Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta

(2017) Young-Jun Choi et al.   PLoS Genetics

Does Increasing Treatment Frequency Address Suboptimal Responses to Ivermectin for the Control and Elimination of River Blindness?

(2016) Kwadwo K. Frempong et al.   CLINICAL INFECTIOUS DISEASES

Discrimination between Onchocerca volvulus and O. ochengi filarial larvae in Simulium damnosum (s.l.) and their distribution throughout central Ghana using a versatile high-resolution speciation assay

(2016) Stephen R. Doyle et al.   Parasites & Vectors

Modelling Neglected Tropical Diseases diagnostics: the sensitivity of skin snips for Onchocerca volvulus in near elimination and surveillance settings

(2016) Christian Bottomley et al.   Parasites & Vectors

Evidence of suppression of onchocerciasis transmission in the Venezuelan Amazonian focus

(2016) Carlos Botto et al.   Parasites & Vectors

Still mesoendemic onchocerciasis in two Cameroonian community-directed treatment with ivermectin projects despite more than 15 years of mass treatment

(2016) Guy-Roger Kamga et al.   Parasites & Vectors

Curiouser and Curiouser: The Macrocyclic Lactone, Abamectin, Is also a Potent Inhibitor of Pyrantel/Tribendimidine Nicotinic Acetylcholine Receptors of Gastro-Intestinal Worms

(2016) Melanie Abongwa et al.   PLoS One

Stage-Specific Transcriptome and Proteome Analyses of the Filarial Parasite Onchocerca volvulus and Its Wolbachia Endosymbiont

(2016) Sasisekhar Bennuru et al.   mBio

Ongoing Transmission of Onchocerca volvulus after 25 Years of Annual Ivermectin Mass Treatments in the Vina du Nord River Valley, in North Cameroon

(2016) Albert Eisenbarth et al.   PLoS Neglected Tropical Diseases

Research for new drugs for elimination of onchocerciasis in Africa

(2016) Annette C. Kuesel   International Journal for Parasitology-Drugs and Drug Resistance

Progress towards onchocerciasis elimination in the participating countries of the African Programme for Onchocerciasis Control: epidemiological evaluation results

(2016) Afework H. Tekle et al.   Infectious Diseases of Poverty

The genome of Onchocerca volvulus, agent of river blindness

(2016) James A. Cotton et al.   Nature Microbiology

Genomic diversity in Onchocerca volvulus and its Wolbachia endosymbiont

(2016) Young-Jun Choi et al.   Nature Microbiology

One Hundred Years After Its Discovery in Guatemala by Rodolfo Robles, Onchocerca volvulus Transmission Has Been Eliminated from the Central Endemic Zone

(2015) Frank Richards et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Pooled Sequencing and Rare Variant Association Tests for Identifying the Determinants of Emerging Drug Resistance in Malaria Parasites

(2015) Ian H. Cheeseman et al.   MOLECULAR BIOLOGY AND EVOLUTION

Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: a comparative modelling analysis

(2015) Wilma A. Stolk et al.   Parasites & Vectors

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data

(2015) Hugo C Turner et al.   Parasites & Vectors

Macrocyclic lactone resistance in Dirofilaria immitis: Failure of heartworm preventives and investigation of genetic markers for resistance

(2015) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

Onchocerciasis Transmission in Ghana: Persistence under Different Control Strategies and the Role of the Simuliid Vectors

(2015) Poppy H. L. Lamberton et al.   PLoS Neglected Tropical Diseases

Expression of five acetylcholine receptor subunit genes in Brugia malayi adult worms

(2015) Ben-Wen Li et al.   International Journal for Parasitology-Drugs and Drug Resistance

Reaching the London Declaration on Neglected Tropical Diseases Goals for Onchocerciasis: An Economic Evaluation of Increasing the Frequency of Ivermectin Treatment in Africa

(2014) Hugo C. Turner et al.   CLINICAL INFECTIOUS DISEASES

Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

(2014) Martin Walker et al.   CLINICAL INFECTIOUS DISEASES

Population-Genetic Inference from Pooled-Sequencing Data

(2014) Michael Lynch et al.   Genome Biology and Evolution

Sequencing pools of individuals — mining genome-wide polymorphism data without big funding

(2014) Christian Schlötterer et al.   NATURE REVIEWS GENETICS

Caenorhabditis elegans Neuromuscular Junction: GABA Receptors and Ivermectin Action

(2014) Guillermina Hernando et al.   PLoS One

Elimination of African Onchocerciasis: Modeling the Impact of Increasing the Frequency of Ivermectin Mass Treatment

(2014) Luc E. Coffeng et al.   PLoS One

Interruption of Infection Transmission in the Onchocerciasis Focus of Ecuador Leading to the Cessation of Ivermectin Distribution

(2014) Raquel Lovato et al.   PLoS Neglected Tropical Diseases

Reproductive Status of Onchocerca volvulus after Ivermectin Treatment in an Ivermectin-Naïve and a Frequently Treated Population from Cameroon

(2014) Hugues C. Nana-Djeunga et al.   PLoS Neglected Tropical Diseases

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

(2014) Kwablah Awadzi et al.   PLoS Neglected Tropical Diseases

Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions

(2014) Andrew C. Kotze et al.   International Journal for Parasitology-Drugs and Drug Resistance

The disappearance of onchocerciasis from the Itwara focus, western Uganda after elimination of the vector Simulium neavei and 19 years of annual ivermectin treatments

