Long non-coding RNA GAS5 acts as proliferation “brakes” in CD133+ cells responsible for tumor recurrence

Gas5 is an essential lncRNA regulator for self-renewal and pluripotency of mouse embryonic stem cells and induced pluripotent stem cells

(2018) Jiajie Tu et al.   Stem Cell Research & Therapy

Metabolic reprogramming of acute lymphoblastic leukemia cells in response to glucocorticoid treatment

(2018) Matheus Dyczynski et al.   Cell Death & Disease

Chemotherapy resistance and stemness in mitotically quiescent human breast cancer cells identified by fluorescent dye retention

(2018) Lewis A. Quayle et al.   CLINICAL & EXPERIMENTAL METASTASIS

lncRNA GAS5 Reverses EMT and Tumor Stem Cell-Mediated Gemcitabine Resistance and Metastasis by Targeting miR-221/SOCS3 in Pancreatic Cancer

(2018) Bingyan Liu et al.   Molecular Therapy-Nucleic Acids

NFκB-Mediated Invasiveness in CD133 + Pancreatic TICs Is Regulated by Autocrine and Paracrine Activation of IL1 Signaling

(2017) Alice Nomura et al.   MOLECULAR CANCER RESEARCH

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Dormant glioblastoma cells acquire stem cell characteristics and are differentially affected by Temozolomide and AT101 treatment

(2017) Vivian Adamski et al.   Oncotarget

Characterization of a new murine cell line of sarcomatoid hepatocellular carcinoma and its application for biomarker/therapy development

(2017) Chia-Hung Yen et al.   Scientific Reports

Inhibition of hypoxic response decreases stemness and reduces tumorigenic signaling due to impaired assembly of HIF1 transcription complex in pancreatic cancer

(2017) Olivia McGinn et al.   Scientific Reports

Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling

(2016) Chen Xu et al.   Nature Communications

Microenvironment mediated alterations to metabolic pathways confer increased chemo-resistance in CD133+ tumor initiating cells

(2016) Alice Nomura et al.   Oncotarget

Long Noncoding RNA GAS5: A Novel Marker Involved in Glucocorticoid Response

(2015) M. Lucafo et al.   CURRENT MOLECULAR MEDICINE

Minnelide effectively eliminates CD133+ side population in pancreatic cancer

(2015) Alice Nomura et al.   Molecular Cancer

Famine versus feast: understanding the metabolism of tumors in vivo

(2015) Jared R. Mayers et al.   TRENDS IN BIOCHEMICAL SCIENCES

CD133 initiates tumors, induces epithelial-mesenchymal transition and increases metastasis in pancreatic cancer

(2015) Alice Nomura et al.   Oncotarget

lncRNA GAS5 enhances G1 cell cycle arrest via binding to YBX1 to regulate p21 expression in stomach cancer

(2015) Yongchao Liu et al.   Scientific Reports

GAS5 Inhibits Gastric Cancer Cell Proliferation Partly by Modulating CDK6

(2015) Xiaoqiang Guo et al.   Oncology Research and Treatment

Aerobic Glycolysis: Beyond Proliferation

(2015) William Jones et al.   Frontiers in Immunology

Glucose-6-phosphate dehydrogenase plays a critical role in hypoxia-induced CD133+ progenitor cells self-renewal and stimulates their accumulation in the lungs of pulmonary hypertensive rats

(2014) Sukrutha Chettimada et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

CD133+ Tumor Initiating Cells in a Syngenic Murine Model of Pancreatic Cancer Respond to Minnelide

(2014) S. Banerjee et al.   CLINICAL CANCER RESEARCH

Downregulation of gas5 increases pancreatic cancer cell proliferation by regulating CDK6

(2013) Xiongxiong Lu et al.   CELL AND TISSUE RESEARCH

Colon Cancer Cells Escape 5FU Chemotherapy-Induced Cell Death by Entering Stemness and Quiescence Associated with the c-Yes/YAP Axis

(2013) Y. Touil et al.   CLINICAL CANCER RESEARCH

Downregulation of GAS5 Promotes Bladder Cancer Cell Proliferation, Partly by Regulating CDK6

(2013) Zhihong Liu et al.   PLoS One

Proliferation State and Polo-Like Kinase1 Dependence of Tumorigenic Colon Cancer Cells

(2012) Federica Francescangeli et al.   STEM CELLS

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Stem Cell Quiescence

(2011) L. Li et al.   CLINICAL CANCER RESEARCH

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Biological and Molecular Heterogeneity of Breast Cancers Correlates with Their Cancer Stem Cell Content

(2010) Salvatore Pece et al.   CELL

Quiescent Fibroblasts Exhibit High Metabolic Activity

(2010) Johanna M. S. Lemons et al.   PLOS BIOLOGY

Characterization and functional analysis of a slow cycling stem cell-like subpopulation in pancreas adenocarcinoma

(2009) Jennifer L. Dembinski et al.   CLINICAL & EXPERIMENTAL METASTASIS

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Growth arrest in human T-cells is controlled by the non-coding RNA growth-arrest-specific transcript 5 (GAS5)

(2008) M. Mourtada-Maarabouni et al.   JOURNAL OF CELL SCIENCE