Article
Biochemistry & Molecular Biology
Dalia O. Saleh, Maha Nasr, Azza Hassan, Sally A. El-Awdan, Gehad A. Abdel Jaleel
Summary: The aim of this study was to investigate the therapeutic effects of curcumin nanoemulsion (NC) on cerebral damage in diabetic rats. The results showed that NC treatment reduced neurological deficit and redox imbalance, decreased inflammation and apoptosis, and restored glucose transporter 1 expression in the brain.
JOURNAL OF FOOD BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Niyaz Ahmad, Rizwan Ahmad, Mohd Amir, Md Aftab Alam, Mortaja Zaki Almakhamel, Abuzer Ali, Ayaz Ahmad, Kamran Ashraf
Summary: A novel GRL-loaded-nanoemulsion (GRL-MNE) was developed for intranasal delivery to the brain, significantly improving brain bioavailability and playing a significant role in the treatment of cerebral ischemia.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Food Science & Technology
Bing Han, Xiaoyu Han, Huan Deng, Tianyang Wu, Chenyu Li, Jicheng Zhan, Weidong Huang, Yilin You
Summary: This study determined the occurrence of biogenic amines (BAs) in wine samples available to Chinese consumers and investigated the dynamics of BAs during the spontaneous fermentation of two wine varieties. The results showed significant variations in BA levels among different wines and identified specific fermentation stages as critical control points. The study also highlighted the potential of certain BAs as indicators of wine quality and safety.
Article
Plant Sciences
Fan Zhang, Yu Yan, Kang Ding, Wen-Wen Lian, Li Li, Wen-Ping Wang, Cong-Yuan Xia, Hua Yang, Jun He, Wei-Ku Zhang, Jie-Kun Xu
Summary: This study aimed to investigate the pharmacokinetic characteristics and tissue distribution of loganin after oral administration in rats. The results showed that loganin was quickly absorbed and eliminated in rats, with low bioavailability. Loganin was highly distributed in the cortex compared to the hippocampus.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Chemistry, Multidisciplinary
Xuegu Xu, Shunbin Luo, Qiang Yang, Yingjie Wang, Wenlong Li, Guanyang Lin, Ren-ai Xu
Summary: An advanced UPLC-MS/MS method was developed to determine avapritinib concentration in rat plasma, demonstrating good linearity and a lower limit of quantification suitable for pharmacokinetic studies. The method involved the addition of acetonitrile and a gradient elution procedure, with reliable precision and accuracy for avapritinib analysis.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Yuxiang Xu, Xiaonan Gao, Yunfang Zhu, Qi Zhang, Hongxin Qie, Haopeng Zhao, Jinglin Gao, Mingxia Wang
Summary: In this study, a UPLC-MS/MS method was developed for the quantitative analysis of pentoxifylline in beagle dog plasma and applied to a pharmacokinetic study. It was found that the administration of pentoxifylline sustained-release tablets with food significantly increased the AUC(0-t) and C-max values.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2023)
Article
Pharmacology & Pharmacy
Wei Liu, Xiuyun Li, Na Li, Ze Mi, Na Li, Jinjing Che
Summary: A UPLC-MS/MS method was developed to quantify Icariin and its metabolites in the whole blood of mice. The study found that Icariin was rapidly converted into Icariside II after intravenous administration, and Icariin and Icariside I were not detected after intragastric administration.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Ying Wang, Guan-An Zhao, Xia Li, En Zhang, Wei Tan, Jia-qi Chen
Summary: A fast, simple, and sensitive UPLC-MS/MS method was established for the quantification of safinamide in rat plasma. The method showed high stability, low noise, short chromatographic run time, wide linear range, small sample and injection volumes, and high sensitivity, making it suitable for pharmacokinetics and preclinical and clinical studies.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Li Ping, Xinwei Dong, Minjuan Zuo, Yawen Hong, Difeng Zhu
Summary: This study developed a method for measuring Hu7691 in dog plasma, a selective AKT inhibitor developed at Zhejiang University. The method utilized ultra-performance liquid chromatography-tandem mass spectrometry for fast and efficient drug quantification. The results showed that Hu7691 exhibited high bioavailability in dogs, providing a basis for its clinical application.
