Autophagy in the Regulation of Tissue Differentiation and Homeostasis

Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

(2020) Jessica Segalés et al.   Nature Communications

The Emerging Roles of Endoplasmic Reticulum Stress in Balancing Immunity and Tolerance in Health and Diseases: Mechanisms and Opportunities

(2020) Anqi Li et al.   Frontiers in Immunology

Autophagy in endothelial cells regulates their haematopoiesis-supporting ability

(2020) Zhong-Shi Lyu et al.   EBioMedicine

Autophagy and Stem Cells: Self-Eating for Self-Renewal

(2020) Natasha C. Chang   Frontiers in Cell and Developmental Biology

Autophagy lipidation machinery regulates axonal microtubule dynamics but is dispensable for survival of mammalian neurons

(2020) A. Negrete-Hurtado et al.   Nature Communications

Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis

(2020) Selma Maacha et al.   Stem Cells International

VEGF Triggers Transient Induction of Autophagy in Endothelial Cells via AMPKα1

(2020) Katrin Spengler et al.   Cells

Dual Role of Autophagy in Regulation of Mesenchymal Stem Cell Senescence

(2020) Raffaella Rastaldo et al.   Frontiers in Cell and Developmental Biology

Vascular autophagy in health and disease

(2020) William E. Hughes et al.   BASIC RESEARCH IN CARDIOLOGY

3-Methyladenine Alleviates Experimental Subretinal Fibrosis by Inhibiting Macrophages and M2 Polarization Through the PI3K/Akt Pathway

(2020) Qiyu Bo et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Autophagy in Neuronal Development and Plasticity

(2020) Angeleen Fleming et al.   TRENDS IN NEUROSCIENCES

MBNL1 reverses the proliferation defect of skeletal muscle satellite cells in myotonic dystrophy type 1 by inhibiting autophagy via the mTOR pathway

(2020) Kai-Yi Song et al.   Cell Death & Disease

Effects of acute and chronic strength training on skeletal muscle autophagy in frail elderly men and women

(2020) Sigve N. Aas et al.   EXPERIMENTAL GERONTOLOGY

Autophagy displays divergent roles during intermittent amino acid starvation and toxic stress‐induced senescence in cultured skeletal muscle cells

(2020) Darin Bloemberg et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Polyphenol Pterostilbene Ameliorates the Myopathic Phenotype of Collagen VI Deficient Mice via Autophagy Induction

(2020) Samuele Metti et al.   Frontiers in Cell and Developmental Biology

Defective lysosome reformation during autophagy causes skeletal muscle disease

(2020) Meagan J. McGrath et al.   JOURNAL OF CLINICAL INVESTIGATION

Autophagy Is Required for Memory Formation and Reverses Age-Related Memory Decline

(2019) Mélissa Glatigny et al.   CURRENT BIOLOGY

Human Dendritic Cells: Their Heterogeneity and Clinical Application Potential in Cancer Immunotherapy

(2019) Thiago A. Patente et al.   Frontiers in Immunology

Autophagy within the mushroom body protects from synapse aging in a non-cell autonomous manner

(2019) Anuradha Bhukel et al.   Nature Communications

Neuronal AMP-activated protein kinase hyper-activation induces synaptic loss by an autophagy-mediated process

(2019) Manon Domise et al.   Cell Death & Disease

Autophagy in endothelial cells and tumor angiogenesis

(2019) Marco B. Schaaf et al.   CELL DEATH AND DIFFERENTIATION

Normalizing Function of Tumor Vessels: Progress, Opportunities, and Challenges

(2019) John D. Martin et al.   Annual Review of Physiology

Autophagy in regulatory T cells: A double-edged sword in disease settings

(2019) Jing Zhang et al.   MOLECULAR IMMUNOLOGY

Autophagy induction in atrophic muscle cells requires ULK1 activation by TRIM32 through unanchored K63-linked polyubiquitin chains

(2019) M. Di Rienzo et al.   Science Advances

Endothelial-Specific Deficiency of ATG5 (Autophagy Protein 5) Attenuates Ischemia-Related Angiogenesis

(2019) David Sprott et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Autophagy: a potential key contributor to the therapeutic action of mesenchymal stem cells

(2019) Sabrina Ceccariglia et al.   Autophagy

Pathogenic WDFY3 variants cause neurodevelopmental disorders and opposing effects on brain size

(2019) Diana Le Duc et al.   BRAIN

ULK2 is essential for degradation of ubiquitinated protein aggregates and homeostasis in skeletal muscle

(2019) Jordan D. Fuqua et al.   FASEB JOURNAL

Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells

(2019) Jennifer Niven et al.   Cell Reports

Effect of aging on behaviour of mesenchymal stem cells

(2019) Juan Antonio Fafián-Labora et al.   World Journal of Stem Cells

mTORC2 activation protects retinal ganglion cells via Akt signaling after autophagy induction in traumatic optic nerve injury

(2019) Yao-Tseng Wen et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Human Cachexia Induces Changes in Mitochondria, Autophagy and Apoptosis in the Skeletal Muscle

(2019) Gabriela S. de Castro et al.   Cancers

Autophagy inhibition induces the repolarisation of tumour-associated macrophages and enhances chemosensitivity of laryngeal cancer cells to cisplatin in mice

(2019) Ying Guo et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Autophagy inhibits the mesenchymal stem cell aging induced by D‐galactose through ROS/JNK/p38 signalling

(2019) Dayong Zhang et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Endothelial PKA activity regulates angiogenesis by limiting autophagy through phosphorylation of ATG16L1

(2019) Xiaocheng Zhao et al.   eLife

Autophagy in T Cell Function and Aging

(2019) Fernando Macian   Frontiers in Cell and Developmental Biology

The Synaptic Autophagy Cycle

(2019) Ori J. Lieberman et al.   JOURNAL OF MOLECULAR BIOLOGY

Autophagy is induced by resistance exercise in young men, but unfolded protein response is induced regardless of age

(2018) J. Hentilä et al.   Acta Physiologica

Modulation of autophagy as new approach in mesenchymal stem cell-based therapy

(2018) Jelena Jakovljevic et al.   BIOMEDICINE & PHARMACOTHERAPY

Different Adaptive Responses to Hypoxia in Normal and Multiple Myeloma Endothelial Cells

(2018) Irene Filippi et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Neuronal autophagy and intercellular regulation of homeostasis in the brain

(2018) Aditi Kulkarni et al.   CURRENT OPINION IN NEUROBIOLOGY

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

(2018) Patricia Boya et al.   DEVELOPMENT

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis

(2018) Nina Zeng et al.   EXPERIMENTAL GERONTOLOGY

B1a B cells require autophagy for metabolic homeostasis and self-renewal

(2018) Alexander J. Clarke et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Autophagy and MHC-restricted antigen presentation

(2018) Jan Valečka et al.   MOLECULAR IMMUNOLOGY

M1-like macrophages change tumor blood vessels and microenvironment in murine melanoma

(2018) Magdalena Jarosz-Biej et al.   PLoS One

Concise Review: Cell Therapy for Critical Limb Ischemia: An Integrated Review of Preclinical and Clinical Studies

(2018) Mohammad Qadura et al.   STEM CELLS

Autophagy promotes MSC-mediated vascularization in cutaneous wound healing via regulation of VEGF secretion

(2018) Y. An et al.   Cell Death & Disease

Chloroquine modulates antitumor immune response by resetting tumor-associated macrophages toward M1 phenotype

(2018) Degao Chen et al.   Nature Communications

Attenuation of autophagy impacts on muscle fibre development, starvation induced stress and fibre regeneration following acute injury

(2018) Andrea Paolini et al.   Scientific Reports

Autophagy in Stem Cell Biology: A Perspective on Stem Cell Self-Renewal and Differentiation

(2018) Xihang Chen et al.   Stem Cells International

Regulation of Cytokine Production by the Unfolded Protein Response; Implications for Infection and Autoimmunity

(2018) Judith A. Smith   Frontiers in Immunology

CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3

(2018) Lucía Sanjurjo et al.   Frontiers in Immunology

The Role of Mitophagy in Innate Immunity

(2018) Ilias Gkikas et al.   Frontiers in Immunology

Autophagy controls neonatal myogenesis by regulating the GH-IGF1 system through a NFE2L2- and DDIT3-mediated mechanism

(2018) Silvia Zecchini et al.   Autophagy

ATG5 is required for B cell polarization and presentation of particulate antigens

