Role of Fibroblast Growth Factors Receptors (FGFRs) in Brain Tumors, Focus on Astrocytoma and Glioblastoma

The Role of Rho GTPases in Motility and Invasion of Glioblastoma Cells

(2020) Houssam Al-Koussa et al.   Analytical Cellular Pathology

FGFR- gene family alterations in low-grade neuroepithelial tumors

(2020) Tejus A. Bale   Acta Neuropathologica Communications

FGF Signaling Pathway: A Key Regulator of Stem Cell Pluripotency

(2020) Majid Mossahebi-Mohammadi et al.   Frontiers in Cell and Developmental Biology

Pediatric low-grade glioma in the era of molecular diagnostics

(2020) Scott Ryall et al.   Acta Neuropathologica Communications

Phase 1, First-in-Human Study of Futibatinib, a Highly Selective, Irreversible FGFR1–4 Inhibitor in Patients with Advanced Solid Tumors

(2020) R. Bahleda et al.   ANNALS OF ONCOLOGY

Futibatinib is a novel irreversible FGFR 1-4 inhibitor that shows selective antitumor activity against FGFR-deregulated tumors

(2020) Hiroshi Sootome et al.   CANCER RESEARCH

TAS-120 Cancer Target Binding: Defining Reactivity and Revealing the First Fibroblast Growth Factor Receptor 1 (FGFR1) Irreversible Structure

(2019) Maria Kalyukina et al.   ChemMedChem

Headache and Brain Tumor

(2019) Shahram Hadidchi et al.   NEUROIMAGING CLINICS OF NORTH AMERICA

Tannic Acid Accelerates Cutaneous Wound Healing in Rats Via Activation of the ERK 1/2 Signaling Pathways

(2019) Yaqin Chen et al.   Advances in Wound Care

Cross-Talk between Fibroblast Growth Factor Receptors and Other Cell Surface Proteins

(2019) Latko et al.   Cells

Differential regulation of fibroblast growth factor receptor 1 trafficking and function by extracellular galectins

(2019) Marika Kucińska et al.   Cell Communication and Signaling

DNA repair in personalized brain cancer therapy with temozolomide and nitrosoureas

(2019) Bernd Kaina et al.   DNA REPAIR

Fibroblast Growth Factor Receptors (FGFRs): Structures and Small Molecule Inhibitors

(2019) Shuyan Dai et al.   Cells

Fibroblast Growth Factor Receptor Functions in Glioblastoma

(2019) Ana Jimenez-Pascual et al.   Cells

First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant Fibroblast Growth Factor 19 Signaling as a Driver Event in Hepatocellular Carcinoma

(2019) Richard D Kim et al.   Cancer Discovery

Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma

(2019) Megan A. Hatlen et al.   Cancer Discovery

P-glycoprotein (ABCB1/MDR1) limits brain accumulation and Cytochrome P450-3A (CYP3A) restricts oral availability of the novel FGFR4 inhibitor fisogatinib (BLU-554)

(2019) Wenlong Li et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Actionable FGFR1 and BRAF mutations in adult circumscribed gliomas

(2019) Elena Trisolini et al.   JOURNAL OF NEURO-ONCOLOGY

The role of fibroblast growth factor receptor (FGFR) protein-tyrosine kinase inhibitors in the treatment of cancers including those of the urinary bladder

(2019) Robert Roskoski   PHARMACOLOGICAL RESEARCH

Tumor-related epilepsy: epidemiology, pathogenesis and management

(2018) Dillon Y. Chen et al.   JOURNAL OF NEURO-ONCOLOGY

Reactive Astrocytes in Glioblastoma Multiforme

(2018) Xiudong Guan et al.   MOLECULAR NEUROBIOLOGY

WHO 2016 Classification of gliomas

(2018) P. Wesseling et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

A systemic insight into astrocytoma biology across different grades

(2018) Sohini Chakraborty et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A metabolic function of FGFR3-TACC3 gene fusions in cancer

(2018) Véronique Frattini et al.   NATURE

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

(2018) Brendan Farrell et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Receptor-Targeted Glial Brain Tumor Therapies

(2018) Puja Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

OUP accepted manuscript

(2017)   NEURO-ONCOLOGY

The 2016 WHO Classification of Tumours of the Central Nervous System: The Major Points of Revision

