FGF Receptors: Cancer Biology and Therapeutics

Epithelial mesenchymal transition and tumor budding in aggressive colorectal cancer: Tumor budding as oncotarget

(2015)   Oncotarget

Activity of the Fibroblast Growth Factor Receptor Inhibitors Dovitinib (TKI258) and NVP-BGJ398 in Human Endometrial Cancer Cells

(2013) G. E. Konecny et al.   MOLECULAR CANCER THERAPEUTICS

Cancer genetics and genomics of human FOX family genes

(2012) Masuko Katoh et al.   CANCER LETTERS

AZD4547: An Orally Bioavailable, Potent, and Selective Inhibitor of the Fibroblast Growth Factor Receptor Tyrosine Kinase Family

(2012) P. R. Gavine et al.   CANCER RESEARCH

A comprehensive survey of genomic alterations in gastric cancer reveals systematic patterns of molecular exclusivity and co-occurrence among distinct therapeutic targets

(2012) Niantao Deng et al.   GUT

Ponatinib (AP24534), a Multitargeted Pan-FGFR Inhibitor with Activity in Multiple FGFR-Amplified or Mutated Cancer Models

(2012) J. M. Gozgit et al.   MOLECULAR CANCER THERAPEUTICS

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

Exome sequencing of gastric adenocarcinoma identifies recurrent somatic mutations in cell adhesion and chromatin remodeling genes

(2012) Zhi Jiang Zang et al.   NATURE GENETICS

FGFR2 Point Mutations in 466 Endometrioid Endometrial Tumors: Relationship with MSI, KRAS, PIK3CA, CTNNB1 Mutations and Clinicopathological Features

(2012) Sara A. Byron et al.   PLoS One

Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

(2012) D. Singh et al.   SCIENCE

FGF Receptor Inhibitors: Role in Cancer Therapy

(2012) Gennaro Daniele et al.   Current Oncology Reports

NP603, a novel and potent inhibitor of FGFR1 tyrosine kinase, inhibits hepatic stellate cell proliferation and ameliorates hepatic fibrosis in rats

(2011) Nan Lin et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Wnt3a stimulation elicits G-protein-coupled receptor properties of mammalian Frizzled proteins

(2011) Alexey Koval et al.   BIOCHEMICAL JOURNAL

Receptor Tyrosine Kinases and Targeted Cancer Therapeutics

(2011) Kenji Takeuchi et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

FGFR2 genotype and risk of radiation-associated breast cancer in Hodgkin lymphoma

(2011) Y. P. Ma et al.   BLOOD

A FGFR2 inhibitor, Ki23057, enhances the chemosensitivity of drug-resistant gastric cancer cells

(2011) Hong Qiu et al.   CANCER LETTERS

Overexpressed fibroblast growth factor receptor 2 in the invasive front of colorectal cancer: A potential therapeutic target in colorectal cancer

(2011) Yoko Matsuda et al.   CANCER LETTERS

E-3810 Is a Potent Dual Inhibitor of VEGFR and FGFR that Exerts Antitumor Activity in Multiple Preclinical Models

(2011) Ezia Bello et al.   CANCER RESEARCH

Beyond VEGF: Inhibition of the Fibroblast Growth Factor Pathway and Antiangiogenesis

(2011) C. Lieu et al.   CLINICAL CANCER RESEARCH

Development of RET Kinase Inhibitors for Targeted Cancer Therapy

(2011) L. Mologni   CURRENT MEDICINAL CHEMISTRY

Network of WNT and Other Regulatory Signaling Cascades in Pluripotent Stem Cells and Cancer Stem Cells

(2011) Masaru Katoh   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

FGF/MAPK/Ets signaling renders pigment cell precursors competent to respond to Wnt signal by directly controlling Ci-Tcf transcription

(2011) Paola Squarzoni et al.   DEVELOPMENT

Anti-VEGF and beyond: shaping a new generation of anti-angiogenic therapies for cancer

(2011) Francesco Bertolini et al.   DRUG DISCOVERY TODAY

ZNF703is a common Luminal B breast cancer oncogene that differentially regulates luminal and basal progenitors in human mammary epithelium

