Article
Acoustics
Harshani Iresha, Takaomi Kobayashi
Summary: A ultrasound-triggered nicotine release system was developed using a cellulose hydrogel drug carrier, showing that cellulose concentration had significant impact on nicotine release efficiency; hydrogels prepared with 0.9 wt% cellulose exhibited the best nicotine release performance under ultrasound irradiation.
ULTRASONICS SONOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Xiangyu Lin, Lizhen Guo, Hiba Shaghaleh, Yousef Alhaj Hamoud, Xu Xu, He Liu
Summary: A novel MOF MIL-100(Fe)@CNFs hydrogel for slow-release fertilizers with temperature and pH response was prepared. Characterization of the hydrogels and evaluation using urea as a model fertilizer showed that MC10% hydrogels exhibited superior swelling capacity, water-retention, and slow-release performance. Additionally, wheat fertilized with MC hydrogels showed increased growth and photosynthetic rate.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Polymer Science
Tanpong Chaiwarit, Baramee Chanabodeechalermrung, Nutthapong Kantrong, Chuda Chittasupho, Pensak Jantrawut
Summary: Water hyacinth is a rapidly growing aquatic weed that negatively impacts the aquatic environment. However, it is rich in cellulose, a biodegradable material. This study isolated cellulose from water hyacinth and used it to fabricate composite hydrogels. The hydrogel exhibited good physical properties, antibacterial activity, and no toxicity to human cells.
Article
Chemistry, Applied
Hossam E. Emam, Tharwat Shaheen
Summary: In this study, new stimuli-responsive hybrid hydrogels were successfully created by incorporating succinylated cellulose nanocrystals (Su-CNC) into the hydrogel network. The hydrogels exhibited pH and thermo-responsive characteristics, with significant swelling behavior at pH 6 and shrinkage at temperatures above 35 degrees C.
CARBOHYDRATE POLYMERS
(2022)
Article
Nanoscience & Nanotechnology
Hongyue Wang, Lin Wang, Shasha Guo, Zehao Liu, Luqing Zhao, Renzhong Qiao, Chao Li
Summary: An active flavonoid compound, rutin, was incorporated into a guanosine phenylborate hydrogel (GBR) for the treatment of inflammatory bowel disease (IBD). The hydrogel exhibited good stability and injectability, and achieved dual-responsive release in an acidic pH and excessive ROS-containing medium. In vivo studies showed that the GBR hydrogel had higher therapeutic efficacy than free rutin and could suppress the expression of inflammatory cytokines.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Li Ching Wong, Jia Huey Poh, Wan Ting Tan, Boon-Keat Khor, Vikneswaran Murugaiyah, Cheu Peng Leh, Choon Fu Goh
Summary: This study aims to develop a hydrogel for dermal drug delivery using cellulose extracted from oil palm empty fruit bunches, and evaluate the effects of alkali solvent compositions on hydrogel formation. The hydrogels formed with 7%w/v NaOH and 4%w/v urea showed excellent biodegradability, low cytotoxicity, and high drug permeation into the skin.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Polymer Science
Mohamed F. Attia, Ahmed S. Montaser, Md Arifuzzaman, Megan Pitz, Khouloud Jlassi, Angela Alexander-Bryant, Stephen S. Kelly, Frank Alexis, Daniel C. Whitehead
Summary: In this study, electrospun cellulose acetate nanofibers loaded with a non-steroidal anti-inflammatory drug and coated with poly(acrylamide) hydrogel polymer were developed and characterized. The presence of the poly-AAm hydrogel polymer significantly affected the release kinetics of the drug, promoting a more consistent release rate compared to non-coated nanofibers. The coated nanofibers showed significantly higher drug release concentrations compared to non-coated nanofibers, and overall demonstrated excellent cytocompatibility.
Article
Polymer Science
Golnar Shekari, Maryam Kalantari, Hassan Hashemipour
Summary: This study investigated the synthesis of hydrogel and nanocomposite based on modified cellulose. The synthesized hydrogel showed high water absorbency and exhibited good performance in biomedical applications. The drug release experiment demonstrated sustained control release from the synthesized hydrogel and the CNT nanocomposite structure. MTT assay results indicated that the synthesized hydrogel had no toxicity at various concentrations.