(2017) Takashi KOMORI   NEUROLOGIA MEDICO-CHIRURGICA

Glioma Subclassifications and Their Clinical Significance

(2017) Ricky Chen et al.   Neurotherapeutics

Glioma epigenetics: From subclassification to novel treatment options

(2017) Olga Gusyatiner et al.   SEMINARS IN CANCER BIOLOGY

Neural Cell Adhesion Molecules of the Immunoglobulin Superfamily Regulate Synapse Formation, Maintenance, and Function

(2017) Vladimir Sytnyk et al.   TRENDS IN NEUROSCIENCES

Characterization of gliomas: from morphology to molecules

(2017) Sean P. Ferris et al.   VIRCHOWS ARCHIV

Extent of Resection in Glioma–A Review of the Cutting Edge

(2017) Randy S. D’Amico et al.   World Neurosurgery

N-Cadherin and Fibroblast Growth Factor Receptors crosstalk in the control of developmental and cancer cell migrations

(2016) Thao Nguyen et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Expression patterns of Wnt signaling component, secreted frizzled-related protein 3 in astrocytoma and glioblastoma

(2016) NIVES PEĆINA-ŠLAUS et al.   Molecular Medicine Reports

FGFR-TACC gene fusions in human glioma

(2016) Anna Lasorella et al.   NEURO-ONCOLOGY

Radiation plus Procarbazine, CCNU, and Vincristine in Low-Grade Glioma

(2016) Jan C. Buckner et al.   NEW ENGLAND JOURNAL OF MEDICINE

Mechanism of FGF receptor dimerization and activation

(2016) Sarvenaz Sarabipour et al.   Nature Communications

Inhibition of the fibroblast growth factor receptor (FGFR) pathway: the current landscape and barriers to clinical application

(2016) Young Kwang Chae et al.   Oncotarget

FGFR3-TACC3 fusion in solid tumors: mini review

(2016) Ricardo Costa et al.   Oncotarget

Effects of Temozolomide and Radiotherapy on Brain Metastatic Tumor: A Systematic Review and Meta-Analysis

(2016) Wenhua Ma et al.   World Neurosurgery

Critical Care Management of Cerebral Edema in Brain Tumors

(2016) Yoshua Esquenazi et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Identification of Oncogenic and Drug-Sensitizing Mutations in the Extracellular Domain of FGFR2

(2015) J. Tanizaki et al.   CANCER RESEARCH

Targeting FGFR Signaling in Cancer

(2015) M. Touat et al.   CLINICAL CANCER RESEARCH

Overcoming the blood–brain tumor barrier for effective glioblastoma treatment

(2015) O. van Tellingen et al.   DRUG RESISTANCE UPDATES

Phase I Dose-Escalation Study of JNJ-42756493, an Oral Pan–Fibroblast Growth Factor Receptor Inhibitor, in Patients With Advanced Solid Tumors

(2015) Josep Tabernero et al.   JOURNAL OF CLINICAL ONCOLOGY

Current challenges in designing GBM trials for immunotherapy

(2015) Shiao-Pei Weathers et al.   JOURNAL OF NEURO-ONCOLOGY

The Activity of Malignancy May Determine Stroke Pattern in Cancer Patients

(2015) Anna G. Karlińska et al.   Journal of Stroke & Cerebrovascular Diseases

Heparan sulfate and heparin interactions with proteins

(2015) Maria C. Z. Meneghetti et al.   Journal of the Royal Society Interface

Isocitrate dehydrogenase mutations in gliomas

(2015) Matthew S. Waitkus et al.   NEURO-ONCOLOGY

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

Glioma Groups Based on 1p/19q, IDH, and TERT Promoter Mutations in Tumors

(2015) Jeanette E. Eckel-Passow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glioblastoma multiforme: Pathogenesis and treatment

(2015) Constantinos Alifieris et al.   PHARMACOLOGY & THERAPEUTICS

Fibroblast Growth Factor (FGF) Receptor/FGF Inhibitors: Novel Targets and Strategies for Optimization of Response of Solid Tumors

(2015) Cinta Hierro et al.   SEMINARS IN ONCOLOGY

L1-CAM and N-CAM: From Adhesion Proteins to Pharmacological Targets

(2015) Federico Colombo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The Blood–Brain Barrier