(2011) Daniel G. Holland et al.   EMBO Molecular Medicine

Physiological inhibitors of Wnt signaling

(2011) Alexandra Filipovich et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Mammary branch initiation and extension are inhibited by separate pathways downstream of TGFβ in culture

(2011) Amira L. Pavlovich et al.   EXPERIMENTAL CELL RESEARCH

Targeting fibroblast-growth-factor-receptor-dependent signaling for cancer therapy

(2011) Christine Heinzle et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Obesity short-circuits stemness gene network in human adipose multipotent stem cells

(2011) Mar Roldan et al.   FASEB JOURNAL

miRNAs and regulation of cell signaling

(2011) Atsuhiko Ichimura et al.   FEBS Journal

Heparanase and Syndecan-1 Interplay Orchestrates Fibroblast Growth Factor-2-induced Epithelial-Mesenchymal Transition in Renal Tubular Cells

(2011) Valentina Masola et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional analysis of microRNAs in human hepatocellular cancer stem cells

(2011) Fanyin Meng et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

MiR-125b, a MicroRNA Downregulated in Psoriasis, Modulates Keratinocyte Proliferation by Targeting FGFR2

(2011) Ning Xu et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Wnt5a as an Effector of TGFβ in Mammary Development and Cancer

(2011) Rosa Serra et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

N-(2-{3-[3,5-Bis(trifluoromethyl)phenyl]ureido}ethyl)-glycyrrhetinamide (6b): A Novel Anticancer Glycyrrhetinic Acid Derivative that Targets the Proteasome and Displays Anti-Kinase Activity

(2011) Benjamin Lallemand et al.   JOURNAL OF MEDICINAL CHEMISTRY

Contribution of Epithelial-to-Mesenchymal Transition and Cancer Stem Cells to Pancreatic Cancer Progression

(2011) Seth B. Krantz et al.   JOURNAL OF SURGICAL RESEARCH

Deep sequencing of gastric carcinoma reveals somatic mutations relevant to personalized medicine

(2011) Joanna D Holbrook et al.   Journal of Translational Medicine

FOXO1–FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma

(2011) Jinglan Liu et al.   MODERN PATHOLOGY

FGFR2 alterations in endometrial carcinoma

(2011) Sonia Gatius et al.   MODERN PATHOLOGY

Insertional mutagenesis identifies multiple networks of cooperating genes driving intestinal tumorigenesis

(2011) H Nikki March et al.   NATURE GENETICS

MicroRNA Expression Signatures of Bladder Cancer Revealed by Deep Sequencing

(2011) Yonghua Han et al.   PLoS One

Polarized Endocytosis of the Keratinocyte Growth Factor Receptor in Migrating Cells: Role of Src-Signaling and Cortactin

(2011) Francesca Belleudi et al.   PLoS One

Expression of DNMT1 and DNMT3a Are Regulated by GLI1 in Human Pancreatic Cancer

(2011) ShanShan He et al.   PLoS One

Targeting mutant fibroblast growth factor receptors in cancer

(2011) Heidi Greulich et al.   TRENDS IN MOLECULAR MEDICINE

Genetic basis of potential therapeutic strategies for craniosynostosis

(2010) Heather Melville et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Risk of aggressive breast cancer in women of Han nationality carrying TGFB1 rs1982073 C allele and FGFR2 rs1219648 G allele in North China

(2010) Xiao-Hui Chen et al.   BREAST CANCER RESEARCH AND TREATMENT

RNA technology targeted to the WNT signaling pathway

(2010) Masaru Katoh   CANCER BIOLOGY & THERAPY

Blockade of FGF signaling: Therapeutic promise for ovarian cancer

(2010) Mircea Ivan et al.   CANCER BIOLOGY & THERAPY

Fibroblast Growth Factor Receptor Signaling Dramatically Accelerates Tumorigenesis and Enhances Oncoprotein Translation in the Mouse Mammary Tumor Virus–Wnt-1 Mouse Model of Breast Cancer

(2010) Adam C. Pond et al.   CANCER RESEARCH

MK-2461, a Novel Multitargeted Kinase Inhibitor, Preferentially Inhibits the Activated c-Met Receptor

