Repurposing Auranofin as a Lead Candidate for Treatment of Lymphatic Filariasis and Onchocerciasis

A Randomized, Single-Ascending-Dose, Ivermectin-Controlled, Double-Blind Study of Moxidectin in Onchocerca volvulus Infection

(2014) Kwablah Awadzi et al.   PLoS Neglected Tropical Diseases

Auranofin Is Highly Efficacious against Toxoplasma gondii In Vitro and in an In Vivo Experimental Model of Acute Toxoplasmosis

(2014) Rosa M. Andrade et al.   PLoS Neglected Tropical Diseases

Auranofin Is an Apoptosis-Simulating Agent with in Vitro and in Vivo Anti-leishmanial Activity

(2013) Elizabeth R. Sharlow et al.   ACS Chemical Biology

A Reprofiled Drug, Auranofin, Is Effective against Metronidazole-Resistant Giardia lamblia

(2013) Noa Tejman-Yarden et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target

(2012) Anjan Debnath et al.   NATURE MEDICINE

Thioredoxin Glutathione Reductase as a Novel Drug Target: Evidence from Schistosoma japonicum

(2012) LiJun Song et al.   PLoS One

WormAssay: A Novel Computer Application for Whole-Plate Motion-based Screening of Macroscopic Parasites

(2012) Chris Marcellino et al.   PLoS Neglected Tropical Diseases

The biological activity of auranofin: implications for novel treatment of diseases

(2012) J. M. Madeira et al.   INFLAMMOPHARMACOLOGY

Investigation of a potential mechanism for the inhibition of SmTGR by Auranofin and its implications for Plasmodium falciparum inhibition

(2011) Antonia Caroli et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Investigations of the Catalytic Mechanism of Thioredoxin Glutathione Reductase fromSchistosoma mansoni

(2011) Hsin-Hung Huang et al.   BIOCHEMISTRY

Filariasis in Africa—treatment challenges and prospects

(2011) A. Hoerauf et al.   CLINICAL MICROBIOLOGY AND INFECTION

Bioinorganic and medicinal chemistry: aspects of gold(i)-protein complexes

(2011) Krishna P. Bhabak et al.   DALTON TRANSACTIONS

Selective activity of extracts of Margaritaria discoidea and Homalium africanum on Onchocerca ochengi

(2010) Fidelis Cho-Ngwa et al.   BMC Complementary and Alternative Medicine

Lymphatic filariasis and onchocerciasis

(2010) Mark J Taylor et al.   LANCET

In vitro killing action of auranofin on Taenia crassiceps metacestode (cysticerci) and inactivation of thioredoxin–glutathione reductase (TGR)

(2010) José J. Martínez-González et al.   PARASITOLOGY RESEARCH

Inhibition ofSchistosoma mansoniThioredoxin-glutathione Reductase by Auranofin

(2009) Francesco Angelucci et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

New uses for old drugs. Auranofin, a clinically established antiarthritic metallodrug, exhibits potent antimalarial effects in vitro : Mechanistic and pharmacological implications

(2008) Anna Rosa Sannella et al.   FEBS LETTERS

Platyhelminth Mitochondrial and Cytosolic Redox Homeostasis Is Controlled by a Single Thioredoxin Glutathione Reductase and Dependent on Selenium and Glutathione

(2008) Mariana Bonilla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY