Nose-to-Brain Delivery of Antioxidants as a Potential Tool for the Therapy of Neurological Diseases

Uptake in the Central Nervous System of Geraniol Oil Encapsulated in Chitosan Oleate Following Nasal and Oral Administration

(2019) Maria Bonferoni et al.   Pharmaceutics

Nanoemulsions for “Nose-to-Brain” Drug Delivery

(2019) Maria Bonferoni et al.   Pharmaceutics

Nanostructured lipid carriers engineered for intranasal delivery of teriflunomide in multiple sclerosis: optimization and in vivo studies

(2019) Dnyandev G. Gadhave et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Nanosized Transferosome-Based Intranasal In Situ Gel for Brain Targeting of Resveratrol: Formulation, Optimization, In Vitro Evaluation, and In Vivo Pharmacokinetic Study

(2019) Heba F. Salem et al.   AAPS PHARMSCITECH

Vitamin E Loaded Naringenin Nanoemulsion via Intranasal Delivery for the Management of Oxidative Stress in a 6-OHDA Parkinson’s Disease Model

(2019) Bharti Gaba et al.   Biomed Research International

Nanosized nasal emulgel of Resveratrol: preparation, optimization, in vitro evaluation and in vivo pharmacokinetic study

(2019) Heba F. Salem et al.   DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY

Increased Nose-to-Brain Delivery of Melatonin Mediated by Polycaprolactone Nanoparticles for the Treatment of Glioblastoma

(2019) Edilson Ribeiro de Oliveira Junior et al.   PHARMACEUTICAL RESEARCH

Role of Catalase in Oxidative Stress- and Age-Associated Degenerative Diseases

(2019) Ankita Nandi et al.   Oxidative Medicine and Cellular Longevity

Neuroprotective and Antioxidant Effect of Naringenin-Loaded Nanoparticles for Nose-to-Brain Delivery

(2019) Shadab Md et al.   Brain Sciences

Poloxamer-chitosan-based Naringenin nanoformulation used in brain targeting for the treatment of cerebral ischemia

(2019) Niyaz Ahmad et al.   SAUDI JOURNAL OF BIOLOGICAL SCIENCES

Box-Behnken design optimization of mucoadhesive chitosan-coated nanoemulsions for rosmarinic acid nasal delivery— in vitro studies

(2018) Flávia Nathiely Silveira Fachel et al.   CARBOHYDRATE POLYMERS

Lipophilic antioxidants in neurodegenerative diseases

(2018) Kuo-Hsuan Chang et al.   CLINICA CHIMICA ACTA

Brain targeting of resveratrol by nasal administration of chitosan-coated lipid microparticles

(2018) Valentina Trotta et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Pramipexole dihydrochloride loaded chitosan nanoparticles for nose to brain delivery: Development, characterization and in vivo anti-Parkinson activity

(2018) Ruhi Raj et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro

(2018) Mariana Colombo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Curcumin Cocrystal Micelles—Multifunctional Nanocomposites for Management of Neurodegenerative Ailments

(2018) Preshita P. Desai et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Mechanism of intranasal drug delivery directly to the brain

(2018) Tyler P. Crowe et al.   LIFE SCIENCES

Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer’s disease

(2018) Hui Wang et al.   TOXICOLOGY LETTERS

In situ nanostructured hydrogel of resveratrol for brain targeting: in vitro-in vivo characterization

(2018) Amarjitsing Rajput et al.   Drug Delivery and Translational Research

The Potential Use of Plant Natural Products and Plant Extracts with Antioxidant Properties for the Prevention/Treatment of Neurodegenerative Diseases: In Vitro, In Vivo and Clinical Trials

(2018) Franziska Pohl et al.   MOLECULES

An overview of the neuroprotective potential of rosmarinic acid and its association with nanotechnology-based delivery systems: A novel approach to treating neurodegenerative disorders

(2018) Flávia Nathiely Silveira Fachel et al.   NEUROCHEMISTRY INTERNATIONAL

Intranasal Delivery of Genistein-Loaded Nanoparticles as a Potential Preventive System against Neurodegenerative Disorders

(2018) Giovanna Rassu et al.   Pharmaceutics

Melatonin-loaded silica coated with hydroxypropyl methylcellulose phthalate for enhanced oral bioavailability: Preparation, and in vitro-in vivo evaluation

(2017) Yuanyuan Li et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Development of Nasal Lipid Nanocarriers Containing Curcumin for Brain Targeting

(2017) Gustavo Richter Vaz et al.   JOURNAL OF ALZHEIMERS DISEASE

VPA and MEL induce apoptosis by inhibiting the Nrf2-ARE signaling pathway in TMZ-resistant U251 cells

(2017) Hao Pan et al.   Molecular Medicine Reports

Fabrication of an ionic-sensitive in situ gel loaded with resveratrol nanosuspensions intended for direct nose-to-brain delivery

(2016) Jifu Hao et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Rutin-encapsulated chitosan nanoparticles targeted to the brain in the treatment of Cerebral Ischemia

(2016) Niyaz Ahmad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Quantification and evaluation of thymoquinone loaded mucoadhesive nanoemulsion for treatment of cerebral ischemia

(2016) Niyaz Ahmad et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Phytochemical-loaded mesoporous silica nanoparticles for nose-to-brain olfactory drug delivery

(2016) Shital Lungare et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Particulate formulations based on chitosan for nose-to-brain delivery of drugs. A review

(2016) Giovanna Rassu et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Protective Effect of Genistein against Neuronal Degeneration in ApoE−/− Mice Fed a High-Fat Diet

