The fructose-2,6-bisphosphatase TIGAR suppresses NF-κB signaling by directly inhibiting the linear ubiquitin assembly complex LUBAC

The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux

(2016) Varman T. Samuel et al.   JOURNAL OF CLINICAL INVESTIGATION

Endoplasmic reticulum stress and the unfolded protein response in pancreatic islet inflammation

(2016) Kira Meyerovich et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Structure of a HOIP/E2~ubiquitin complex reveals RBR E3 ligase mechanism and regulation

(2016) Bernhard C. Lechtenberg et al.   NATURE

Alternative splicing of MALT1 controls signalling and activation of CD4+ T cells

(2016) Isabel Meininger et al.   Nature Communications

Inflammatory cause of metabolic syndrome via brain stress and NF-κB

(2016) Dongsheng Cai et al.   Aging-US

Roles of linear ubiquitinylation, a crucial regulator of NF-κB and cell death, in the immune system

(2015) Katsuhiro Sasaki et al.   IMMUNOLOGICAL REVIEWS

Linear ubiquitination in immunity

(2015) Yutaka Shimizu et al.   IMMUNOLOGICAL REVIEWS

Fyn Activation of mTORC1 Stimulates the IRE1α-JNK Pathway, Leading to Cell Death

(2015) Yichen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Congenital generalized lipodystrophies—new insights into metabolic dysfunction

(2015) Nivedita Patni et al.   Nature Reviews Endocrinology

TIGAR regulates DNA damage and repair through pentosephosphate pathway and Cdk5-ATM pathway

(2015) Hong-Pei Yu et al.   Scientific Reports

Identification of TP53-induced glycolysis and apoptosis regulator (TIGAR) as the phosphoglycolate-independent 2,3-bisphosphoglycerate phosphatase

(2014) Isabelle Gerin et al.   BIOCHEMICAL JOURNAL

An unexpected twist to the activation of IKKβ: TAK1 primes IKKβ for activation by autophosphorylation

(2014) Jiazhen Zhang et al.   BIOCHEMICAL JOURNAL

Mechanism Underlying I B Kinase Activation Mediated by the Linear Ubiquitin Chain Assembly Complex

(2014) H. Fujita et al.   MOLECULAR AND CELLULAR BIOLOGY

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

(2014) Veronique Schaeffer et al.   MOLECULAR CELL

Adipocyte-Specific IKKβ Signaling Suppresses Adipose Tissue Inflammation through an IL-13-Dependent Paracrine Feedback Pathway

(2014) Hyokjoon Kwon et al.   Cell Reports

To be, or not to be

(2013) Shang-Jui Wang et al.   CURRENT OPINION IN ONCOLOGY

TIGAR Is Required for Efficient Intestinal Regeneration and Tumorigenesis

(2013) Eric C. Cheung et al.   DEVELOPMENTAL CELL

Bidirectional regulation of NF-κB by reactive oxygen species: A role of unfolded protein response

(2013) Shotaro Nakajima et al.   FREE RADICAL BIOLOGY AND MEDICINE

Cycle Checkpoint Abnormalities during Dementia: A Plausible Association with the Loss of Protection against Oxidative Stress in Alzheimer’s Disease

(2013) Pavel Katsel et al.   PLoS One

Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

(2013) C. H. Emmerich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ATM-NFκB axis-driven TIGAR regulates sensitivity of glioma cells to radiomimetics in the presence of TNFα

(2013) S Sinha et al.   Cell Death & Disease

A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation

(2013) Smarajit Polley et al.   PLOS BIOLOGY

Adipokines Mediate Inflammation and Insulin Resistance

(2013) Hyokjoon Kwon et al.   Frontiers in Endocrinology

A Census of Human Soluble Protein Complexes

(2012) Pierre C. Havugimana et al.   CELL

NF- B, the first quarter-century: remarkable progress and outstanding questions

(2012) M. S. Hayden et al.   GENES & DEVELOPMENT

Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

(2012) Christina Wanka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

T-cell receptor-induced JNK activation requires proteolytic inactivation of CYLD by MALT1

(2011) Jens Staal et al.   EMBO JOURNAL

LUBAC regulates NF-κB activation upon genotoxic stress by promoting linear ubiquitination of NEMO

(2011) Jixiao Niu et al.   EMBO JOURNAL

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

(2011) Atsushi Hoshino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

SHARPIN is a component of the NF-κB-activating linear ubiquitin chain assembly complex

(2011) Fuminori Tokunaga et al.   NATURE

SHARPIN forms a linear ubiquitin ligase complex regulating NF-κB activity and apoptosis

(2011) Fumiyo Ikeda et al.   NATURE

Linear ubiquitination prevents inflammation and regulates immune signalling

(2011) Björn Gerlach et al.   NATURE

Return to homeostasis: downregulation of NF-κB responses

(2011) Jürgen Ruland   NATURE IMMUNOLOGY

Autophagy in cancer associated fibroblasts promotes tumor cell survival

(2010) Ubaldo E. Martinez-Outschoorn et al.   CELL CYCLE

Inhibition of c-Met downregulates TIGAR expression and reduces NADPH production leading to cell death

(2010) V W Y Lui et al.   ONCOGENE

Regulation and Function of NF-κB Transcription Factors in the Immune System

(2009) Sivakumar Vallabhapurapu et al.   Annual Review of Immunology

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

(2009) Simin Rahighi et al.   CELL

CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

(2009) S-C Sun   CELL DEATH AND DIFFERENTIATION

Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

(2009) Tobias L. Haas et al.   MOLECULAR CELL

Involvement of linear polyubiquitylation of NEMO in NF-κB activation

(2009) Fuminori Tokunaga et al.   NATURE CELL BIOLOGY

The histidine phosphatase superfamily: structure and function

(2008) Daniel J. Rigden   BIOCHEMICAL JOURNAL

Structural and Biochemical Studies of TIGAR (TP53-induced Glycolysis and Apoptosis Regulator)

(2008) Hua Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

(2008) Keiko Kawauchi et al.   NATURE CELL BIOLOGY