TIGAR Attenuates High Glucose-Induced Neuronal Apoptosis via an Autophagy Pathway

TIGAR promotes neural stem cell differentiation through acetyl-CoA-mediated histone acetylation

(2019) Wenjuan Zhou et al.   Cell Death & Disease

[Express] Downregulation of Glucose-6-phosphate dehydrogenase contributes to diabetic neuropathic pain through up-regulation of toll-like receptor 4 in rats

(2019) Qian Sun et al.   Molecular Pain

TIGAR alleviates ischemia/reperfusion-induced autophagy and ischemic brain injury

(2019) Ding-Mei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Wnt Signaling Activates TP53-Induced Glycolysis and Apoptosis Regulator and Protects Against Cisplatin-Induced Spiral Ganglion Neuron Damage in the Mouse Cochlea

(2018) Wenwen Liu et al.   ANTIOXIDANTS & REDOX SIGNALING

TIGAR inhibits ischemia/reperfusion-induced inflammatory response of astrocytes

(2018) Jieyu Chen et al.   NEUROPHARMACOLOGY

Activation of Sirtuin 1 Attenuates High Glucose-Induced Neuronal Apoptosis by Deacetylating p53

(2018) Xiajie Shi et al.   Frontiers in Endocrinology

HGSD attenuates neuronal apoptosis through enhancing neuronal autophagy in the brain of diabetic mice: The role of AMP-activated protein kinase

(2016) Huan Xue et al.   LIFE SCIENCES

Adenosine Monophosphate-Activated Protein Kinase Abates Hyperglycaemia-Induced Neuronal Injury in Experimental Models of Diabetic Neuropathy: Effects on Mitochondrial Biogenesis, Autophagy and Neuroinflammation

(2016) Veera Ganesh Yerra et al.   MOLECULAR NEUROBIOLOGY

p62 improves AD-like pathology by increasing autophagy

(2016) A Caccamo et al.   MOLECULAR PSYCHIATRY

Hyperglycemic Stress and Carbon Stress in Diabetic Glucotoxicity

(2016) Xiaoting Luo et al.   Aging and Disease

Glucose-6-phosphate dehydrogenase contributes to the regulation of glucose uptake in skeletal muscle

(2016) Robert S. Lee-Young et al.   Molecular Metabolism

TIGAR contributes to ischemic tolerance induced by cerebral preconditioning through scavenging of reactive oxygen species and inhibition of apoptosis

(2016) Jun-Hao Zhou et al.   Scientific Reports

HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection

(2015) Valerie P Tan et al.   Autophagy

Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease

(2015) Jing Yan et al.   NEUROBIOLOGY OF AGING

Identification of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase as a novel autophagy regulator by high content shRNA screening

(2015) A M Strohecker et al.   ONCOGENE

Autophagic neuron death in neonatal brain ischemia/hypoxia

(2014) Yasuo Uchiyama et al.   Autophagy

MAPK14/p38α-dependent modulation of glucose metabolism affects ROS levels and autophagy during starvation

(2014) Enrico Desideri et al.   Autophagy

TIGAR Has a Dual Role in Cancer Cell Survival through Regulating Apoptosis and Autophagy

(2014) J.-M. Xie et al.   CANCER RESEARCH

A TIGAR-Regulated Metabolic Pathway Is Critical for Protection of Brain Ischemia

(2014) M. Li et al.   JOURNAL OF NEUROSCIENCE

Pathogenesis of Chronic Hyperglycemia: From Reductive Stress to Oxidative Stress

(2014) Liang-Jun Yan   Journal of Diabetes Research

Vulnerability for apoptosis in the hippocampal dentate gyrus of STZ-induced diabetic rats with cognitive impairment

(2014) Yi-jing Guo et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Cerebral ischemia-reperfusion-induced autophagy protects against neuronal injury by mitochondrial clearance

(2013) Xiangnan Zhang et al.   Autophagy

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

p53-TIGAR axis attenuates mitophagy to exacerbate cardiac damage after ischemia

(2011) Atsushi Hoshino et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

HDAC3 Is a Critical Negative Regulator of Long-Term Memory Formation

(2011) S. C. McQuown et al.   JOURNAL OF NEUROSCIENCE

Diabetic neuropathy: cellular mechanisms as therapeutic targets

(2011) Andrea M. Vincent et al.   Nature Reviews Neurology

Autophagy was activated in injured astrocytes and mildly decreased cell survival following glucose and oxygen deprivation and focal cerebral ischemia

(2010) Ai-Ping Qin et al.   Autophagy

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Diabetic neuropathy: Mechanisms to management

(2008) James L. Edwards et al.   PHARMACOLOGY & THERAPEUTICS