(2016) Yoon-Jin Park et al.   Nutrients

Development of an optimized hyaluronic acid-based lipidic nanoemulsion co-encapsulating two polyphenols for nose to brain delivery

(2015) Maha Nasr   DRUG DELIVERY

Exosomes as drug delivery vehicles for Parkinson's disease therapy

(2015) Matthew J. Haney et al.   JOURNAL OF CONTROLLED RELEASE

Solid microparticles based on chitosan or methyl-β-cyclodextrin: A first formulative approach to increase the nose-to-brain transport of deferoxamine mesylate

(2015) Giovanna Rassu et al.   JOURNAL OF CONTROLLED RELEASE

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease

(2015) R. Scott Turner et al.   NEUROLOGY

Kaempferol and inflammation: From chemistry to medicine

(2015) Kasi Pandima Devi et al.   PHARMACOLOGICAL RESEARCH

Formulation and Evaluation of Piroxicam Transferosomal Gel: An Approach for Penetration Enhancement

(2015) S. Ghanbarzadeh et al.   JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY

Development, characterization and nasal delivery of rosmarinic acid-loaded solid lipid nanoparticles for the effective management of Huntington’s disease

(2014) Rahul Bhatt et al.   DRUG DELIVERY

Liver cancer cells: targeting and prolonged-release drug carriers consisting of mesoporous silica nanoparticles and alginate microspheres

(2014) Kevin Wu et al.   International Journal of Nanomedicine

Vitamin E loaded resveratrol nanoemulsion for brain targeting for the treatment of Parkinson’s disease by reducing oxidative stress

(2014) Rudra Pangeni et al.   NANOTECHNOLOGY

Preparation of quercetin and rutin-loaded ceramide liposomes and drug-releasing effect in liposome-in-hydrogel complex system

(2013) Soo Nam Park et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Intranasal pyrrolidine dithiocarbamate decreases brain inflammatory mediators and provides neuroprotection after brain hypoxia–ischemia in neonatal rats

(2013) Zhi Wang et al.   EXPERIMENTAL NEUROLOGY

Naringenin protects against 6-OHDA-induced neurotoxicity via activation of the Nrf2/ARE signaling pathway

(2013) Haiyan Lou et al.   NEUROPHARMACOLOGY

Sesamol and naringenin reverse the effect of rotenone-induced PD rat model

(2013) M. Sonia Angeline et al.   NEUROSCIENCE

Exosomes: Current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials

(2012) Alexander V. Vlassov et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention

(2012) Allen Y. Chen et al.   FOOD CHEMISTRY

Kaempferol nanoparticles achieve strong and selective inhibition of ovarian cancer cell viability

(2012) Bingyun Li et al.   International Journal of Nanomedicine

Anatomical and Histological Factors Affecting Intranasal Drug and Vaccine Delivery

(2012) Sveinbjorn Gizurarson   Current Drug Delivery

Neuroprotective properties of resveratrol and derivatives

(2011) Tristan Richard et al.   Annals of the New York Academy of Sciences

Hesperidin ameliorates functional and histological outcome and reduces neuroinflammation in experimental stroke

(2011) Syed Shadab Raza et al.   BRAIN RESEARCH

Nose-to-brain transport of melatonin from polymer gel suspensions: a microdialysis study in rats

(2011) R. Jayachandra Babu et al.   JOURNAL OF DRUG TARGETING

Sol–gel one-pot synthesis in soft conditions of mesoporous silica materials ready for drug delivery system

(2011) Corine Tourne-Peteilh et al.   JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY

Treatment of Brain Inflammatory Diseases by Delivering Exosome Encapsulated Anti-inflammatory Drugs From the Nasal Region to the Brain

(2011) Xiaoying Zhuang et al.   MOLECULAR THERAPY

Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells

(2011) Matthew J Haney et al.   Nanomedicine

Pre-Clinical Safety Evaluation of Pyrrolidine Dithiocarbamate

(2010) Monika Chabicovsky et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Exciting New Advances in Neuro-Oncology: The Avenue to a Cure for Malignant Glioma

(2010) E. G. Van Meir et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Clinical Uses of Melatonin: Evaluation of Human Trials

(2010) E.J. Sanchez-Barcelo et al.   CURRENT MEDICINAL CHEMISTRY

Influence of Chitosan Glutamate on the in vivo Intranasal Absorption of Rokitamycin from Microspheres

(2010) Elisabetta Gavini et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

The effect of curcumin (turmeric) onAlzheimer′s disease: An overview

(2009) Shrikant Mishra et al.   Annals of Indian Academy of Neurology

Hydrolysis of Rosmarinic Acid from Rosemary Extract with Esterases and Lactobacillus johnsonii in Vitro and in a Gastrointestinal Model

(2009) Rachid Bel-Rhlid et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Ageing populations: the challenges ahead

(2009) Kaare Christensen et al.   LANCET

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

Effect of Cyclodextrins on the Complexation and Nasal Permeation of Melatonin

(2008) R. Jayachandra Babu et al.   DRUG DELIVERY

Therapeutic Actions of Melatonin in Cancer: Possible Mechanisms

(2008) Venkataramanujan Srinivasan et al.   INTEGRATIVE CANCER THERAPIES

Increased oxidative damage in peripheral blood correlates with severity of Parkinson's disease

(2008) Chiung-Mei Chen et al.   NEUROBIOLOGY OF DISEASE

Electrons, life and the evolution of Earth's oxygen cycle

(2008) P. G Falkowski et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

The crucial role of metal ions in neurodegeneration: the basis for a promising therapeutic strategy

(2005) Alessandra Gaeta et al.   BRITISH JOURNAL OF PHARMACOLOGY