JOURNAL OF POLYMER RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Seulgi Kim, Myeongkwan Song, Minseon Lee, Soonjo Kwon
Summary: Although quercetin inhibits melanogenesis, it is cytotoxic at high concentrations. Porous hydrogel carriers made of hydroxypropyl methylcellulose (HPMC) and gellan gum were prepared for the controlled release of quercetin, acting as a whitening agent. The release rate of quercetin from the hydrogel decreased with increasing content of gellan gum, making the HPMC/gellan gum hydrogel a potential delivery vehicle for non-cytotoxic release of quercetin.
KOREAN JOURNAL OF CHEMICAL ENGINEERING
(2023)
Article
Chemistry, Applied
Huazhong Ma, Juan Yu, Liang Liu, Yimin Fan
Summary: This study prepared TEMPO-oxidized nanocellulose and nanochitin-based hydrogels, demonstrating the diversity of release capacity of the hydrogels in different pH environments, with potential applications in specific areas such as drug delivery, wound dressing, and food packaging.
CARBOHYDRATE POLYMERS
(2021)
Review
Polymer Science
Zhenghui Li, Ming Zhang
Summary: The development of slow-release fertilizer (SRF) is important for addressing challenges in agriculture such as water scarcity, low fertilizer utilization, food security, and environmental sustainability. This study analyzes various methods for preparing stimulus-responsive cellulose hydrogels and their combinations with different fertilizers. The application and release mechanism of stimulus-responsive cellulose hydrogels in SRF are summarized, and potential issues and solutions are discussed, along with future research directions.
Article
Chemistry, Physical
Mahdiye Poorsargol, Abbas Rahdar, Francesco Baino, Pouya Karimi
Summary: In this study, a quercetin-loaded microemulsion was designed and the mechanism of action of quercetin in both bulk and microemulsion forms was investigated using simulation techniques. The simulation results showed that quercetin molecules quickly accumulated around 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radicals in the bulk form, while the accumulation was slower in the microemulsion form. The stable release of quercetin in the microemulsion form was found to be due to strong van der Waals interactions between quercetin and F127.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Pharmacology & Pharmacy
Diana Elena Ciolacu, Raluca Nicu, Dana Mihaela Suflet, Daniela Rusu, Raluca Nicoleta Darie-Nita, Natalia Simionescu, Georgeta Cazacu, Florin Ciolacu
Summary: Considering the complex process of wound healing, an ideal wound dressing should possess multiple functionalities, including biocompatibility, biodegradability, moisture retention, antibacterial properties, wound protection, and wound healing promotion. In this study, a multifunctional hydrogel was designed using cellulose and chemically modified lignin, showing promising structural and morphological characteristics. The results demonstrate that the hydrogel has improved drug encapsulation and release, antibacterial properties, and mucoadhesion compared to cellulose-based hydrogels.
Article
Biochemistry & Molecular Biology
Ankit Verma, Bhawna Sharma, Susheel Kalia, Walaa Fahad Alsanie, Sourbh Thakur, Vijay Kumar Thakur
Summary: The current research focuses on synthesizing and improving the NaCMC-cl-DMAA/AAc hydrogel and controlling the release of gentamicin in different pH environments. The hydrogel was modified using boron nitride nanosheets to enhance adsorption rate. Various analyses were conducted on the hydrogel, including FTIR, XRD, FESEM, TGA/DSC, swelling, and cell viability analysis. The results showed that the hydrogel had cytocompatibility and the drug release properties could be controlled by changing the pH environment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Review
Biochemistry & Molecular Biology
Ilker S. Bayer
Summary: Polymer nanofibers have high surface area for efficient transport, while hydrogels combine flexibility and customizable transport properties. Combining nanofibers with hydrogels advances biomedical applications, especially in sustained drug delivery. Nanofiber hydrogels can maintain drug release rates for days to months and are crucial for 3D or 4D printable systems.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)