Moxidectin: an oral treatment for human onchocerciasis

Individuals living in an onchocerciasis focus and treated three-monthly with ivermectin develop fewer new onchocercal nodules than individuals treated annually

(2020) Jérémy T. Campillo et al.   Parasites & Vectors

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis

(2019) W. David Hong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical development of an oral anti-Wolbachia macrolide drug for the treatment of lymphatic filariasis and onchocerciasis

(2019) Mark J. Taylor et al.   Science Translational Medicine

Population genomic and evolutionary modelling analyses reveal a single major QTL for ivermectin drug resistance in the pathogenic nematode, Haemonchus contortus

(2019) Stephen R. Doyle et al.   BMC GENOMICS

Refugia and anthelmintic resistance: Concepts and challenges

(2019) Jane E. Hodgkinson et al.   International Journal for Parasitology-Drugs and Drug Resistance

Perspectives on the utility of moxidectin for the control of parasitic nematodes in the face of developing anthelmintic resistance

(2019) Roger K. Prichard et al.   International Journal for Parasitology-Drugs and Drug Resistance

Implementation of test-and-treat with doxycycline and temephos ground larviciding as alternative strategies for accelerating onchocerciasis elimination in an area of loiasis co-endemicity: the COUNTDOWN consortium multi-disciplinary study protocol

(2019) Samuel Wanji et al.   Parasites & Vectors

Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial

(2018) Nicholas O Opoku et al.   LANCET

Audit of the community-directed treatment with ivermectin (CDTI) for onchocerciasis and factors associated with adherence in three regions of Cameroon

(2018) Guy-Roger Kamga et al.   Parasites & Vectors

Alternative treatment strategies to accelerate the elimination of onchocerciasis

(2018) Michel Boussinesq et al.   International Health

Transitioning from river blindness control to elimination: steps toward stopping treatment

(2018) Paul T Cantey et al.   International Health

Progress toward elimination of onchocerciasis in the Americas

(2018) Mauricio Sauerbrey et al.   International Health

Onchocerca volvulus infection and serological prevalence, ocular onchocerciasis and parasite transmission in northern and central Togo after decades of Simulium damnosum s.l. vector control and mass drug administration of ivermectin

(2018) Kossi Komlan et al.   PLoS Neglected Tropical Diseases

From river blindness control to elimination: bridge over troubled water

(2018) Robert Colebunders et al.   Infectious Diseases of Poverty

Is onchocerciasis elimination in Africa feasible by 2025: a perspective based on lessons learnt from the African control programmes

(2018) Yankum Dadzie et al.   Infectious Diseases of Poverty

Evaluation of the Cardiac Safety of Long-Acting Endectocide Moxidectin in a Randomized Concentration-QT Study

(2018) Sally A. Kinrade et al.   CTS-Clinical and Translational Science

First assessment of the comparative toxicity of ivermectin and moxidectin in adult dung beetles: Sub-lethal symptoms and pre-lethal consequences

(2018) José R. Verdú et al.   Scientific Reports

Community-directed vector control to supplement mass drug distribution for onchocerciasis elimination in the Madi mid-North focus of Northern Uganda

(2018) Benjamin G. Jacob et al.   PLoS Neglected Tropical Diseases

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Assessment of P-glycoprotein gene expression in adult stage of Haemonchus contortus in vivo exposed to ivermectin

(2018) L. Maté et al.   VETERINARY PARASITOLOGY

The end of a dogma: the safety of doxycycline use in young children for malaria treatment

(2017) Tiphaine Gaillard et al.   MALARIA JOURNAL

A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa–Endemic Areas

(2017) Joseph Kamgno et al.   NEW ENGLAND JOURNAL OF MEDICINE

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachiacurative treatments in preclinical models of filariasis

(2017) Joseph D. Turner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Programmatic factors associated with the limited impact of Community-Directed Treatment with Ivermectin to control Onchocerciasis in three drainage basins of South West Cameroon

(2017) Christian Tetteh Duamor et al.   PLoS Neglected Tropical Diseases

Comparison of Doxycycline, Minocycline, Doxycycline plus Albendazole and Albendazole Alone in Their Efficacy against Onchocerciasis in a Randomized, Open-Label, Pilot Trial

(2017) Ute Klarmann-Schulz et al.   PLoS Neglected Tropical Diseases

Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

(2017) Stephen R. Doyle et al.   PLoS Neglected Tropical Diseases

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis

(2017) Ghaith Aljayyoussi et al.   Scientific Reports

Does Increasing Treatment Frequency Address Suboptimal Responses to Ivermectin for the Control and Elimination of River Blindness?

