Article
Immunology
Ankit Tanwar, Pamela Stanley
Summary: Glycosylation of Notch receptors by O-fucose glycans regulates the production and development of lymphoid and myeloid cells during hematopoiesis.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Dermatology
Mitchell E. Fane, Yash Chhabra, Loredana Spoerri, Jacinta L. Simmons, Raquelle Ludwig, Elise Bonvin, Colin R. Goding, Richard A. Sturm, Glen M. Boyle, Nikolas K. Haass, Michael Piper, Aaron G. Smith
Summary: A reciprocal relationship between BRN2 and NOTCH1/2 signaling exists in melanoma cells, bolstering acquisition of invasiveness. Working through the epigenetic modulator EZH2, the BRN2-NOTCH1/2 axis is potentially a key mechanism by which the invasive phenotype is maintained.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Xiyan Xiang, Kazufumi Ohshiro, Sobia Zaidi, Xiaochun Yang, Krishanu Bhowmick, Anil K. Vegesna, David Bernstein, James M. Crawford, Bibhuti Mishra, Patricia S. Latham, Nancy R. Gough, Shuyun Rao, Lopa Mishra
Summary: This study reveals the significance of reciprocal regulation between transforming growth factor-beta (TGF-beta) signaling pathway and SIRT6 in liver pathologies, which is crucial for the development of fatty liver and hepatocellular cancer.
Review
Endocrinology & Metabolism
Yongxiang Li, Qingyan Jiang, Lina Wang
Summary: Appetite is essential for normal metabolism, and inflammation can impact both homeostatic and non-homeostatic systems of appetite, with the physiological functions still largely unknown. This review focuses on the structures of these systems and discusses how TLR4-induced inflammatory signaling contributes to regulating appetite in both systems, providing potential for new therapeutic interventions.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Immunology
Hongli Mao, Jinlin Jia, Jinxiu Sheng, Shanfeng Zhang, Kaida Huang, Hongle Li, Fucheng He
Summary: The study found that Regenerating islet-derived protein 1-alpha (REG1A) was significantly increased in inflamed colorectal tissues of inflammatory bowel disease (IBD) patients, and it could inhibit inflammatory responses, promote cell proliferation, and suppress epithelial apoptosis. IL-6 and IL-22 activated REG1A transcription through the JAK/STAT3 signaling pathway. Overexpression of REG1A in mice alleviated DSS-induced inflammatory injury and maintained intestinal mucosal barrier integrity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Guijie Guo, Ming Gao, Xiaochen Gao, Bibo Zhu, Jinzhou Huang, Xinyi Tu, Wootae Kim, Fei Zhao, Qin Zhou, Shouhai Zhu, Zheming Wu, Yuanliang Yan, Yong Zhang, Xiangyu Zeng, Qian Zhu, Ping Yin, Kuntian Luo, Jie Sun, Min Deng, Zhenkun Lou
Summary: The study reveals that RIG-I is recruited to double-stranded breaks, suppressing non-homologous end joining and compromising DNA repair, while XRCC4 plays a crucial role in RIG-I immune signaling. This reciprocal regulation uncovers a new function of RIG-I in suppressing virus integration and DNA repair, while endowing XRCC4 with a pivotal role in enhancing innate immune response.
NATURE COMMUNICATIONS
(2021)
Review
Cell Biology
Shawn Ying Xuan Tan, Jieqiong Zhang, Wee-Wei Tee
Summary: This review discusses the interplay between epigenetics and inflammation. External and internal microenvironments contribute to epigenetic processes, and dysregulation of these processes can lead to cancer. Chronic inflammation plays a crucial role in the tumor microenvironment, and inflammatory signaling can modulate changes in the global epigenetic landscape.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Xue-Mei Yi, Mi Li, Yun-Da Chen, Hong-Bing Shu, Shu Li
Summary: The negative regulator USP38 and the E3 ubiquitin ligase TRAF6 reciprocally regulate the level and signaling of IL-33R through K27-linked polyubiquitination and deubiquitination, which is critical in the regulation of IL-33-triggered lung inflammatory response and pulmonary fibrosis.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemical Research Methods
Emma K. Jennings, David A. J. Lecky, Masahiro Ono, David Bending
Summary: This protocol utilizes Nr4a1-GFP Nr4a3-Tocky mice to study T cell receptor signaling, identifying optimal transgenic status and compatible fluorochromes for dual reporting. It has applications in TCR signaling and emphasizes the immediate analysis of cells post-staining to ensure high-quality datasets.
Review
Cell Biology
Lisa Mueller, Mechthild Hatzfeld, Rene Keil
Summary: Desmosomes are intercellular junctions that preserve tissue integrity by responding to context-dependent signals and transmitting them to change cell behavior. Their composition and size vary depending on tissue specific expression and differentiation state, and their constituent proteins are highly regulated by posttranslational modifications. This review summarizes how signaling pathways control desmosomes to modulate cell behavior.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tijana Suboticki, Olivera Mitrovic Ajtic, Emilija Zivkovic, Milos Diklic, Dragoslava Dikic, Milica Tosic, Bojana Beleslin-Cokic, Teodora Dragojevic, Mirjana Gotic, Juan F. Santibanez, Vladan Cokic
Summary: Chronic inflammation plays a crucial role in neoplastic disorders like myeloproliferative neoplasm, regulating angiogenesis. This study found that VEGF and IL-6 have different impacts on the expression of angiogenic factors in patients with MPN and HEL cells. VEGF was shown to regulate angiogenic factors in PMF while increasing their expression in PV through inflammation-related signaling pathways.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yeqing Ren, Biao Yang, Geng Guo, Jianping Zhang, Yanqi Sun, Dong Liu, Shihao Guo, Yongqiang Wu, Xiaogang Wang, Shule Wang, Wenju Zhang, Xiaolong Guo, Xuepeng Li, Ren Li, Jianhang He, Zihan Zhou
Summary: GBP2 plays a critical role in glioma by regulating the EGFR signaling pathway and interacting with KIF22, which suggests its potential as a therapeutic target for glioma treatment.
CELL DEATH DISCOVERY
(2022)
Review
Emergency Medicine
Xiaoxiang Wang, Yinghui Liu, Jia He, Jingru Wang, Xiaodong Chen, Ronghua Yang
Summary: This article reviews the regulation of hair follicles, HFSCs and related signaling pathways, summarizes previous research results, and reveals the regulatory mechanisms of HFSC proliferation and differentiation.
Article
Endocrinology & Metabolism
Vijay K. Sirohi, Theresa Medrano, Ana M. Mesa, Athilakshmi Kannan, Indrani C. Bagchi, Paul S. Cooke
Summary: This study reveals the importance of AKT activation in promoting uterine epithelial proliferation even when it is independent of E2/ESR1 signaling. Additionally, the role of membrane ESR1 in AKT activation is emphasized.
Article
Medicine, Research & Experimental
Genki Kiyama, Ken-ichi Nakashima, Kazumasa Shimada, Naoko Murono, Wataru Kakihana, Hideki Imai, Makoto Inoue, Takao Hirai
Summary: The study found that 3-O-acetyloleanolic acid stimulated the production of FGF21 and drove its expression through TGR5 receptor signaling. It was also shown that the activation of p38 mediator Nr4a1 expression is involved in this process.
BIOMEDICINE & PHARMACOTHERAPY
(2021)