Article
Biochemistry & Molecular Biology
Hsin-Ying Clair Chiou, Chih-Wen Wang, Szu-Chia Chen, Mei-Lan Tsai, Ming-Hong Lin, Chih-Hsing Hung, Chao-Hung Kuo
Summary: Copper is an essential trace element in the human body, but excessive exposure to it can harm human health. This study evaluated the effect of copper on lung fibrosis using in vitro cell culture models and epidemiologic studies. It was found that copper treatment decreased cell viability and promoted epithelial-mesenchymal transition (EMT) and autophagy in lung cells. Flavonoids were shown to inhibit the effects of copper-induced EMT. In humans, increased urinary copper was associated with an increased risk of lung fibrotic changes. These findings highlight the risk of copper in lung fibrosis and suggest potential remedies.
Article
Multidisciplinary Sciences
Shunhao Wang, Jingchao Li, Mei Chen, Liting Ren, Wenya Feng, Lining Xu, Xiaolan Chen, Tian Xia, Nanfeng Zheng, Sijin Liu
Summary: Palladium nanoplates inhibit lung metastasis by suppressing EMT signaling in breast cancer cells and interacting with TGF-beta proteins, leading to reduced downstream signaling activation. NIR irradiation enhances the inhibitory effects of PdPL on both primary tumors and metastasis.
NATIONAL SCIENCE REVIEW
(2021)
Article
Cell Biology
Buse Cevatemre, Engin Ulukaya, Egemen Dere, Sukru Dilege, Ceyda Acilan
Summary: There has been growing interest in the role of mitochondria in metastatic cascade. This study demonstrates that inhibiting PDH can induce EMT and result in chemoresistance.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Medicine, Research & Experimental
Yan Sun, Lang Xiong, Xiaoran Wang, Liping Wang, Baoxin Chen, Jingqi Huang, Mi Huang, Jieping Chen, Jing Wu, Shan Huang, Yizhi Liu
Summary: This study demonstrated that TGF-beta 2 induces autophagy flux during EMT progression of LECs, with autophagy activation enhancing fibrogenic responses and cell migration, while autophagy inhibition alleviates EMT markers and cell migration. Additionally, modulation of Smad signaling by autophagy was observed, and ATG7-silenced LECs showed antifibrosis effect induced by TGF-beta 2. Overall, intervention/inhibition of autophagy could attenuate TGF-beta 2-induced EMT in LECs, providing insights for preventing and treating fibrotic cataracts and other fibrotic diseases.
Review
Biochemistry & Molecular Biology
Ming-Yu Chou, Muh-Hwa Yang
Summary: The interplay between EMT and immune metabolic changes in cancer cells during tumor metastasis has gained interest among researchers. Understanding how they influence each other may provide novel explanations for immune surveillance during metastasis. Studying immunometabolism in the regulatory loop between tumor-infiltrating immune cells and EMT is crucial for cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Ji-Yong Sung, Jae-Ho Cheong
Summary: Genomic classification has identified a distinct molecular subtype of clinically refractory cancers associated with EMT. Metabolic profiling across different cancer types revealed high carbohydrate and energy metabolism linked to high EMT activity in 80 to 90% of cases. CHST14 was highlighted as a potential metabolic target for stomach cancer, indicating the importance of metabolism-associated genes in targeting therapy for cancer subtypes.
Article
Biology
Valentina Cutano, Jessica Marianne Ferreira Mendes, Sara Escudeiro-Lopes, Susana Machado, Judith Vinaixa Forner, Juan M. Gonzales-Morena, Martin Prevorovsky, Viacheslav Zemlianski, Yuxiong Feng, Petra Kralova Viziova, Andrea Hartmanova, Beata Malcekova, Pavel Jakoube, Sonia Iyer, Zuzana Keckesova
Summary: This study demonstrates the tumor suppressor properties of mitochondrial protein LACTB in ovarian cancer, showing its ability to inhibit cancer cell growth and migration through the regulation of cell differentiation and stemness properties. By targeting the EMT program and Snail2/Slug transcription factor, LACTB presents a new therapeutic approach for ovarian cancer.
