An Integrated Approach to Identify New Anti-Filarial Leads to Treat River Blindness, a Neglected Tropical Disease

Molecular characterization of a Trichinella spiralis aspartic protease and its facilitation role in larval invasion of host intestinal epithelial cells

(2020) Jia Xu et al.   PLoS Neglected Tropical Diseases

Anthelmintic drug discovery: target identification, screening methods and the role of open science

(2020) Frederick A Partridge et al.   Beilstein Journal of Organic Chemistry

Moxidectin: an oral treatment for human onchocerciasis

(2020) Philip Milton et al.   Expert Review of Anti-Infective Therapy

Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

(2020) Marc P. Hübner et al.   PLoS Neglected Tropical Diseases

Unpacking the Pathogen Box

(2019) Clinton Veale   ChemMedChem

Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms

(2019) Denis Voronin et al.   PLoS Neglected Tropical Diseases

Identification of small molecule enzyme inhibitors as broad-spectrum anthelmintics

(2019) Rahul Tyagi et al.   Scientific Reports

The safety of double- and triple-drug community mass drug administration for lymphatic filariasis: A multicenter, open-label, cluster-randomized study

(2019) Gary J. Weil et al.   PLOS MEDICINE

Emodepside has sex-dependent immobilizing effects on adult Brugia malayi due to a differentially spliced binding pocket in the RCK1 region of the SLO-1 K channel

(2019) Sudhanva S. Kashyap et al.   PLoS Pathogens

WormBase: a modern Model Organism Information Resource

(2019) Todd W Harris et al.   NUCLEIC ACIDS RESEARCH

A guide to chemokines and their receptors

(2018) Catherine E. Hughes et al.   FEBS Journal

Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial

(2018) Nicholas O Opoku et al.   LANCET

Primaquine-induced haemolysis in females heterozygous for G6PD deficiency

(2018) Cindy S. Chu et al.   MALARIA JOURNAL

Comparative genomics of the major parasitic worms

(2018)   NATURE GENETICS

A Trial of a Triple-Drug Treatment for Lymphatic Filariasis

(2018) Christopher L. King et al.   NEW ENGLAND JOURNAL OF MEDICINE

ChEMBL: towards direct deposition of bioassay data

(2018) David Mendez et al.   NUCLEIC ACIDS RESEARCH

The ReFRAME library as a comprehensive drug repurposing library and its application to the treatment of cryptosporidiosis

(2018) Jeff Janes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effectiveness of a triple-drug regimen for global elimination of lymphatic filariasis: a modelling study

(2017) Michael A Irvine et al.   LANCET INFECTIOUS DISEASES

DrugBank 5.0: a major update to the DrugBank database for 2018

(2017) David S Wishart et al.   NUCLEIC ACIDS RESEARCH

Successful long-term maintenance of Mansonella perstans in an in vitro culture system

(2017) Abdel Jelil Njouendou et al.   Parasites & Vectors

Functional genomics inBrugia malayireveal diverse muscle nAChRs and differences between cholinergic anthelmintics

(2017) Saurabh Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

(2017) Stephen R. Doyle et al.   PLoS Neglected Tropical Diseases

Characterisation of sterol biosynthesis and validation of 14α-demethylase as a drug target in Acanthamoeba

(2017) Scott Thomson et al.   Scientific Reports

New directions for protease inhibitors directed drug discovery

(2016) Yoshio Hamada et al.   BIOPOLYMERS

Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic

(2016) Jennifer R. Pace et al.   JOURNAL OF MEDICINAL CHEMISTRY

Global, regional, and national incidence, prevalence, and years lived with disability for 310 diseases and injuries, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015

(2016) Theo Vos et al.   LANCET

The ChEMBL database in 2017

(2016) Anna Gaulton et al.   NUCLEIC ACIDS RESEARCH

25 Years of the Onchocerca ochengi Model

(2016) Benjamin L. Makepeace et al.   TRENDS IN PARASITOLOGY

Literature information in PubChem: associations between PubChem records and scientific articles

(2016) Sunghwan Kim et al.   Journal of Cheminformatics

Neglected tropical diseases in Africa: a new paradigm

(2016) Adrian D. Hopkins   International Health

The genome of Onchocerca volvulus, agent of river blindness

(2016) James A. Cotton et al.   Nature Microbiology

Saccharin: A lead compound for structure-based drug design of carbonic anhydrase IX inhibitors

(2015) Brian P. Mahon et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Why Can dl-Sotalol Prolong the QT Interval In Vivo Despite Its Weak Inhibitory Effect on hERG K+ Channels In Vitro? Electrophysiological and Pharmacokinetic Analysis with the Halothane-Anesthetized Guinea Pig Model

(2015) Jun Katagi et al.   Cardiovascular Toxicology

Doxycycline Leads to Sterility and Enhanced Killing of FemaleOnchocerca volvulusWorms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

(2015) Alexander Yaw Debrah et al.   CLINICAL INFECTIOUS DISEASES

HIF-1 at the crossroads of hypoxia, inflammation, and cancer

(2015) Kuppusamy Balamurugan   INTERNATIONAL JOURNAL OF CANCER

Twenty years of theMEROPSdatabase of proteolytic enzymes, their substrates and inhibitors

(2015) Neil D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data

(2015) Hugo C Turner et al.   Parasites & Vectors

Point-of-care quantification of blood-borne filarial parasites with a mobile phone microscope

(2015) Michael V. D’Ambrosio et al.   Science Translational Medicine

Control, Elimination, and Eradication of River Blindness: Scenarios, Timelines, and Ivermectin Treatment Needs in Africa

