Genetically engineered oncolytic bacteria as drug delivery systems for targeted cancer theranostics

Bioinspired oral delivery of gut microbiota by self-coating with biofilms

(2020) Xinyue Wang et al.   Science Advances

An engineered E. coli Nissle improves hyperammonemia and survival in mice and shows dose-dependent exposure in healthy humans

(2019) Caroline B. Kurtz et al.   Science Translational Medicine

Vaccine Strategies to Improve Anti-cancer Cellular Immune Responses

(2019) Karim Vermaelen   Frontiers in Immunology

Nanophotosensitizer-engineered Salmonella bacteria with hypoxia targeting and photothermal-assisted mutual bioaccumulation for solid tumor therapy

(2019) Fuming Chen et al.   BIOMATERIALS

Camouflaging bacteria by wrapping with cell membranes

(2019) Zhenping Cao et al.   Nature Communications

Polyethyleneimine modification of aluminum hydroxide nanoparticle enhances antigen transportation and cross-presentation of dendritic cells

(2018) Heng Dong et al.   International Journal of Nanomedicine

Bacteria-Mediated Tumor Therapy Utilizing Photothermally-Controlled TNF-α Expression via Oral Administration

(2018) Jin-Xuan Fan et al.   NANO LETTERS

Engineering bacteria for diagnostic and therapeutic applications

(2018) David T. Riglar et al.   NATURE REVIEWS MICROBIOLOGY

Remodeling the Tumor Microenvironment with Emerging Nanotherapeutics

(2018) Qin Chen et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

VEGF–neuropilin-2 signaling promotes stem-like traits in breast cancer cells by TAZ-mediated repression of the Rac GAP β2-chimaerin

(2018) Ameer L. Elaimy et al.   Science Signaling

White paper on microbial anti-cancer therapy and prevention

(2018) Neil S. Forbes et al.   Journal for ImmunoTherapy of Cancer

Apatinib affect VEGF-mediated cell proliferation, migration, invasion via blocking VEGFR2/RAF/MEK/ERK and PI3K/AKT pathways in cholangiocarcinoma cell

(2018) Manping Huang et al.   BMC GASTROENTEROLOGY

The inhibition of indoleamine 2, 3-dioxygenase 1 by connexin 43

(2017) Han-Chen Lin et al.   International Journal of Medical Sciences

Targeting the Tumor Stroma: the Biology and Clinical Development of Pegylated Recombinant Human Hyaluronidase (PEGPH20)

(2017) Kit Man Wong et al.   Current Oncology Reports

32-Phosphorus selectively delivered by listeria to pancreatic cancer demonstrates a strong therapeutic effect

(2017) Dinesh Chandra et al.   Oncotarget

Implications of Increase in Vascular Permeability in Tumors by VEGF: A Commentary on the Pioneering Work of Harold Dvorak

(2016) M. W. Dewhirst et al.   CANCER RESEARCH

Tumor Cell Invasion Can Be Blocked by Modulators of Collagen Fibril Alignment That Control Assembly of the Extracellular Matrix

(2016) Moran Grossman et al.   CANCER RESEARCH

Exploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment

(2016) Ping-Pui Wong et al.   CURRENT BIOLOGY

Combined prokaryotic–eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop

(2016) Lei Shi et al.   JOURNAL OF CONTROLLED RELEASE

Matrix metalloproteinases (MMPs), the main extracellular matrix (ECM) enzymes in collagen degradation, as a target for anticancer drugs

(2016) Agata Jabłońska-Trypuć et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Hyaluronidase Embedded in Nanocarrier PEG Shell for Enhanced Tumor Penetration and Highly Efficient Antitumor Efficacy

(2016) Hao Zhou et al.   NANO LETTERS

RGD Peptide Cell-Surface Display Enhances the Targeting and Therapeutic Efficacy of Attenuated Salmonella-mediated Cancer Therapy

(2016) Seung-Hwan Park et al.   Theranostics

The design of reversible hydrogels to capture extracellular matrix dynamics

(2016) Adrianne M. Rosales et al.   Nature Reviews Materials

Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues

(2016) Qing Chang et al.   Scientific Reports

Reactive oxygen species involved in CT26 immunogenic cell death induced by Clostridium difficile toxin B

(2015) Chunli Sun et al.   IMMUNOLOGY LETTERS

An orally administered DNA vaccine targeting vascular endothelial growth factor receptor-3 inhibits lung carcinoma growth

(2015) Yan Chen et al.   TUMOR BIOLOGY

Salmonella typhimurium Suppresses Tumor Growth via the Pro-Inflammatory Cytokine Interleukin-1β

(2015) Jung-Eun Kim et al.   Theranostics

Vasculature Disruption Enhances Bacterial Targeting of Autochthonous Tumors

(2015) Jeremy J. Drees et al.   Journal of Cancer

Spores of Clostridium engineered for clinical efficacy and safety cause regression and cure of tumors in vivo

(2015) John T. Heap et al.   Oncotarget

Effect of TLR4 and B7-H1 on Immune Escape of Urothelial Bladder Cancer and its Clinical Significance