(2018) Florent Arbogast et al.   Autophagy

Antidepressants act by inducing autophagy controlled by sphingomyelin–ceramide

(2018) Anne Gulbins et al.   MOLECULAR PSYCHIATRY

Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy

(2018) Eleonora Napoli et al.   Scientific Reports

Elevated arterial shear rate increases indexes of endothelial cell autophagy and nitric oxide synthase activation in humans

(2018) Seul-Ki Park et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Autophagy promotes angiogenesis via AMPK/Akt/mTOR signaling during the recovery of heat-denatured endothelial cells

(2018) Pengfei Liang et al.   Cell Death & Disease

Autophagy as a regulator of cardiovascular redox homeostasis

(2017) Ye Yan et al.   FREE RADICAL BIOLOGY AND MEDICINE

Atg7 Regulates Brain Angiogenesis via NF-κB-Dependent IL-6 Production

(2017) Shi-Fang Zhuang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Tregs restrain dendritic cell autophagy to ameliorate autoimmunity

(2017) Themis Alissafi et al.   JOURNAL OF CLINICAL INVESTIGATION

Akt Signaling Pathway in Macrophage Activation and M1/M2 Polarization

(2017) Eleni Vergadi et al.   JOURNAL OF IMMUNOLOGY

The origins of memory T cells

(2017) Kyla D. Omilusik et al.   NATURE

Autophagy maintains the metabolism and function of young and old stem cells

(2017) Theodore T. Ho et al.   NATURE

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

(2017) Fiona M. Menzies et al.   NEURON

Bassoon Controls Presynaptic Autophagy through Atg5

(2017) Nathan D. Okerlund et al.   NEURON

ATG-dependent phagocytosis in dendritic cells drives myelin-specific CD4+T cell pathogenicity during CNS inflammation

(2017) Christian W. Keller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Autophagy is required for endothelial cell alignment and atheroprotection under physiological blood flow

(2017) Anne-Clemence Vion et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A switch from canonical to noncanonical autophagy shapes B cell responses

(2017) Nuria Martinez-Martin et al.   SCIENCE

A brief review: the therapeutic potential of bone marrow mesenchymal stem cells in myocardial infarction

(2017) Chi Miao et al.   Stem Cell Research & Therapy

Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling

(2016) Anna S. Nichenko et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Restoration of autophagy in endothelial cells from patients with diabetes mellitus improves nitric oxide signaling

(2016) Jessica L. Fetterman et al.   ATHEROSCLEROSIS

Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration

(2016) Alfonso Saera-Vila et al.   Autophagy

Autophagy activation in COL6 myopathic patients by a low-protein-diet pilot trial

(2016) Silvia Castagnaro et al.   Autophagy

Proper autophagy is indispensable for angiogenesis during chick embryo development

(2016) Wen-hui Lu et al.   CELL CYCLE

Autophagy regulates satellite cell ability to regenerate normal and dystrophic muscles

(2016) E Fiacco et al.   CELL DEATH AND DIFFERENTIATION

Systemic Analysis of Atg5 -Null Mice Rescued from Neonatal Lethality by Transgenic ATG5 Expression in Neurons

(2016) Saori R. Yoshii et al.   DEVELOPMENTAL CELL

Autophagy core machinery: overcoming spatial barriers in neurons

(2016) Aileen R. Ariosa et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Disrupted autophagy undermines skeletal muscle adaptation and integrity

(2016) Elliot J. Jokl et al.   MAMMALIAN GENOME

Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

(2016) H-J Kim et al.   MOLECULAR PSYCHIATRY

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

(2016) Francesca Vittoria Sbrana et al.   Stem Cell Reviews and Reports

Autophagy regulates Notch degradation and modulates stem cell development and neurogenesis

(2016) Xiaoting Wu et al.   Nature Communications

Angiogenic Factor AGGF1 Activates Autophagy with an Essential Role in Therapeutic Angiogenesis for Heart Disease

(2016) Qiulun Lu et al.   PLOS BIOLOGY

Mutation in ATG5 reduces autophagy and leads to ataxia with developmental delay

(2016) Myungjin Kim et al.   eLife

The Role of Autophagy in the Maintenance of Stemness and Differentiation of Mesenchymal Stem Cells

(2016) Francesca Vittoria Sbrana et al.   Stem Cell Reviews and Reports

EVA1A/TMEM166 Regulates Embryonic Neurogenesis by Autophagy

(2016) Mengtao Li et al.   Stem Cell Reports

Roles and regulation of autophagy and apoptosis in the remodelling of the lepidopteran midgut epithelium during metamorphosis

(2016) Davide Romanelli et al.   Scientific Reports

Intact endothelial autophagy is required to maintain vascular lipid homeostasis

(2015) Kumiko Torisu et al.   AGING CELL

The PRKAA1/AMPKα1 pathway triggers autophagy during CSF1-induced human monocyte differentiation and is a potential target in CMML

(2015) Sandrine Obba et al.   Autophagy

Common γ-chain cytokine signaling is required for macroautophagy induction during CD4+T-cell activation

(2015) Yair Botbol et al.   Autophagy

Impaired macrophage autophagy increases the immune response in obese mice by promoting proinflammatory macrophage polarization

(2015) Kun Liu et al.   Autophagy

Autophagy is dispensable for B-cell development but essential for humoral autoimmune responses

(2015) J Arnold et al.   CELL DEATH AND DIFFERENTIATION

AMPK Activation of Muscle Autophagy Prevents Fasting-Induced Hypoglycemia and Myopathy during Aging

(2015) Adam L. Bujak et al.   Cell Metabolism

Increased autophagy and apoptosis contribute to muscle atrophy in a myotonic dystrophy type 1 Drosophila model

(2015) A. Bargiela et al.   Disease Models & Mechanisms

AKT mediated glycolytic shift regulates autophagy in classically activated macrophages

(2015) Sumit Kumar Matta et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Autophagy as a Potential Target for Sarcopenia

(2015) Jingjing Fan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Autophagy and neurodegeneration

(2015) Rebecca A. Frake et al.   JOURNAL OF CLINICAL INVESTIGATION

Requirement for Autophagy in the Long-Term Persistence but not Initial Formation of Memory B cells

(2015) Min Chen et al.   JOURNAL OF IMMUNOLOGY

Transcription Factors STAT6 and KLF4 Implement Macrophage Polarization via the Dual Catalytic Powers of MCPIP

(2015) Nidhi Kapoor et al.   JOURNAL OF IMMUNOLOGY

Massive accumulation of luminal protease-deficient axonal lysosomes at Alzheimer’s disease amyloid plaques

(2015) Swetha Gowrishankar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Changes in autophagy, proteasome activity and metabolism to determine a specific signature for acute and chronic senescent mesenchymal stromal cells

(2015) Stefania Capasso et al.   Oncotarget

Autophagy and mammalian development

(2015) Xiaoting Wu et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

High Glucose Induces Bone Marrow-Derived Mesenchymal Stem Cell Senescence by Upregulating Autophagy

(2015) Tzu-Ching Chang et al.   PLoS One

Autophagy Regulates Vascular Endothelial Cell eNOS and ET-1 Expression Induced by Laminar Shear Stress in an Ex Vivo Perfused System

(2014) Fengxia Guo et al.   ANNALS OF BIOMEDICAL ENGINEERING

Autophagy and Its Normal and Pathogenic States in the Brain

(2014) Ai Yamamoto et al.   Annual Review of Neuroscience

Autophagy is not required to sustain exercise and PRKAA1/AMPK activity but is important to prevent mitochondrial damage during physical activity

(2014) Francesca Lo Verso et al.   Autophagy

Impairment of autophagy in endothelial cells prevents shear-stress-induced increases in nitric oxide bioavailability

(2014) Leena P. Bharath et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Tumor Vessel Normalization by Chloroquine Independent of Autophagy

(2014) Hannelore Maes et al.   CANCER CELL

Autophagy Protects Against Senescence and Apoptosis via the RAS-Mitochondria in High-Glucose-Induced Endothelial Cells

(2014) Fei Chen et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

B cell Biology: An Overview

(2014) Hermann Eibel et al.   CURRENT ALLERGY AND ASTHMA REPORTS

Autophagy induction is a survival response against oxidative stress in bone marrow–derived mesenchymal stromal cells

(2014) Chunjuan Song et al.   CYTOTHERAPY

Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway

(2014) Sandra Maday et al.   DEVELOPMENTAL CELL

Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation

(2014) Ann H Tang et al.   EMBO JOURNAL

T cell receptor-mediated activation is a potent inducer of macroautophagy in human CD8+CD28+ T cells but not in CD8+CD28− T cells

(2014) Christoph R. Arnold et al.   EXPERIMENTAL GERONTOLOGY

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Autophagy Gene Atg16l1 Prevents Lethal T Cell Alloreactivity Mediated by Dendritic Cells

