Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals

Sestrin modulator NV-5138 produces rapid antidepressant effects via direct mTORC1 activation

(2019) Taro Kato et al.   JOURNAL OF CLINICAL INVESTIGATION

Sestrins are differentially expressed with age in the skeletal muscle of men: A cross-sectional analysis

(2018) Nina Zeng et al.   EXPERIMENTAL GERONTOLOGY

Exploration of Novel Anti-Oxidant Protein Sestrin in Frailty Syndrome in Elderly

(2018) Nitish Rai et al.   Aging and Disease

A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells

(2017) Jun-Kyu Byun et al.   Cell Reports

FoxO-dependent atrogenes vary among catabolic conditions and play a key role in muscle atrophy induced by hindlimb suspension

(2016) Lorenza Brocca et al.   JOURNAL OF PHYSIOLOGY-LONDON

Autophagy maintains stemness by preventing senescence

(2016) Laura García-Prat et al.   NATURE

Biochemical Basis of Sestrin Physiological Activities

(2016) Allison Ho et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sestrin2 is a leucine sensor for the mTORC1 pathway

(2015) R. L. Wolfson et al.   SCIENCE

Regulation of autophagy and the ubiquitin–proteasome system by the FoxO transcriptional network during muscle atrophy

(2015) Giulia Milan et al.   Nature Communications

Sestrin 3 Protein Enhances Hepatic Insulin Sensitivity by Direct Activation of the mTORC2-Akt Signaling

(2014) Rongya Tao et al.   DIABETES

Molecular analyses provide insight into mechanisms underlying sarcopenia and myofibre denervation in old skeletal muscles of mice

(2014) Mitchell Barns et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sestrins Orchestrate Cellular Metabolism to Attenuate Aging

(2013) Jun Hee Lee et al.   Cell Metabolism

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

Signaling pathways controlling skeletal muscle mass

(2013) Marc A. Egerman et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

SESN-1 is a positive regulator of lifespan in Caenorhabditis elegans

(2013) Ya-Luen Yang et al.   EXPERIMENTAL GERONTOLOGY

BMP signaling controls muscle mass

(2013) Roberta Sartori et al.   NATURE GENETICS

Maintenance of Metabolic Homeostasis by Sestrin2 and Sestrin3

(2012) Jun Hee Lee et al.   Cell Metabolism

PAI-1–regulated miR-21 defines a novel age-associated fibrogenic pathway in muscular dystrophy

(2012) Esther Ardite et al.   JOURNAL OF CELL BIOLOGY

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

(2011) Eugenia Morselli et al.   JOURNAL OF CELL BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

Quantitation of "autophagic flux" in mature skeletal muscle

(2010) Jeong-Sun Ju et al.   Autophagy

Sestrin as a Feedback Inhibitor of TOR That Prevents Age-Related Pathologies

(2010) J. H. Lee et al.   SCIENCE

Autophagy Is Required to Maintain Muscle Mass

(2009) Eva Masiero et al.   Cell Metabolism

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

(2009) Chang Hwa Jung et al.   MOLECULAR BIOLOGY OF THE CELL

Measuring Mechanical Properties, Including Isotonic Fatigue, of Fast and Slow MLC/mIgf-1 Transgenic Skeletal Muscle

(2008) Zaccaria Del Prete et al.   ANNALS OF BIOMEDICAL ENGINEERING

Meta-analysis of expression signatures of muscle atrophy: gene interaction networks in early and late stages

(2008) Enrica Calura et al.   BMC GENOMICS

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

(2008) Andrei V. Budanov et al.   CELL

Fibrinogen drives dystrophic muscle fibrosis via a TGF /alternative macrophage activation pathway

(2008) B. Vidal et al.   GENES & DEVELOPMENT