(2010) B.-S. Pan et al.   CANCER RESEARCH

Monoclonal Antibodies to Fibroblast Growth Factor Receptor 2 Effectively Inhibit Growth of Gastric Tumor Xenografts

(2010) W.-m. Zhao et al.   CLINICAL CANCER RESEARCH

The Role of Notch Signaling Pathway in Epithelial-Mesenchymal Transition (EMT) During Development and Tumor Aggressiveness

(2010) Zhiwei Wang et al.   CURRENT DRUG TARGETS

Genetic alterations of FGF receptors: an emerging field in clinical cancer diagnostics and therapeutics

(2010) Masaru Katoh   Expert Review of Anticancer Therapy

8p11 myeloproliferative syndrome: a review

(2010) Courtney C. Jackson et al.   HUMAN PATHOLOGY

Differential Phosphoproteomics of Fibroblast Growth Factor Signaling: Identification of Src Family Kinase-Mediated Phosphorylation Events

(2010) Debbie L. Cunningham et al.   JOURNAL OF PROTEOME RESEARCH

ErbB family receptor inhibitors as therapeutic agents in breast cancer: Current status and future clinical perspective

(2010) Ruchi Saxena et al.   MEDICINAL RESEARCH REVIEWS

Mitogen-Activated Protein Kinases Promote WNT/ -Catenin Signaling via Phosphorylation of LRP6

(2010) I. Cervenka et al.   MOLECULAR AND CELLULAR BIOLOGY

The Wnt/beta-catenin pathway in adrenocortical development and cancer

(2010) Abeer El Wakil et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Asymmetric tyrosine kinase arrangements in activation or autophosphorylation of receptor tyrosine kinases

(2010) Jae Hyun Bae et al.   MOLECULES AND CELLS

Antiglioma effects of a new, low molecular mass, inhibitor of fibroblast growth factor

(2010) Pedro Cuevas et al.   NEUROSCIENCE LETTERS

Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer

(2010) Eunice L. Kwak et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrative molecular profiling of triple negative breast cancers identifies amplicon drivers and potential therapeutic targets

(2010) N Turner et al.   ONCOGENE

Frequent and Focal FGFR1 Amplification Associates with Therapeutically Tractable FGFR1 Dependency in Squamous Cell Lung Cancer

(2010) J. Weiss et al.   Science Translational Medicine

Epigenetic regulation of WNT signaling in chronic lymphocytic leukemia

(2010) Lynda B Bennett et al.   Epigenomics

Role of epigenomics in ovarian and endometrial cancers

(2010) Curtis Balch et al.   Epigenomics

Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

(2010) Mia M. Gaudet et al.   PLoS Genetics

Systematic detection of putative tumor suppressor genes through the combined use of exome and transcriptome sequencing

(2010) Qi Zhao et al.   GENOME BIOLOGY

AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance

(2009) Thomas O'Hare et al.   CANCER CELL

The Role of Fibroblast Growth Factors in Tumor Growth

(2009) M. Korc et al.   CURRENT CANCER DRUG TARGETS

Hedgehog Target Genes: Mechanisms of Carcinogenesis Induced by Aberrant Hedgehog Signaling Activation

(2009) Y. Katoh et al.   CURRENT MOLECULAR MEDICINE

Cell Cycle Control of Wnt Receptor Activation

(2009) Gary Davidson et al.   DEVELOPMENTAL CELL

Fibroblast growth factor 8 increases breast cancer cell growth by promoting cell cycle progression and by protecting against cell death

(2009) Emeli M. Nilsson et al.   EXPERIMENTAL CELL RESEARCH

FGFR2 variants and breast cancer risk: fine-scale mapping using African American studies and analysis of chromatin conformation

(2009) Miriam S. Udler et al.   HUMAN MOLECULAR GENETICS

The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects

(2009) Sara Ota et al.   HUMAN MOLECULAR GENETICS

FGFR2-related pathogenesis and FGFR2-targeted therapeutics (Review)

