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

Calcium Signaling and Reactive Oxygen Species in Mitochondria

(2018) Edoardo Bertero et al.   CIRCULATION RESEARCH

High expression of synthesis of cytochrome c oxidase 2 and TP53 -induced glycolysis and apoptosis regulator can predict poor prognosis in human lung adenocarcinoma

(2018) Jiabin Liu et al.   HUMAN PATHOLOGY

The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC

(2018) Yan Tang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of TIGAR Induces Oxidative Stress and Meiotic Defects in Oocytes from Obese Mice

(2018) Haichao Wang et al.   MOLECULAR & CELLULAR PROTEOMICS

Metabolic remodelling in heart failure

(2018) Edoardo Bertero et al.   Nature Reviews Cardiology

TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes

(2018) Jieyu Chen et al.   NEUROPHARMACOLOGY

TIGAR inclusion pathology is specific for Lewy body diseases

(2018) Karla L. Robles López et al.   BRAIN RESEARCH

Reduced Nicotinamide Adenine Dinucleotide Phosphate Inhibits MPTP-Induced Neuroinflammation and Neurotoxicity

(2018) Ying Zhou et al.   NEUROSCIENCE

Inhibition of MUC1-C regulates metabolism by AKT pathway in esophageal squamous cell carcinoma

(2018) Xin GongSun et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Melatonin ameliorates hypoglycemic stress-induced brain endothelial tight junction injury by inhibiting protein nitration of TP53-induced glycolysis and apoptosis regulator

(2017) Cheng-kun Wang et al.   JOURNAL OF PINEAL RESEARCH

Targeting MUC1-C inhibits the AKT-S6K1-elF4A pathway regulating TIGAR translation in colorectal cancer

(2017) Rehan Ahmad et al.   Molecular Cancer

How do reactive oxygen species and calcium trigger mitochondrial membrane permeabilisation?

(2016) Nicolas Tajeddine   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Reprogramming metabolism by histone methyltransferase NSD2 drives endocrine resistance via coordinated activation of pentose phosphate pathway enzymes

(2016) Junjian Wang et al.   CANCER LETTERS

Deletion or Inhibition of the Oxygen Sensor PHD1 Protects against Ischemic Stroke via Reprogramming of Neuronal Metabolism

(2016) Annelies Quaegebeur et al.   Cell Metabolism

Evolving Concepts of Myocardial Energy Metabolism

(2016) Gary D. Lopaschuk et al.   CIRCULATION RESEARCH

Investigating mitochondrial redox state using NADH and NADPH autofluorescence

(2016) Thomas S. Blacker et al.   FREE RADICAL BIOLOGY AND MEDICINE

TIGAR cooperated with glycolysis to inhibit the apoptosis of leukemia cells and associated with poor prognosis in patients with cytogenetically normal acute myeloid leukemia

(2016) Sixuan Qian et al.   Journal of Hematology & Oncology

Acetylation Is Crucial for p53-Mediated Ferroptosis and Tumor Suppression

(2016) Shang-Jui Wang et al.   Cell Reports

TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis

(2016) Jun-Hao Zhou et al.   Scientific Reports

MiR-144 Inhibits Proliferation and Induces Apoptosis and Autophagy in Lung Cancer Cells by Targeting TIGAR

(2015) Shanshan Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ischemia/reperfusion-induced upregulation of TIGAR in brain is mediated by SP1 and modulated by ROS and hormones involved in glucose metabolism

(2015) Meiling Sun et al.   NEUROCHEMISTRY INTERNATIONAL

Reduced Nicotinamide Adenine Dinucleotide Phosphate, a Pentose Phosphate Pathway Product, Might Be a Novel Drug Candidate for Ischemic Stroke

(2015) Mei Li et al.   STROKE

p53- and p73-independent activation of TIGAR expression in vivo

(2015) P Lee et al.   Cell Death & Disease

Endogenous level of TIGAR in brain is associated with vulnerability of neurons to ischemic injury

(2015) Lijuan Cao et al.   Neuroscience Bulletin

TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway

(2015) Hong-Pei Yu et al.   Scientific Reports

Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase

(2014) Isabelle Gerin et al.   BIOCHEMICAL JOURNAL

TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy

(2014) J.-M. Xie et al.   CANCER RESEARCH

Radiosensitization of glioma cells by TP53-induced glycolysis and apoptosis regulator knockdown is dependent on thioredoxin-1 nuclear translocation

(2014) Haowen Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

(2014) M. Li et al.   JOURNAL OF NEUROSCIENCE

TP53-induced glycolysis and apoptosis regulator promotes proliferation and invasiveness of nasopharyngeal carcinoma cells

(2014) ELAINE YUE LING WONG et al.   Oncology Letters

TigarBcauses mitochondrial dysfunction and neuronal loss in PINK1 deficiency

(2013) Laura J. Flinn et al.   ANNALS OF NEUROLOGY

CREB, another culprit for TIGAR promoter activity and expression

(2013) Shubiao Zou et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydroxylase-dependent regulation of the NF-κB pathway

(2013) Carsten C. Scholz et al.   BIOLOGICAL CHEMISTRY

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Acetylation mediated by the p300/CBP-associated factor determines cellular energy metabolic pathways in cancer

(2013) RAMKUMAR RAJENDRAN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease

(2013) Pavel Katsel et al.   PLoS One

Antioxidant and bioenergetic coupling between neurons and astrocytes

(2012) Seila Fernandez-Fernandez et al.   BIOCHEMICAL JOURNAL

TIGAR induces p53-mediated cell-cycle arrest by regulation of RB–E2F1 complex

(2012) E Madan et al.   BRITISH JOURNAL OF CANCER

Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

(2012) Christina Wanka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial localization of TIGAR under hypoxia stimulates HK2 and lowers ROS and cell death

(2012) E. C. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte - neuron lactate shuttle may boost more ATP supply to the neuron under hypoxic conditions - in silico study supported by in vitro expression data

(2011) Seda Genc et al.   BMC Systems Biology

Role of reactive oxygen and nitrogen species in the vascular responses to inflammation

(2011) Peter R. Kvietys et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

(2011) Kyu Yeoun Won et al.   HUMAN PATHOLOGY

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

(2011) Atsushi Hoshino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SP1 plays a pivotal role for basal activity of TIGAR promoter in liver cancer cell lines

(2011) Shubiao Zou et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

p53 and TIGAR regulate cardiac myocyte energy homeostasis under hypoxic stress

(2010) Masaki Kimata et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Exercise training attenuates oxidative stress and decreases p53 protein content in skeletal muscle of type 2 diabetic Goto-Kakizaki rats

(2010) Zhengtang Qi et al.   FREE RADICAL BIOLOGY AND MEDICINE

Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease

(2010) Zoltan Derdak et al.   JOURNAL OF HEPATOLOGY

Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death

(2010) V W Y Lui et al.   ONCOGENE

The mitochondrial permeability transition pore and ischemia-reperfusion injury

(2009) Christopher P. Baines   BASIC RESEARCH IN CARDIOLOGY

Regulation of Translation Initiation in Eukaryotes: Mechanisms and Biological Targets

(2009) Nahum Sonenberg et al.   CELL

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

The histidine phosphatase superfamily: structure and function

(2008) Daniel J. Rigden   BIOCHEMICAL JOURNAL

Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

(2008) Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY