Concise Review: Cell Therapy for Critical Limb Ischemia: An Integrated Review of Preclinical and Clinical Studies

A futile cycle in cell therapy

(2017)   NATURE BIOTECHNOLOGY

High Aldehyde Dehydrogenase Activity Identifies a Subset of Human Mesenchymal Stromal Cells with Vascular Regenerative Potential

(2017) Stephen E. Sherman et al.   STEM CELLS

A Proinflammatory Secretome Mediates the Impaired Immunopotency of Human Mesenchymal Stromal Cells in Elderly Patients with Atherosclerosis

(2017) Özge Kizilay Mancini et al.   Stem Cells Translational Medicine

Expanded Hematopoietic Progenitor Cells Reselected for High Aldehyde Dehydrogenase Activity Demonstrate Islet Regenerative Functions

(2016) Ayesh K. Seneviratne et al.   STEM CELLS

Comprehensive Proteomic Analysis of Mesenchymal Stem Cell Exosomes Reveals Modulation of Angiogenesis via Nuclear Factor-KappaB Signaling

(2016) Johnathon D. Anderson et al.   STEM CELLS

Characteristics of responders to autologous bone marrow cell therapy for no-option critical limb ischemia

(2016) Juraj Madaric et al.   Stem Cell Research & Therapy

Adipose-Derived Stem Cells Induce Angiogenesis via Microvesicle Transport of miRNA-31

(2016) Ting Kang et al.   Stem Cells Translational Medicine

Effect of Repetitive Intra-Arterial Infusion of Bone Marrow Mononuclear Cells in Patients With No-Option Limb Ischemia: The Randomized, Double-Blind, Placebo-Controlled Rejuvenating Endothelial Progenitor Cells via Transcutaneous Intra-arterial Supplementation (JUVENTAS) Trial

(2015) M. Teraa et al.   CIRCULATION

Modulating the Vascular Response to Limb Ischemia: Angiogenic and Cell Therapies

(2015) J. P. Cooke et al.   CIRCULATION RESEARCH

Epidemiology of Peripheral Artery Disease

(2015) M. H. Criqui et al.   CIRCULATION RESEARCH

Bone Marrow derived Cell Therapy in Critical Limb Ischemia: A Meta-analysis of Randomized Placebo Controlled Trials

(2015) S.M.O. Peeters Weem et al.   EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY

Introduction

(2015) Michael S. Conte et al.   JOURNAL OF VASCULAR SURGERY

Cell Therapy in Patients with Critical Limb Ischemia

(2015) Rita Compagna et al.   Stem Cells International

Rationale and Design for PACE: Patients with Intermittent Claudication Injected with ALDH Bright Cells

(2014) Emerson C. Perin et al.   AMERICAN HEART JOURNAL

Intussusceptive angiogenesis: expansion and remodeling of microvascular networks

(2014) Steven J. Mentzer et al.   ANGIOGENESIS

The analysis, roles and regulation of quiescence in hematopoietic stem cells

(2014) A. Nakamura-Ishizu et al.   DEVELOPMENT

Neovascularization Capacity of Mesenchymal Stromal Cells From Critical Limb Ischemia Patients Is Equivalent to Healthy Controls

(2014) Hendrik Gremmels et al.   MOLECULAR THERAPY

Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal

(2014) I. Fares et al.   SCIENCE

Autologous Bone Marrow–Derived Cell Therapy in Patients With Critical Limb Ischemia

(2013) Martin Teraa et al.   ANNALS OF SURGERY

Porous decellularized adipose tissue foams for soft tissue regeneration

(2013) Claire Yu et al.   BIOMATERIALS

Management of Patients With Peripheral Artery Disease (Compilation of 2005 and 2011 ACCF/AHA Guideline Recommendations)

(2013) Jeffrey L. Anderson et al.   CIRCULATION

Cell Therapy of Peripheral Arterial Disease

(2013) Zankhana Raval et al.   CIRCULATION RESEARCH

Peripheral blood-derived autologous stem cell therapy for the treatment of patients with late-stage peripheral artery disease—results of the short- and long-term follow-up

(2013) Gábor Viktor Szabó et al.   CYTOTHERAPY

Autologous Bone Marrow Mononuclear Cells Transplant in Patients With Critical Leg Ischemia: Preliminary Clinical Results

(2013) Min Li et al.   Experimental and Clinical Transplantation

A double blind randomized placebo controlled phase I/II study assessing the safety and efficacy of allogeneic bone marrow derived mesenchymal stem cell in critical limb ischemia

(2013) Pawan K Gupta et al.   Journal of Translational Medicine

Comparison of global estimates of prevalence and risk factors for peripheral artery disease in 2000 and 2010: a systematic review and analysis

(2013) F Gerald R Fowkes et al.   LANCET

Decellularized homologous tissue-engineered heart valves as off-the-shelf alternatives to xeno- and homografts

(2012) Petra E. Dijkman et al.   BIOMATERIALS

Linking Diabetes With Oxidative Stress, Adipokines, and Impaired Endothelial Precursor Cell Function

(2012) David A. Hess et al.   CANADIAN JOURNAL OF CARDIOLOGY

Rapid Expansion of Human Hematopoietic Stem Cells by Automated Control of Inhibitory Feedback Signaling

(2012) Elizabeth Csaszar et al.   Cell Stem Cell

Nonatherosclerotic Arterial Disorders of the Lower Extremities

(2012) Ido Weinberg et al.   CIRCULATION

A Randomized, Controlled Pilot Study of Autologous CD34+ Cell Therapy for Critical Limb Ischemia

(2012) Douglas W. Losordo et al.   Circulation-Cardiovascular Interventions

Infusion of Mesenchymal Stem Cells Ameliorates Hyperglycemia in Type 2 Diabetic Rats: Identification of a Novel Role in Improving Insulin Sensitivity

(2012) Y. Si et al.   DIABETES

Therapeutical potential of autologous peripheral blood mononuclear cell transplantation in patients with type 2 diabetic critical limb ischemia

(2012) Ahmet Ozturk et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

RETRACTED: Engineered whole organs and complex tissues

(2012) Stephen F Badylak et al.   LANCET

Cellular Therapy With Ixmyelocel-T to Treat Critical Limb Ischemia: The Randomized, Double-blind, Placebo-controlled RESTORE-CLI Trial

(2012) Richard J Powell et al.   MOLECULAR THERAPY

Umbilical Cord Blood-Derived Aldehyde Dehydrogenase-Expressing Progenitor Cells Promote Recovery from Acute Ischemic Injury

(2012) David M. Putman et al.   STEM CELLS

Bioengineered Vascular Grafts: Can We Make Them Off-the-Shelf?

(2012) Shannon L.M. Dahl et al.   TRENDS IN CARDIOVASCULAR MEDICINE

Macrophages in Collateral Arteriogenesis

(2012) Erik Fung et al.   Frontiers in Physiology

An overview of tissue and whole organ decellularization processes

(2011) Peter M. Crapo et al.   BIOMATERIALS

A randomized, controlled study of autologous therapy with bone marrow-derived aldehyde dehydrogenase bright cells in patients with critical limb ischemia

(2011) Emerson C. Perin et al.   CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS

The MSC: An Injury Drugstore

(2011) Arnold I. Caplan et al.   Cell Stem Cell

Intraarterial Administration of Bone Marrow Mononuclear Cells in Patients With Critical Limb Ischemia

(2011) Dirk H. Walter et al.   Circulation-Cardiovascular Interventions

Autologous Bone-Marrow Mononuclear Cell Implantation Reduces Long-Term Major Amputation Risk in Patients With Critical Limb Ischemia

(2011) Naomi Idei et al.   Circulation-Cardiovascular Interventions

Comparison of bone marrow mesenchymal stem cells with bone marrow-derived mononuclear cells for treatment of diabetic critical limb ischemia and foot ulcer: A double-blind, randomized, controlled trial

(2011) Debin Lu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The role of amputation as an outcome measure in cellular therapy for critical limb ischemia: implications for clinical trial design

(2011) Eric Benoit et al.   Journal of Translational Medicine

Readily Available Tissue-Engineered Vascular Grafts

(2011) S. L. M. Dahl et al.   Science Translational Medicine

Decreased number and impaired functionality of endothelial progenitor cells in subjects with metabolic syndrome: Implications for increased cardiovascular risk

(2010) I. Jialal et al.   ATHEROSCLEROSIS

Cell Therapy, a New Standard in Management of Chronic Critical Limb Ischemia and Foot Ulcer

(2010) V. Procházka et al.   CELL TRANSPLANTATION

Decreased Circulating Progenitor Cell Number and Failed Mechanisms of Stromal Cell-Derived Factor-1α Mediated Bone Marrow Mobilization Impair Diabetic Tissue Repair

(2010) Oren M. Tepper et al.   DIABETES

Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity

(2009) B. J. Capoccia et al.   BLOOD

Endothelial progenitor cell: ongoing controversy for defining these cells and their role in neoangiogenesis in the murine system

(2009) Mervin C Yoder et al.   CURRENT OPINION IN HEMATOLOGY

Circulating endothelial progenitor cells, endothelial function, carotid intima–media thickness and circulating markers of endothelial dysfunction in people with type 1 diabetes without macrovascular disease or microalbuminuria

(2009) L. Sibal et al.   DIABETOLOGIA

Long-term clinical outcome after intramuscular implantation of bone marrow mononuclear cells (Therapeutic Angiogenesis by Cell Transplantation [TACT] trial) in patients with chronic limb ischemia

(2008) Satoaki Matoba et al.   AMERICAN HEART JOURNAL

The Systematic Production of Cells for Cell Therapies

(2008) Daniel C. Kirouac et al.   Cell Stem Cell

A Perivascular Origin for Mesenchymal Stem Cells in Multiple Human Organs

(2008) Mihaela Crisan et al.   Cell Stem Cell

Macrophage Phenotype as a Determinant of Biologic Scaffold Remodeling

(2008) Stephen F. Badylak et al.   TISSUE ENGINEERING PART A