(2015) Richard Daneman et al.   Cold Spring Harbor Perspectives in Biology

The Activity of Malignancy May Determine Stroke Pattern in Cancer Patients

(2015) Anna G. Karlińska et al.   Journal of Stroke & Cerebrovascular Diseases

The Fibroblast Growth Factor signaling pathway

(2015) David M. Ornitz et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Growth-Factor-Driven Rescue to Receptor Tyrosine Kinase (RTK) Inhibitors through Akt and Erk Phosphorylation in Pediatric Low Grade Astrocytoma and Ependymoma

(2015) Mariska Sie et al.   PLoS One

Epidemiologic and Molecular Prognostic Review of Glioblastoma

(2014) J. P. Thakkar et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Kinase Domain Activation of FGFR2 Yields High-Grade Lung Adenocarcinoma Sensitive to a Pan-FGFR Inhibitor in a Mouse Model of NSCLC

(2014) Jeremy H. Tchaicha et al.   CANCER RESEARCH

The epidemiology of glioma in adults: a "state of the science" review

(2014) Q. T. Ostrom et al.   NEURO-ONCOLOGY

Genomic aberrations in the FGFR pathway: opportunities for targeted therapies in solid tumors

(2013) R. Dienstmann et al.   ANNALS OF ONCOLOGY

Fibroblast growth factor receptor 2 tyrosine kinase fusions define a unique molecular subtype of cholangiocarcinoma

(2013) Yasuhito Arai et al.   HEPATOLOGY

Glioblastoma and Other Malignant Gliomas

(2013) Antonio Omuro   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emergence of FGFR family gene fusions as therapeutic targets in a wide spectrum of solid tumours

(2013) Brittany C Parker et al.   JOURNAL OF PATHOLOGY

High rate of FGFR1 amplifications in brain metastases of squamous and non-squamous lung cancer

(2013) Matthias Preusser et al.   LUNG CANCER

FGF Receptors: Cancer Biology and Therapeutics

(2013) Masaru Katoh et al.   MEDICINAL RESEARCH REVIEWS

Activity of the Fibroblast Growth Factor Receptor Inhibitors Dovitinib (TKI258) and NVP-BGJ398 in Human Endometrial Cancer Cells

(2013) G. E. Konecny et al.   MOLECULAR CANCER THERAPEUTICS

The integrated landscape of driver genomic alterations in glioblastoma

(2013) Veronique Frattini et al.   NATURE GENETICS

Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma

(2013) David T W Jones et al.   NATURE GENETICS

Exploring mechanisms of FGF signalling through the lens of structural biology

(2013) Regina Goetz et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

N-cadherin/FGFR promotes metastasis through epithelial-to-mesenchymal transition and stem/progenitor cell-like properties

(2013) X Qian et al.   ONCOGENE

Targeting Wild-Type and Mutationally Activated FGFR4 in Rhabdomyosarcoma with the Inhibitor Ponatinib (AP24534)

(2013) Samuel Q. Li et al.   PLoS One

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

(2013) P. J. Killela et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Targetable FGFR Gene Fusions in Diverse Cancers

(2013) Yi-Mi Wu et al.   Cancer Discovery

Fibroblast Growth Factor Receptor Inhibitors as a Cancer Treatment: From a Biologic Rationale to Medical Perspectives

(2013) Maria Vittoria Dieci et al.   Cancer Discovery

Deregulated Signaling Pathways in Glioblastoma Multiforme: Molecular Mechanisms and Therapeutic Targets

(2012) Hua Mao et al.   CANCER INVESTIGATION

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

(2012) P. R. Gavine et al.   CANCER RESEARCH

L1CAM stimulates glioma cell motility and proliferation through the fibroblast growth factor receptor

(2012) Vishnu Mohanan et al.   CLINICAL & EXPERIMENTAL METASTASIS

Fibroblast growth factor receptor 2 gene amplification status and its clinicopathologic significance in gastric carcinoma

(2012) Eun-Jung Jung et al.   HUMAN PATHOLOGY

Adjuvant Procarbazine, Lomustine, and Vincristine Chemotherapy in Newly Diagnosed Anaplastic Oligodendroglioma: Long-Term Follow-Up of EORTC Brain Tumor Group Study 26951

(2012) Martin J. van den Bent et al.   JOURNAL OF CLINICAL ONCOLOGY

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

(2012) D. Singh et al.   SCIENCE

FGFR Genetic Alterations Predict for Sensitivity to NVP-BGJ398, a Selective Pan-FGFR Inhibitor