(2014) Vanessa M. Hubbard-Lucey et al.   IMMUNITY

Essential role for autophagy in the maintenance of immunological memory against influenza infection

(2014) Min Chen et al.   NATURE MEDICINE

Hematopoietic stem cell niche maintenance during homeostasis and regeneration

(2014) Avital Mendelson et al.   NATURE MEDICINE

Mesenchymal stem/stromal cells as a pharmacological and therapeutic approach to accelerate angiogenesis

(2014) Annelies Bronckaers et al.   PHARMACOLOGY & THERAPEUTICS

Zebrafish ambra1a and ambra1b Knockdown Impairs Skeletal Muscle Development

(2014) Tatjana Skobo et al.   PLoS One

The Crucial Role of Atg5 in Cortical Neurogenesis During Early Brain Development

(2014) Xiaohui Lv et al.   Scientific Reports

Skeletal Muscle Homeostasis in Duchenne Muscular Dystrophy: Modulating Autophagy as a Promising Therapeutic Strategy

(2014) Clara De Palma et al.   Frontiers in Aging Neuroscience

From Monocytes to M1/M2 Macrophages: Phenotypical vs. Functional Differentiation

(2014) Paola Italiani et al.   Frontiers in Immunology

Multicomponent exercises including muscle power training enhance muscle mass, power output, and functional outcomes in institutionalized frail nonagenarians

(2013) Eduardo L. Cadore et al.   AGE

Resveratrol attenuates vascular endothelial inflammation by inducing autophagy through the cAMP signaling pathway

(2013) Ming-liang Chen et al.   Autophagy

Autophagic flux and oxidative capacity of skeletal muscles during acute starvation

(2013) Mahroo Mofarrahi et al.   Autophagy

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

Defects of Vps15 in skeletal muscles lead to autophagic vacuolar myopathy and lysosomal disease

(2013) Ivan Nemazanyy et al.   EMBO Molecular Medicine

Transcription factor EB (TFEB) is a new therapeutic target for Pompe disease

(2013) Carmine Spampanato et al.   EMBO Molecular Medicine

Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance

(2013) Vitor A. Lira et al.   FASEB JOURNAL

Epigallocatechin Gallate (EGCG) Stimulates Autophagy in Vascular Endothelial Cells

(2013) Hae-Suk Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma cells require autophagy for sustainable immunoglobulin production

(2013) Niccolò Pengo et al.   NATURE IMMUNOLOGY

Axonal transport deficits and neurodegenerative diseases

(2013) Stéphanie Millecamps et al.   NATURE REVIEWS NEUROSCIENCE

Trehalose induced antidepressant-like effects and autophagy enhancement in mice

(2013) N. Z. Kara et al.   PSYCHOPHARMACOLOGY

Oxidative stress in vascular disease and its pharmacological prevention

(2013) Huige Li et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Autophagy is required for CSF-1-induced macrophagic differentiation and acquisition of phagocytic functions

(2012) A. Jacquel et al.   BLOOD

Induction of autophagy is essential for monocyte-macrophage differentiation

(2012) Y. Zhang et al.   BLOOD

Neuronal autophagy and neurodegenerative diseases

(2012) Jin H. Son et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Bcl-2-associated autophagy regulator Naf-1 required for maintenance of skeletal muscle

(2012) N. C. Chang et al.   HUMAN MOLECULAR GENETICS

Metabolism and autophagy in the immune system: immunometabolism comes of age

(2012) Jeffrey C. Rathmell   IMMUNOLOGICAL REVIEWS

Defective Autophagy and mTORC1 Signaling in Myotubularin Null Mice

(2012) K. M. Fetalvero et al.   MOLECULAR AND CELLULAR BIOLOGY

Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis

(2012) Congcong He et al.   NATURE

Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy

(2012) Thomas Cullup et al.   NATURE GENETICS

Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy

(2012) Jaakko Sarparanta et al.   NATURE GENETICS

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

(2012) Kook Hwan Kim et al.   NATURE MEDICINE

Regulation of Presynaptic Neurotransmission by Macroautophagy

(2012) Daniela Hernandez et al.   NEURON

Canonical autophagy dependent on the class III phosphoinositide-3 kinase Vps34 is required for naive T-cell homeostasis

