- Home
- Publications
- Publication Search
- Publication Details
Title
New directions for protease inhibitors directed drug discovery
Authors
Keywords
-
Journal
BIOPOLYMERS
Volume 106, Issue 4, Pages 563-579
Publisher
Wiley
Online
2015-11-20
DOI
10.1002/bip.22780
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Lilly buys back into the BACE race for Alzheimer's disease
- (2014) Megan Cully NATURE REVIEWS DRUG DISCOVERY
- Treatment of HCV with ABT-450/r–Ombitasvir and Dasabuvir with Ribavirin
- (2014) Jordan J. Feld et al. NEW ENGLAND JOURNAL OF MEDICINE
- Structure–activity relationship study of BACE1 inhibitors possessing a chelidonic or 2,6-pyridinedicarboxylic scaffold at the P2 position
- (2013) Yoshio Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Advances in the identification of β-secretase inhibitors
- (2013) Yoshio Hamada et al. Expert Opinion on Drug Discovery
- Novel BACE1 inhibitors possessing a 5-nitroisophthalic scaffold at the P2 position
- (2012) Yoshio Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- The application of bioisosteres in drug design for novel drug discovery: focusing on acid protease inhibitors
- (2012) Yoshio Hamada et al. Expert Opinion on Drug Discovery
- Discovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides
- (2012) Heinrich Rueeger et al. JOURNAL OF MEDICINAL CHEMISTRY
- Preliminary Study of Two Antiviral Agents for Hepatitis C Genotype 1
- (2012) Anna S. Lok et al. NEW ENGLAND JOURNAL OF MEDICINE
- Discovery of MK-5172, a Macrocyclic Hepatitis C Virus NS3/4a Protease Inhibitor
- (2012) Steven Harper et al. ACS Medicinal Chemistry Letters
- Telaprevir: An oral protease inhibitor for hepatitis C virus infection
- (2011) J. J. Kim et al. AMERICAN JOURNAL OF HEALTH-SYSTEM PHARMACY
- Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor
- (2011) Noriyasu Kato et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Design and synthesis of several small-size HTLV-I protease inhibitors with different hydrophilicity profiles
- (2011) Jeffrey-Tri Nguyen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Structure based design, synthesis and SAR of cyclic hydroxyethylamine (HEA) BACE-1 inhibitors
- (2011) Heinrich Rueeger et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Tripeptidic BACE1 inhibitors devised by in-silico conformational structure-based design
- (2011) Yoshio Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Boceprevir for Untreated Chronic HCV Genotype 1 Infection
- (2011) Fred Poordad et al. NEW ENGLAND JOURNAL OF MEDICINE
- Telaprevir for Retreatment of HCV Infection
- (2011) Stefan Zeuzem et al. NEW ENGLAND JOURNAL OF MEDICINE
- Telaprevir for Previously Untreated Chronic Hepatitis C Virus Infection
- (2011) Ira M. Jacobson et al. NEW ENGLAND JOURNAL OF MEDICINE
- BACE1 Inhibitor Peptides: Can an Infinitely Small kcat Value Turn the Substrate of an Enzyme into Its Inhibitor?
- (2011) Yoshio Hamada et al. ACS Medicinal Chemistry Letters
- Rapid P1 SAR of brain penetrant tertiary carbinamine derived BACE inhibitors
- (2010) Hong Zhu et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Macrocyclic BACE inhibitors: Optimization of a micromolar hit to nanomolar leads
- (2010) Yifang Huang et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice
- (2010) Wan-Pin Chang et al. FASEB JOURNAL
- A Noncompetitive BACE1 Inhibitor TAK-070 Ameliorates A Pathology and Behavioral Deficits in a Mouse Model of Alzheimer's Disease
- (2010) H. Fukumoto et al. JOURNAL OF NEUROSCIENCE
- Telaprevir for Previously Treated Chronic HCV Infection
- (2010) John G. McHutchison et al. NEW ENGLAND JOURNAL OF MEDICINE
- In Vitro Activity and Preclinical Profile of TMC435350, a Potent Hepatitis C Virus Protease Inhibitor
- (2009) T.-I Lin et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- MK-7009, a Potent and Selective Inhibitor of Hepatitis C Virus NS3/4A Protease
- (2009) N. J. Liverton et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Significance of interactions of BACE1–Arg235 with its ligands and design of BACE1 inhibitors with P2 pyridine scaffold
- (2009) Yoshio Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Recent progress in the drug discovery of non-peptidic BACE1 inhibitors
- (2009) Yoshio Hamada et al. Expert Opinion on Drug Discovery
- Structure of HIV-1 protease in complex with potent inhibitor KNI-272 determined by high-resolution X-ray and neutron crystallography
- (2009) M. Adachi et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)
- (2008) S. D. Seiwert et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- BACE1 inhibitors: Optimization by replacing the residue with non-acidic moiety
- (2008) Yoshio Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Novel non-peptidic and small-sized BACE1 inhibitors
- (2008) Yoshio Hamada et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Truncation and non-natural amino acid substitution studies on HTLV-I protease hexapeptidic inhibitors
- (2007) Jeffrey-Tri Nguyen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the substrate binding pocket
- (2007) Lee D. Jennings et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets
- (2007) Derek C. Cole et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation