Tp53-induced Glycolysis and Apoptosis Regulator (TIGAR) Protects Glioma Cells from Starvation-induced Cell Death by Up-regulating Respiration and Improving Cellular Redox Homeostasis

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

(2012) Patrick S. Ward et al.   CANCER CELL

Analysis of Tumor Metabolism Reveals Mitochondrial Glucose Oxidation in Genetically Diverse Human Glioblastomas in the Mouse Brain In Vivo

(2012) Isaac Marin-Valencia et al.   Cell Metabolism

Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells

(2011) Nana-Maria Grüning et al.   Cell Metabolism

Regulatory role of p53 in cancer metabolism via SCO2 and TIGAR in human breast cancer

(2011) Kyu Yeoun Won et al.   HUMAN PATHOLOGY

p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase

(2011) Peng Jiang et al.   NATURE CELL BIOLOGY

Synthesis of cytochrome c oxidase 2: a p53-dependent metabolic regulator that promotes respiratory function and protects glioma and colon cancer cells from hypoxia-induced cell death

(2011) C Wanka et al.   ONCOGENE

Poor outcome in primary non-small cell lung cancers is predicted by transketolase TKTL1 expression

(2011) Gian Kayser et al.   PATHOLOGY

TP53 induced glycolysis and apoptosis regulator (TIGAR) knockdown results in radiosensitization of glioma cells

(2011) Miguel A. Peña-Rico et al.   RADIOTHERAPY AND ONCOLOGY

Hypoxia and succinate antagonize 2-deoxyglucose effects on glioblastoma

(2010) Francesca Pistollato et al.   BIOCHEMICAL PHARMACOLOGY

Silencing of TKTL1 by siRNA inhibits proliferation of human gastric cancer cells in vitro and in vivo

(2010) Weijie Yuan et al.   CANCER BIOLOGY & THERAPY

ROS induced DNA damage and checkpoint responses: Influences on aging?

(2010) Luis Miguel Guachalla et al.   CELL CYCLE

TKTL1 Is Activated by Promoter Hypomethylation and Contributes to Head and Neck Squamous Cell Carcinoma Carcinogenesis through Increased Aerobic Glycolysis and HIF1  Stabilization

(2010) W. Sun et al.   CLINICAL CANCER RESEARCH

Lactate-Dehydrogenase 5 is overexpressed in non-small cell lung cancer and correlates with the expression of the transketolase-like protein 1

(2010) Gian Kayser et al.   Diagnostic Pathology

Metabolomic Patterns in Glioblastoma and Changes during Radiotherapy: A Clinical Microdialysis Study

(2010) Carl Wibom et al.   JOURNAL OF PROTEOME RESEARCH

Modulation of intracellular ROS levels by TIGAR controls autophagy

(2009) Karim Bensaad et al.   EMBO JOURNAL

Co-localisation of hypoxia and perfusion markers with parameters of glucose metabolism in human squamous cell carcinoma (hSCC) xenografts

(2009) Ala Yaromina et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines

(2009) Hani J. Marcus et al.   JOURNAL OF NEURO-ONCOLOGY

Coordinated Activation of Candidate Proto-Oncogenes and Cancer Testes Antigens via Promoter Demethylation in Head and Neck Cancer and Lung Cancer

(2009) Ian M. Smith et al.   PLoS One

Glycolytic metabolism and tumour response to fractionated irradiation

(2009) Ulrike G.A. Sattler et al.   RADIOTHERAPY AND ONCOLOGY

Expression of Transketolase-like 1 and Activation of Akt in Grade IV Glioblastomas Compared With Grades II and III Astrocytic Gliomas

(2008) Hans-Ullrich Völker et al.   AMERICAN JOURNAL OF CLINICAL PATHOLOGY

How mitochondria produce reactive oxygen species

(2008) Michael P. Murphy   BIOCHEMICAL JOURNAL

Transketolase-like protein 1 (TKTL1) is required for rapid cell growth and full viability of human tumor cells

(2008) Xiaojun Xu et al.   INTERNATIONAL JOURNAL OF CANCER

Glucose metabolites, glutamate and glycerol in malignant glioma tumours during radiotherapy

(2008) Pedram Tabatabaei et al.   JOURNAL OF NEURO-ONCOLOGY

ROS-Generating Mitochondrial DNA Mutations Can Regulate Tumor Cell Metastasis

(2008) K. Ishikawa et al.   SCIENCE