LIFE SCIENCE ALLIANCE
(2022)
Article
Oncology
Andreia S. Margarido, Rebeca Uceda-Castro, Kerstin Hahn, Roebi de Bruijn, Lennart Kester, Ingrid Hofland, Jeroen Lohuis, Danielle Seinstra, Annegien Broeks, Jos Jonkers, Marike L. D. Broekman, Pieter Wesseling, Claire Vennin, Miguel Vizoso, Jacco van Rheenen
Summary: The study demonstrates that breast cancer brain metastasis cells undergo epithelial-to-mesenchymal transition (EMT) when infiltrating the brain parenchyma, and removing these infiltrated tumor cells can improve surgical efficacy, providing new avenues for patient treatment.
Article
Medicine, Research & Experimental
Jiaxin Zhang, Jie Peng, Deqin Kong, Xiang Wang, Zhao Wang, Jiangzheng Liu, Weihua Yu, Hao Wu, Zi Long, Wei Zhang, Rui Liu, Chunxu Hai
Summary: The NAD+-dependent protein-modifying enzyme SIRT1 plays a crucial role in regulating gene expression, DNA damage repair, cell metabolism, and mitochondrial functions, influencing epithelial-to-mesenchymal transition in lung cancer cells by modulating mitochondrial status.
Article
Medicine, Research & Experimental
Vignesh Ramesh, Paradesi Naidu Gollavilli, Luisa Pinna, Mohammad Aarif Siddiqui, Adriana Martinez Turtos, Francesca Napoli, Yasmin Antonelli, Aldo Leal-Egana, Jesper Foged Havelund, Simon Toftholm Jakobsen, Elisa Le Boiteux, Marco Volante, Nils Joakim Faergeman, Ole N. Jensen, Rasmus Siersbaek, Kumar Somyajit, Paolo Ceppi
Summary: This study found an inverse association between short-chain fatty acids and EMT in non-small cell lung cancer patients. In vitro experiments showed that propionate treatment enhanced the epithelial transcriptional program and reduced the EMT phenotype in lung cancer cell lines. Animal experiments also confirmed that propionate can reduce lung cancer metastasis and lymph node spread. Further mechanistic investigation revealed that propionate treatment caused chromatin remodeling through p300-mediated histone acetylation.
EMBO MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Huiyan Niu, Anna Qu, Chunyan Guan
Summary: The study revealed that miR-188-5p inhibits invasion and migration of lung cancer cells by regulating the MGAT3 gene, thereby suppressing the EMT process, suggesting potential therapeutic value for the management of metastatic lung cancer.
BIOMEDICAL JOURNAL
(2021)
Article
Oncology
Iori Motoo, Sohachi Nanjo, Takayuki Ando, Satoshi Yamashita, Toshikazu Ushijima, Ichiro Yasuda
Summary: The study reveals that in diffuse-type gastric cancers, ULK2 is methylated and knockdown of ULK2 can induce autophagy, cell migration, and EMT. mRNA microarray analysis showed that knockdown of ULK2 altered the expressions of oncogenic genes associated with cell migration and EMT.
Article
Cardiac & Cardiovascular Systems
Yan Li, Bei Song, Chengchao Ruan, WenJie Xue, Jianrong Zhao
Summary: The study demonstrated that AdipoRon inhibits EMT in the kidney by activating the AMPK/ULK1 pathway, leading to the improvement of renal fibrosis induced by hypertension. This suggests that AdipoRon could be a potential therapeutic option for preventing renal fibrosis in hypertensive patients.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Food Science & Technology
Yuting Hao, Dongliang Feng, Huarui Ye, Wenzhen Liao
Summary: NOB can protect hepatocytes from undergoing EMT during liver fibrosis by inducing autophagy and subsequently modulating the Hippo/YAP pathway. Nobiletin significantly suppresses liver fibrosis in CCl4-induced mice and mitigates EMT in hepatocytes. Further investigation demonstrates that NOB can protect hepatocytes from undergoing EMT during liver fibrosis by regulating autophagy and the Hippo/YAP pathway.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
Article
Cell Biology
Zhenhua Zhou, Huiyan Wang, Xiwen Zhang, Minmin Song, Simin Yao, Peipei Jiang, Dan Liu, Zhiyin Wang, Haining Lv, Ruotian Li, Ying Hong, Jianwu Dai, Yali Hu, Guangfeng Zhao
Summary: Defective autophagy plays an important role in endometrial fibrosis by regulating EEC-EMT through the DIO2-MAPK/ERK-MTOR pathway.