(2016) Kwadwo K. Frempong et al.   CLINICAL INFECTIOUS DISEASES

How do the macrocyclic lactones kill filarial nematode larvae?

(2016) Adrian J. Wolstenholme et al.   INVERTEBRATE NEUROSCIENCE

Ongoing Transmission of Onchocerca volvulus after 25 Years of Annual Ivermectin Mass Treatments in the Vina du Nord River Valley, in North Cameroon

(2016) Albert Eisenbarth et al.   PLoS Neglected Tropical Diseases

Research for new drugs for elimination of onchocerciasis in Africa

(2016) Annette C. Kuesel   International Journal for Parasitology-Drugs and Drug Resistance

Doxycycline Leads to Sterility and Enhanced Killing of FemaleOnchocerca volvulusWorms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial

(2015) Alexander Yaw Debrah et al.   CLINICAL INFECTIOUS DISEASES

Haemonchus contortus P-glycoprotein-2: in situ localisation and characterisation of macrocyclic lactone transport

(2015) Pablo Godoy et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

Required duration of mass ivermectin treatment for onchocerciasis elimination in Africa: a comparative modelling analysis

(2015) Wilma A. Stolk et al.   Parasites & Vectors

The potential impact of moxidectin on onchocerciasis elimination in Africa: an economic evaluation based on the Phase II clinical trial data

(2015) Hugo C Turner et al.   Parasites & Vectors

Relationship between oral declaration on adherence to ivermectin treatment and parasitological indicators of onchocerciasis in an area of persistent transmission despite a decade of mass drug administration in Cameroon

(2015) Samuel Wanji et al.   Parasites & Vectors

Managing the Fight against Onchocerciasis in Africa: APOC Experience

(2015) Grace Fobi et al.   PLoS Neglected Tropical Diseases

Transgenically expressed Parascaris P-glycoprotein-11 can modulate ivermectin susceptibility in Caenorhabditis elegans

(2015) I. Jana I. Janssen et al.   International Journal for Parasitology-Drugs and Drug Resistance

Hypo-endemic onchocerciasis hotspots: defining areas of high risk through micro-mapping and environmental delineation

(2015) Louise A. Kelly-Hope et al.   Infectious Diseases of Poverty

Therapeutic Efficacy and Macrofilaricidal Activity of Doxycycline for the Treatment of River Blindness

(2014) Martin Walker et al.   CLINICAL INFECTIOUS DISEASES

Moxidectin causes adult worm mortality of human lymphatic filarial parasite Brugia malayi in rodent models

(2014) Meenakshi Verma et al.   FOLIA PARASITOLOGICA

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

(2014) Kwablah Awadzi et al.   PLoS Neglected Tropical Diseases

High level expression of a glutamate-gated chloride channel gene in reproductive tissues of Brugia malayi may explain the sterilizing effect of ivermectin on filarial worms

(2014) Ben Wen Li et al.   International Journal for Parasitology-Drugs and Drug Resistance

Utilization of computer processed high definition video imaging for measuring motility of microscopic nematode stages on a quantitative scale: “The Worminator”

(2014) Bob Storey et al.   International Journal for Parasitology-Drugs and Drug Resistance

Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis

(2013) MARK J. TAYLOR et al.   PARASITOLOGY

Genetic Variants and Increased Expression of Parascaris equorum P-glycoprotein-11 in Populations with Decreased Ivermectin Susceptibility

(2013) I. Jana I. Janssen et al.   PLoS One

Dynamics of Onchocerca volvulus Microfilarial Densities after Ivermectin Treatment in an Ivermectin-naïve and a Multiply Treated Population from Cameroon

(2013) Sébastien D. S. Pion et al.   PLoS Neglected Tropical Diseases

Uncertainty Surrounding Projections of the Long-Term Impact of Ivermectin Treatment on Human Onchocerciasis

(2013) Hugo C. Turner et al.   PLoS Neglected Tropical Diseases

The Effect of a High-Fat Breakfast on the Pharmacokinetics of Moxidectin in Healthy Male Subjects: A Randomized Phase I Trial