(2009) Katoh   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Transcriptional mechanisms of WNT5A based on NF-κB, Hedgehog, TGFβ, and Notch signaling cascades

(2009) Katoh   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Antibody-based targeting of FGFR3 in bladder carcinoma and t(4;14)-positive multiple myeloma in mice

(2009) Jing Qing et al.   JOURNAL OF CLINICAL INVESTIGATION

FGFR2 Abnormalities Underlie a Spectrum of Bone, Skin, and Cancer Pathologies

(2009) Masaru Katoh   JOURNAL OF INVESTIGATIVE DERMATOLOGY

A Wnt Survival Guide: From Flies to Human Disease

(2009) Andy J. Chien et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Loss-of-Function Fibroblast Growth Factor Receptor-2 Mutations in Melanoma

(2009) Michael G. Gartside et al.   MOLECULAR CANCER RESEARCH

Wnt/Planar cell polarity signaling: A new paradigm for cancer therapy

(2009) Y. Wang   MOLECULAR CANCER THERAPEUTICS

The FGF family: biology, pathophysiology and therapy

(2009) Andrew Beenken et al.   NATURE REVIEWS DRUG DISCOVERY

Evolutionary history of the Snail/Scratch superfamily

(2009) Alejandro Barrallo-Gimeno et al.   TRENDS IN GENETICS

Variation in the miRNA-433 Binding Site of FGF20 Confers Risk for Parkinson Disease by Overexpression of α-Synuclein

(2008) Gaofeng Wang et al.   AMERICAN JOURNAL OF HUMAN GENETICS

FGF10 maintains distal lung bud epithelium and excessive signaling leads to progenitor state arrest, distalization, and goblet cell metaplasia

(2008) Pia Nyeng et al.   BMC DEVELOPMENTAL BIOLOGY

Inhibition of Fibroblast Growth Factor 19 Reduces Tumor Growth by Modulating  -Catenin Signaling

(2008) R. Pai et al.   CANCER RESEARCH

BIBF 1120: Triple Angiokinase Inhibitor with Sustained Receptor Blockade and Good Antitumor Efficacy

(2008) F. Hilberg et al.   CANCER RESEARCH

Brivanib Alaninate, a Dual Inhibitor of Vascular Endothelial Growth Factor Receptor and Fibroblast Growth Factor Receptor Tyrosine Kinases, Induces Growth Inhibition in Mouse Models of Human Hepatocellular Carcinoma

(2008) H. Huynh et al.   CLINICAL CANCER RESEARCH

Genetic Susceptibility Loci for Breast Cancer by Estrogen Receptor Status

(2008) M. Garcia-Closas et al.   CLINICAL CANCER RESEARCH

WNT Signaling in Stem Cell Biology and Regenerative Medicine

(2008) Masaru Katoh   CURRENT DRUG TARGETS

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

The expanding world of small RNAs

(2008) Helge Großhans et al.   NATURE

Structural diversity of G protein-coupled receptors and significance for drug discovery

(2008) Malin C. Lagerström et al.   NATURE REVIEWS DRUG DISCOVERY

Neural tube derived Wnt signals cooperate with FGF signaling in the formation and differentiation of the trigeminal placodes

(2008) Claire A Canning et al.   Neural Development

EGFR Antagonists in Cancer Treatment

(2008) Fortunato Ciardiello et al.   NEW ENGLAND JOURNAL OF MEDICINE

Drug-sensitive FGFR2 mutations in endometrial carcinoma

(2008) A. Dutt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antisera induced by infusions of autologous Ad-CD154-leukemia B cells identify ROR1 as an oncofetal antigen and receptor for Wnt5a

(2008) T. Fukuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combined targeting of EGFR-dependent and VEGF-dependent pathways: rationale, preclinical studies and clinical applications

(2008) Giampaolo Tortora et al.   Nature clinical practice. Oncology

Mechanisms of Disease: epithelial–mesenchymal transition—does cellular plasticity fuel neoplastic progression?

(2008) Eva A Turley et al.   Nature clinical practice. Oncology

Advances in MicroRNAs: Implications for Gene Therapists

(2007) Rebecca T. Marquez et al.   HUMAN GENE THERAPY