Review
Oncology
Nathan M. Hawkey, Amanda Broderick, Daniel J. George, Oliver Sartor, Andrew J. Armstrong
Summary: Prostate cancer, the most common cancer among men, can be improved by precision medicine through the use of molecular and genomic biomarkers. However, this benefit is limited to a minority of patients, and phenotypic precision medicine may provide a more individualized approach. This review article discusses the background, clinical benefits, and limitations of genomic and phenotypic precision medicine in prostate cancer.
Review
Oncology
Edina C. Wang, W. Robert Lee, Andrew J. Armstrong
Summary: Recent data suggest that the use of abiraterone acetate and prednisone may improve overall survival, disease-free survival, and metastasis-free survival in men with high-risk localized, node positive, and oligometastatic hormone-sensitive prostate cancer. The addition of potent androgen receptor inhibitors after radiation therapy may be considered after informed decision making.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Editorial Material
Oncology
Landon C. Brown, Andrew J. Armstrong
JCO ONCOLOGY PRACTICE
(2023)
Article
Medicine, General & Internal
Amanda Broderick, Matthew K. Labriola, Neal Shore, Andrew J. Armstrong
Summary: A man with metastatic hormone-sensitive prostate cancer presented with foreign accent syndrome (FAS), characterized by an uncontrollable 'Irish brogue' accent. Despite no Irish background, the FAS was identified as the presenting manifestation of transformation to small cell neuroendocrine prostate cancer (NEPC). The patient's NEPC progressed despite chemotherapy, resulting in brain metastases and likely paraneoplastic ascending paralysis leading to death.
Article
Oncology
Hannah D. McManus, Dylan Zhang, Fides R. Schwartz, Yuan Wu, Jordan Infield, Ethan Ho, Andrew J. Armstrong, Daniel J. George, Danielle Kruse, Rajan T. Gupta, Michael R. Harrison
Summary: Radiographically assessed body composition variables, including muscle and adipose tissue, may serve as prognostic biomarkers in patients with metastatic renal cell carcinoma. Low skeletal muscle index and low subcutaneous adipose tissue index were associated with significantly better progression-free survival.
CLINICAL GENITOURINARY CANCER
(2023)
Article
Oncology
Michael J. Morris, Glenn Heller, David W. Hillman, Olivia Bobek, Charles Ryan, Emmanuel S. Antonarakis, Alan H. Bryce, Olwen Hahn, Himisha Beltran, Andrew J. Armstrong, Lawrence Schwartz, Lionel D. Lewis, Jan H. Beumer, Brooke Langevin, Eric C. McGary, Paul T. Mehan, Amir Goldkorn, Bruce J. Roth, Han Xiao, Colleen Watt, Mary-Ellen Taplin, Susan Halabi, Eric J. Small
Summary: The purpose of this study was to determine whether the addition of abiraterone acetate and prednisone (AAP) to enzalutamide prolongs overall survival (OS) in patients with metastatic castration-resistant prostate cancer (mCRPC) in the first-line setting. The results showed that the addition of AAP did not provide a statistically significant benefit in OS compared to enzalutamide treatment alone.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Hannah D. Mcmanus, Andrew J. Armstrong
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Oncology
Susan Halabi, Qian Yang, Akash Roy, Bin Luo, John C. Araujo, Christopher Logothetis, Cora N. Sternberg, Andrew J. Armstrong, Michael A. Carducci, Kim N. Chi, Johann S. de Bono, Daniel P. Petrylak, Karim Fizazi, Celestia S. Higano, Michael J. Morris, Dana E. Rathkopf, Fred Saad, Charles J. Ryan, Eric J. Small, William Kevin Kelly
Summary: This study validated a prognostic model of overall survival in men with metastatic, castration-resistant prostate cancer treated with docetaxel. The model accurately predicts the survival of patients and performs well across different racial, age, and treatment subgroups.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Seemadri Subhadarshini, Joel Markus, Sarthak Sahoo, Mohit Kumar Jolly
Summary: Epithelial-mesenchymal plasticity (EMP) is a crucial factor in cancer metastasis and therapeutic resistance, allowing cancer cells to alter their characteristics along the epithelial-mesenchymal spectrum. Single-cell studies have provided valuable insights into the dynamics of EMP, showing the heterogeneity of hybrid epithelial/mesenchymal phenotypes and their impact on patient survival.