(2012) Joan M. Korth-Bradley et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Treatment of MDR1 Mutant Dogs with Macrocyclic Lactones

(2012) Joachim Geyer et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Measurement of ivermectin concentrations in target worms and host gastrointestinal tissues: Influence of the route of administration on the activity against resistant Haemonchus contortus in lambs

(2012) M. Lloberas et al.   EXPERIMENTAL PARASITOLOGY

Moxidectin has a lower neurotoxic potential but comparable brain penetration in P-glycoprotein-deficient CF-1 mice compared to ivermectin

(2012) C. JANKO et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Retarded Onchocerca volvulus L1 to L3 larval development in the Simulium damnosum vector after anti-wolbachial treatment of the human host

(2012) Anna Albers et al.   Parasites & Vectors

Long term impact of large scale community-directed delivery of doxycycline for the treatment of onchocerciasis

(2012) Francesca Tamarozzi et al.   Parasites & Vectors

Inhibition of P-glycoprotein enhances sensitivity of Caenorhabditis elegans to ivermectin

(2012) Bernadette F. Ardelli et al.   VETERINARY PARASITOLOGY

Moxidectin and the avermectins: Consanguinity but not identity

(2012) Roger Prichard et al.   International Journal for Parasitology-Drugs and Drug Resistance

Relative Bioavailability of Liquid and Tablet Formulations of the Antiparasitic Moxidectin

(2012) J. M. Korth-Bradley et al.   Clinical Pharmacology in Drug Development

Doxycycline for Malaria Chemoprophylaxis and Treatment: Report from the CDC Expert Meeting on Malaria Chemoprophylaxis

(2011) Kathrine R. Tan et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Excretion of Moxidectin into Breast Milk and Pharmacokinetics in Healthy Lactating Women

(2011) Joan M. Korth-Bradley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Onchocerciasis: the Role of Wolbachia Bacterial Endosymbionts in Parasite Biology, Disease Pathogenesis, and Treatment

(2011) F. Tamarozzi et al.   CLINICAL MICROBIOLOGY REVIEWS

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Compliance with eight years of annual ivermectin treatment of onchocerciasis in Cameroon and Nigeria

(2011) William R Brieger et al.   Parasites & Vectors

P-glycoproteins and other multidrug resistance transporters in the pharmacology of anthelmintics: Prospects for reversing transport-dependent anthelmintic resistance

(2011) Anne Lespine et al.   International Journal for Parasitology-Drugs and Drug Resistance

Role of P-Glycoprotein in the Disposition of Macrocyclic Lactones: A Comparison between Ivermectin, Eprinomectin, and Moxidectin in Mice

(2010) S. Kiki-Mvouaka et al.   DRUG METABOLISM AND DISPOSITION

Ivermectin disrupts the function of the excretory-secretory apparatus in microfilariae of Brugia malayi

(2010) Y. Moreno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Does onchocerciasis transmission take place in hypoendemic areas? a study from the North Region of Cameroon

(2010) Moses N. Katabarwa et al.   TROPICAL MEDICINE & INTERNATIONAL HEALTH

Macrofilaricidal Activity after Doxycycline Only Treatment of Onchocerca volvulus in an Area of Loa loa Co-Endemicity: A Randomized Controlled Trial

(2010) Joseph D. Turner et al.   PLoS Neglected Tropical Diseases

In vitro and in vivo interaction of moxidectin with BCRP/ABCG2

(2009) Miriam Perez et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Community-directed delivery of doxycycline for the treatment of onchocerciasis in areas of co-endemicity with loiasis in Cameroon

(2009) Samuel Wanji et al.   Parasites & Vectors

Identifying sub-optimal responses to ivermectin in the treatment of River Blindness

(2009) T. S. Churcher et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Pharmacokinetics and Interactions of Ivermectin in Humans—A Mini-review

(2008) Aránzazu González Canga et al.   AAPS Journal

Effect of single-dose ivermectin on Onchocerca volvulus: a systematic review and meta-analysis

(2008) María-Gloria Basáñez et al.   LANCET INFECTIOUS DISEASES

Rates of microfilarial production by Onchocerca volvulus are not cumulatively reduced by multiple ivermectin treatments

(2008) CHRISTIAN BOTTOMLEY et al.   PARASITOLOGY