APPLIED SCIENCES-BASEL
(2022)
Article
Biochemical Research Methods
Hongli Mu, Wenyu Zhang, Yuanming Song, Rui Liang, Hengli Zhao, Chunhong Song, Qing Wen
Summary: An ultra-performance liquid chromatography-tandem mass spectrometry method was developed for the determination of baloxavir acid (BXA) and baloxavir marboxil (BXM) concentrations, as well as for studying the pharmacokinetics of BXA. The method showed good linearity and accuracy, with a lower limit of quantification of 3.00 ng/mL. This method is suitable for clinical research on BXA determination and pharmacokinetic studies.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Biochemical Research Methods
Hongli Mu, Wenyu Zhang, Yuanming Song, Rui Liang, Hengli Zhao, Chunhong Song, Qing Wen
Summary: In this study, an ultra-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of baloxavir acid concentrations and active ingredients in the antiviral drug baloxavir marboxil. The method was successfully applied to study the pharmacokinetics of baloxavir acid. The developed method showed good linearity and accuracy, making it suitable for clinical research in drug determination and pharmacokinetic studies.
BIOMEDICAL CHROMATOGRAPHY
(2023)
Article
Medicine, Research & Experimental
Yu Long, Songyu Liu, Jinyan Wan, Yulu Zhang, Dan Li, Shuang Yu, Ai Shi, Nan Li, Fei He
Summary: This study investigated the effect of BO-BA-LP on improving blood-brain barrier integrity. The results showed that BO-BA-LP could increase the ability of BA to penetrate the cell membrane, leading to increased concentrations of BA in plasma and brain tissues. BO-BA-LP also improved neurological function and histopathology in CIRI mice.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Gabriele Vilkickyte, Vida Motiekaityte, Rimanta Vainoriene, Mindaugas Liaudanskas, Lina Raudone
Summary: This study established a rapid, simple, and validated method for analyzing and authenticating Vaccinium berry samples.
JOURNAL OF BERRY RESEARCH
(2021)
Article
Chemistry, Multidisciplinary
Xuegu Xu, Chaojie Chen, Ya-nan Liu, Xiaolei Meng, Jian-ping Cai, Ren-ai Xu
Summary: This study optimized an analytical method using UPLC-MS/MS for the determination of Infigratinib concentrations in rat plasma and pharmacokinetic studies. The method demonstrated high linearity and accuracy, with good reproducibility and rapidity.
ARABIAN JOURNAL OF CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Pengfei Zhao, Ying Qi
Summary: In this study, a reliable UPLCESI-MS/MS method was developed for the quantification of TA in human plasma after a single intramuscular injection. The method was validated and shown to accurately determine TA concentrations in plasma with high precision and accuracy. The results indicated that the test and reference formulations of TA exhibited bioequivalence in healthy Chinese volunteers.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Engineering, Chemical
Muzaffar Iqbal, Mohammad Raish, Ajaz Ahmad, Essam A. Ali, Yousef A. Bin Jardan, Mushtaq A. Ansari, Mudassar Shahid, Abdul Ahad, Khalid M. Alkharfy, Fahad I. Al-Jenoobi
Summary: The study found that when Ibrutinib interacts with Sinapic acid, it may influence the pharmacokinetics of Ibrutinib and result in increased bioavailability. This may be due to the inhibition of IBR metabolism in the liver and intestines by SA.
Article
Plant Sciences
Mohd Amir, Ameeduzzafar Zafar, Rizwan Ahmad, Wasim Ahmad, Mohammad Sarafroz, Mohammad Khalid, Mohammed M. Ghoneim, Sultan Alshehri, Shadma Wahab, Sayeed Ahmad, Mohd Mujeeb
Summary: The increase in the use of herbal medicines has led to more stringent regulations for quality variation and standardization. This study aimed to standardize Prunus domestica Linn. using various evaluation techniques, advanced instrumental analysis, and biological and toxicological techniques. The results showed that the fruit met quality requirements and did not contain harmful substances beyond the permissible limits.
Article
Instruments & Instrumentation
Pavitra Solanki, Mohd Danish Ansari, Mohd Iqbal Alam, Mohd Aqil, Farhan J. Ahmad, Yasmin Sultana
Summary: This study developed an orally effective nanoformulation of disodium pamidronate for the treatment of osteoporosis. Through rational design and optimization, a commercially potential self nano-emulsifying drug delivery system (SNEDDS) was developed, which showed improved oral bioavailability and enhanced anti-osteoporotic activity. The study provided significant achievements in the treatment of postmenopausal osteoporosis and may lead to the use of nanotherapeutic-driven emerging biodegradable carriers-based drug delivery.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Mohammad Sameer Khan, Sauban Ahmed Khan, Shaheen Shabbir, Md Umar, Sradhanjali Mohapatra, Tahir Khuroo, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Zeenat Iqbal, Mohd Aamir Mirza
Summary: 4D printing, an advanced version of 3D printing, combines smart materials and the fourth dimension of time. It is widely used in sectors such as healthcare, with applications including self-adjusting stents, artificial muscles, and drug delivery. Further research is needed to explore more responsive materials and technologies.
Article
Pharmacology & Pharmacy
Sradhanjali Mohapatra, Mohd. Aamir Mirza, Sayeed Ahmad, Uzma Farooq, Mohammad Javed Ansari, Kanchan Kohli, Zeenat Iqbal
Summary: Black cohosh is a popular herb used to alleviate menopausal symptoms. This study aimed to develop an ethosomal gel containing a triterpene enriched fraction from black cohosh and evaluate its efficacy through transdermal application. By using a quality by design approach, the optimized ethosomal gel showed better performance compared to the conventional gel. Additional animal studies are needed to further validate these results.
Review
Infectious Diseases
Athar Shamim, Asgar Ali, Zeenat Iqbal, Mohd Aamir Mirza, Mohd Aqil, S. M. Kawish, Ayesha Siddiqui, Vijay Kumar, Punnoth Poonkuzhi Naseef, Abdulkhaliq Ali F. Alshadidi, Mohamed Saheer Kuruniyan
Summary: Studies on biofilm-related infections are gaining prominence due to their involvement in most clinical infections and serious threat to global public health. Biofilm is a natural form of bacterial growth that is ubiquitous in ecological niches and acts as a survival mechanism for both pathogenic and non-pathogenic microorganisms. Quorum sensing plays a crucial role in biofilm development. Biofilm formation leads to increased resistance to antibiotics and antimicrobial agents. Natural plant-derived phytomedicines, including various compounds such as flavonoids, terpenoids, lectins, alkaloids, polypeptides, polyacetylenes, phenolics, and essential oils, are being explored as alternative and safe therapies with minimal side effects for controlling biofilm production and growth.
Article
Chemistry, Multidisciplinary
Manvi Singh, Abdul Rehman, Nazia Hassan, Abdul Anfey Faheem, Ayan Das, Mohammad Akhlaquer Rahman, Mohammad Javed Ansari, Nilima Sharma, Mridu Dudeja, Mohd Aqil, Mohd Aamir Mirza, Zeenat Iqbal
Summary: A ciprofloxacin-loaded water-in-oil nanoemulsion (CPX-NE) was prepared and evaluated for its antimicrobial effect against oral biofilms produced by Enterococcus faecalis. The CPX-NE showed optimal rheological parameters, similar pH to the oral cavity, uniform spherical nanodroplets with narrow size distribution and stable charge. In vitro drug release demonstrated sustained release for 48 hours. CPX-NE exhibited significant inhibitory and eradication effect compared to the plain drug solution. Therefore, CPX-NE has effective antibiofilm activity against E. faecalis and may be useful in the prevention and treatment of dental caries.
Review
Chemistry, Medicinal
Ashraf Ullah Khan, Adnan Khan, Bushra Shal, Salman Khan, Majid Khan, Rizwan Ahmad, Muhammad Riaz
Summary: Cancer is a major global health issue, with increasing cases each year. The development of cancer is influenced by various factors such as radiation, lifestyle, smoking, environment, and genetics. The cell cycle, regulated by molecular signaling proteins, is disrupted when these proteins are altered, affecting cellular growth and proliferation. Natural products, including phytosterols, have shown promising anti-cancer activities by modulating molecular signaling pathways involved in the tumor microenvironment. Further research is required to establish the clinical efficacy and safety of phytosterols.
PHYTOTHERAPY RESEARCH
(2023)
Article
Acoustics
Rizwan Ahmad, Mohammed Aldholmi, Aljawharah Alqathama, Ebtihal Althomali, Fatema Aljishi, Ahmed Mostafa, Abdulmalik M. Alqarni, Heba Shaaban
Summary: This is the first report to evaluate the effect of natural antioxidants, pH, and green solvents on the yield and stability of catechins during the extraction process from green tea leaves. The results showed that using green solvents augmented with natural antioxidants and at a low pH of 2 resulted in the highest yield and better stability of catechins.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Acoustics
Rizwan Ahmad, Aljawharah Alqathama, Mohammed Aldholmi, Muhammad Riaz, Sayed M. Eldin, Mohammad Mahtab Alam, Shaimaa A. M. Abdelmohsen
Summary: This study reports the simultaneous determination of flavonoids in fenugreek seeds samples using a green UHPLC-DAD analysis. Different polarity solvents were used for the ultrasound-assisted extraction of flavonoids. The results showed significant variations in the flavonoid content among different origins of fenugreek seeds.
ULTRASONICS SONOCHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Nazia Hassan, Uzma Farooq, Ayan Kumar Das, Kalicharan Sharma, Mohd. Aamir Mirza, Suhail Fatima, Omana Singh, Mohammad Javed Ansari, Asgar Ali, Zeenat Iqbal
Summary: This study aims to develop a tailored vaginal drug delivery system for the treatment of drug-resistant Candida vulvovaginitis involving multispecies of Candida and epithelium-bound biofilm. A luliconazole-loaded nanostructured lipid carrier-based transvaginal gel was fabricated to combat Candida albicans biofilm and alleviate the disease. In silico tools were used to assess the interaction and binding affinity of luliconazole against C. albicans proteins and biofilm. The optimized nanogel formulation showed suitable characteristics, such as small particle size, non-Newtonian flow behavior, and high drug release and permeation rates.
Article
Chemistry, Medicinal
Rizwan Ahmad, Aljawharah Alqathama, Mohammed Aldholmi, Muhammad Riaz, Ashraf N. Abdalla, Fatema Aljishi, Ebtihal Althomali, Mohd Amir, Omeima Abdullah, Muntathir Ali Alamer, Deema Alaswad, Wala Alsulais, Ahad Alsulays
Summary: This study comprehensively screened the biological activities of all four parts of mango fruit from twelve different origins and found that the seed part exhibited significant biological activities. Further metabolomic and in vivo studies are essential to effectively utilize the seed part for the treatment of various diseases.
Review
Biochemistry & Molecular Biology
Mohammad Sameer Khan, Sradhanjali Mohapatra, Vaibhav Gupta, Ahsan Ali, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kurunian, Abdulkhaliq Ali F. Alshadidi, Md Shamsher Alam, Mohd. Aamir Mirza, Zeenat Iqbal
Summary: In recent years, the pharmaceutical and biomedical fields have achieved remarkable advancements in medicine, diagnostics, and drug delivery, with nanotechnology-based tools playing a major role. The use of nanotechnology in drug delivery has led to the development of innovative strategies and materials to improve patient compliance. Lipid-based nanocarriers offer a potential solution to overcome biological barriers, such as the skin and blood-brain barrier, by facilitating drug penetration and enhancing their effectiveness.
Article
Polymer Science
Rahmuddin Khan, Mohd. Aamir Mirza, Mohd Aqil, Thomson Santosh Alex, Nafis Raj, Nikhat Manzoor, Punnoth Poonkuzhi Naseef, Mohamed Saheer Kuruniyan, Zeenat Iqbal
Summary: This study developed a nanotherapeutic consisting of bioactives to improve the treatment outcomes of psoriasis.
