Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro

In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis

(2020) Alexandra Ehrens et al.   PLoS Neglected Tropical Diseases

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

(2019) W. David Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical toxicity and pharmacokinetics of a new orally bioavailable flubendazole formulation and the impact for clinical trials and risk/benefit to patients

(2019) Sophie Lachau-Durand et al.   PLoS Neglected Tropical Diseases

Efficacy of subcutaneous doses and a new oral amorphous solid dispersion formulation of flubendazole on male jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi

(2019) Chelsea Fischer et al.   PLoS Neglected Tropical Diseases

Macrofilaricidal efficacy of single and repeated oral and subcutaneous doses of flubendazole in Litomosoides sigmodontis infected jirds

(2019) Marc P. Hübner et al.   PLoS Neglected Tropical Diseases

Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models

(2019) Hanna T. Sjoberg et al.   PLoS Neglected Tropical Diseases

Development of a preliminary in vitro drug screening assay based on a newly established culturing system for pre-adult fifth-stage Onchocerca volvulus worms

(2019) Denis Voronin et al.   PLoS Neglected Tropical Diseases

Mouse models of Loa loa

(2019) Nicolas P. Pionnier et al.   Nature Communications

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

(2019) Mark J. Taylor et al.   Science Translational Medicine

Boron-Pleuromutilins as Anti-Wolbachia Agents with Potential for Treatment of Onchocerciasis and Lymphatic Filariasis

(2019) Robert T. Jacobs et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections

(2019) Malina A. Bakowski et al.   Science Translational Medicine

Development and validation of an Onchocerca ochengi adult male worm gerbil model for macrofilaricidal drug screening

(2019) Fidelis Cho-Ngwa et al.   PLoS Neglected Tropical Diseases

In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae

(2019) Marc P. Hübner et al.   PLoS Neglected Tropical Diseases

Macrofilaricidal Benzimidazole–Benzoxaborole Hybrids as an Approach to the Treatment of River Blindness: Part 1. Amide Linked Analogs

(2019) Tsutomu Akama et al.   ACS Infectious Diseases

Short-course quinazoline drug treatments are effective in the Litomosoides sigmodontis and Brugia pahangi jird models

(2019) Marc P. Hübner et al.   International Journal for Parasitology-Drugs and Drug Resistance

Evaluation of oxfendazole in the treatment of zoonotic Onchocerca lupi infection in dogs

(2018) Vito Colella et al.   PLoS Neglected Tropical Diseases

Development of Onchocerca volvulus in humanized NSG mice and detection of parasite biomarkers in urine and serum

(2018) John B. Patton et al.   PLoS Neglected Tropical Diseases

Effectiveness of a triple-drug regimen for global elimination of lymphatic filariasis: a modelling study

(2017) Michael A Irvine et al.   LANCET INFECTIOUS DISEASES

Migratory phase of Litomosoides sigmodontis filarial infective larvae is associated with pathology and transient increase of S100A9 expressing neutrophils in the lung

(2017) Gregory Karadjian et al.   PLoS Neglected Tropical Diseases

An In Vitro/In Vivo Model to Analyze the Effects of Flubendazole Exposure on Adult Female Brugia malayi

(2016) Maeghan O’Neill et al.   PLoS Neglected Tropical Diseases

Efficacy, Safety, and Pharmacokinetics of Coadministered Diethylcarbamazine, Albendazole, and Ivermectin for Treatment of Bancroftian Filariasis

(2015) Edward K. Thomsen et al.   CLINICAL INFECTIOUS DISEASES

Preclinical Studies on the Pharmacokinetics, Safety, and Toxicology of Oxfendazole

(2015) Ellen E. Codd et al.   INTERNATIONAL JOURNAL OF TOXICOLOGY

The Contributions of Onchocerciasis Control and Elimination Programs toward the Achievement of the Millennium Development Goals

(2015) Caitlin Dunn et al.   PLoS Neglected Tropical Diseases

Repurposing Auranofin as a Lead Candidate for Treatment of Lymphatic Filariasis and Onchocerciasis

(2015) Christina A. Bulman et al.   PLoS Neglected Tropical Diseases

Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

(2014) Martin Walker et al.   CLINICAL INFECTIOUS DISEASES

A murine macrofilaricide pre-clinical screening model for onchocerciasis and lymphatic filariasis

(2014) Alice Halliday et al.   Parasites & Vectors

Vaccination with recombinant Brugia malayi cystatin proteins alters worm migration, homing and final niche selection following a subcutaneous challenge of Mongolian gerbils (Meriones unguiculatus) with B. malayi infective larvae

(2014) Sridhar Arumugam et al.   Parasites & Vectors

ST2 Deficiency Does Not Impair Type 2 Immune Responses during Chronic Filarial Infection but Leads to an Increased Microfilaremia Due to an Impaired Splenic Microfilarial Clearance

(2014) Jesuthas Ajendra et al.   PLoS One

In vivo preliminary investigations of the effects of the benzimidazole anthelmintic drug flubendazole on rat embryos and fetuses

(2014) Monica Longo et al.   REPRODUCTIVE TOXICOLOGY

Animal versus human oral drug bioavailability: Do they correlate?

(2013) Helen Musther et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Fitness Cost ofLitomosoides sigmodontisFilarial Infection in Mite Vectors; Implications of Infected Haematophagous Arthropod Excretory Products in Host-Vector Interactions

(2013) Adélaïde Nieguitsila et al.   Biomed Research International

Efficacy of Diverse Antiparasitic Treatments for Cysticercosis in the Pig Model

(2012) Armando E. Gonzalez et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Loiasis: New Epidemiologic Insights and Proposed Treatment Strategy

(2012) Michel Boussinesq   JOURNAL OF TRAVEL MEDICINE

Immunization with L. sigmodontis Microfilariae Reduces Peripheral Microfilaraemia after Challenge Infection by Inhibition of Filarial Embryogenesis

(2012) Sebastian Ziewer et al.   PLoS Neglected Tropical Diseases

Filariasis in Africa—treatment challenges and prospects

(2011) A. Hoerauf et al.   CLINICAL MICROBIOLOGY AND INFECTION

Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and Treatment

(2011) F. Tamarozzi et al.   CLINICAL MICROBIOLOGY REVIEWS

Progress and challenges in the discovery of macrofilaricidal drugs

(2011) Timothy G Geary et al.   Expert Review of Anti-Infective Therapy

Flubendazole: a candidate macrofilaricide for lymphatic filariasis and onchocerciasis field programs

(2011) Charles D Mackenzie et al.   Expert Review of Anti-Infective Therapy

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

The Operational Multiple Dosing Half-life: A Key to Defining Drug Accumulation in Patients and to Designing Extended Release Dosage Forms

(2008) Selma Sahin et al.   PHARMACEUTICAL RESEARCH