Article
Cell Biology
Harold F. Dvorak
Summary: VEGF has the dual function of promoting angiogenesis and increasing vascular permeability, which contributes to the formation of vascular connective tissue stroma in wound healing, solid tumors, and chronic inflammatory diseases. This complex pathophysiological process initiated by VEGF plays a crucial role in tissue repair and disease progression.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Syeda Mahak Zahra Bokhari, Peter Hamar
Summary: Vascular endothelial growth factors (VEGFs) play a crucial role in regulating blood vessel formation in both normal and cancer development. VEGF-A is the most well-studied angiogenic factor secreted by tumor cells, making it a rational target for anticancer therapy. However, inhibiting VEGF-A can lead to the upregulation of VEGF-D, which has been shown to have comparable blood angiogenic potential and may facilitate tumor growth. This review focuses on summarizing the angiogenic role of VEGF-D in blood vessel formation and its potential as a therapeutic target for antiangiogenic therapy in cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ophthalmology
Anri Nishinaka, Miruto Tanaka, Kentaro Ohara, Eiji Sugaru, Yuji Shishido, Akemi Sugiura, Yukiko Moriguchi, Amane Toui, Shinsuke Nakamura, Kaoru Shimada, Shuzo Watanabe, Hideaki Hara, Masamitsu Shimazawa
Summary: This study investigated the role of TRPV4 in retinal vascular disease. TRPV4 expression and localization were examined in a mouse model of retinal vein occlusion (RVO). The effects of TRPV4 antagonists on retinal edema, blood flow, and ischemic areas were evaluated in RVO mice.
EXPERIMENTAL EYE RESEARCH
(2023)
Article
Food Science & Technology
Isabela Ferreira, Isadora Oliveira, Karla Bordon, Mouzarllem Reis, Gisele Wiezel, Caroline Sanchez, Luisa Santos, Norival Santos-Filho, Manuela Pucca, Lusania Antunes, Daiana Lopes, Eliane Arantes
Summary: This study focuses on the isolation, evaluation, assays, and PEGylation of a novel vascular endothelial growth factor (CdtVEGF and PEG-CdtVEGF) derived from Crotalus durissus terrificus venom. The researchers successfully isolated CdtVEGF from crude venom and determined its primary sequence. Both native and PEGylated CdtVEGF showed positive effects on wound closure and vascular activity, with PEG-CdtVEGF showing less inflammatory activity. This study highlights the importance of investigating minor components of snake venom for potential therapeutic applications.
Article
Cell Biology
Yiwei Lu, Guoyong Han, Yao Zhang, Long Zhang, Zhi Li, Qingyuan Wang, Zhiqiang Chen, Xuehao Wang, Jindao Wu
Summary: Tumor-associated macrophage-derived miR-23a-3p enhances HCC metastasis by promoting EMT and angiogenesis, as well as increasing vascular permeability.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Chemistry, Medicinal
Miaomiao Tian, Kan Chen, Jianhua Huang, Dongqing Chu, Jialin Li, Keqiang Huang, Chunyu Ma
Summary: Asiatic acid (AA) has demonstrated inhibitory effects on angiogenesis in breast cancer models both in vitro and in vivo, potentially through downregulating the VEGF/VEGFR2 signal axis to inhibit cancer growth and metastasis.
PHYTOTHERAPY RESEARCH
(2021)
Article
Medicine, Research & Experimental
Dan-Yang Chen, Ning-He Sun, Xiang Chen, Jun-Jie Gong, Song-Tao Yuan, Zi-Zhong Hu, Nan-Nan Lu, Jakob Korbelin, Kohji Fukunaga, Qing-Huai Liu, Ying-Mei Lu, Feng Han
Summary: Semaphorin 3G plays a crucial role in vascular remodeling and improvement of ischemic retinopathy by enhancing healthy vascular network formation and promoting diseased vasculature regression. Loss of Sema3G exacerbates pathological angiogenesis in retinal vasculature. Sema3G coordinates the functional interaction between beta-catenin and VE-cadherin, leading to increased beta-catenin stability and aiding in vascular remodeling.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Li Wang, Matteo Astone, Sk Kayum Alam, Zhu Zhu, Wuhong Pei, David A. Frank, Shawn M. Burgess, Luke H. Hoeppner
Summary: Vascular permeability triggered by inflammation or ischemia promotes edema and worsens disease progression, while VEGF plays a crucial role in regulating vascular barrier function. Targeting STAT3 can effectively reduce vascular permeability induced by VEGF.
DISEASE MODELS & MECHANISMS
(2021)
Article
Ophthalmology
Casey Zhang, Scott Friedman, Prithvi Mruthyunjaya, Ravi Parikh
Summary: This study aimed to investigate the cost impact of biosimilars on the US healthcare system and patients. The results showed that if an intraocular bevacizumab biosimilar were priced at $500, costs to Medicare would increase by $457 million and patient responsibility would increase by $117 million. Therefore, this study supports the need for an exemption of section 503B of the DQSA and continued use of repackaged off-label bevacizumab.
Article
Microbiology
Jiawang Gao, Zhengyuan Guo, Wei Li, Xiaowei Zhang, Xian-En Zhang, Zongqiang Cui
Summary: Ebola virus disrupts the inner blood-retinal barrier (iBRB) by stimulating the release of vascular endothelial growth factor (VEGF) from retinal pericytes, leading to ocular complications and disease recurrence. This study provides a mechanistic insight into the virus's impact on the iBRB and offers potential strategies for treating Ebola virus persistence.
Article
Biochemistry & Molecular Biology
Hitomi Matsuno, Shoko Tsuchimine, Kazunori O'Hashi, Kazuhisa Sakai, Kotaro Hattori, Shinsuke Hidese, Shingo Nakajima, Shuichi Chiba, Aya Yoshimura, Noriko Fukuzato, Mayumi Kando, Megumi Tatsumi, Shintaro Ogawa, Noritaka Ichinohe, Hiroshi Kunugi, Kazuhiro Sohya
Summary: Several lines of evidence suggest that stress-induced neurovascular dysfunction and increased blood-brain barrier permeability are important pathological links between stress and psychiatric disorders. This study demonstrates the crucial role of vascular endothelial growth factor in stress-induced blood-brain barrier dysfunction and depressive-like behavior development.
MOLECULAR PSYCHIATRY
(2022)
Article
Ophthalmology
Pascal N. Bernatchez, Bo Tao, Ralph A. Bradshaw, David Eveleth, William C. Sessa
Summary: The study aimed to identify a novel CPP for improved delivery of a truncated Cav modulator. Results showed that fusion with peptide RRPPR efficiently blocked NO release and VEGF-induced permeability, reducing immune-mediated retinal damage.
TRANSLATIONAL VISION SCIENCE & TECHNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Weibin Zhou, Keli Liu, Lei Zeng, Jiaqi He, Xinbo Gao, Xinyu Gu, Xun Chen, Jing Jing Li, Minghui Wang, Duoguang Wu, Zhixiong Cai, Lena Claesson-Welsh, Rong Ju, Jingfeng Wang, Feng Zhang, Yangxin Chen
Summary: This study found that VEGF-A/VEGFR2 Y949-dependent vascular permeability plays a significant role in the pathogenesis of PH and may serve as an attractive therapeutic target pathway for this disease.
Review
Oncology
Anette L. Magnussen, Ian G. Mills
Summary: The article emphasizes the importance of a functional vascular system for drug delivery and responsiveness of the tumour microenvironment, as well as the beneficial role of vessel normalisation in anti-cancer treatments. The article highlights the challenges of controlled neovascular remodelling and how vascular normalisation can impact disease management.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biotechnology & Applied Microbiology
Claudia Hernandez-Jimenez, J. Raul Olmos-Zuniga, Matilde Baltazares-Lipp, Rogelio Jasso-Victoria, Adrian Polo-Jerez, Maria Teresa Perez-Lopez, Luis Florentino Vazquez-Justiniano, Nestor Emmanuel Diaz-Martinez, Miguel Gaxiola-Gaxiola, Laura Romero-Romero, Axel Edmundo Guzman-Cedillo, Mario Enrique Baltazares-Lipp, Juan Carlos Vazquez-Minero, Luis Horacio Gutierrez-Gonzalez, Marcelino Alonso-Gomez, Mariana Silva-Martinez
Summary: This study investigated the quantification of ECE-1 and VEGF in a swine model of EVLP with standard hypothermic preservation. The results showed that ECE-1 levels remained constant over time, while VEGF levels were initially higher after prolonged preservation but decreased during EVLP. Additionally, parameters such as hemodynamics, gas exchange, mechanical ventilation, and histology tended to improve after 12 hours of hypothermic preservation in the delayed initiation group.
Editorial Material
Oncology
Mark Oldham, Suk W. Yoon, Justus Adamson, Xiaofeng Zhang, Peter Fecci, Mark Dewhirst
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Oncology
Suk W. Yoon, Vadim Tsvankin, Zachary Shrock, Boyu Meng, Xiaofeng Zhang, Mark Dewhirst, Peter Fecci, Justus Adamson, Mark Oldham
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Oncology
Kathleen A. Ashcraft, Devin Miles, Mary E. Sunday, Kingshuk Roy Choudhury, Kenneth H. Young, Gregory M. Palmer, Pranalee Patel, Emily C. Woska, Ray Zhang, Mark Oldham, Mark W. Dewhirst, Bridget F. Koontz
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2018)
Article
Biochemical Research Methods
Gregory M. Palmer, Hengtao Zhang, Chen-Ting Lee, Husam Mikati, Joseph A. Herbert, Marlee Krieger, Jesko von Windheim, Dave Koester, Daniel Stevenson, Daniel J. Rocke, Ramon Esclamado, Alaatin Erkanli, Nirmala Ramanujam, Mark W. Dewhirst, Walter T. Lee
JOURNAL OF BIOMEDICAL OPTICS
(2018)
Article
Chemistry, Multidisciplinary
Eric M. Mastria, Leon Y. Cai, Matthew J. Kan, Xinghai Li, Jeffrey L. Schaal, Steven Fiering, Michael D. Gunn, Mark W. Dewhirst, Smita K. Nair, Ashutosh Chilkoti
JOURNAL OF CONTROLLED RELEASE
(2018)
Article
Engineering, Civil
Mehdi Alhaddad, Mark Dewhirst, Kenichi Soga, Michael Devriendt
PROCEEDINGS OF THE INSTITUTION OF CIVIL ENGINEERS-TRANSPORT
(2019)
Article
Biology
Kathleen A. Ashcraft, Kingshuk Roy Choudhury, Sam R. Birer, Hansford C. Hendargo, Pranalee Patel, Gary Eichenbaum, Mark W. Dewhirst
RADIATION RESEARCH
(2018)
Letter
Oncology
Mark D. Dewhirst
INTERNATIONAL JOURNAL OF HYPERTHERMIA
(2018)
Article
Oncology
Kathleen A. Ashcraft, Johanna L. Hannan, Gary Eichenbaum, Xiaojie Zhang, Elena S. Pak, Austin M. Faught, Pranalee Patel, Mark W. Dewhirst, Bridget F. Koontz
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Editorial Material
Medicine, Research & Experimental
Mark W. Dewhirst, Yvonne M. Mowery, James B. Mitchell, Murali K. Cherukuri, Timothy W. Secomb
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Editorial Material
Multidisciplinary Sciences
Mark W. Dewhirst
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Oncology
Kathleen A. Ashcraft, Allison Betof Warner, Lee W. Jones, Mark W. Dewhirst
SEMINARS IN RADIATION ONCOLOGY
(2019)
Review
Oncology
Samuel B. Bader, Mark W. Dewhirst, Ester M. Hammond
Summary: Hypoxia refers to insufficient levels of oxygen in biological situations, which can occur in various diseases including cancer. Tumor hypoxia is known to lead to more aggressive and difficult-to-treat diseases. Tumor hypoxia is not static, and dynamic changes in oxygen levels have significant biological consequences.
Article
Oncology
Ashlyn G. Rickard, Husam Mikati, Antoine Mansourati, Daniel Stevenson, Marlee Krieger, Daniel Rocke, Ramon Esclamado, Mark W. Dewhirst, Nirmala Ramanujam, Walter T. Lee, Gregory M. Palmer
Summary: Diffuse reflectance spectroscopy (DRS) is a powerful tool for quantifying optical and physiological tissue properties. In this clinical study, a pressure-sensing and automatic self-calibration DRS was assessed and validated in patients with head and neck squamous cell carcinoma (HNSCC). The results showed that cancerous tissues have a significantly lower hemoglobin saturation compared to normal tissues, suggesting tumor hypoxia. The study also demonstrated the feasibility of conducting optical spectroscopy measurements on intact lesions prior to removal during HNSCC procedures.
Article
Oncology
Min Lu, Sydney M. Sanderson, Amelia Zessin, Kathleen A. Ashcraft, Lee W. Jones, Mark W. Dewhirst, Jason W. Locasale, David S. Hsu
CANCER & METABOLISM
(2018)