Article
Oncology
William Butler, Colin McDowell, Qing Yang, Yiping He, Yue Zhao, J. Spencer Hauck, Yinglu Zhou, Hong Zhang, Andrew J. Armstrong, Daniel J. George, Richard Drake, Jiaoti Huang
Summary: The glycome in prostate cancer undergoes significant changes during disease progression and therapy resistance, with specific glycosylation patterns correlating with remission, resistance, recurrence, and neuroendocrine differentiation. These findings have important implications for the diagnosis and treatment of prostate cancer.
NPJ PRECISION ONCOLOGY
(2023)
Article
Mathematical & Computational Biology
Kishore Hari, William Duncan, Mohammed Adil Ibrahim, Mohit Kumar Jolly, Breschine Cummins, Tomas Gedeon
Summary: Mathematical modeling of gene regulatory networks (GRN) is challenging due to parameter dependence and lack of reliable experimental parameters. This study compares two approaches, RACIPE and DSGRN, for describing GRN dynamics across unknown parameters and finds agreement in simulation and predictions for cellular decision making. The observation is important as DSGRN parameter domains accurately predict ODE model dynamics within a biologically reasonable range of parameters.
NPJ SYSTEMS BIOLOGY AND APPLICATIONS
(2023)
Review
Computer Science, Interdisciplinary Applications
Maalavika Pillai, Emilia Hojel, Mohit Kumar Jolly, Yogesh Goyal
Summary: Computational models and tools have been used to understand the origins and nature of non-genetic heterogeneity in cancer, which has significant clinical implications. Non-genetic heterogeneity is increasingly associated with therapy resistance and metastasis in cancer. Identifying the origins of non-genetic heterogeneity is crucial for making clinical breakthroughs.
NATURE COMPUTATIONAL SCIENCE
(2023)
Article
Multidisciplinary Sciences
Paras Jain, Sophia Corbo, Kulsoom Mohammad, Sarthak Sahoo, Santhalakshmi Ranganathan, Jason T. George, Herbert Levine, Joseph Taube, Michael Toneff, Mohit Kumar Jolly
Summary: Epithelial-mesenchymal transition (EMT) and its reverse mesenchymal-epithelial transition (MET) play crucial roles in embryonic development, wound healing, and cancer metastasis. While short-term EMT induction can lead to reversible phenotypic changes, long-term EMT induction is often associated with irreversibility. In this study, we demonstrate that the phenotypic changes observed in MCF10A cells during long-term EMT induction by TGF-beta can in fact have longer timescales of reversibility. We also propose a mathematical model that explains how the epigenetic memory gained during long-term EMT induction can slow down the recovery to the epithelial state after TGF-beta withdrawal.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2023)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Andrology
Zoe D. Michael, Srinath Kotamarti, Rohith Arcot, Kostantinos Morris, Anand Shah, John Anderson, Andrew J. Armstrong, Rajan T. Gupta, Steven Patierno, Nadine J. Barrett, Daniel J. George, Glenn M. Preminger, Judd W. Moul, Kevin C. Oeffinger, Kevin Shah, Thomas J. Polascik
Summary: Preliminary outcomes of a multidisciplinary screening algorithm showed that prostate cancer could be detected in a small percentage of men in their forties, highlighting the importance of early risk stratification and detection of high-risk patients.
WORLD JOURNAL OF MENS HEALTH
(2023)