Article
Chemistry, Multidisciplinary
Manvi Singh, Abdul Rehman, Nazia Hassan, Abdul Anfey Faheem, Ayan Das, MohammadAkhlaquer Rahman, Mohammad Javed Ansari, Nilima Sharma, Mridu Dudeja, Mohd Aqil, Mohd. Aamir Mirza, Zeenat Iqbal
Summary: A ciprofloxacin-loaded nanoemulsion was prepared and found to have effective antimicrobial activity against oral biofilms produced by Enterococcus faecalis, suggesting potential applications in the prevention and treatment of dental caries.
Article
Biochemistry & Molecular Biology
Wei-Han Hui, Yen-Lin Chen, Shu-Wei Chang
Summary: Crosslinking affects the mechanical behavior and tissue metabolism of collagen-based tissues. Aging and diabetes alter the crosslinking type and density, thus changing tissue properties. High-connectivity enzymatic crosslinking and advanced-glycation end-products result in uniform deformation under daily activity, while low-connectivity enzymatic crosslinking does not. High-connectivity model displays more sliding, while AGEs induce instability in structures near the binding sites.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yao-Bin Ma, Xiao-Qiu Zhou, Wei-Dan Jiang, Pei Wu, Yang Liu, Shu-Wei Li, Ling Tang, Lu Zhang, Hai-Feng Mi, Lin Feng
Summary: Tea polyphenols (TPs) are an inexpensive feed additive that can protect the gill function of fish against Flavobacterium columnare (F. columnare) through various mechanisms, including suppression of oxidative stress, apoptosis, and inflammation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Yan-Jia Guo, Jing-Ru Pang, Yu Zhang, Zhong-Rui Li, Xiao-Lin Zi, Hong-Min Liu, Ning Wang, Li-Juan Zhao, Ya Gao, Bo Wang, Piet Herdewijn, Cheng-Yun Jin, Ying Liu, Yi-Chao Zheng
Summary: This study identifies the conjugation of NEDD8 to LSD1 and its impact on GC cells, revealing the significance of LSD1 neddylation in GC.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Geum-Jae Jeong, Fazlurrahman Khan, Nazia Tabassum, Young-Mog Kim
Summary: Vibrio species are motile gram-negative bacteria commonly found in aquatic environments. They can adapt to environmental fluctuations and develop protective mechanisms against host immune systems. Different types of sigma and anti-sigma factors play important roles in regulating gene expression and virulence in Vibrio species.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Zahra Mohammadbagheri, Behrooz Movahedi, Shaghayegh Saeedi, Abbas Rahmati
Summary: In this study, a reusable biobased composite hydrogel was successfully synthesized and used for the removal of Tl(I) from aqueous solutions. The hydrogel exhibited high adsorption capacity and thermal stability, and the adsorption process was found to be thermodynamically spontaneous. The results demonstrated that the hydrogel can be reused multiple times without significant loss of its adsorption capacity.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Iqra Batool, Muhammad Imran, Ayesha Anwar, Farhan Ahmed Khan, Afrah E. Mohammed, Ashwag Shami, Hafiz Iqbal
Summary: Enzyme immobilization on ZnO/SnO2 and ZnO/SnO2/SA nanocomposites was studied, and the catalytic and biochemical characteristics of the immobilized enzyme were investigated. The results showed that ZnO/SnO2 and ZnO/SnO2/SA nanostructures are suitable carriers for enzyme immobilization.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Elias Mosaffa, Dhruvi Patel, Nasim Amiri Ramsheh, Rishikumar Indravadan Patel, Atanu Banerjee, Hossein Ghafuri
Summary: In this study, a unique 3D bead structure of adsorbent, composed of bacterial cellulose microfilaments reinforced chitosan adorned with melamine 2D plates, was synthesized for anionic dye removal. The adsorbent showed high specific surface area and abundant functional groups, resulting in exceptional adsorption capacity. The characteristics and optimal conditions of the adsorbent were assessed and analyzed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Carolina Gismene, Jorge Enrique Hernandez Gonzalez, Marilia de Freitas Calmon, Andrey Fabricio Ziem Nascimento, Angela Rocio Nino Santisteban, Felipe Antunes Calil, Alana Della Torre da Silva, Paula Rahal, Rejane Maira Goes, Raghuvir Krishnaswamy Arni, Ricardo Barros Mariutti