(2015) Young Eun Kim et al.   PLoS Neglected Tropical Diseases

Repurposing Auranofin as a Lead Candidate for Treatment of Lymphatic Filariasis and Onchocerciasis

(2015) Christina A. Bulman et al.   PLoS Neglected Tropical Diseases

The role of lipoxygenases in pathophysiology; new insights and future perspectives

(2015) Ryuichi Mashima et al.   Redox Biology

Clotrimazole as a Potent Agent for Treating the Oomycete Fish Pathogen Saprolegnia parasitica through Inhibition of Sterol 14α-Demethylase (CYP51)

(2014) Andrew G. S. Warrilow et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Reaching the London Declaration on Neglected Tropical Diseases Goals for Onchocerciasis: An Economic Evaluation of Increasing the Frequency of Ivermectin Treatment in Africa

(2014) Hugo C. Turner et al.   CLINICAL INFECTIOUS DISEASES

Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models

(2014) Meenakshi Verma et al.   FOLIA PARASITOLOGICA

Adenosine Receptors: Expression, Function and Regulation

(2014) Sandeep Sheth et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antiretroviral Treatment of Adult HIV Infection

(2014) Huldrych F. Günthard et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Multidimensional complexities of filariasis control in an era of large-scale mass drug administration programmes: a can of worms

(2014) David H Molyneux et al.   Parasites & Vectors

Innovative tools for assessing risks for severe adverse events in areas of overlapping Loa loa and other filarial distributions: the application of micro-stratification mapping

(2014) Louise A Kelly-Hope et al.   Parasites & Vectors

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

(2014) Kwablah Awadzi et al.   PLoS Neglected Tropical Diseases

Sertaconazole: an antifungal agent for the topical treatment of superficial candidiasis

(2013) Alfonso Javier Carrillo-Muñoz et al.   Expert Review of Anti-Infective Therapy

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Uncertainty Surrounding Projections of the Long-Term Impact of Ivermectin Treatment on Human Onchocerciasis

(2013) Hugo C. Turner et al.   PLoS Neglected Tropical Diseases

Azole Affinity of Sterol 14α-Demethylase (CYP51) Enzymes from Candida albicans and Homo sapiens

(2012) Andrew G. Warrilow et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Quantifying the chemical beauty of drugs

(2012) G. Richard Bickerton et al.   Nature Chemistry

Molecular characterization of 45kDa aspartic protease of Trichinella spiralis

(2012) Jong Nam Park et al.   VETERINARY PARASITOLOGY

Quinoline: A versatile heterocyclic

(2012) Akranth Marella et al.   SAUDI PHARMACEUTICAL JOURNAL

A Research Agenda for Helminth Diseases of Humans: Intervention for Control and Elimination

(2012) Roger K. Prichard et al.   PLoS Neglected Tropical Diseases

A Research Agenda for Helminth Diseases of Humans: Towards Control and Elimination

(2012) Boakye A. Boatin et al.   PLoS Neglected Tropical Diseases

A Research Agenda for Helminth Diseases of Humans: The Problem of Helminthiases

(2012) Sara Lustigman et al.   PLoS Neglected Tropical Diseases

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

(2012) Chris Marcellino et al.   PLoS Neglected Tropical Diseases

Proof-of-Principle of Onchocerciasis Elimination with Ivermectin Treatment in Endemic Foci in Africa: Final Results of a Study in Mali and Senegal

(2012) Mamadou O. Traore et al.   PLoS Neglected Tropical Diseases

Filariasis in Africa—treatment challenges and prospects

(2011) A. Hoerauf et al.   CLINICAL MICROBIOLOGY AND INFECTION

Inhibition of sensory neuronal TRPs contributes to anti-nociception by butamben

(2011) Sangsu Bang et al.   NEUROSCIENCE LETTERS

Structure-based discovery of prescription drugs that interact with the norepinephrine transporter, NET

(2011) A. Schlessinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

(2011) Mike Y. Osei-Atweneboana et al.   PLoS Neglected Tropical Diseases

Tafenoquine, an Antiplasmodial 8-Aminoquinoline, Targets Leishmania Respiratory Complex III and Induces Apoptosis

(2010) L. Carvalho et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

Emerging principles in protease-based drug discovery

(2010) Marcin Drag et al.   NATURE REVIEWS DRUG DISCOVERY

New Algorithms and Methods to Estimate Maximum-Likelihood Phylogenies: Assessing the Performance of PhyML 3.0

(2010) Stéphane Guindon et al.   SYSTEMATIC BIOLOGY

The Economic Benefits Resulting from the First 8 Years of the Global Programme to Eliminate Lymphatic Filariasis (2000–2007)

(2010) Brian K. Chu et al.   PLoS Neglected Tropical Diseases

Jalview Version 2--a multiple sequence alignment editor and analysis workbench

(2009) A. M. Waterhouse et al.   BIOINFORMATICS

Feasibility of Onchocerciasis Elimination with Ivermectin Treatment in Endemic Foci in Africa: First Evidence from Studies in Mali and Senegal

(2009) Lamine Diawara et al.   PLoS Neglected Tropical Diseases

Design of Potent Aspartic Protease Inhibitors to Treat Various Diseases

(2008) Jeffrey-Tri Nguyen et al.   ARCHIV DER PHARMAZIE

ChemmineR: a compound mining framework for R

(2008) Y. Cao et al.   BIOINFORMATICS

Cathepsin D—Many functions of one aspartic protease

(2008) Petr Benes et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

The Global Programme to Eliminate Lymphatic Filariasis: Health Impact after 8 Years

(2008) Eric A. Ottesen et al.   PLoS Neglected Tropical Diseases