(2013) T.L. Lakwo et al.   ACTA TROPICA

Interruption of Onchocerca volvulus Transmission in the Abu Hamed Focus, Sudan

(2013) Tarig B. Higazi et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Next-generation sequencing for molecular ecology: a caveat regarding pooled samples

(2013) Eric C. Anderson et al.   MOLECULAR ECOLOGY

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

Interruption of Onchocerca volvulus transmission in Northern Venezuela

(2013) Jacinto Convit et al.   Parasites & Vectors

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

(2013) MARK J. TAYLOR et al.   PARASITOLOGY

Validation of SNP Allele Frequencies Determined by Pooled Next-Generation Sequencing in Natural Populations of a Non-Model Plant Species

(2013) Christian Rellstab et al.   PLoS One

Malaria life cycle intensifies both natural selection and random genetic drift

(2013) H.-H. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites

(2013) C. L. L. Valentim et al.   SCIENCE

Dynamics of Onchocerca volvulus Microfilarial Densities after Ivermectin Treatment in an Ivermectin-naïve and a Multiply Treated Population from Cameroon

(2013) Sébastien D. S. Pion et al.   PLoS Neglected Tropical Diseases

Uncertainty Surrounding Projections of the Long-Term Impact of Ivermectin Treatment on Human Onchocerciasis

(2013) Hugo C. Turner et al.   PLoS Neglected Tropical Diseases

Interruption of Transmission of Onchocerca volvulus in the Southern Chiapas Focus, México

(2013) Mario A. Rodríguez-Pérez et al.   PLoS Neglected Tropical Diseases

Impact of long-term treatment of onchocerciasis with ivermectin in Kaduna State, Nigeria: first evidence of the potential for elimination in the operational area of the African Programme for Onchocerciasis Control

(2012) Afework Tekle et al.   Parasites & Vectors

The Transcriptional Response of Caenorhabditis elegans to Ivermectin Exposure Identifies Novel Genes Involved in the Response to Reduced Food Intake

(2012) Steven T. Laing et al.   PLoS One

Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite

(2012) D. J. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Proof-of-Principle of Onchocerciasis Elimination with Ivermectin Treatment in Endemic Foci in Africa: Final Results of a Study in Mali and Senegal

(2012) Mamadou O. Traore et al.   PLoS Neglected Tropical Diseases

Genotypic analysis of β-tubulin in Onchocerca volvulus from communities and individuals showing poor parasitological response to ivermectin treatment

(2012) Mike Y. Osei-Atweneboana et al.   International Journal for Parasitology-Drugs and Drug Resistance

Seventeen Years of Annual Distribution of Ivermectin Has Not Interrupted Onchocerciasis Transmission in North Region, Cameroon

(2011) Moses N. Katabarwa et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

PoPoolation2: identifying differentiation between populations using sequencing of pooled DNA samples (Pool-Seq)

(2011) R. Kofler et al.   BIOINFORMATICS

Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance

(2011) T. Downing et al.   GENOME RESEARCH

A framework for variation discovery and genotyping using next-generation DNA sequencing data

(2011) Mark A DePristo et al.   NATURE GENETICS

PoPoolation: A Toolbox for Population Genetic Analysis of Next Generation Sequencing Data from Pooled Individuals

(2011) Robert Kofler et al.   PLoS One

Correlation between loss of efficacy of macrocyclic lactone heartworm anthelmintics and P-glycoprotein genotype

(2011) Catherine Bourguinat et al.   VETERINARY PARASITOLOGY

Phenotypic Evidence of Emerging Ivermectin Resistance in Onchocerca volvulus

(2011) Mike Y. Osei-Atweneboana et al.   PLoS Neglected Tropical Diseases

Individual host factors associated with Onchocerca volvulus microfilarial densities 15, 80 and 180 days after a first dose of ivermectin

(2010) Sébastien D.S. Pion et al.   ACTA TROPICA

Interruption of Transmission of Onchocerca volvulus in the Oaxaca Focus, Mexico

(2010) Mario A. Rodríguez-Pérez et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

A statistical method for the detection of variants from next-generation resequencing of DNA pools

(2010) V. Bansal   BIOINFORMATICS

Design of association studies with pooled or un-pooled next-generation sequencing data

(2010) Su Yeon Kim et al.   GENETIC EPIDEMIOLOGY

The Next Generation of Molecular Markers From Massively Parallel Sequencing of Pooled DNA Samples

(2010) Andreas Futschik et al.   GENETICS

The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

(2010) A. McKenna et al.   GENOME RESEARCH

Identifying sub-optimal responses to ivermectin in the treatment of River Blindness

(2009) T. S. Churcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Successful Interruption of Transmission of Onchocerca volvulus in the Escuintla-Guatemala Focus, Guatemala

(2009) Rodrigo J. Gonzalez et al.   PLoS Neglected Tropical Diseases

adegenet: a R package for the multivariate analysis of genetic markers

(2008) Thibaut Jombart   BIOINFORMATICS

Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis

(2008) María-Gloria Basáñez et al.   LANCET INFECTIOUS DISEASES

P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulus

(2008) Catherine Bourguinat et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

High-throughput sequencing provides insights into genome variation and evolution in Salmonella Typhi

(2008) Kathryn E Holt et al.   NATURE GENETICS

FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans

(2008) Niels Ringstad et al.   NATURE NEUROSCIENCE

Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments

(2008) CHRISTIAN BOTTOMLEY et al.   PARASITOLOGY

After a decade of annual dose mass ivermectin treatment in Cameroon and Uganda, onchocerciasis transmission continues

(2008) Moses Katabarwa et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH