Function of the endolysosomal network in cholesterol homeostasis and metabolic-associated fatty liver disease (MAFLD)

MAFLD: A consensus-driven proposed nomenclature for metabolic associated fatty liver disease

(2020) Mohammed Eslam et al.   GASTROENTEROLOGY

NAFLD 2020: The State of the Disease

(2020) Thomas G. Cotter et al.   GASTROENTEROLOGY

Staying in touch with the endocytic network: the importance of contacts for cholesterol transport

(2020) Andrea Martello et al.   TRAFFIC

Cholesterol Stabilizes TAZ in Hepatocytes to Promote Experimental Non-alcoholic Steatohepatitis

(2020) Xiaobo Wang et al.   Cell Metabolism

Aster proteins regulate the accessible cholesterol pool in the plasma membrane

(2020) Alessandra Ferrari et al.   MOLECULAR AND CELLULAR BIOLOGY

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

(2020) Michael N. Trinh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

POST1/C12ORF49 regulates the SREBP pathway by promoting site-1 protease maturation

(2020) Jian Xiao et al.   Protein & Cell

Low-density Lipoprotein-Cholesterol Lowering Strategies for Prevention of Atherosclerotic Cardiovascular Disease: Focus on siRNA Treatment Targeting PCSK9 (Inclisiran)

(2020) David Sinning et al.   Current Cardiology Reports

Hepatocyte Sortilin 1 knockout and treatment with a Sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice

(2019) Cheng Chen et al.   JOURNAL OF LIPID RESEARCH

Inflammasomes, Neutrophil Extracellular Traps, and Cholesterol

(2019) Alan R. Tall et al.   JOURNAL OF LIPID RESEARCH

Role of sortilin in lipid metabolism

(2019) Donna M. Conlon   CURRENT OPINION IN LIPIDOLOGY

Metabolic regulation through the endosomal system

(2019) Jerome Gilleron et al.   TRAFFIC

COMMD1 and PtdIns(4,5)P2 interaction maintain ATP7B copper transporter trafficking fidelity in HepG2 cells

(2019) Davis J. Stewart et al.   JOURNAL OF CELL SCIENCE

Annexin A6 modulates TBC1D15/Rab7/StARD3 axis to control endosomal cholesterol export in NPC1 cells

(2019) Elsa Meneses-Salas et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

PDZD8 mediates a Rab7-dependent interaction of the ER with late endosomes and lysosomes

(2019) Andrés Guillén-Samander et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endosomal PI(3)P regulation by the COMMD/CCDC22/CCDC93 (CCC) complex controls membrane protein recycling

(2019) Amika Singla et al.   Nature Communications

Movement of accessible plasma membrane cholesterol by the GRAMD1 lipid transfer protein complex

(2019) Tomoki Naito et al.   eLife

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

(2018) Michael S. Brown et al.   Annual Review of Biochemistry

Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis

(2018) Yifeng Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The COMMD Family Regulates Plasma LDL Levels and Attenuates Atherosclerosis Through Stabilizing the CCC Complex in Endosomal LDLR TraffickingNovelty and Significance

(2018) Alina Fedoseienko et al.   CIRCULATION RESEARCH

(Pro)renin Receptor Inhibition Reprograms Hepatic Lipid Metabolism and Protects Mice From Diet-Induced Obesity and HepatosteatosisNovelty and Significance

(2018) Liwei Ren et al.   CIRCULATION RESEARCH

The complex molecular genetics of familial hypercholesterolaemia

(2018) Amanda J. Berberich et al.   Nature Reviews Cardiology

GRAM domain proteins specialize functionally distinct ER-PM contact sites in human cells

(2018) Marina Besprozvannaya et al.   eLife

Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells

(2018) Jaspreet Sandhu et al.   CELL

To degrade or not to degrade: mechanisms and significance of endocytic recycling

(2018) Peter J. Cullen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The adaptor protein PID1 regulates receptor-dependent endocytosis of postprandial triglyceride-rich lipoproteins

(2018) Alexander W. Fischer et al.   Molecular Metabolism

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis

(2018) Natalie Krahmer et al.   DEVELOPMENTAL CELL

Retromer has a selective function in cargo sorting via endosome transport carriers

(2018) Yi Cui et al.   JOURNAL OF CELL BIOLOGY

Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

(2018) Jie Luo et al.   TRENDS IN BIOCHEMICAL SCIENCES

Sigma-2 Receptor/TMEM97 and PGRMC-1 Increase the Rate of Internalization of LDL by LDL Receptor through the Formation of a Ternary Complex

(2018) Aladdin Riad et al.   Scientific Reports

Regulation of selective autophagy: the p62/SQSTM1 paradigm

(2017) Trond Lamark et al.   Essays in Biochemistry

Low-density lipoproteins cause atherosclerotic cardiovascular disease. 1. Evidence from genetic, epidemiologic, and clinical studies. A consensus statement from the European Atherosclerosis Society Consensus Panel

(2017) Brian A. Ference et al.   EUROPEAN HEART JOURNAL

The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases

(2017) Naga Chalasani et al.   HEPATOLOGY

Retriever is a multiprotein complex for retromer-independent endosomal cargo recycling

(2017) Kerrie E. McNally et al.   NATURE CELL BIOLOGY

SREBP-regulated lipid metabolism: convergent physiology — divergent pathophysiology

(2017) Hitoshi Shimano et al.   Nature Reviews Endocrinology

Oxysterol-Binding Protein-Related Protein 1L Regulates Cholesterol Egress from the Endo-Lysosomal System

(2017) Kexin Zhao et al.   Cell Reports

Continuous transport of a small fraction of plasma membrane cholesterol to endoplasmic reticulum regulates total cellular cholesterol

(2017) Rodney Elwood Infante et al.   eLife

Expression of SREBP-1c Requires SREBP-2-mediated Generation of a Sterol Ligand for LXR in Livers of Mice

(2017) Shunxing Rong et al.   eLife

Pathophysiology and Mechanisms of Nonalcoholic Fatty Liver Disease

(2016) Joel T. Haas et al.   Annual Review of Physiology

An ER-Associated Pathway Defines Endosomal Architecture for Controlled Cargo Transport

(2016) Marlieke L.M. Jongsma et al.   CELL

Reduction of TMEM97 increases NPC1 protein levels and restores cholesterol trafficking in Niemann-pick type C1 disease cells

(2016) Darius Ebrahimi-Fakhari et al.   HUMAN MOLECULAR GENETICS

Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1

(2016) Jibiao Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rab24 interacts with the Rab7/Rab interacting lysosomal protein complex to regulate endosomal degradation

(2016) Celina Amaya et al.   TRAFFIC

Genomics of human fatty liver disease reveal mechanistically linked lipid droplet–associated gene regulations in bland steatosis and nonalcoholic steatohepatitis

(2016) Nishika Sahini et al.   Translational Research

Arf6 controls retromer traffic and intracellular cholesterol distribution via a phosphoinositide-based mechanism

(2016) Catherine Marquer et al.   Nature Communications

CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL

(2016) Paulina Bartuzi et al.   Nature Communications

SORTILIN: Many Headed Hydra

(2015) M. Westerterp et al.   CIRCULATION RESEARCH

The life cycle of the low-density lipoprotein receptor

(2015) Melinde Wijers et al.   CURRENT OPINION IN LIPIDOLOGY

The small GTPase Rab7 as a central regulator of hepatocellular lipophagy

(2015) Barbara Schroeder et al.   HEPATOLOGY

Sortilin deficiency improves the metabolic phenotype and reduces hepatic steatosis of mice subjected to diet-induced obesity

(2015) Liane Rabinowich et al.   JOURNAL OF HEPATOLOGY

COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A

(2015) Christine A. Phillips-Krawczak et al.   MOLECULAR BIOLOGY OF THE CELL

Repeated ER–endosome contacts promote endosome translocation and neurite outgrowth

(2015) Camilla Raiborg et al.   NATURE

Retromer Ensures the Degradation of Autophagic Cargo by Maintaining Lysosome Function in Drosophila

(2015) Tamás Maruzs et al.   TRAFFIC

Regulation of Liver Metabolism by the Endosomal GTPase Rab5

(2015) Anja Zeigerer et al.   Cell Reports

Reduced Lysosomal Acid Lipase Activity in Adult Patients With Non-alcoholic Fatty Liver Disease

(2015) Francesco Baratta et al.   EBioMedicine

Lysosomal acid lipase deficiency – An under-recognized cause of dyslipidaemia and liver dysfunction

(2014) Željko Reiner et al.   ATHEROSCLEROSIS

A cell-type-specific role for murine Commd1 in liver inflammation

(2014) Paulina Bartuzi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

ER Contact Sites Define the Position and Timing of Endosome Fission

(2014) Ashley A. Rowland et al.   CELL

Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome

(2014) Mateusz Kolanczyk et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Small regulators, major consequences - Ca2+ and cholesterol at the endosome-ER interface

(2014) R. van der Kant et al.   JOURNAL OF CELL SCIENCE

Role of autophagy in the pathophysiology of nonalcoholic fatty liver disease: A controversial issue

(2014) Wilhelmus J Kwanten   WORLD JOURNAL OF GASTROENTEROLOGY

High susceptibility to fatty liver disease in two-pore channel 2-deficient mice

(2014) Christian Grimm et al.   Nature Communications

Mutation in VPS35 associated with Parkinson’s disease impairs WASH complex association and inhibits autophagy

(2014) Eszter Zavodszky et al.   Nature Communications

Three pools of plasma membrane cholesterol and their relation to cholesterol homeostasis

(2014) Akash Das et al.   eLife

Organization and function of membrane contact sites

(2013) Sebastian C.J. Helle et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Autophagy regulation by nutrient signaling

(2013) Ryan C Russell et al.   CELL RESEARCH

LDL Cholesterol Recycles to the Plasma Membrane via a Rab8a-Myosin5b-Actin-Dependent Membrane Transport Route

(2013) Kristiina Kanerva et al.   DEVELOPMENTAL CELL

WASH inhibits autophagy through suppression of Beclin 1 ubiquitination

(2013) Pengyan Xia et al.   EMBO JOURNAL

A novel mutation inKIAA0196: identification of a gene involved in Ritscher–Schinzel/3C syndrome in a First Nations cohort

(2013) Alison M Elliott et al.   JOURNAL OF MEDICAL GENETICS

IDOL Stimulates Clathrin-Independent Endocytosis and Multivesicular Body-Mediated Lysosomal Degradation of the Low-Density Lipoprotein Receptor

(2013) E. Scotti et al.   MOLECULAR AND CELLULAR BIOLOGY

A global analysis of SNX27–retromer assembly and cargo specificity reveals a function in glucose and metal ion transport

(2013) Florian Steinberg et al.   NATURE CELL BIOLOGY

Retromer-mediated endosomal protein sorting: all WASHed up!

(2013) Matthew N.J. Seaman et al.   TRENDS IN CELL BIOLOGY

Low-Density Lipoprotein Receptor Gene Familial Hypercholesterolemia Variant Database: Update and Pathological Assessment

(2012) Ebele Usifo et al.   ANNALS OF HUMAN GENETICS

Increased Hepatic Synthesis and Dysregulation of Cholesterol Metabolism Is Associated with the Severity of Nonalcoholic Fatty Liver Disease

(2012) Hae-Ki Min et al.   Cell Metabolism

The Scap/SREBP Pathway Is Essential for Developing Diabetic Fatty Liver and Carbohydrate-Induced Hypertriglyceridemia in Animals

(2012) Young-Ah Moon et al.   Cell Metabolism

Impaired proteolysis underlies autophagic dysfunction in Niemann–Pick type C disease

(2012) Matthew J. Elrick et al.   HUMAN MOLECULAR GENETICS

Trafficking defects in WASH-knockout fibroblasts originate from collapsed endosomal and lysosomal networks

(2012) Timothy S. Gomez et al.   MOLECULAR BIOLOGY OF THE CELL

Recommendations for the diagnosis and management of Niemann–Pick disease type C: An update

(2012) Marc C. Patterson et al.   MOLECULAR GENETICS AND METABOLISM

Rab5 is necessary for the biogenesis of the endolysosomal system in vivo

(2012) Anja Zeigerer et al.   NATURE

Cholesterol metabolism and the pathogenesis of non-alcoholic steatohepatitis

(2012) Giovanni Musso et al.   PROGRESS IN LIPID RESEARCH

Recruitment of the endosomal WASH complex is mediated by the extended ‘tail’ of Fam21 binding to the retromer protein Vps35

(2011) Michael E. Harbour et al.   BIOCHEMICAL JOURNAL

The copper-transporting capacity of ATP7A mutants associated with Menkes disease is ameliorated by COMMD1 as a result of improved protein expression

(2011) Willianne I. M. Vonk et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hepatic Free Cholesterol Accumulates in Obese, Diabetic Mice and Causes Nonalcoholic Steatohepatitis

(2011) Derrick M. Van Rooyen et al.   GASTROENTEROLOGY

A role for oxysterol-binding protein–related protein 5 in endosomal cholesterol trafficking

(2011) Ximing Du et al.   JOURNAL OF CELL BIOLOGY

CCDC22: a novel candidate gene for syndromic X-linked intellectual disability

(2011) I Voineagu et al.   MOLECULAR PSYCHIATRY

Liver-Specific Commd1 Knockout Mice Are Susceptible to Hepatic Copper Accumulation

(2011) Willianne I. M. Vonk et al.   PLoS One

Implication of mouse Vps26b–Vps29–Vps35 retromer complex in sortilin trafficking

(2010) Ekyune Kim et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Roles of COMM-domain-containing 1 in stability and recruitment of the copper-transporting ATPase in a mouse hepatoma cell line

(2010) Takamitsu Miyayama et al.   BIOCHEMICAL JOURNAL

Lysosomal fusion and SNARE function are impaired by cholesterol accumulation in lysosomal storage disorders

(2010) Alessandro Fraldi et al.   EMBO JOURNAL

Npc1 haploinsufficiency promotes weight gain and metabolic features associated with insulin resistance

(2010) D. Jelinek et al.   HUMAN MOLECULAR GENETICS

Niemann-Pick disease type C

(2010) Marie T Vanier   Orphanet Journal of Rare Diseases

Identification of Cholesterol-Regulating Genes by Targeted RNAi Screening

(2009) Fabian Bartz et al.   Cell Metabolism

The Arp2/3 Activator WASH Controls the Fission of Endosomes through a Large Multiprotein Complex

(2009) Emmanuel Derivery et al.   DEVELOPMENTAL CELL

A FAM21-Containing WASH Complex Regulates Retromer-Dependent Sorting

(2009) Timothy S. Gomez et al.   DEVELOPMENTAL CELL

Dissection of the Endogenous Cellular Pathways of PCSK9-induced Low Density Lipoprotein Receptor Degradation

(2009) Steve Poirier et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7–RILP–p150Gluedand late endosome positioning

(2009) Nuno Rocha et al.   JOURNAL OF CELL BIOLOGY

Enhanced free cholesterol, SREBP-2 and StAR expression in human NASH

(2009) Francisco Caballero et al.   JOURNAL OF HEPATOLOGY

Autophagy regulates lipid metabolism

(2009) Rajat Singh et al.   NATURE

Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations

(2009) David Meyre et al.   NATURE GENETICS

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Cellular cholesterol trafficking and compartmentalization

(2008) Elina Ikonen   NATURE REVIEWS MOLECULAR CELL BIOLOGY

NPC2 facilitates bidirectional transfer of cholesterol between NPC1 and lipid bilayers, a step in cholesterol egress from lysosomes

(2008) R. E. Infante et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural requirements for PCSK9-mediated degradation of the low-density lipoprotein receptor

(2008) D.-W. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol Level Regulates Endosome Motility via Rab Proteins

(2007) Hongtao Chen et al.   BIOPHYSICAL JOURNAL