(2012) V. Guagnano et al.   Cancer Discovery

Fibroblast growth factors and their receptors in cancer

(2011) Jørgen Wesche et al.   BIOCHEMICAL JOURNAL

Surgical treatment of brain metastasis: A review

(2011) Melike Mut   CLINICAL NEUROLOGY AND NEUROSURGERY

Discovery of 3-(2,6-Dichloro-3,5-dimethoxy-phenyl)-1-{6-[4-(4-ethyl-piperazin-1-yl)-phenylamino]-pyrimidin-4-yl}-1-methyl-urea (NVP-BGJ398), A Potent and Selective Inhibitor of the Fibroblast Growth Factor Receptor Family of Receptor Tyrosine Kinase

(2011) Vito Guagnano et al.   JOURNAL OF MEDICINAL CHEMISTRY

Detailed Characterization of Alterations of Chromosomes 7, 9, and 10 in Glioblastomas as Assessed by Single-Nucleotide Polymorphism Arrays

(2011) Inês Crespo et al.   JOURNAL OF MOLECULAR DIAGNOSTICS

Corticosteroids in brain cancer patients: benefits and pitfalls

(2011) Jörg Dietrich et al.   Expert Review of Clinical Pharmacology

Polysialic Acid Neural Cell Adhesion Molecule (PSA-NCAM) is an adverse prognosis factor in glioblastoma, and regulates olig2 expression in glioma cell lines

(2010) Marie-Claude Amoureux et al.   BMC CANCER

Dynamic roles of FGF-2 and Anosmin-1 in the migration of neuronal precursors from the subventricular zone during pre- and postnatal development

(2010) Diego García-González et al.   EXPERIMENTAL NEUROLOGY

8p11 myeloproliferative syndrome: a review

(2010) Courtney C. Jackson et al.   HUMAN PATHOLOGY

Biochemical dissection of Anosmin-1 interaction with FGFR1 and components of the extracellular matrix

(2010) Verónica Murcia-Belmonte et al.   JOURNAL OF NEUROCHEMISTRY

Specification and Morphogenesis of Astrocytes

(2010) M. R. Freeman   SCIENCE

Fibroblast Growth Factors: Biology, Function, and Application for Tissue Regeneration

(2010) Ye-Rang Yun et al.   Journal of Tissue Engineering

Genomic imbalances in rhabdomyosarcoma cell lines affect expression of genes frequently altered in primary tumors: An approach to identify candidate genes involved in tumor development

(2009) Edoardo Missiaglia et al.   GENES CHROMOSOMES & CANCER

The binding of NCAM to FGFR1 induces a specific cellular response mediated by receptor trafficking

(2009) Chiara Francavilla et al.   JOURNAL OF CELL BIOLOGY

Pediatric Low-Grade Gliomas

(2009) Angela J. Sievert et al.   JOURNAL OF CHILD NEUROLOGY

Classification of brain tumor type and grade using MRI texture and shape in a machine learning scheme

(2009) Evangelia I. Zacharaki et al.   MAGNETIC RESONANCE IN MEDICINE

Analysis of the fibroblastic growth factor receptor-RAS/RAF/MEK/ERK-ETS2/brachyury signalling pathway in chordomas

(2009) Asem AE Shalaby et al.   MODERN PATHOLOGY

IDH1andIDH2Mutations in Gliomas

(2009) Hai Yan et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Precise Sequence of FGF Receptor Autophosphorylation Is Kinetically Driven and Is Disrupted by Oncogenic Mutations

(2009) E. D. Lew et al.   Science Signaling

Comprehensive genomic characterization defines human glioblastoma genes and core pathways

(2008) Roger McLendon et al.   NATURE

Malignant Gliomas in Adults

(2008) Patrick Y. Wen et al.   NEW ENGLAND JOURNAL OF MEDICINE

FGF5 as an oncogenic factor in human glioblastoma multiforme: autocrine and paracrine activities

(2008) S Allerstorfer et al.   ONCOGENE

Drug-sensitive FGFR2 mutations in endometrial carcinoma

(2008) A. Dutt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An Integrated Genomic Analysis of Human Glioblastoma Multiforme

(2008) D. W. Parsons et al.   SCIENCE

The TACC proteins: TACC-ling microtubule dynamics and centrosome function

(2008) Isabel Peset et al.   TRENDS IN CELL BIOLOGY