Summary: Mammaliicoccus sciuri, a bacterium of clinical and veterinary relevance, expresses the virulence factor Exfoliative Toxin C (ExhC), which binds specifically to desmoglein-1 (Dsg1) and plays a role in tissue integrity. This study investigates the necrotic activity of ExhC and identifies a variant lacking necrotic potential but retaining enzymatic activity through mutagenesis experiments and crystal structure determination.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Bibhas K. Bhunia, Ashutosh Bandyopadhyay, Souradeep Dey, Biman B. Mandal
Summary: Intervertebral disc degeneration is a major cause of chronic low back pain and disability. Researchers have developed a bioactive silk-based hybrid hydrogel system functionalized with decellularized human Wharton's jelly extracellular matrix as bioactive cues. The hydrogels mimic the rheological and mechanical properties of the native nucleus pulposus tissue and support cell viability, proliferation, and tissue maturation.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Qun Zhang, Yonggan Yan, Zhao Li, Jing Du, Kai Zhang, Liguo Zhang, Ting Wang, Alberto Bianco, Shaohua Ge, Baojin Ma
Summary: A new crosslinking strategy has been devised to construct injectable sodium alginate hydrogels, which can be regulated for injectability and have great potential in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Seong Eun Hong, Ji-Soo Lee, Hyeon Gyu Lee
Summary: The potential of multi-layer nanoemulsions for improving the cellular uptake, antioxidant activity, and in vitro bioaccessibility of alpha-tocopherol was examined. The results showed that the multi-layer nanoemulsions significantly enhanced the cellular uptake and antioxidant activity of alpha-tocopherol compared to free coumarin 6. Furthermore, the use of chitosan and dextran sulfate as wall materials in the multi-layer nanoemulsions led to even higher cellular uptake, in vitro bioaccessibility, and antioxidant activity of alpha-tocopherol.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jingjing Yu, Yanhui Zhang, Ruoning Zhang, Yanxiang Gao, Like Mao
Summary: High internal phase emulsions (HIPEs) based on beeswax (BW) oleogels and octenyl succinic acid starch (OSA starch) were prepared by a simple one-step method. The results showed that oleogelation improved the stability and encapsulation capability of the HIPEs, which is significant for the development of novel healthy food.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Bi-Feng Yao, Xiu-Ju Luo, Jun Peng
Summary: The balanced and continuous fission and fusion of mitochondria, regulated by OPA1, are important for maintaining mitochondrial dynamics in cardiovascular disorders. Understanding the role of OPA1 in mitochondrial fusion can provide insights into the pathogenesis of cardiovascular diseases.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Review
Biochemistry & Molecular Biology
Gokul Paramasivam, Anandhavelu Sanmugam, Vishnu Vardhan Palem, Murugan Sevanan, Ananda Babu Sairam, Nachiappan Nachiappan, Buhyun Youn, Jung Sub Lee, Muthuchamy Nallal, Kang Hyun Park
Summary: Nanomaterials are being used to deliver therapeutic agents in living systems. Different nanotechnological applications such as immunosensors, immune assays, and drug delivery are being implemented using nanotechnology. Genomics plays a crucial role in selecting appropriate drugs for personalized cancer therapy. It helps in analyzing gene and protein expression, disease classification, and designing disease models. Delivering drugs to specific areas using nanoparticles is a challenging issue.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Article
Biochemistry & Molecular Biology
Jing Li, Wei Wang, Han Wu, Feng Peng, Hui Gao, Ying Guan
Summary: In this study, CMH-based CPF films were prepared and their thermal and barrier properties were successfully regulated. The tensile strength and water vapor barrier property of CPF films were significantly improved, making them promising for food packaging applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