(2014) Yong-Hua Wang et al.   Asian Pacific Journal of Cancer Prevention

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure

(2014) Vikash P. Chauhan et al.   CANCER CELL

Tumor-targetingSalmonella typhimuriumA1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy

(2014) Shuya Yano et al.   CELL CYCLE

Salmonella entericaserovar Typhimurium immunotherapy for B-cell lymphoma induces broad anti-tumour immunity with therapeutic effect

(2014) Sofía Grille et al.   IMMUNOLOGY

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

A review of the current status of siRNA nanomedicines in the treatment of cancer

(2013) Pauline Resnier et al.   BIOMATERIALS

Engineered Salmonella typhimurium expressing E7 fusion protein, derived from human papillomavirus, inhibits tumor growth in cervical tumor-bearing mice

(2013) Wonsuck Yoon et al.   BIOTECHNOLOGY LETTERS

Salmonella engineered to express CD20-targeting antibodies and a drug-converting enzyme can eradicate human lymphomas

(2013) P. E. Massa et al.   BLOOD

Myeloid-derived suppressor cells have a central role in attenuated Listeria monocytogenes-based immunotherapy against metastatic breast cancer in young and old mice

(2013) D Chandra et al.   BRITISH JOURNAL OF CANCER

A Non-classical Assembly Pathway ofEscherichia coliPore-forming Toxin Cytolysin A

(2013) Monifa Fahie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Expression of tumour-specific antigens underlies cancer immunoediting

(2012) Michel DuPage et al.   NATURE

Heterogeneity and Tumor History

(2012) D. Shibata   SCIENCE

Engineering of Escherichia coli for targeted delivery of transgenes to HER2/neu-positive tumor cells

(2011) Chih-Hsiang Chang et al.   BIOTECHNOLOGY AND BIOENGINEERING

In tumors Salmonella migrate away from vasculature toward the transition zone and induce apoptosis

(2011) S Ganai et al.   CANCER GENE THERAPY

The Chemistry of Bioluminescence: An Analysis of Chemical Functionalities

(2011) Isabelle Navizet et al.   CHEMPHYSCHEM

A Live-Attenuated Listeria Vaccine (ANZ-100) and a Live-Attenuated Listeria Vaccine Expressing Mesothelin (CRS-207) for Advanced Cancers: Phase I Studies of Safety and Immune Induction

(2011) D. T. Le et al.   CLINICAL CANCER RESEARCH

Cancer immunotherapy comes of age

(2011) Ira Mellman et al.   NATURE

Autophagy in Tumor Immunity

(2011) R. K. Amaravadi   SCIENCE

Oral administration of attenuatedS. typhimuriumcarrying shRNA-expressing vectors as a cancer therapeutic

(2010) Nan Yang et al.   CANCER BIOLOGY & THERAPY

Structural insights into RNA interference

(2010) Dipali G. Sashital et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

Bacteria-Induced Gap Junctions in Tumors Favor Antigen Cross-Presentation and Antitumor Immunity

(2010) F. Saccheri et al.   Science Translational Medicine

Tumour-targeted delivery of TRAIL using Salmonella typhimurium enhances breast cancer survival in mice

(2009) S Ganai et al.   BRITISH JOURNAL OF CANCER

High Efficacy of a Listeria-Based Vaccine against Metastatic Breast Cancer Reveals a Dual Mode of Action

(2009) S. H. Kim et al.   CANCER RESEARCH

Genetically Engineered Salmonella typhimurium as an Imageable Therapeutic Probe for Cancer

(2009) V. H. Nguyen et al.   CANCER RESEARCH

Visualizing Implanted Tumors in Mice with Magnetic Resonance Imaging Using Magnetotactic Bacteria

(2009) M. R. Benoit et al.   CLINICAL CANCER RESEARCH

Bacterial delivery of a novel cytolysin to hypoxic areas of solid tumors

(2009) R M Ryan et al.   GENE THERAPY

Tumor Invasion of Salmonella enterica Serovar Typhimurium Is Accompanied by Strong Hemorrhage Promoted by TNF-α

(2009) Sara Leschner et al.   PLoS One

IL-18-producing Salmonella inhibit tumor growth

(2008) M Loeffler et al.   CANCER GENE THERAPY

Tumor-targeting prodrug-activating bacteria for cancer therapy

(2008) C-M Cheng et al.   CANCER GENE THERAPY

Salmonella Promoters Preferentially Activated Inside Tumors

(2008) N. Arrach et al.   CANCER RESEARCH

Escherichia coli Nissle 1917 Facilitates Tumor Detection by Positron Emission Tomography and Optical Imaging

(2008) P. Brader et al.   CLINICAL CANCER RESEARCH

Bacterial therapies: completing the cancer treatment toolbox

(2008) Adam T St Jean et al.   CURRENT OPINION IN BIOTECHNOLOGY

Inhibition of Tumor Growth Using Salmonella Expressing Fas Ligand

(2008) Markus Loeffler et al.   JNCI-Journal of the National Cancer Institute

History of Bacillus Calmette-Guerin and Bladder Cancer: An Immunotherapy Success Story

(2007) Harry W. Herr et al.   JOURNAL OF UROLOGY