(2012) T. Willinger et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Autophagy Activation: A Novel Mechanism of Atorvastatin to Protect Mesenchymal Stem Cells from Hypoxia and Serum Deprivation via AMP-Activated Protein Kinase/Mammalian Target of Rapamycin Pathway

(2012) Qian Zhang et al.   STEM CELLS AND DEVELOPMENT

Autophagy as a new therapeutic target in Duchenne muscular dystrophy

(2012) C De Palma et al.   Cell Death & Disease

Role of autophagy in angiogenesis in aortic endothelial cells

(2011) Jianhai Du et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Physical exercise stimulates autophagy in normal skeletal muscles but is detrimental for collagen VI-deficient muscles

(2011) Paolo Grumati et al.   Autophagy

Beclin 1 deficiency is associated with increased hypoxia-induced angiogenesis

(2011) Seon-Jin Lee et al.   Autophagy

Autophagy: Renovation of Cells and Tissues

(2011) Noboru Mizushima et al.   CELL

Autophagy promotes T-cell survival through degradation of proteins of the cell death machinery

(2011) J R Kovacs et al.   CELL DEATH AND DIFFERENTIATION

Autophagy and cytokines

(2011) James Harris   CYTOKINE

Autophagy is increased in laminin α2 chain-deficient muscle and its inhibition improves muscle morphology in a mouse model of MDC1A

(2011) Virginie Carmignac et al.   HUMAN MOLECULAR GENETICS

Temporal Regulation of Intracellular Organelle Homeostasis in T Lymphocytes by Autophagy

(2011) W. Jia et al.   JOURNAL OF IMMUNOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

In Vivo Requirement for Atg5 in Antigen Presentation by Dendritic Cells

(2010) Heung Kyu Lee et al.   IMMUNITY

Autophagy Regulates Endoplasmic Reticulum Homeostasis and Calcium Mobilization in T Lymphocytes

(2010) W. Jia et al.   JOURNAL OF IMMUNOLOGY

Macroautophagy Regulates Energy Metabolism during Effector T Cell Activation

(2010) V. M. Hubbard et al.   JOURNAL OF IMMUNOLOGY

The Selective Macroautophagic Degradation of Aggregated Proteins Requires the PI3P-Binding Protein Alfy

(2010) Maria Filimonenko et al.   MOLECULAR CELL

Autophagy and the Integrated Stress Response

(2010) Guido Kroemer et al.   MOLECULAR CELL

Autophagy in mammalian development and differentiation

(2010) Noboru Mizushima et al.   NATURE CELL BIOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

Autophagy is defective in collagen VI muscular dystrophies and its reactivation rescues myofiber degeneration

(2010) Paolo Grumati et al.   NATURE MEDICINE

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

Neural-specific Deletion of FIP200 Leads to Cerebellar Degeneration Caused by Increased Neuronal Death and Axon Degeneration

(2009) Chun-Chi Liang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Coordination of membrane events during autophagy by multiple class III PI3-kinase complexes

(2009) Anne Simonsen et al.   JOURNAL OF CELL BIOLOGY

Autophagy Is Essential for Mitochondrial Clearance in Mature T Lymphocytes

(2009) H. H. Pua et al.   JOURNAL OF IMMUNOLOGY

Enhancing Immunity Through Autophagy

(2008) Christian Münz   Annual Review of Immunology

Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity

(2008) Gabriella Dobrowolny et al.   Cell Metabolism

Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease

(2008) N. Raben et al.   HUMAN MOLECULAR GENETICS

The B Cell Receptor Governs the Subcellular Location of Toll-like Receptor 9 Leading to Hyperresponses to DNA-Containing Antigens

(2008) Akanksha Chaturvedi et al.   IMMUNITY

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

(2008) Elizabeth L. Axe et al.   JOURNAL OF CELL BIOLOGY

FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells

(2008) Taichi Hara et al.   JOURNAL OF CELL BIOLOGY

The Atg8 Conjugation System Is Indispensable for Proper Development of Autophagic Isolation Membranes in Mice

(2008) Yu-shin Sou et al.   MOLECULAR BIOLOGY OF THE CELL

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

Autophagy fights disease through cellular self-digestion

(2008) Noboru Mizushima et al.   NATURE

Mutations that impair interaction properties of TRIM32 associated with limb-girdle muscular dystrophy 2H

(2007) Valentina Saccone et al.   HUMAN MUTATION